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Autistic symptoms represent a frequent feature in schizophrenia spectrum disorders (SSD). However, the prevalence and the cognitive and functional correlates of autistic symptoms in unaffected first-degree relatives of people with SSD remain to be assessed.
Methods
A total of 342 unaffected first-degree relatives related to 247 outpatients with schizophrenia were recruited as part of the multicenter study of the Italian Network for Research on Psychoses (NIRP). Autistic features were measured with the PANSS Autism Severity Scale. Three groups of participants, defined on the presence and severity of autistic symptoms, were compared on a wide array of cognitive and functional measures.
Results
Of the total sample, 44.9% presented autistic symptoms; 22.8% showed moderate levels of autistic symptoms, which can be observed in the majority of people with SSD. Participants with higher levels of autistic symptoms showed worse performance on Working Memory (p = 0.014) and Social Cognition (p = 0.025) domains and in the Global Cognition composite score (p = 0.008), as well as worse on functional capacity (p = 0.001), global psychosocial functioning (p < 0.001), real-world interpersonal relationships (p < 0.001), participation in community activities (p = 0.017), and work skills (p = 0.006).
Conclusions
A high prevalence of autistic symptoms was observed in first-degree relatives of people with SSD. Autistic symptoms severity showed a negative correlation with cognitive performance and functional outcomes also in this population and may represent a diagnostic and treatment target of considerable scientific and clinical interest in both patients and their first-degree relatives.
Deficits in social cognition (SC) are significantly related to community functioning in schizophrenia (SZ). Few studies investigated longitudinal changes in SC and its impact on recovery. In the present study, we aimed: (a) to estimate the magnitude and clinical significance of SC change in outpatients with stable SZ who were assessed at baseline and after 4 years, (b) to identify predictors of reliable and clinically significant change (RCSC), and (c) to determine whether changes in SC over 4 years predicted patient recovery at follow-up.
Methods
The reliable change index was used to estimate the proportion of true change in SC, not attributable to measurement error. Stepwise multiple logistic regression models were used to identify the predictors of RCSC in a SC domain (The Awareness of Social Inference Test [TASIT]) and the effect of change in TASIT on recovery at follow-up.
Results
In 548 participants, statistically significant improvements were found for the simple and paradoxical sarcasm of TASIT scale, and for the total score of section 2. The reliable change index was 9.8. A cut-off of 45 identified patients showing clinically significant change. Reliable change was achieved by 12.6% and RCSC by 8% of participants. Lower baseline TASIT sect. 2 score predicted reliable improvement on TASIT sect. 2. Improvement in TASIT sect. 2 scores predicted functional recovery, with a 10-point change predicting 40% increase in the probability of recovery.
Conclusions
The RCSC index provides a conservative way to assess the improvement in the ability to grasp sarcasm in SZ, and is associated with recovery.
In this paper we present an experimental study of edge turbulence in the Large Plasma Device at UCLA. We utilize a scan of discharge power and prefill pressure (neutral density) to show experimentally that turbulent density fluctuations decrease with decreasing density gradient, as predicted for resistive drift-wave turbulence (RDWT). As expected for RDWT, we observe that the cross-phase between the density and potential fluctuations is close to 0. Moreover, the addition of an electron temperature gradient leads to a reduction in the amplitude of the density fluctuations, as expected for RDWT. However, counter to theoretical expectations, we find that the potential fluctuations do not follow the same trends as the density fluctuations for changes either in density gradients or the addition of a temperature gradient. The disconnect between the density and potential fluctuations is connected to changes in the parallel flows as a result of differences in the prefill pressure, i.e. neutral density. Further analysis of the density and potential fluctuation spectra show that the electron temperature gradient reduces the low frequency fluctuations up to $10 \,{\rm kHz}$ and the introduction of a temperature gradient leads to an unexpected ${\sim }{\rm \pi}$ shift of the density–potential cross-phase at ${\sim }10\,{\rm kHz}$, while maintaining the typical resistive drift-wave cross-phase at lower frequencies. These experiments partly confirm existing knowledge on resistive drift-wave turbulence, but also introduce new observations that indicate a need for dedicated nonlinear three-dimensional turbulence simulations that include neutrals.
As part of the project reported on in this special issue, the present study provides an overview of the types of action accomplished by other-repetition in Italian, with particular reference to the variety of the language spoken in the northeastern province of Trento. The analysis surveys actions within the domain of initiating repair, actions that extend beyond initiating repair, and actions that are alternative to initiating repair. Pitch contour emerges as a central design feature of other-repetition in Italian, with six nuclear contours associated with distinct types of action, sequential trajectories, and response patterns. The study also documents the interplay of pitch contour with other prosodic features (pitch span and register) and visible behavior (head nods, eyebrow movements). (Repetition, conversation, prosody, intonation, action, Italian)*
In this article, I introduce the aims and scope of a project examining other-repetition in natural conversation. This introduction provides the conceptual and methodological background for the five language-specific studies contained in this special issue, focussing on other-repetition in English, Finnish, French, Italian, and Swedish. Other-repetition is a recurrent conversational phenomenon in which a speaker repeats all or part of what another speaker has just said, typically in the next turn. Our project focusses particularly on other-repetitions that problematise what is being repeated and typically solicit a response. Previous research has shown that such repetitions can accomplish a range of conversational actions. But how do speakers of different languages distinguish these actions? In addressing this question, we put at centre stage the resources of prosody—the nonlexical acoustic-auditory features of speech—and bring its systematic analysis into the growing field of pragmatic typology—the comparative study of language use and conversational structure. (Repetition, conversation, prosody, pragmatics, typology)*
Depression is an important risk factor for suicide. However, other dimensions may contribute to the suicidal risk and to the transition from ideas to acts. We aimed to test the relative involvement of hopelessness, temperament, childhood trauma, and aggression in suicide risk in a large sample of patients with mood disorders.
Methods:
We assessed 306 patients with major depressive and bipolar disorders for clinical characteristics including hopelessness, temperament, childhood trauma, and aggression. We tested their associations with suicidal ideation and acts using standard univariate/bivariate methods, followed by multivariate logistic regression models.
Results:
In multivariate analyses, the loss of expectations subscore of the hopelessness scale was associated with lifetime suicidal ideation but not suicide attempt. Childhood emotional abuse, severity of current depression, and female gender were associated with lifetime suicide attempts, whereas hyperthymic temperament was protective. Only hyperthymic temperament differentiated patients with a history of suicidal ideas vs. those with a history of suicide attempt.
Conclusions:
Findings support the association of hopelessness with suicidal ideation and point to considering in suicidal acts not only depression, but also childhood emotional abuse, hyperthymic temperament, and gender.
People often begin stories in conversation by referring to person, time, and place. We study story beginnings in three societies and find place reference is recurrently used to (i) set the stage, foreshadowing the type of story and the kind of response due, and to (ii) make the story cohere, anchoring elements of the developing story. Recipients orient to these interactional affordances of place reference by responding in ways that attend to the relevance of place for the story and by requesting clarification when references are incongruent or noticeably absent. The findings are based on 108 story beginnings in three unrelated languages: Cha'palaa, a Barbacoan language of Ecuador; Northern Italian, a Romance language of Italy; and Siwu, a Kwa language of Ghana. The commonalities suggest we have identified generic affordances of place reference, and that storytelling in conversation offers a robust sequential environment for systematic comparative research. (Storytelling, place, narrative, conversation analysis, interactional linguistics)*
Published in 1803, this is the third part of a three-volume descriptive catalogue of the Hebrew codices in the personal library of Giovanni Bernardo De Rossi (1742–1831), professor of oriental languages at the University of Parma. Each codex is numbered and its contents briefly described in Latin. Volume 3 features descriptions of codices 859–1,377 as well as an appendix of his codices in other languages. De Rossi was an important collector of manuscripts and incunabula, and an authority on Hebrew typography and textual variants. The Hebrew manuscripts described in this catalogue were obtained as a result of his exhaustive researches into variant readings of the Old Testament, the results of which he published as Variae lectiones veteris testamenti (1784–8). He also produced groundbreaking studies of printed Hebrew texts, and a catalogue of Jewish anti-Christian polemics, Bibliotheca judaica antichristiana (also reissued in this series).
Published in 1803, this is the second part of a three-volume descriptive catalogue of the Hebrew codices in the personal library of Giovanni Bernardo De Rossi (1742–1831), professor of oriental languages at the University of Parma. Each codex is numbered and its contents briefly described in Latin. Volume 2 features descriptions of codices 347–858 from a total of 1,377. De Rossi was an important collector of manuscripts and incunabula, and an authority on Hebrew typography and textual variants. The Hebrew manuscripts described in this catalogue were obtained as a result of his exhaustive researches into variant readings of the Old Testament, the results of which he published as Variae lectiones veteris testamenti (1784–8). He also produced groundbreaking studies of printed Hebrew texts, and a catalogue of Jewish anti-Christian polemics, Bibliotheca judaica antichristiana (also reissued in this series).
Published in 1803, this is the first part of a three-volume descriptive catalogue of the Hebrew codices in the personal library of Giovanni Bernardo De Rossi (1742–1831), professor of oriental languages at the University of Parma. Each codex is numbered and its contents briefly described in Latin. Volume 1 includes an introduction (in Latin) and descriptions of codices 1–346 from a total of 1,377. De Rossi was an important collector of manuscripts and incunabula, and an authority on Hebrew typography and textual variants. The manuscripts described in this catalogue were obtained as a result of his exhaustive researches into variant readings of the Old Testament, the results of which he published in Variae lectiones veteris testamenti (1784–8). He also produced groundbreaking studies of printed Hebrew texts, and a catalogue of Jewish anti-Christian polemics, Bibliotheca judaica antichristiana (also reissued in this series).
The future space debris environment will be dominated by the production of fragments coming from massive fragmentations. In order to identify the most relevant parameters influencing the long term evolution of the environment and to assess the criticality of selected space objects in different regions of the circumterrestrial space, a large parametric study was performed. In this framework some indicators were produced to quantify and rank the relevance of selected fragmentations on the long term evolution of the space debris population. Based on the results of the fragmentation studies, a novel analytic index, the Criticality of Spacecraft Index, aimed at ranking the environmental criticality of abandoned objects in LEO, has been devised and tested on a sample population of orbiting objects.
Giovanni Bernardo De Rossi (1742–1831) first studied Hebrew in Turin as a requirement for his theology degree. Having swiftly mastered several Semitic languages and been ordained a priest, he was appointed professor of oriental languages at the University of Parma in 1769. Despite offers from Pavia, Madrid and Rome, he remained there until his death. An important collector of manuscripts and incunabula - in 1785 Pius VI tried to acquire his library for the Vatican - De Rossi published extensively on Hebrew typography and textual variants in the Old Testament. This 1800 catalogue of 182 Jewish polemics against Christianity - printed by Giambattista Bodoni, a noted typographer at the court of Parma - gives the texts' predominantly Hebrew titles and Latin content summaries. Also included is an 1812 Italian catalogue of books from De Rossi's library. Together they illuminate contemporary theological concerns and De Rossi's own bibliographic interests.
We prove a version of Kontsevich’s formality theorem for two subspaces (branes) of a vector space X. The result implies, in particular, that the Kontsevich deformation quantizations of S(X*) and ∧(X) associated with a quadratic Poisson structure are Koszul dual. This answers an open question in Shoikhet’s recent paper on Koszul duality in deformation quantization.
Large-signal radiofrequency performances of surface channel diamond MESFET fabricated on hydrogenated polycrystalline diamond are investigated. The adopted device structure is a typical coplanar two-finger gate layout, characterized in DC by an accumulation-like behavior with threshold voltage Vt ∼ 0-0.5 V and maximum DC drain current of 120 mA/mm. The best radiofrequency performances (in terms of fT and fmax) were obtained close to the threshold voltage. Realized devices are analyzed in standard class A operation, at an operating frequency of 2 GHz. The MESFET devices show a linear power gain of 8 dB and approximately 0.2 Wmm RF output power with 22% power added efficiency. An output power density of about 0.8 W/mm can be then extrapolated at 1 GHz, showing the potential of surface channel MESFET technology on polycrystalline diamond for microwave power devices.
Legislation in 1978 led to the gradual replacement of mental hospitals in Italy with a full range of community-based services, including facilities for acute in-patient care.
Aims
To survey the main characteristics of Italian public and private in-patient facilities for acute psychiatric disorders.
Method
Structured interviews were conducted with each facility's head psychiatrist in all Italian regions, with the exception of Sicily.
Results
Overall, Italy (except Sicily) has atotal of 4108 public in-patient beds in 319 facilities, with 0.78 beds for every 10 000 inhabitants, and 4862 beds in 54 private in-patient facilities, with 0.94 beds per 10 000 inhabitants. In 2001 the rates of psychiatric admissions and admitted patients per 10 000 inhabitants were 26.7 and 17.8 respectively. In the same year the percentage of involuntary admissions was 12.9%, for atotal of 114 570 hospital days. Many in-patient facilities showed significant limitations in terms of architectural and logistic characteristics. Staffing showed a great variability among facilities.
Conclusions
The overall number of acute beds per 10 000 inhabitants is one of the lowest in Europe. The survey has provided evidence of two parallel systems of in-patient care, a public one and a private one, which are not fully interchangeable.
Gliosis is strongly implicated in the development and maintenance of persistent pain states following chronic constriction injury of the sciatic nerve. Here we demonstrate that in the dorsal horn of the spinal cord, gliosis is accompanied by changes in glial amino acid transporters examined by immunoblot, immunohistochemistry and RT-PCR. Cytokines, proinflammatory mediators and microglia increase up to postoperative day (pd) 3 before decreasing on pd 7. Then, spinal glial fibrillary acidic protein increases on pd 7, lasting until pd 14 and later. Simultaneously, the expression of glial amino acid transporters for glycine and glutamate (GlyT1 and GLT1) is reduced on pd 7 and pd 14. Consistent with a reduced expression of GlyT1 and GLT1, high performance liquid chromatography reveals a net increase in the concentration of glutamate and glycine on pd 7 and pd 14 in tissue from the lumbar spinal cord of neuropathic mice. In this study we have confirmed that microglial activation precedes astrogliosis. Such a glial cytoskeletal rearrangement correlates with a marked decrease in glycine and glutamate transporters, which might, in turn, be responsible for the increased concentration of these neurotransmitters in the spinal cord. We speculate that these phenomena might contribute, via over-stimulation of NMDA receptors, to the changes in synaptic functioning that are responsible for the maintenance of persistent pain.
We investigate secular changes in the distribution of personal expenditure in Italy. To this end we present a new data set, consisting of 4,370 family-level budgets scattered over the years 1881–1961. Our methodology is innovative for this kind of study. Italy's secular trend proves to have been egalitarian, and to have accelerated in periods of fast output growth. Sectoral, residential, and demographic changes associated with “modern economic growth” account for a minor part of the observed changes in expenditure distribution, suggesting that other factors, such as wage differentials, play a dominant role in explaining the dynamics of inequality.