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The flow field of a bluff body, a circular disk, that moves horizontally in a stratified environment is studied using large-eddy simulations. Five levels of stratification (body Froude numbers of ${{Fr}} = 0.5, 1, 1.5, 2$ and $5$) are simulated at Reynolds number of ${{Re}} = 5000$ and Prandtl number of $Pr =1$. A higher ${{Re}} = 50\,000$ database at ${{Fr}} = 2, 10$ and $Pr =1$ is also examined for comparison. The wavelengths and amplitudes of steady lee waves are compared with a linear-theory analysis. Excellent agreement is found over the entire range of ${{Fr}}$ if an ‘equivalent body’ that includes the separation region is employed for the linear theory. For asymptotically large distances, the velocity amplitude varies theoretically as ${{Fr}}^{-1}$ but a correction owing to the dependence of the separation zone on ${{Fr}}$ is needed. The wake waves propagate in a narrow band of angles with the vertical, and have a wavelength that increases with increasing ${{Fr}}$. The envelope of wake waves, demarcated using buoyancy variance, exhibits self-similar behaviour. The higher ${{Re}}$ results are consistent with the buoyancy effects exhibited at the lower ${{Re}}$. The wake wave energy is larger at ${{Re}} = 50\,000$. Nevertheless, independent of ${{Fr}}$ and ${{Re}}$, the ratio of the wake wave potential energy to the wake turbulent energy increases to approximately 0.6–0.7 in the non-equilibrium stage showing their energetic importance besides suggesting universality in this statistic. There is a crossover of energetic dominance of lee waves at ${{Fr}} <2$ to wake-wave dominance at ${{Fr}} \approx 5$.
Rhino-orbito-cerebral mucormycosis is a rapidly progressive disease with high mortality rates of about 60 per cent. The increasing incidence of rhino-orbito-cerebral mucormycosis in coronavirus disease 2019 patients in India and worldwide has become a matter of concern owing to the case fatality rate. This study explored the use of low dose aspirin in decreasing the mortality rate of coronavirus disease 2019 associated mucormycosis.
Method
This was a retrospective observational study. Patients suffering from post-coronavirus disease 2019 mucormycosis were included in the study. Each patient was treated with surgical debridement and systemic amphotericin B. Low dose aspirin was added, and mortality rates were compared with the patients who did not receive aspirin.
Results
The demographic data and rhino-orbito-cerebral mucormycosis staging between the two groups were not significantly different. There was a statistically significant difference in mortality outcomes between the two groups (p = 0.029) and a 1.77 times higher risk of dying for patients not receiving aspirin. Kaplan–Meier survival indicated that patients receiving aspirin had better survival rates (p = 0.04).
Major advances in biology and ecology have sharpened our understanding of what the goals of biodiversity conservation might be, but less progress has been made on how to achieve conservation in the complex, multi-sectoral world of human affairs. The failure to deliver conservation outcomes is especially severe in the rapidly changing landscapes of tropical low-income countries. We describe five techniques we have used to complement and strengthen long-term attempts to achieve conservation outcomes in the landscapes and seascapes of such regions; these are complex social-ecological systems shaped by interactions between biological, ecological and physical features mediated by the actions of people. Conservation outcomes occur as a result of human decisions and the governance arrangements that guide change. However, much conservation science in these countries is not rooted in a deep understanding of how these social-ecological systems work and what really determines the behaviour of the people whose decisions shape the future of landscapes. We describe five scientific practices that we have found to be effective in building relationships with actors in landscapes and influencing their behaviour in ways that reconcile conservation and development. We have used open-ended inductive enquiry, theories of change, simulation models, network analysis and multi-criteria analysis. These techniques are all widely known and well tested, but seldom figure in externally funded conservation projects. We have used these techniques to complement and strengthen existing interventions of international conservation agencies. These five techniques have proven effective in achieving deeper understanding of context, engagement with all stakeholders, negotiation of shared goals and continuous learning and adaptation.
Sheet-defined functions (SDFs) bring modularity and abstraction to the world of spreadsheets. Alas, end users naturally write SDFs that work over fixed-size arrays, which limits their reusability. To help end user programmers write more reusable SDFs, we describe a principled approach to generalising such functions to become elastic SDFs that work over inputs of arbitrary size. We prove that under natural, checkable conditions, our algorithm returns the principal generalisation of an input SDF. We describe a formal semantics and several efficient implementation strategies for elastic SDFs. A user study with spreadsheet users compares the human experience of programming with elastic SDFs to the alternative of relying on array-processing combinators. Our user study finds that the cognitive load of elastic SDFs is lower than for SDFs with map/reduce array combinators, the closest alternative solution.
Ethics are important in psychiatry since psychiatrydeals mainly with human conduct and behaviour. Ethics are principles, notlaws but standards of conduct, which define the essentials of honourablebehaviour for the physician. Indian Psychiatric Society approved ethical guideline in 1989Cuttack conference.
Hypothesis-
Ethical issues depend on the following theories –
Utilitarian Theory– A fundamental obligation in making decision and is to try to producethe greatest possible happiness for the greatest benefit.
Parentalism-A person performing actions for another benefit without the person's consent.
Autonomy Theory –It is based on writing of Imanuel Kant. Relationship between a physician and anadult patient is conceived as relationship between two responsible persons.
Observation –
Some common causes of malpractice in psychiatry seen in India arei) Negligence in diagnosis ii) Overlooking basic human rights iii) Consent nottaken from patient iv) Risk of suicide v) Experimentation by doctor vi)Negligence in physical methods of treatment vii) Seaxual relation with clientand Exploitation.
Conclusion –
Now a days following forces are to be considered as new ethical challenges a)Rapidly increasing cost of mental health care b) Influence of new technologies likeMRI, CT SCAN Brain c) Societal reengineering for better mental health d)Increasing pressure by patient party e) Current market forces are demandinghigh quality health care.
Discussion–
Apracticing psychiatrist has to take more responsibility in management of mentaldisorders. One has to take it as normal inevitable professionalhazards.
This paper describes a model of electron energization and cyclotron-maser emission applicable to astrophysical magnetized collisionless shocks. It is motivated by the work of Begelman, Ergun and Rees [Astrophys. J. 625, 51 (2005)] who argued that the cyclotron-maser instability occurs in localized magnetized collisionless shocks such as those expected in blazar jets. We report on recent research carried out to investigate electron acceleration at collisionless shocks and maser radiation associated with the accelerated electrons. We describe how electrons accelerated by lower-hybrid waves at collisionless shocks generate cyclotron-maser radiation when the accelerated electrons move into regions of stronger magnetic fields. The electrons are accelerated along the magnetic field and magnetically compressed leading to the formation of an electron velocity distribution having a horseshoe shape due to conservation of the electron magnetic moment. Under certain conditions the horseshoe electron velocity distribution function is unstable to the cyclotron-maser instability [Bingham and Cairns, Phys. Plasmas 7, 3089 (2000); Melrose, Rev. Mod. Plasma Phys. 1, 5 (2017)].
We describe a simple model for turbulence in a marginally unstable, forced, stratified shear flow. The model illustrates the essential physics of marginally unstable turbulence, in particular the tendency of the mean flow to fluctuate about the marginally unstable state. Fluctuations are modelled as an oscillatory interaction between the mean shear and the turbulence. The interaction is made quantitative using empirically established properties of stratified turbulence. The model also suggests a practical way to estimate both the mean kinetic energy of the turbulence and its viscous dissipation rate. Solutions compare favourably with observations of fluctuating ‘deep cycle’ turbulence in the equatorial oceans.
We developed a protocol for comprehensive evaluation of nutrient management (NM) technologies for production of eggplant taking its yield, produce quality, profitability, energy balance and environmental sustainability in terms of upkeeping soil quality as the goal variables. Fifteen NM technologies comprising of three sources of nutrients viz., organics [vermicompost (VC), farmyard manure (FYM) and mustard oil cake (MOC)], inorganic fertilizations [recommended N–P–K at the rate of 100–22–42 kg ha−1 and 150% of recommended N–P–K (NPK^)] and their selected combinations were tested for growing the plants. Integrated NM technology was proved to be socio-economically sound and environment-friendly practice. It helped to upkeep soil quality by improving soil organic carbon stock, microbial biomass carbon, bulk density and available nutrients in soils. Combining all the parameters by employing non-parametric evaluation of regression factor scores through principal component analysis, the NM technology of VC3 Mg ha−1+NPK^ was found to be the best when considering the marketable fruits (12.27 Mg ha−1), economic return (benefit-cost ratio 3.3; marginal rate of return 8.7), energy conserving efficiency (net energy 113.8 GJ ha−1), soil and crop quality for human welfare. Only organics were less productive and profitable, and energetically less efficient than the integrated and inorganic NM systems and as such may not be sustainable for eggplant production in subtropical India.
Combined free and forced convection Couette-Hartmann flow of a viscous, incompressible and electrically conducting fluid in rotating channel with arbitrary conducting walls in the presence of Hall current is investigated. Boundary conditions for magnetic field and expressions for shear stresses at the walls and mass flow rate are derived. Asymptotic analysis of solution for large values of rotation and magnetic parameters is performed to highlight nature of modified Ekmann and Hartmann boundary layers. Numerical solution of non-linear energy equation and rate of heat transfer at the walls are computed with the help of MATHEMATICA. It is found that velocity depends on wall conductance ratio of moving wall and on the sum of wall conductance ratios of both the walls of channel. There arises reverse flow in the secondary flow direction near central region of the channel due to thermal buoyancy force. Thermal buoyancy force, rotation, Hall current and wall conductance ratios resist primary fluid velocity whereas thermal buoyancy force and Hall current favor secondary fluid velocity in the region near lower wall of the channel. Magnetic field favors both the primary and secondary fluid velocities in the region near lower wall of the channel.
A comprehensive study based on U–Pb and Hf isotope analyses of zircons from gneisses has been conducted along the western part (Babina area) of the E–W-trending Bundelkhand Tectonic Zone in the central part of the Archaean Bundelkhand Craton. 207Pb–206Pb zircon ages and Hf isotopic data indicate the existence of a felsic crust at ~ 3.59 Ga, followed by a second tectonothermal event at ~ 3.44 Ga, leading to calc-alkaline magmatism and subsequent crustal growth. The study hence suggests that crust formation in the Bundelkhand Craton occurred in a similar time-frame to that recorded from the Singhbhum and Bastar cratons of the North Indian Shield.
Diarrhoeal diseases are major causes of morbidity and mortality in developing countries. This longitudinal study aimed to identify controllable environmental drivers of intestinal infections amidst a highly contaminated drinking water supply in urban slums and villages of Vellore, Tamil Nadu in southern India. Three hundred households with children (<5 years) residing in two semi-urban slums and three villages were visited weekly for 12–18 months to monitor gastrointestinal morbidity. Households were surveyed at baseline to obtain information on environmental and behavioural factors relevant to diarrhoea. There were 258 diarrhoeal episodes during the follow-up period, resulting in an overall incidence rate of 0·12 episodes/person-year. Incidence and longitudinal prevalence rates of diarrhoea were twofold higher in the slums compared to rural communities (P < 0·0002). Regardless of study site, diarrhoeal incidence was highest in infants (<1 year) at 1·07 episodes/person-year, and decreased gradually with increasing age. Increasing diarrhoeal rates were associated with presence of children (<5 years), domesticated animals and low socioeconomic status. In rural communities, open-field defecation was associated with diarrhoea in young children. This study demonstrates the contribution of site-specific environmental and behavioural factors in influencing endemic rates of urban and rural diarrhoea in a region with highly contaminated drinking water.
While the cause of Parkinson's disease (PD) remains unknown, evidence suggests certain environmental factors, such as well water drinking, herbicides, pesticides exposure and neurotoxins, may trigger the chain of oxidative reactions culminating in the death of dopaminergic neurons in substantia nigra to cause Parkinsonism. To investigate the possible impact of environmental risk factors for idiopathic PD, a case-control study was performed in the Eastern India.
Methods:
During the period from January 1st, 2006 and December 10th, 2009, 175 PD patients (140 men, 35 women) and 350 non-Parkinson age-sex matched controls were included in the study. Subjects were given a structured neurological examination and completed an administered questionnaire which elicited detailed information on demographic data, pesticides, herbicides family history, occupation, dietary and smoking habits.
Results:
The multivariate analysis revealed that family history of PD, pesticide exposure, exposure to toxins other than pesticides and herbicides, rural living and previous history of depression were associated with increased risk of PD, whereas, smoking appeared to be a protective factor. Well water drinking for at least five years, though a significant risk factor on univariate analysis (OR=4.5, 95% CI=2.1-9.9), could not be proved significant in multivariate analysis. Head trauma, vegetarian dietary habit, occupation involving physical exertion and exposure to domestic pets were not as significant risk factors.
Conclusion:
Results of our study support the hypothesis of multifactorial etiology of PD with environmental factors acting on a genetically susceptible host.
Development of a representative and well-diversified core with minimum duplicate accessions and maximum diversity from a larger population of germplasm is highly essential for breeders involved in crop improvement programmes. Most of the existing methodologies for the identification of a core set are either based on qualitative or quantitative data. In this study, an approach to the identification of a core set of germplasm based on the response from a mixture of qualitative (single nucleotide polymorphism genotyping) and quantitative data was proposed. For this purpose, six different combined distance measures, three for quantitative data and two for qualitative data, were proposed and evaluated. The combined distance matrices were used as inputs to seven different clustering procedures for classifying the population of germplasm into homogeneous groups. Subsequently, an optimum number of clusters based on all clustering methodologies using different combined distance measures were identified on a consensus basis. Average cluster robustness values across all the identified optimum number of clusters under each clustering methodology were calculated. Overall, three different allocation methods were applied to sample the accessions that were selected from the clusters identified under each clustering methodology, with the highest average cluster robustness value being used to formulate a core set. Furthermore, an index was proposed for the evaluation of diversity in the core set. The results reveal that the combined distance measure A1B2 – the distance based on the average of the range-standardized absolute difference for quantitative data with the rescaled distance based on the average absolute difference for qualitative data – from which three clusters that were identified by using the k-means clustering algorithm along with the proportional allocation method was suitable for the identification of a core set from a collection of rice germplasm.
Socio-behavioural factors and pathogens associated with childhood diarrhoea are of global public health concern. Our survey in 696 children aged ⩽2 years in rural West Bengal detected rotavirus as sole pathogen in 8% (17/199) of diarrhoeic stool specimens. Other organisms were detected along with rotavirus in 11% of faecal specimens. A third of the children with rotavirus diarrhoea, according to Vesikari score, had severe illness. The top four rotavirus genotypes were G9P[4] (28%), G1P[8] (19%), G2P[4] (14%) and G8P[4] (8%). In the multivariate model, the practice of ‘drawing drinking water by dipping a pot in the storage vessel’ [adjusted odds ratio (aOR) 2·21, 95% confidence interval (CI) 1·03–4·74, P = 0·041], and ‘children aged ⩽6 months with non-exclusive breastfeeding’ (aOR 2·07, 95% CI 1·1–3·82, P = 0·024) had twice the odds of having diarrhoea. Incidence of rotavirus diarrhoea was 24/100 child-years in children aged >6–18 months, 19/100 child-years in children aged >18–24 months and 5/100 child-years in those aged ⩽6 months. Results have translational implications for future interventions including vaccine development.
Investigation of optical absorption in ∼25μm thick, monocrystalline silicon (Si) substrates obtained from a novel exfoliation technique is done by fabricating solar cells with single heterojunction architecture (without using intrinsic amorphous silicon layer) with diffused back junction and local back contact. The ease of process flow and the rugged and flexible nature of the substrates due to thick metal backing enables use of various light-trapping and optical absorption enhancement schemes traditionally practiced in the industry for thicker (>120μm) substrates. Optical measurement of solar cells using antireflective coating, texturing on both surfaces, and back surface dielectric/metal stack as mirror to reflect the long wavelength light from the back surface show a very low front surface reflectance of 4.6% in the broadband spectrum (300nm-1200nm). The illuminated current voltage (IV) and external quantum efficiency (EQE) measurement of such solar cell shows a high integrated current density of 34.4mA/cm2, which implies significant internal photon reflection. Our best cell with intrinsic amorphous silicon (i-a-Si) layer with only rear surface textured shows an efficiency of 14.9%. EQE data shows improved blue response and current density due to better front surface passivation. Simulations suggest that with optimized light trapping and surface passivation, such thin c-Si cells can reach efficiencies >20%.
The effectiveness of different routes of equal channel angular pressing (A, Bc, and C) is studied for commercially pure copper. The stored energy and the activation energy of recrystallization for the deformed samples were quantified using differential scanning calorimetry and X-ray diffraction line profile analysis. Results of the study revealed that the dislocation density and the stored energy are higher in the case of route Bc deformed sample. The activation energy for recrystallization is lower for route Bc.
Children with conduct disorder (CD) are at increased risk of developing antisocial personality disorder (ASPD) and psychopathy in adulthood. The biological basis for this is poorly understood. A preliminary diffusion tensor magnetic resonance imaging (DT-MRI) study of psychopathic antisocial adults reported significant differences from controls in the fractional anisotropy (FA) of the uncinate fasciculus (UF), a white-matter tract that connects the amygdala to the frontal lobe. However, it is unknown whether developmental abnormalities are present in the UF of younger individuals with CD.
Method
We used DT-MRI tractography to investigate, for the first time, the microstructural integrity of the UF in adolescents with CD, and age-related differences in this tract. We compared FA and perpendicular diffusivity of the UF in 27 adolescents with CD and 16 healthy controls (12 to 19 years old) who did not differ significantly in age, IQ or substance use history. To confirm that these findings were specific to the UF, the same measurements were extracted from two non-limbic control tracts. Participants in the CD group had a history of serious aggressive and violent behaviour, including robbery, burglary, grievous bodily harm and sexual assault.
Results
Individuals with CD had a significantly increased FA (p = 0.006), and reduced perpendicular diffusivity (p = 0.002), in the left UF. Furthermore, there were significant age-related between-group differences in perpendicular diffusivity of the same tract (Zobs = 2.40, p = 0.01). Controls, but not those with CD, showed significant age-related maturation. There were no significant between-group differences in any measure within the control tracts.
Conclusions
Adolescents with CD have significant differences in the ‘connectivity’ and maturation of UF.
The historical deforestation of the Upper Brahmaputra Valley in the Indian state of Assam has resulted in the transformation of its once-contiguous lowland rainforests into many isolated forest fragments that are still rich in species, including primates. We report the recent history and current status of six diurnal primates in one large (2,098 ha) and three small (<500 ha) fragments of the Upper Brahmaputra Valley. We censused primates in the small fragments during 2002, 2005, 2009, in the large fragment in 2008, and used other published census data to derive population trends. We also used key informant surveys to obtain historical occurrence data for these populations. Our analyses reveal the recent extinction of some populations and the simultaneous long-term persistence of others in these fragments over 16 years. Most populations appeared to have declined in the small fragments but primate abundance has increased significantly in the largest fragment over the last decade. Addressing the biomass needs of the local human populations, which appears to drive habitat degradation, and better protection of these forests, will be crucial in ensuring the future survival of this diverse and unique primate assemblage in the last rainforest fragments of the human-dominated Upper Brahmaputra Valley.
Knowledge of the genetic diversity of germplasm of breeding material is invaluable in crop improvement programmes. Frequently, qualitative and quantitative data are used separately to assess genetic diversity of crop genotypes. While assessing diversity based on qualitative and quantitative traits separately, there may occur a problem when the degree of correspondence between the clusters formed does not agree with each other. This study compares five different procedures of clustering based on the criterion of weighted average of observed proportion of misclassification in black gram genotypes using qualitative, quantitative traits and mixture data. The INDOMIX- and PRINQUAL-based clustering procedures, i.e. INDOMIX and PRINQUAL methods in conjunction with the k-means clustering procedure, show better performance compared with other clustering procedures, followed by clustering based on either quantitative or qualitative data alone. The use of the INDOMIX- and PRINQUAL-based procedures can help breeders in capturing the variation present in both qualitative and quantitative trait data simultaneously and solving the problem of ambiguity over the degree of correspondence between clustering based on either qualitative or quantitative traits alone.
Over a 2-year period, 25 families comprising of 181 individuals of all ages were longitudinally observed for the excretion of Campylobacter species. Faecal samples were taken from all persons with diarrhoea. Specimens were also taken from apparently healthy individuals and from domestic animals living within the confines of the study families at monthly intervals.
The overall diarrhoea attack rate was 19 episodes per 100 person-years with peak incidence in the 1- to 4-year-old age group (76/100 person-years). Eight (11·5%) of the total episodes were campylobacter-associated and the overall rate of campylobacter positive diarrhoeal episodes were 2·2 per 100 person-years. Of the 1002 stool samples from healthy individuals 32 (3·2/100 samples) were positive for campylobacter. The organism was most frequently isolated from children under 1 year of age both during diarrhoeal episodes (11·5 per 100 person-years) and non-diarrhoeal (11·1 per 100 samples). Multiple infections in a family were rare. In 19·4% of the occasions one or more animals were campylobacter positive. However, only in 7·7% of these occasions was a human infection recorded within 1 month after the animal was found to be positive.
The study showed that the epidemiology of campylobacteriosis in this community was distinct compared to that observed in developed countries.