Cross-cutting issues like nutrition have not been adequately addressed for children with severe visual impairment studying in integrated schools of Nepal. To support advocacy, this study aimed to determine the nutritional status of this vulnerable group, using a descriptive cross-sectional design involving 101 students aged 5–19 years from two integrated public schools near Kathmandu Valley and two in western Nepal. The weight-for-age z-score (WAZ), height-for-age z-score (HAZ), and body mass index-for-age z-score (BAZ) were computed and categorised using World Health Organization cut-off values (overnutrition: z-score > +2.0 standard deviations (SD), healthy weight: z-score −2.0SD to +2.0SD, moderate undernutrition: z-score ≥ −3.0SD to <−2.0SD, severe undernutrition: z-score < −3.0 SD) to assess nutritional status. A child was considered to have undernutrition for any z-scores <−2.0SD. Multivariate logistic regression was used to analyse variables linked to undernutrition. The mean age of participants was 11.86 ± 3.66 years, and the male-to-female ratio was nearly 2:1. Among the participants, 71.29% had blindness, and 28.71% had low vision. The mean BAZ and HAZ scores decreased with age. The WAZ, HAZ, and BAZ scores indicated that 6.46% were underweight, 20.79% were stunted, and 5.94% were thin, respectively. Overall, 23.76% of students had undernutrition and 7.92% had overnutrition. More than three in ten students had malnutrition and stunting was found to be prevalent. Older students and females were more likely to have undernutrition. These findings highlight the need for nutrition interventions within inclusive education settings, particularly targeting girls with visual impairments who may face compounded vulnerabilities.

This article analyzes whether the development of the Responsibility to Protect (R2P) principle can serve to protect populations from genocide, war crimes, crimes against humanity, and ethnic cleansing, given the abuse of veto power by the United Nations Security Council (UNSC). Although several proposals have been made to restrain the use of the veto, the absence of an intent to eliminate it in its entirety has obstructed UN institutions in their efforts to build an inclusive and peaceful society.

In this context, the authors discuss the debate on the utility of R2P as a norm; its historical background; the relevance of the Responsibility Not to Veto (RN2V) through the example of the ongoing Russia-Ukraine conflict; and the role of the UN General Assembly (UNGA) and other UN organs in aiding the UNSC to implement R2P and maintain international peace and security.

The article focuses on preventing mass atrocities through R2P to safeguard vulnerable populations’ access to basic rights and economic opportunities. Further, RN2V, by limiting UNSC paralysis during a crisis, would help avert protracted conflicts that exacerbate poverty, displacement, and environmental degradation. The R2P and RN2V principles collectively have the potential to strengthen UN institutions and reinforce the emphasis on equity, resilience, and peace by ensuring that violence, conflicts, and political inaction do not undo developmental gains.

Nutrition is the critical nongenetic factor that has a major influence on the health status of an organism. The nutritional status of the mother during gestation and lactation plays a vital role in defining the offspring’s health. Undernutrition during these critical periods may induce chronic metabolic disorders like obesity and cardiovascular diseases in mothers as well as in offspring. The present study aims to evaluate the impact of undernutrition during gestational and lactational periods on the plasma metabolic profile of dams. Additionally, we investigated the potential synergistic mitigating effects of astaxanthin and docosahexaenoic acid (DHA) on dysregulated plasma metabolic profiles. Evaluation of plasma lipid profile revealed that undernourishment resulted in elevated levels of total cholesterol, triglycerides, low density and very low-density lipoproteins in dams. Liquid chromatography-tandem mass spectrometry (LC–MS/MS) based untargeted metabolomics illustrated that pathways related to lipid metabolism, such as cholesterol metabolism, steroid biosynthesis and metabolism of amine-derived hormones, were dysregulated by undernourishment. Additionally, pathway enrichment analysis predicted that there is a high incidence of development of desmosterolosis, hypercholesterolaemia, lysosomal acid lipase deficiency and Smith–Lemli–Opitz syndrome in the offspring, reflecting predisposition in mothers. However, synergistic supplementation of astaxanthin and DHA ameliorated these adverse effects by regulating a separate set of metabolic pathways associated with lipid metabolism. They included branched chain amino acid degradation such as valine, leucine and isoleucine, metabolism of alpha-linolenic acid, lipoic acid, lysine degradation, biosynthesis, elongation and degradation of fatty acids.

Leishmaniasis, caused by obligate intracellular Leishmania parasites, poses a significant global health burden. The control of Leishmania infection relies on an effective T cell-dependent immune response; however, various factors impede the host’s ability to mount a successful defence. Alterations in the chemokine profile, responsible for cell trafficking to the infection site, can disrupt optimal immune responses and influence the outcome of pathogenesis by facilitating parasite persistence. This review aims to emphasize the significance of the chemokine system in T cell responses and to summarize the current knowledge on the dysregulation of chemokines and their receptors associated with different subsets of T lymphocytes during Leishmaniasis. A comprehensive understanding of the dynamic nature of the chemokine system during Leishmaniasis is crucial for the development of successful immunotherapeutic approaches.

Oscillatory flows have become an indispensable tool in microfluidics, inducing inertial effects for displacing and manipulating fluid-borne objects in a reliable, controllable and label-free fashion. However, the quantitative description of such effects has been confined to limit cases and specialized scenarios. Here we develop an analytical formalism yielding the equation of motion of density-mismatched spherical particles in oscillatory background flows, generalizing previous work. Inertial force terms are systematically derived from the geometry of the flow field together with analytically known Stokes number dependences. Supported by independent, first-principles direct numerical simulations, we find that these forces are important even for nearly density-matched objects such as cells or bacteria, enabling their fast displacement and separation. Our formalism thus consistently incorporates particle inertia into the Maxey–Riley equation, and in doing so provides a generalization of Auton's modification to added mass, as well as recovering the description of acoustic radiation forces on particles as a limiting case.

This manuscript presents a 50 Ω microstrip-fed quad-element high isolated ultra-wideband (UWB) multiple-input multiple-output (MIMO) antenna with band-notched characteristics. The overall area of the proposed structure is 0.33λo × 0.33λo mm2 (where λo depicts the free space wavelength corresponding to the lower cutoff frequency, i.e. 2.54 GHz), etched on an FR-4 substrate of thickness 0.8 mm. The top layer has four semicircular disc-shaped radiating elements that are identical and orthogonal to obtain better inter-element isolation and compactness. A reverse two-shaped slot is etched onto the radiating patches to attain a band-rejection capability. Moreover, a decoupling structure is also placed at the top layer to suppress the unwanted surface waves. The bottom layer consists of a ground plane, which is further modified with quasi-self complementary and meandered line slots. A rectangular slot is also etched below the feed line to better match the impedance near the lower cutoff frequencies. The simulated reflection coefficients (S11) of the proposed antenna are less than −10 dB over 2.54 to 10.74 GHz frequencies except at 3.37 to 4.15 GHz (WiMAX/C band), and the simulated inter-port isolation (S21) is greater than −15 dB over the entire UWB range of frequencies (3.1 to 10.6 GHz). Also, the measured S-parameter results well agreed with the simulated ones. Furthermore, the simulation study of the 20-element UWB-MIMO antenna is also investigated using the proposed quad-element structure.

Sustainability of maize production systems is threatened by poor economic returns and resource intensiveness. Therefore, an experiment was conducted at the ICAR-Indian Agricultural Research Institute, New Delhi during 2016–17 to 2017–18 to assess the effect of tillage and microbial inoculantsintegrated phosphorus (P) management on productivity, quality, economic outcome and energy dynamics of maize. Three tillage practices viz., CT–R (conventional tillage with no residue), ZT–R (zero tillage with no residue) and ZT + R (zero tillage with wheat crop residue at 2.5 Mg/ha) were assigned in main plots and five P management practices viz., P1 (control–NK as per recommendation, but no P), P2 (17.2 kg P/ha), P3 (17.2 kg P/ha + PSB), P4 (17.2 kg P/ha + compost inoculants) and P5 (34.4 kg P/ha) were allocated in subplots in three times replicated split-plot design. The maximum grain yield (5.96 Mg/ha), protein content (9.13%), protein yield (546 kg/ha) and gross energy returns (209 × 103 MJ/ha) were recorded under ZT + R while higher benefit: cost ratio (B: C ratio – the amount of economic gain per unit investment) (1.53) and energy efficiency (12.5) was noticed under ZT–R. Among the P management practices, the application of 34.4 kg P/ha recorded the highest grain yield (6.45 Mg/ha), protein content (9.34%), protein yield (603 kg/ha), B: C ratio (1.65) and energy efficiency (10.1). The results suggested that the application of P at the rate of 34.4 kg/ha under ZT + R is an economically robust approach for the quality maize production in semi-arid region.

We prove Reilly-type upper bounds for the first nonzero eigenvalue of the Steklov problem associated with the p-Laplace operator on submanifolds of manifolds with sectional curvature bounded from above by a nonnegative constant.

Inadequate protein intake and lack of micronutrients may affect neurodevelopment in infants. This randomised controlled trial was conducted to measure the effect of two milk–cereal mixes with modest and high amounts of protein and enriched with multiple micronutrients, given between 6 and 12 months, on cognitive, language, motor and behavioural scores at 12 and 24 months of age, compared with no-supplementation. The two supplements were also compared with each other. The study was conducted in urban Delhi, India, and the infants were randomised in a 1:1:1 ratio to the three study groups. At 12 and 24 months of age, 1134 and 1214 children were available, respectively. At 12 months of age, compared with no-supplement group, an increase in the motor scores (mean difference, MD 1·52, 95 % CI: 0·28, 2·75) and a decrease in the infant temperament scores (MD − 2·76, 95 % CI: −4·23, −1·29) in the modest-protein group was observed. Those in the high-protein group had lower socio-emotional scores (MD − 1·40, 95 % CI: −2·43, −0·37) and higher scores on Infant Temperament Scale (MD 2·05, 95 % CI: 0·62, 3·48) when compared with modest-protein group. At 24 months, no significant differences in any of the neurodevelopment scores between the three study groups was found. In conclusion, supplementation with modest amount of protein and multiple micronutrients may lead to short-term small improvements in motor function and infant temperament. There appears no advantage of supplementing with high protein, rather negative effects on infant behaviour were observed

This study assessed the impact of improved green fodder production activities on technical efficiency (TE) of dairy farmers in climate vulnerable landscapes of central India. We estimated stochastic production frontiers, considering potential self-selection bias stemming from both observable and unobservable factors in adoption of fodder interventions at farm level. The empirical results show that TE for treated group ranges from 0.55 to 0.59 and that for control ranges from 0.41 to 0.48, depending on how biases are controlled. Additionally, the efficiency levels of both adopters and non-adopters would be underestimated if the selectivity bias is not appropriately accounted. As the average TE is consistently higher for adopter farmers than the control group, promoting improved fodder cultivation would increase input use efficiency, especially in resource-deprived small holder dairy farmers in the semi-arid tropics.

Weeds are a major biotic constraint to the production of crops. Studies on the critical period of weed control (CPWC) consider the yield loss due to the presence of all weeds present in the crop cycle. The CPWC is the time interval between the critical timing of weed removal (CTWR) and the critical weed-free period (CWFP), and the weed presence before and after the extremes of CTWR and CWFP may not significantly reduce crop yield. The crop yield is taken into consideration and weed density or biomass of individual weeds (annual or perennial) is not so important while calculating the CPWC. Only weed density or biomass is considered for calculating weed control efficiency of a particular management practice for which the weed seed bank is also a criterion. However, weed biomass is the outcome after competition experienced by each weed species with the fellow crop and the weeds. Consequently, the weed pressure in the subsequent season will be the cumulative effect of the preceding season too, which is unaccounted for in CPWC. It is argued that in organic farming or low-input farming systems, where herbicides are not used, the concept of CPWC can be misleading and should be avoided. It is concluded that CTWR is more meaningful than the CPWC.

An experimental study is conducted on unsteady pressure fluctuations occurring near the nozzle exit and just outside the shear layer of compressible jets. These fluctuations are related to ‘trapped waves’ within the jet's potential core, as investigated and reported recently by other researchers. Round nozzles of three different diameters and rectangular nozzles of various aspect ratios are studied. The fluctuations manifest as a series of peaks in the spectra of the fluctuating pressure. Usually the first peak at the lowest frequency (fundamental) has the highest amplitude and the amplitude decreases progressively for successive peaks at higher frequencies. These ‘trapped wave spectral peaks’ are found to occur with all jets at high subsonic conditions and persist into the supersonic regime. Their characteristics and variations with axial and radial distances, jet Mach number and aspect ratio of the nozzle are documented. For round nozzles, the frequency of the fundamental is found to be independent of the jet's exit boundary layer characteristics and scales with the nozzle diameter. On a Strouhal number (based on diameter) versus jet Mach number plot it is represented by a unique curve. Relative to the fundamental the frequencies of the successive peaks are found to bear the ratios of 5/3, 7/3, 9/3 and so on, at a given Mach number. For rectangular nozzles, the number of peaks observed on the major axis is found to be greater than that observed on the minor axis by a factor approximately equal to the nozzle's aspect ratio; the fundamental is the same on either edge. For all nozzles the onset of screech tones appears as a continuation of the evolution of these peaks; it is as if one of these peaks abruptly increases in amplitude and turns into a screech tone as the jet Mach number is increased.

In this research study, a compact dual-polarized co-radiator ultra-wideband (UWB) multiple-input multiple-output (MIMO) antenna with improved impedance bandwidth and isolation is proposed for wireless applications. The designed co-radiator has an overall area of 0.3λo × 0.3λo mm2 (where, λo is free space wavelength corresponding to the lower cut-off frequency, i.e., 3.1 GHz). The proposed resonator comprises of a hybrid geometry which is created with the combinations of a circular-shaped patch, a square, and two rectangular stubs. It is centrally aligned between two 50 Ω micro-strip feed lines that are positioned orthogonal to each other. Further, the modified ground plane is attached with the end-loaded line which provides broadband isolation over entire UWB frequency band. The simulated results of the proposed antenna exhibit wideband characteristics with impedance bandwidth of 3.1–16.9 GHz with minimum isolation of −15 dB. Moreover, all the radiation performance parameters are analyzed and discussed. Some important diversity parameters such as envelope correlation coefficient, mean effective gain, effective diversity gain, and channel capacity loss have also been evaluated. Furthermore, all the measured results of proposed antenna agree well with the simulated results which make the proposed antenna a suitable candidate for UWB-MIMO wireless applications.

This study used a series of individual-level datasets from National Family Health Surveys conducted in 1998–99, 2005–06 and 2015–16 to assess the factors behind the reduction in childhood stunting and underweight in India between the years 1998–99 and 2015–16. A multivariable decomposition regression analysis was performed. Results showed that the prevalence of childhood stunting declined from 49.4% in 1998–99 to 34.9% in 2015–16. Over the same period, the prevalence of childhood underweight declined from 41.9% in 1998–99 to 33.1% in 2015–16. The reduction in the prevalence of stunting was found to be contributed largely by a reduction in the combined prevalence of stunting and underweight (60%), followed by stunted only (21%) and the combined prevalence of stunting, underweight and wasting (19%). Likewise, the reduction in the prevalence of underweight was contributed by a reduction in the combined prevalence of stunting and underweight and the combined prevalence of stunting, underweight and wasting. Results of the decomposition analysis showed that over the period 1998–99 to 2015–16, improvement in wealth status and maternal education led to 13% and 12% declines, respectively, in childhood stunting and to 31% and 19% declines, respectively, in childhood underweight. Furthermore, reductions in childhood stunting and underweight were due to an increased average number of antenatal care visits, lower average birth order, decreased share of children with below-average birth size, increased use of clean fuel for cooking and a reduction in the practice of open defecation. These findings suggest that further reduction in the prevalence of childhood stunting and underweight could be attained through more equitable household economic growth, investment in girl’s education, greater access to improved toilet facilities, more widespread use of clean fuel for cooking, reduction in average birth order, increased antenatal care visits and greater consumption of IFA tablets by pregnant women. Policymakers need to prioritize these measures to further reduce malnutrition among Indian children.

Parthenium hysterophorus Linnaeus (Asteraceae) is a toxic weed found abundantly in major agroecosystems of the world. The weed is inhabited by both phytophagous Chrysomelidae (Coleoptera), used as biocontrol agents, and the predaceous Coccinellidae (Coleoptera). The present investigation was designed to assess the feeding attributes and larval development of Zygogramma bicolorata Pallister (Coleoptera: Chrysomelidae) in the presence of semiochemical tracks of coccinellid beetles. Results revealed that the presence of coccinellid semiochemical tracks on the weed reduced larval consumption rates, conversion efficiencies, and growth rates. The feeding deterrent effects of the semiochemical tracks were species specific. Larvae accumulated lower concentrations of glucose, proteins, and triacylglycerols and exhibited reduced body biomass in the presence of semiochemical tracks. The coccinellid semiochemical tracks also promoted Z. bicolorata larvae to accelerate their developmental rates and develop faster than the larvae reared in the absence of semiochemical tracks. While the fourth instars consumed food maximally and were heavier, their food use efficiencies were lower than the other instars. Our findings, therefore, suggest that the presence of semiochemical tracks of coccinellids on P. hysterophorus impedes its biological control by Z. bicolorata larvae.

Using longitudinal data from the first and second waves of the Young Lives Study (YLS) in Ethiopia, India (Andhra Pradesh), Peru and Vietnam, conducted in 2002 and 2006–07, and a repeated measures mixed model, this study examined the effect of the use of solid fuels for cooking on childhood stunting among children aged 5–76 months. The analysis showed that in all four populations, the average height-for-age z-score (HAZ score) was much lower among children living in households using solid fuels than among children in households using cleaner fuels for cooking. The average HAZ score was lower among children living in households that used solid fuels in both waves of the YLS compared with those whose households used solid fuels in only one of the two waves. A significant reduction was noted in the average HAZ score between the two waves in all countries except Ethiopia. The results of the repeated measures mixed model suggest that household use of solid fuels was significantly associated with lower HAZ scores in all populations, except Ethiopia. The findings also indicate that the reduction in the HAZ scores between waves 1 and 2 was not statistically significant by the type of cooking fuel after controlling for potential confounding factors. The study provides further evidence of a strong association between household use of solid fuels and childhood stunting in low- and middle-income countries using longitudinal data. The findings highlight the need to reduce exposure to smoke from the combustion of solid fuels, by shifting households to cleaner cooking fuels, where feasible, by providing cooking stoves with improved combustion of solid fuels and improved venting, and by designing and implementing public information campaigns to inform people about the health risks of exposure to cooking smoke.

The above article previously published with incorrect author information for Dr Binil Aryal. Dr Aryal’s affiliation should be listed as Central Department of Physics, Tribhuvan University, Kathmandu, Nepal. This error has since been rectified in the online PDF and HTML copies of the article.