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The Manapany day gecko Phelsuma inexpectata is a Critically Endangered species endemic to Réunion Island in the Indian Ocean. Studying its geographical distribution and its evolution is important for developing effective biodiversity conservation strategies. We evaluated past and current distributions of P. inexpectata using records from 2008–2020 and through recent, intensive field surveys (230 person-days, 2020–2022). We found that its past distribution has declined by more than 28% (5.12 ha), from 19.44 ha to 14.32 ha. In natural habitats, the distribution of P. inexpectata has been strongly affected, declining by c. 45%, but we identified new areas of occurrence (10.72 ha) through field surveys. Most of these new areas (79%) were found in anthropogenic habitats where the species had not been documented before. The current distribution of P. inexpectata covers c. 24 ha, of which 75% is located in urban areas such as gardens and green urban spaces. Moreover, our field survey showed that at least 10% of its range is now colonized by the invasive gold-dust day gecko Phelsuma laticauda. This survey provides an essential baseline for tracking the future distribution of this threatened species and its potential invasive competitor, and for monitoring how changes to its habitat affect the distribution of P. inexpectata.
From the near-Earth solar wind to the intracluster medium of galaxy clusters, collisionless, high-beta, magnetized plasmas pervade our universe. Energy and momentum transport from large-scale fields and flows to small-scale motions of plasma particles is ubiquitous in these systems, but a full picture of the underlying physical mechanisms remains elusive. The transfer is often mediated by a turbulent cascade of Alfvénic fluctuations as well as a variety of kinetic instabilities; these processes tend to be multi-scale and/or multi-dimensional, which makes them difficult to study using spacecraft missions and numerical simulations alone. Meanwhile, existing laboratory devices struggle to produce the collisionless, high ion beta ($\beta _i \gtrsim 1$), magnetized plasmas across the range of scales necessary to address these problems. As envisioned in recent community planning documents, it is therefore important to build a next generation laboratory facility to create a $\beta _i \gtrsim 1$, collisionless, magnetized plasma in the laboratory for the first time. A working group has been formed and is actively defining the necessary technical requirements to move the facility towards a construction-ready state. Recent progress includes the development of target parameters and diagnostic requirements as well as the identification of a need for source-target device geometry. As the working group is already leading to new synergies across the community, we anticipate a broad community of users funded by a variety of federal agencies (including National Aeronautics and Space Administration, Department of Energy and National Science Foundation) to make copious use of the future facility.
This article analyses a complex period in Colombian history, from the electoral victory of the Liberal Party in 1930 to the end of the Frente Nacional (National Front) in 1974, from the perspective of constitutional politics and constitutional theory. During this period, Colombia transited from democracy to dictatorship (civilian and military) and back to democracy. We therefore divide the period according to changes in regime type and also to changes in the degree of institutional constraints on power. We show that, due to combinations of regime type and constraints on power, under the same Constitution of 1886 three different constitutionalisms ensued: abusive, window-dressing, and authoritarian constitutionalism. Our analysis on Colombia highlights the role of powerful actors, such as the armed forces and the Catholic Church, that breathed life back into key constitutional provisions when these served as focal points for coordinating their actions even under an authoritarian regime.
Impulsivity and aggression are known risk factors for suicide, with observed age and sex differences in their impact.
Aims
To explore variations in impulsivity and aggression based on sex and age and examine their roles in predicting suicide.
Method
We examined 582 participants (406 individuals who died by suicide, 176 non-suicidal sudden-death controls) using the psychological autopsy method. Measures of impulsivity and aggression included the Barratt Impulsiveness Scale (BIS) and the Brown–Goodwin History of Aggression (BGHA). Participants were categorised into four groups: suicide male, control male, suicide female and control female. For group comparisons, we used analyses of variance and Spearman’s rank correlation to assess the relationship between age and BIS and/or BGHA ratings. Stepwise logistic regression was used to identify predictors of suicide for each sex.
Results
Higher levels of BIS and BGHA ratings were found in the suicide group compared with controls (BIS: 51.3 v. 42.2, P = 0.002, η2 = 0.017; BGHA: 7.1 v. 4.1, P < 0.001, η2 = 0.028), with no significant sex differences. BIS and BGHA ratings decreased with age in the suicide groups (suicide male: impulsivity ρ = −0.327, P < 0.001; suicide female: aggression ρ = −0.175, P = 0.038) but not among controls. Logistic regression analysis revealed that for men, aggression (odds ratio 1.072, 95% CI: 1.032–1.112) was a key predictor. For women, younger age (odds ratio 0.970, 95% CI: 0.948–0.993), low BIS impulsivity ratings (odds ratio 1.018, 95% CI: 1.001–1.036) and living with children (odds ratio 0.448, 95% CI: 0.208–0.966) were protective factors.
Conclusions
Impulsive and aggressive behaviours are critical factors in suicide risk among younger individuals, indicating an age effect but no sex dimorphism, with aggressive behaviours being a better predictor for men and impulsive and aggressive behaviours for women.
This Element analyses how Kant's practical philosophy approaches social suffering, while also taking into account the elusiveness of this concept in his work, especially when viewed through a contemporary lens. It claims that Kant's theory of human dignity is a vital tool for detecting social structures in need of improvement, even if the high demands it imposes on the subject show a propensity to conceal situations of domination and oppression. In his writings, Kant investigated various societal challenges such as widespread poverty, duties towards animals, care for the mentally ill, and motherhood out of wedlock, suggesting that the state should solve most of these through financial support from the wealthier segments of society. Although the direct testimony of victims of social suffering does not play a role in Kant's approach, the author holds that he views social interdependence – including, notably, non-humans – as a fundamental commitment underpinning human development.
Obstetric complications (OCs) are associated with cognitive and brain abnormalities observed in patients with schizophrenia. Gyrification, a measure of cortical integrity sensitive to events occurring during the prenatal and perinatal periods, is also altered in first-episode psychosis (FEP). We examined the relationship between OCs and gyrification in FEP, as well as whether gyrification mediates the relationship between OCs and cognition.
Methods
We examined differences in the Local Gyrification Index (LGI) for the frontal, parietal, temporal, occipital, and cingulate cortices between 139 FEP patients and 125 healthy controls (HCs). Regression analyses explored whether OCs and diagnosis interact to explain LGI variation. Parametric mediation analyses were conducted to assess the effect of LGI on the relationship between OCs and cognition for FEP and HC.
Results
Significant LGI differences were observed between FEP patients and HC in the left parietal and bilateral cingulate and occipital cortices. There was a significant interaction between OCs and diagnosis on the left cingulate cortex (LCC) that was specific to males (p = 0.04) and was driven by gestational rather than intrauterine OCs.
In HCs, OCs had a direct effect on working memory (WM) (p = 0.048) in the mediation analysis, whereas in FEP, we observed no significant effect of OCs on either verbal or WM.
Conclusions
OCs interact with diagnosis to predict LCC gyrification, such that males with FEP exposed to OCs exhibit the lowest LGI. OCs influence WM, and LCC gyrification may mediate this relation only in HC, suggesting a differential neurodevelopmental process in psychosis.
Among body measurements, body weight (BW) is one of the most important within the buffalo production system, due to its association with economic characteristics. In previous research, we have shown that body volume (BV) is an effective predictor of BW in lactating adult water buffalo. As there are no equations to predict BW through BV for growing dairy buffaloes (young animals), we hypothesized that equations should be developed to meet this need. BW, body length (BL) and heart girth (HG) data were collected in 160 growing dairy buffaloes raised in commercial farms in southern Mexico, with body volume (BV) then estimated from BL and HG. The ratio between BV and BW was determined by linear, quadratic and allometric equations. The goodness-of-fit of the regression models was evaluated using the Akaike information criterion (AIC), the Bayesian information criterion (BIC), the coefficient of determination (R2), the mean square error (MSE) and the root MSE (RMSE). After this, the k-folds cross-validation was performed to indicate a better fit. Our results showed that the growing dairy buffaloes presented a BW of 256.6 ± 96.82 kg and a BV of 155.3 ± 74.87 dm3. High and positive correlation were observed among all variables studied. All parameters (R2, MSE, RMSE, AIC and BIC) used to evaluate the regression equations showed that the quadratic regression model was more effective than the linear and allometric models for estimating BW using BV. The criteria for evaluating and validating models showed that the quadratic model presented a better predictive performance. Based on these findings, we conclude that body volume data to estimate body weight of growing dairy buffaloes were best fitted using the quadratic regression model.
Cardiac complications after haematopoietic cell transplantation in paediatric patients are significant yet under-recognised. Pericardial effusion has been associated with worse outcomes and transplant-related mortality.
Objectives:
We aimed to evaluate the incidence, risk factors, and clinical course of pericardial effusion after paediatric allogeneic haematopoietic cell transplantation. We identified transplantation recipients “at risk” for clinically significant pericardial effusion based on our definition, described our clinical experience and provided recommendations for screening and management.
Study Design:
Clinical data of children who underwent allogeneic haematopoietic cell transplantation at Texas Children’s Hospital from January 2010 to April 2021 were analyzed retrospectively. Factors potentially contributing to time to pericardial effusion, time to pericardial effusion resolution, and overall survival were evaluated.
Results:
We included 629 haematopoietic cell transplantation recipients with a median age at transplantation of 8.5 years (0.1–24.3). Seventy-three patients (11.6%) developed pericardial effusion within a median time of 102 days (1–403) post-haematopoietic cell transplantation, and 50 (68.5%) had resolution of pericardial effusion at the time of last evaluation. Older age at the time of haematopoietic cell transplantation, transplant-associated thrombotic microangiopathy, and cytomegalovirus diagnoses independently increased the risk of pericardial effusion development, while cytomegalovirus diagnosis decreased the likelihood of pericardial effusion resolution. Both non-significant pericardial effusion development and clinically significant effusion development were significantly associated with post-haematopoietic cell transplantation mortality, compared to no pericardial effusion development.
Conclusions:
Paediatric haematopoietic cell transplantation recipients with malignant diseases, older age at the time of transplantation, cytomegalovirus infection, or transplant-associated thrombotic microangiopathy are at higher risk for pericardial effusion development, which in turn predicts worse outcomes with increased risk of death. We propose a model for improved detection, evaluation, and management of pericardial effusion post-haematopoietic cell transplantation.
Cognitive deficits and immune system dysregulation are core features of psychotic disorders. Among inflammatory markers, interleukin-6 (IL-6) and tumour necrosis factor-alpha (TNF-α) have been linked to both psychosis pathophysiology and related cognitive impairments.
Methods
We investigated associations among IL-6, TNF-α, and neurocognitive performance in 107 participants: individuals at clinical high risk for psychosis (CHR-P, n = 35), first-episode psychosis (FEP, n = 39), and healthy controls (HC, n = 33). Assessments included memory, processing speed, executive function, and social cognition. Cytokines were measured from fasting serum samples. Analyses included ANOVA, correlations, and multivariate regressions controlling for age, sex, IQ, group, and symptom severity.
Results
TNF-α levels were significantly elevated in FEP compared to CHR-P (p = 0.0251); IL-6 differences were non-significant. FEP showed poorer performance in multiple cognitive domains, especially social cognition. CHR-P individuals exhibited intermediate profiles between FEP and HC in cognition. In adjusted regression models, IL-6 was significantly associated with undermentalization on the MASC task (β = 0.28, p = 0.0337) and showed a trend-level association with slower processing speed (β = 0.98, p = 0.075). TNF-α levels predicted poorer facial emotion recognition (β = −1.37, p = 0.0022). IQ and group were significant covariates in most models.
Conclusions
Our findings suggest that peripheral inflammation, particularly IL-6 and TNF-α, may selectively impact social cognitive functioning in early psychosis. Though modest, these associations highlight potential inflammatory contributions to functional impairment and support further investigation of immunological targets in early intervention.
This study reports on a set of experiments designed to clarify the impact of the rotational transform on confinement quality at the TJ-II stellarator. For this purpose, the net plasma current is controlled using external coils, resulting in the modification of the rotational transform profile. Significant and systematic variations of the edge electron density gradients (up to $50\,\%{-}60\,\%$) and the plasma energy content ($20\,\%{-}30\,\%$) are achieved. The explanation of this behaviour relies on the placement of low-order rational surfaces in relation to the edge gradient region, which affect local turbulence fluctuation levels, facilitating the formation of zonal flows and concomitant transport barriers. This hypothesis is confirmed experimentally on the basis of a broad array of diagnostic measurements. Calculations based on a resistive magnetohydrodynamic turbulence model provide qualitative support for this hypothesis, clarifying the impact on confinement of specific rational surfaces and highlighting the complex nature of magnetically confined fusion plasmas.
Ostracoderms, Paleozoic jawless stem-gnathostomes, are characterized by distinctive bony shields covering the front of their bodies. These headshields exhibit significant variations in morphology across species, boasting frontal, lateral, and dorsal processes. Ostracoderms represent pivotal intermediaries between modern jawless and jawed vertebrates, so understanding their biology and ecology is crucial for unraveling the selective pressures that shaped the early evolution and diversification of jawed vertebrates, which now dominate vertebrate diversity. This study employs virtual paleontology techniques and phylogenetic comparative methods to explore the hydrodynamic and ecological implications of these processes, focusing on pteraspidomorphs, the most diverse ostracoderm group. The analysis reveals widespread convergence in the arrangement and development of headshield processes. Lateral processes enhance hydrodynamic efficiency and generate lift, while combined lateral and dorsal processes provide stability in rolling, yawing, and pitching. Frontal processes reduce drag in many cases. These findings illuminate the enigmatic roles of ostracoderm headshields, showing how the dimensions and arrangement of their processes are biomechanically linked to a range of functions and ecological roles. Collectively, this highlights the intricate evolutionary pathways of lifestyles and ecologies within stem-gnathostomes, challenging the idea of a unidirectional trend toward more active lifestyles in vertebrate evolution and suggesting diverse ecological roles for ostracoderms.
Excavations at the Infantas complex in Chillón Valley, Perú, revealed a U-shaped monumental centre with a central mound, clay staircase and columned atrium. Aligned with structures from the Rímac and Lurín valleys, these complexes anchored ritual-political power, serving as hubs for ideological integration and territorial organisation in early Andean societies.
Human genetic structure of Iberian populations has been thoroughly explored in the last decades. The internal diversity of the Iberian Peninsula becomes visible by the different phylogeographic origins of particular mitochondrial DNA and Y chromosome lineages, which show a high degree of population specificity. In the present study, we combined information on matrilineal and patrilineal variation patterns in two autochthonous populations from Andalusia region (southern Spain). A special focus is made to a male sample set where both uniparental data are available. Gene diversities estimates yielded not statistically significant differences between both types of samples and markers. Genetic ancestry among Andalusians seems to be constituted by three foremost continental origins: European, African, and Middle Eastern. The examined male group has revealed a noticeable proportion of individuals (over 45%) with a non-correspondence between maternal and paternal haplogroup origins, a signal of different population demographic histories linked to both sexes in the past. Andalusian males seem to be well differentiated according to ancestries. As expected, mtDNA diversity was much higher than that for the Y chromosome, a fact that can be caused by patrilocality, which leads to particular social structures with effects on haploid genomes in modern human populations.
Recent years have seen increasing focus, including by the National Institutes for Health (NIH), on developing the field of translational science (TS). TS focuses on improving the process of translational research (TR), including generating knowledge that can facilitate TR across specific diseases or translational stages. With TS as an emerging field, research organizations have an increasing need to understand how to develop capacity for and support the advancement of TS. To support such institutional and infrastructural change, this paper outlines a Translational Science Promotion and Research Capacity (T-SPARC) Framework. The T-SPARC Framework provides a foundation to 1) inform the development of TS-creating and science-supporting interventions and programs, and 2) examine the effectiveness of said interventions and programs. The framework outlines organizational levels that T-SPARC programs can target; mechanisms, or intervention activities, that can foster change; and outcomes, including specific attitudinal or behavioral changes, institutional changes, and domains on which TS changes can focus. T-SPARC’s capacity-building focus builds upon earlier efforts focused on conceptualizing and defining TS. T-SPARC supports movement towards TS goals of reducing longstanding challenges in the TR process, thus accelerating the health impact of TR, and ultimately improving health outcomes.
Fontan-associated liver disease is a condition characterised by structural, functional, and clinical alterations secondary to the haemodynamic changes of this circulation.
Objective:
To describe the experience of a series of paediatric patients with Fontan-associated liver dysfunction.
Methods:
A retrospective study including 12 patients with Fontan-associated liver disease. Patients were selected from the single-ventricle program at a high-complexity centre in Colombia between 2001 and 2024.
Results:
During the study period, 108 patients were in the Fontan stage. Among them, 12 met the criteria for Fontan-associated liver disease (11.1%). The median age at extracardiac Fontan completion was 3.9 years, while the median age at Fontan-associated liver disease diagnosis was 14.5 years. Concomitant protein-losing enteropathy and/or plastic bronchitis were present in 33% of cases. Echocardiographic follow-up showed systolic dysfunction in 41% and diastolic dysfunction in 16% of patients. All patients exhibited some degree of valvular insufficiency, mild in 83.3% and moderate in 16%. Haemodynamic variables at the time of diagnosis did not show significant abnormalities.
Conclusions:
Liver disease is a persistent concern in paediatric patients with Fontan physiology, posing diagnostic and therapeutic challenges. Healthcare professionals managing these patients should be aware of its early identification and appropriate treatment.