The study aims were to present in vitro susceptibilities of clinical isolates from Gram-negative bacteria bloodstream infections (GNBSI) collected in China. GNBSI isolates were collected from 18 tertiary hospitals in 7 regions of China from 2018 to 2020. Minimum inhibitory concentrations were assessed using a Trek Diagnostic System. Susceptibility was determined using CLSI broth microdilution, and breakpoints were interpreted using CLSI M100 (2021). A total of 1,815 GNBSI strains were collected, with E. coli (42.4%) and Klebsiella pneumoniae (28.6%) being the most prevalent species, followed by P. aeruginosa (6.7%). Susceptibility analyses revealed low susceptibilities (<40%) of ESBL-producing E. coli and K. pneumonia to third-/fourth-generation cephalosporins, monobactamases, and fluoroquinolones. High susceptibilities to colistin (95.0%) and amikacin (81.3%) were found for K. pneumoniae, while Acinetobacter baumannii exhibited a high susceptibility (99.2%) to colistin but a low susceptibility to other antimicrobials (<27.5%). Isolates from ICUs displayed lower drug susceptibility rates of K. pneumoniae and A. baumannii than isolates from non-ICUs (all P < 0.05). Carbapenem-resistant and ESBL-producing K. pneumoniae detection was different across regions (both P < 0.05). E. coli and K. pneumoniae were major contributors to GNBSI, while A. baumannii exhibited severe drug resistance in isolates obtained from ICU departments.

Rhopalosiphum padi is an important grain pest, causing severe losses during crop production. As a systemic insecticide, flonicamid can control piercing-sucking pests efficiently. In our study, the lethal effects of flonicamid on the biological traits of R. padi were investigated via a life table approach. Flonicamid is highly efficiently toxic to R. padi, with an LC50 of 9.068 mg L−1. The adult longevity and fecundity of the R. padi F0 generation were markedly reduced under the LC25 and LC50 concentrations of flonicamid exposure. In addition, negative transgenerational effects on R. padi were observed under exposure to lethal concentrations of flonicamid, with noticeable decreases in the reproductive period, adult longevity, total longevity, and total fecundity of the F1 generation under the LC25 concentration of flonicamid. Furthermore, the third nymph stage (N3), preadult stage, duration of the adult pre-reproductive period, duration of the total pre-reproductive period, reproductive period, adult longevity, total longevity, and total fecundity of the F1 generation were significantly lower under treatment with the LC50 concentration of flonicamid. The life table parameters were subsequently analysed, revealing that the intrinsic rate of increase (rm) and the net reproductive rate (R0) were significantly lower but that the finite rate of increase (λ) and the mean generation time (T) were not significantly different under the LC25 and LC50 concentrations of flonicamid. These data are beneficial for grain aphid control and are critical for exploring the role of flonicamid in the integrated management of this key pest.

In this paper, on–off switching digitization of a W-band variable gain power amplifier (VGPA) with above 60 dB dynamic range is introduced for large-scale phased array. Digitization techniques of on–off switching modified stacking transistors with partition are proposed to optimize configuration of control sub-cells. By the proposed techniques, gain control of a radio frequency variable gain amplifier (VGA) could be highly customized for both coarse and fine switching requirements instead of using additional digital-to-analog converters to tune the overall amplifier bias. The designed VGA in 130 nm SiGe has achieved switchable gain range from −46.4 to 20.6 dB and power range from −25.0 to 15.7 dBm at W band. The chip size of the fabricated VGPA is about 0.31 mm × 0.1 mm.

We study the last exit time that a spectrally negative Lévy process is below zero until it reaches a positive level b, denoted by $g_{\tau_b^+}$. We generalize the results of the infinite-horizon last exit time explored by Chiu and Yin (2005) by incorporating a random horizon $\tau_b^+$, which represents the first passage time above b. We derive an explicit expression for the joint Laplace transform of $g_{\tau_b^+}$ and $\tau_b^+$ by utilizing a hybrid observation scheme approach proposed by Li, Willmot, and Wong (2018). We further study the optimal prediction of $g_{\tau_b^+}$ in the $L_1$ sense, and find that the optimal stopping time is the first passage time above a level $y_b^{\ast}$, with an explicit characterization of the stopping boundary $y_b^{\ast}$. As examples, Brownian motion with drift and the Cramér–Lundberg model with exponential jumps are considered.

Reducing nitrogen (N) fertilizer application is a sustainable practice in rice production. The effects of reducing N fertilizer input on grain yield and rice quality of early- and late-season dual-use rice (ELDR) in South China remain uncertain. Therefore, a short-term field trial was conducted with a high-yielding ELDR cultivar (Yuehesimiao, YHSM) and a low-yielding ELDR cultivar (Meixiangzhan 2, MXZ). The rice was cultivated with a 20% reduced N application rate (RN2), a 10% reduced rate (RN1) and the conventional N application rate (CN). In the early season, compared to CN, RN2 reduced the grain yield of YHSM and MXZ by an average of 16.1 and 6.6%, respectively, while RN1 lowered YHSM grain yield by 11.2% on average and had no effect on MXZ yield. In addition, RN2 decreased the milling and eating qualities of the two cultivars in the early season, while RN1 did not alter their milling, appearance or eating qualities. In the late season, neither RN2 nor RN1 affected grain yield or rice quality for both cultivars. Therefore, short-term reductions of 10 and 20% in N application could maintain grain yield and rice quality at current N fertilizer application rates in the late season. However, the early-season results only recommended a 10% reduced N fertilizer application rate for low-yielding ELDR cultivars to sustain grain yield and rice quality. The findings of this study can provide a theoretical basis for N management of ELDR in South China.

This paper proposes an online robust self-learning terminal sliding mode control (RS-TSMC) with stability guarantee for balancing control of reaction wheel bicycle robots (RWBR) under model uncertainties and disturbances, which improves the balancing control performance of RWBR by optimising the constrained output of TSMC. The TSMC is designed for a second-order mathematical model of RWBR. Then robust adaptive dynamic programming based on an actor-critic algorithm is used to optimise the TSMC only by data sampled online. The system closed-loop stability and convergence of the neural network weights are guaranteed based on the Lyapunov analysis. The effectiveness of the proposed algorithm is demonstrated through simulations and experiments.

Controller synthesis offers a correct-by-construction methodology to ensure the correctness and reliability of safety-critical cyber-physical systems (CPS). Controllers are classified based on the types of controls they employ, which include reset controllers, feedback controllers and switching logic controllers. Reset controllers steer the behavior of a CPS to achieve system objectives by restricting its initial set and redefining its reset map associated with discrete jumps. Although the synthesis of feedback controllers and switching logic controllers has received considerable attention, research on reset controller synthesis is still in its early stages, despite its theoretical and practical significance. This paper outlines our recent efforts to address this gap. Our approach reduces the problem to computing differential invariants and reach-avoid sets. For polynomial CPS, the resulting problems can be solved by further reduction to convex optimizations. Moreover, considering the inevitable presence of time delays in CPS design, we further consider synthesizing reset controllers for CPS that incorporate delays.

We systematically study the dissipative anomaly in compressible magnetohydrodynamic (MHD) turbulence using direct numerical simulations, and show that the total dissipation remains finite as viscosity diminishes. The dimensionless dissipation rate $\mathcal {C}_{\varepsilon }$ fits well with the model $\mathcal {C}_{\varepsilon } = \mathcal {C}_{\varepsilon,\infty } + \mathcal {D}/R_L^-$ for all levels of flow compressibility considered here, where $R_L^-$ is the generalized large-scale Reynolds number. The asymptotic value $\mathcal {C}_{\varepsilon,\infty }$ describes the total energy transfer flux, and decreases with increase of the flow compressibility, indicating non-universality of the dimensionless dissipation rate in compressible MHD turbulence. After introducing an empirically modified dissipation rate, the data from compressible cases collapse to a form similar to the incompressible MHD case depending only on the modified Reynolds number.

In order to establish a compact all-optical Thomson scattering source, experimental studies were conducted on the 45 TW Ti: sapphire laser facility. By including a steel wafer, mixed gas, and plasma mirror into a double-exit jet, several mechanisms, such as shock-assisted ionization injection, ionization injection, and driving laser reflection, were integrated into one source. So, the source of complexity was remarkably reduced. Electron bunches with central energy fluctuating from 90 to 160 MeV can be produced. Plasma mirrors were used to reflect the driving laser. The scattering of the reflected laser on the electron bunches led to the generation of X-ray photons. Through comparing the X-ray spots under different experimental conditions, it is confirmed that the X-ray photons are generated by Thomson scattering. For further application, the energy spectra and source size of the Thomson scattering source were measured. The unfolded spectrum contains a large amount of low-energy photons besides a peak near 67 keV. Through importing the electron energy spectrum into the Monte Carlo simulation code, the different contributions of the photons with small and large emitting angles can be used to explain the origin of the unfolded spectrum. The maximum photon energy extended to about 500 keV. The total photon production was 107/pulse. The FWHM source size was about 12 μm.

The third-order law links energy transfer rates in the inertial range of magneto- hydrodynamic (MHD) turbulence with third-order structure functions. Anisotropy, a typical property in the solar wind, challenges the applicability of the third-order law with the isotropic assumption. To shed light on the energy transfer process in the presence of anisotropy, we conducted direct numerical simulations of forced MHD turbulence with normal and hyper-viscosity under various strengths of the external magnetic field ($B_0$), and calculated three forms of third-order structure function with or without averaging of the azimuthal or polar angles with respect to $B_0$ direction. Correspondingly, three estimated energy transfer rates were obtained. The result shows that the peak of normalized third-order structure function occurs at larger scales closer to the $B_0$ direction, and the maximum of longitudinal transfer rates shifts away from the $B_0$ direction at larger $B_0$. Compared with normal viscous cases, hyper-viscous cases can attain better separated inertial range, thus facilitating the estimation of the energy cascade rates. We find that the widespread use of the isotropic form of the third-order law in estimating the energy transfer rates is questionable in some cases, especially when the anisotropy arising from the mean magnetic field is inevitable. In contrast, the direction-averaged third-order structure function properly accounts for the effect of anisotropy and predicts the energy transfer rates and inertial range accurately, even at very high $B_0$. With limited statistics, the third-order structure function shows a stronger dependence on averaging of azimuthal angles than the time, especially for high $B_0$ cases. These findings provide insights into the anisotropic effect on the estimation of energy transfer rates.

This paper considers a model with general regressors and unobservable common factors. An estimator based on iterated principal component analysis is proposed, which is shown to be not only asymptotically normal, but under certain conditions also free of the otherwise so common asymptotic incidental parameters bias. Interestingly, the conditions required to achieve unbiasedness become weaker the stronger the trends in the factors, and if the trending is strong enough, unbiasedness comes at no cost at all. The approach does not require any knowledge of how many factors there are, or whether they are deterministic or stochastic. The order of integration of the factors is also treated as unknown, as is the order of integration of the regressors, which means that there is no need to pre-test for unit roots, or to decide on which deterministic terms to include in the model.

We report a Yb-doped all-fiber laser system generating burst-mode pulses with high energy and high peak power at a GHz intra-burst repetition rate. To acquire the uniform burst envelope, a double-pre-compensation structure with an arbitrary waveform laser diode driver and an acoustic optical modulator is utilized for the first time. The synchronous pumping is utilized for the system to reduce the burst repetition rate to 100 Hz and suppress the amplified spontaneous emission effect. By adjusting the gain of every stage, uniform envelopes with different output energies can be easily obtained. The intra-burst repetition rate can be tuned from 0.5 to 10 GHz actively modulated by an electro-optic modulator. Optimized by timing control of eight channels of analog signal and amplified by seven stages of Yb-doped fiber amplifier, the pulse energy achieves 13.3 mJ at 0.5 ns intra-burst pulse duration, and the maximum peak power reaches approximately 3.6 MW at 48 ps intra-burst pulse duration. To the best of our knowledge, for reported burst-mode all-fiber lasers, this is a record for output energy and peak power with nanosecond-level burst duration, and the widest tuning range of the intra-burst repetition rate. In particular, this flexibly tunable burst-mode laser system can be directly applied to generate high-power frequency-tunable microwaves.

We report a compact, tunable, self-starting, all-fiber laser-based asynchronous optical sampling (ASOPS) system. Two Er-doped fiber oscillators were used as the pulsed-laser source, whose repetition rate could be set at 100 MHz with a tuning range of 1.25 MHz through a fiber delay line. By employing phase-locked and temperature control loops, the repetition rate offset of the two lasers was stabilized with 7.13 × 10−11 fractional instability at an average time of 1 s. Its capabilities in the terahertz regime were demonstrated by terahertz time-domain spectroscopy, achieving a spectral bandwidth of 3 THz with a dynamic range of 30 dB. The large range of repetition rate adjustment in our ASOPS system has the potential to be a powerful tool in the terahertz regime.

We propose a 2.1 μm high-energy dissipative soliton resonant (DSR) fiber laser system based on a mode-locked seed laser and dual-stage amplifiers. In the seed laser, the nonlinear amplifying loop mirror technique is employed to realize mode-locking. The utilization of an in-band pump scheme and long gain fiber enables effectively exciting 2.1 μm pulses. A section of ultra-high numerical aperture fiber (UHNAF) with normal dispersion and high nonlinearity and an output coupler with a large coupling ratio are used to achieve a high-energy DSR system. By optimizing the UHNAF length to 55 m, a 2103.7 nm, 88.1 nJ DSR laser with a 3-dB spectral bandwidth of 0.48 nm and a pulse width of 17.1 ns is obtained under a proper intracavity polarization state and pump power. The output power and conversion efficiency are 0.233 W and 4.57%, respectively, both an order of magnitude higher than those of previously reported holmium-doped DSR seed lasers. Thanks to the high output power and nanosecond pulse width of the seed laser, the average power of the DSR laser is linearly scaled up to 50.4 W via a dual-stage master oscillator power amplifier system. The 3-dB spectral bandwidth broadens slightly to 0.52 nm, and no distortion occurs in the amplified pulse waveform. The corresponding pulse energy reaches 19.1 μJ, which is the highest pulse energy in a holmium-doped mode-locked fiber laser system to the best of our knowledge. Such a 2.1 μm, high-energy DSR laser with relatively wide pulse width has prospective applications in mid-infrared nonlinear frequency conversion.

Many protected areas worldwide have been established to protect the last natural refuges of flagship animal species. However, long-established protected areas do not always match the current distributions of target species under changing environmental conditions. Here we present a case study of the Asian elephant Elephas maximus in Xishuangbanna, south-west China, to evaluate whether the established protected areas match the species’ current distribution and to identify key habitat patches for Asian elephant conservation. Our results show that currently only 24.5% of the predicted Asian elephant distribution in Xishuangbanna is located within Xishuangbanna National Nature Reserve, which was established for elephant conservation. Based on the predicted Asian elephant distribution, we identified the most important habitat patches for elephant conservation in Xishuangbanna. The three most important patches were outside Xishuangbanna National Nature Reserve and together they contained 43.3% of the estimated food resources for Asian elephants in all patches in Xishuangbanna. Thus, we identified a spatial mismatch between immobile protected areas and mobile animals. We recommend the inclusion of the three identified key habitat patches in a new national park currently being planned by the Chinese authorities for the conservation of the Asian elephant.

We conduct direct numerical simulations and study the evolution of a pair of counter-rotating vortices in a stratified and turbulent environment beyond the first vortex linking (which is due to the Crow instability). The initial position of the two vortices is perpendicular to the direction of thermal stratification. We vary the Froude number, the background turbulence intensity and the Reynolds number, covering strong, weak and neutral stratification; low, moderate and high background turbulence; and low and moderate Reynolds numbers. We observe a second vortex linking in a weakly stratified environment for the first time. The second vortex linking is followed by turbulence bursts that lead to the rapid decay of the residual vortices after the first vortex linking, leading to a short-living vortex pair. This challenges the conventional view that residual vortices have a long life span, which is true only in an unstratified environment. In addition to the second vortex linking, we observe the following. First, strong background turbulence quickly breaks the two vortices. Second, the two vortices induce secondary and tertiary vortices and lose energy to gravitational waves in a strongly stratified ($Fr\leqslant 0.7$) environment.

We report the demonstration of a mid-infrared (MIR) supercontinuum (SC) laser delivering a record-breaking average output power of more than 40 W with a long-wavelength edge up to 3.5 μm. The all-fiberized configuration was composed of a thulium-doped fiber amplifier system emitting a broadband spectrum covering 1.9–2.6 μm with pulse repetition rate of 3 MHz, and a short piece of germania fiber. A 41.9 W MIR SC with a whole spectrum of 1.9–3.5 μm was generated in a piece of 0.2-m-long germania fiber, with a power conversion efficiency of 71.4%. For an even shorter germania fiber (0.1 m), an SC with even higher output power of 44.9 W (corresponding to a conversion efficiency of 76.5%) was obtained, but the energy conversion toward the long-wavelength region was slightly limited. A continuous operation for 1 hour with output power of 32.6 W showed outstanding power stability (root mean square 0.17%) of the obtained SC laser. To the best of the authors’ knowledge, for the first time, this work demonstrates the feasibility of germania fiber on generating a 40-W level MIR SC with high efficiency and excellent power stability, paving the way to real applications requiring high power and high reliability of MIR SC lasers.

Nicotine 2,6-dihydroxybenzoate is a nicotine salt that can be used as the nicotine source in tobacco products. X-ray powder diffraction data, unit-cell parameters, and space group for nicotine 2,6-dihydroxybenzoate, C10H15N2⋅C7H5O4, are reported [a = 7.726(8) Å, b = 11.724(3) Å, c = 9.437(1) Å, α = 90°, β = 109.081(3)°, γ = 90°, unit-cell volume V = 802.902 Å3, Z = 2, ρcal = 1.309 g cm−3, and space group P21] at room temperature. All measured lines were indexed and were consistent with the P21 space group.