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Autism spectrum disorders (ASD) are associated with high services use, but European data on costs are scarce.
Objectives
Utilisation and annual costs of 385 individuals with ASD (aged 4-67 years; 18.2% females; 37.4% IQ < 85) from German outpatient clinics were assessed.
Methods
Client Service Receipt Inventory
Results
Average annual costs per person were 3287 EUR, with psychiatric inpatient care (19.8%), pharmacotherapy (11.1%), and occupational therapy (11.1%) being the largest cost components. Females incurred higher costs than males (4864 EUR vs. 2936 EUR). In a regression model, female sex (Cost Ratio: 1.65), lower IQ (1.90), and Asperger syndrome (1.54) were associated with higher costs.
Conclusions
In conclusion, ASD-related health costs are comparable to those of schizophrenia, thus underlining its public health relevance. Higher costs in females demand further research.
The main aim of the current study was to present the abilities of widely used crop models to simulate four different field crops (winter wheat, spring barley, silage maize and winter oilseed rape). The 13 models were tested under Central European conditions represented by three locations in the Czech Republic, selected using temperature and precipitation gradients for the target crops in this region. Based on observed crop phenology and yield from 1991 to 2010, performances of individual models and their ensemble were analyzed. Modelling of anthesis and maturity was generally best simulated by the ensemble median (EnsMED) compared to the ensemble mean and individual models. The yield was better simulated by the best models than estimated by an ensemble. Higher accuracy was achieved for spring crops, with the best results for silage maize, while the lowest accuracy was for winter oilseed rape according to the index of agreement (IA). Based on EnsMED, the root mean square errors (RMSEs) for yield was 1365 kg/ha for winter wheat, 1105 kg/ha for spring barley, 1861 kg/ha for silage maize and 969 kg/ha for winter oilseed rape. The AQUACROP and EPIC models performed best in terms of spread around the line of best fit (RMSE, IA). In some cases, the individual models failed. For crop rotation simulations, only models with reasonable accuracy (i.e. without failures) across all included crops within the target environment should be selected. Application crop models ensemble is one way to increase the accuracy of predictions, but lower variability of ensemble outputs was confirmed.
Childhood maltreatment is associated with altered neural reactivity during autobiographical memory (ABM) recall and a pattern of overgeneral memory (OGM). Altered ABM and OGM have been linked with psychopathology and poorer social functioning. The present study investigated the association between altered ABM and subsequent socio-emotional functioning (measured two years later) in a sample of adolescents with (N = 20; maltreatment group, MT) and without (N = 17; non-MT group) documented childhood maltreatment histories.
Method
At baseline, adolescents (aged 12.6 ± 1.45 years) were administered the Autobiographical Memory Test to measure OGM. Participants also recalled specific ABMs in response to emotionally valenced cue words during functional MRI. Adolescents in both groups underwent assessments measuring depressive symptoms and prosocial behavior at both timepoints. Regression analyses were carried out to predict outcome measures at follow-up controlling for baseline levels.
Results
In the MT group, greater OGM at baseline significantly predicted reduced prosocial behavior at follow-up and showed a trend level association with elevated depressive symptoms. Patterns of altered ABM-related brain activity did not significantly predict future psycho-social functioning.
Conclusions
The current findings highlight the potential value of OGM as a cognitive mechanism that could be targeted to reduce risk of depression in adolescents with prior histories of maltreatment.
Alcohol relapse is often occurring to regulate negative affect during withdrawal. On the neurobiological level, alcoholism is associated with gray matter (GM) abnormalities in regions that regulate emotional experience such as the orbitofrontal cortex (OFC). However, no study to our knowledge has investigated the neurobiological unpinning of affect in alcoholism at early withdrawal and the associations of OFC volume with long-term relapse risk.
Methods:
One hundred and eighty-two participants were included, 95 recently detoxified alcohol dependent patients (ADP) and 87 healthy controls (HC). We measured affective states using the positive and negative affect schedule (PANAS). We collected T1-weighted brain structural images and performed Voxel-based morphometry (VBM).
Results:
Findings revealed GM volume decrease in alcoholics in the prefrontal cortex (including medial OFC), anterior cingulate gyrus, and insula. GM volume in the medial OFC was positively associated with NA in the ADP group. Cox regression analysis predicted that risk to heavy relapse at 6 months increases with decreased GM volume in the medial OFC.
Conclusions:
Negative affect during alcohol withdrawal was positively associated with OFC volume. What is more, increased GM volume in the OFC also moderated risk to heavy relapse at 6 months. Reduced GM in the OFC poses as risk to recovery from alcohol dependence and provides valuable insights into transient negative affect states during withdrawal that can trigger relapse. Implications exist for therapeutic interventions signifying the OFC as a neurobiological marker to relapse and could explain the inability of ADP to regulate internal negative affective states.
The alteration and transformation behaviour of Ceca smectite in two acid and saline solutions (NaCl and KCl) was studied in batch experiments. This type of smectite is proposed as potential backfill material for nuclear waste storage sites. The initial solution was enriched with 500 ppm of U, Th and Eu. The evolution of pH and solution concentrations were measured over a period of 25 months. The mineralogical and chemical evolution of the clays was also studied. X-ray diffraction revealed a significant loss of diffraction intensity and the clays became amorphous to Xrays with increasing reaction time. Deconvolution of the XRD data indicated a continuous collapse of the smectite layers but no illitization. Infrared spectroscopy revealed unchanged smectite spectra at the end of the experiment. Thorium precipitated as amorphous ThO2, but showed an incipient crystallization after 500 days. The Th, Eu and U were neither adsorbed onto the clays nor incorporated into a secondary phase.
This study investigates how the ecosystem services (ES) linked to livestock grazing are perceived across countries. A total of 82 case studies collected from 42 countries via survey (53.7% cases from Europe and 46.3% from outside of Europe) have been analysed through a multivariate approach. In all, 18 non-provisioning ES were considered. Overall, the reported impacts of livestock grazing on the different ES were much more positive than negative. Notably, a large proportion of respondents reported either positive or very positive impacts for some cultural ES, namely cultural, historic and natural heritage (84%), knowledge systems and educational values (77%), landscape values (74%), and for some supporting and regulating ES, namely habitat provision (66%), nutrient cycling (65%), and bush encroachment/fire control (66%). Based on multiple regression analysis, geographic origin, stakeholder type and species category, as well as protection status of the grazing area, had significant effects on the perception of the impacts. Respondents reported those impacts as more positive in Europe, in protected areas and where several species were present in the grazing area. A significantly larger proportion of respondents reported recognition of ES provided by the grazing livestock population in European countries (40.9%) compared with non-European countries (23.7%). Based on the survey responses it appears that in non-European countries absence of formal recognition, especially by policy makers, is a major challenge for the continued provision of ES in grazing systems. In Europe, where such recognition is already often included in legislation, the long-term sustainability of related policies and incentives to provide such services is viewed as a major issue by the respondents.
Alterations in reinforcement-based decision making may be associated with increased psychiatric vulnerability in children who have experienced maltreatment. A probabilistic passive avoidance task and a model-based functional magnetic resonance imaging analytic approach were implemented to assess the neurocomputational components underlying decision making: (a) reinforcement expectancies (the representation of the outcomes associated with a stimulus) and (b) prediction error signaling (the ability to detect the differences between expected and actual outcomes). There were three main findings. First, the maltreated group (n = 18; mean age = 13), relative to nonmaltreated peers (n = 19; mean age = 13), showed decreased activity during expected value processing in a widespread network commonly associated with reinforcement expectancies representation, including the striatum (especially the caudate), the orbitofrontal cortex, and medial temporal structures including the hippocampus and insula. Second, consistent with previously reported hyperresponsiveness to negative cues in the context of childhood abuse, the maltreated group showed increased prediction error signaling in the middle cingulate gyrus, somatosensory cortex, superior temporal gyrus, and thalamus. Third, the maltreated group showed increased activity in frontodorsal regions and in the putamen during expected value representation. These findings suggest that early adverse environments disrupt the development of decision-making processes, which in turn may compromise psychosocial functioning in ways that increase latent vulnerability to psychiatric disorder.
Older people have a higher risk of drug-related problems (DRPs). However, little is known about the prevalence of DRPs in community-dwelling people who screened positive for dementia. Our study aimed to determine (1) the prevalence and types of DRPs and (2) the socio-demographic and clinical variables associated with DRPs in people screened positive for dementia in primary care.
Methods:
The Dementia: life- and person-centered help in Mecklenburg-Western Pomerania (DelpHi-MV) study is a general practitioner (GP)-based cluster-randomized controlled intervention study to implement and evaluate an innovative concept of collaborative dementia care management in the primary care setting in Germany. Medication reviews of 446 study participants were conducted by pharmacists based on a comprehensive baseline assessment that included a computer-based home medication assessment. ClinicalTrials.gov Identifier: NCT01401582.
Results:
A total of 1,077 DRPs were documented. In 414 study participants (93%), at least one DRP was detected by a pharmacist. The most frequent DRPs were administration and compliance problems (60%), drug interactions (17%), and problems with inappropriate drug choice (15%). The number of DRPs was significantly associated with the total number of drugs taken and with a formal diagnosis of a mental or behavioral disorder.
Conclusions:
Degree of cognitive impairment (MMSE defined) and formal diagnosis of dementia were not risk factors for an increased number of DRPs. However, the total number of drug taken and the presence of a diagnosis of mental and behavioral disorders were associated with an increased total number of DRPs.
Rangea is the type genus of the Rangeomorpha, an extinct clade near the base of the evolutionary tree of large, complex organisms which prospered during the late Neoproterozoic. It represents an iconic Ediacaran taxon, but the relatively few specimens previously known significantly hindered an accurate reconstruction. Discovery of more than 100 specimens of Rangea in two gutter casts recovered from Farm Aar in southern Namibia significantly expands this data set, and the well preserved internal and external features on these specimens permit new interpretations of Rangea morphology and lifestyle. Internal structures of Rangea consist of a hexaradial axial bulb that passes into an axial stalk extending the length of the fossil. The axial bulb is typically filled with sediment, which becomes increasingly loosely packed and porous distally, with the end of the stalk typically preserved as an empty, cylindrical cone. This length of the axial structure forms the structural foundation for six vanes arranged radially around the axis, with each vane consisting of a bilaminar sheet composed of a repetitive pattern of elements exhibiting at least three orders of self-similar branching. Rangea was probably an epibenthic frond that rested upright on the sea bottom, and all known fossil specimens were transported prior to their final burial in storm deposits.
Crossbreeding, considering either terminal or rotational crossing, synthetic breed creation or breed replacement, is often promoted as an efficient strategy to increase farmers’ income through the improvement of productivity of local livestock in developing countries. Sustainability of crossbreeding is however frequently challenged by constraints such as poor adaptation to the local environment or lack of logistic support. In this review, we investigate factors that may influence the long-term success or the failure of crossbreeding programs, based on the scientific literature and country reports submitted for The Second Report on the State of the World’s Animal Genetic Resources for Food and Agriculture. Crossbreeding activities vary widely across species and countries. Its sustainability is dependent on different prerequisites such as continual access to adequate breeding stock (especially after the end of externally funded crossbreeding projects), the opportunity of improved livestock to express their genetic potential (e.g. through providing proper inputs) and integration within a reliable market chain. As formal crossbreeding programs are often associated with adoption of other technologies, they can be a catalyst for innovation and development for smallholders. Given the increasing global demand for animal products, as well as the potential environmental consequences of climate change, there is a need for practical research to improve the implementation of long-term crossbreeding programs in developing countries.
The Global Plan of Action (GPA) for Animal Genetic Resources (AnGR) adopted by FAO recognizes the role of AnGR for food security through improved productivity while maintaining genetic diversity. A critical issue for conservation and genetic improvement programmes is the availability of supportive infrastructure. The objective of the present study was to assess existing and needed infrastructure for sustainable use of AnGR in a sample of countries in Southern and Eastern Africa. Information was primarily obtained from semi-structured interviews with key personnel in animal breeding during country visits. Countries studied are at different stages of development. No complete breeding programmes are in place but some conservation programmes exist in most countries. Except for a few cases, livestock recording as basis for R&D and breeding practice is lacking. The institutional setup to support animal breeding programmes is fragmented and needs to be better integrated. Shortage of skilled personnel is noted as the most serious constraint for development. Countries with least university training in animal breeding have least developed AnGR activities. However, since the GPA was agreed upon, many countries have re-casted their policies and make efforts to develop breeding policies. A change in mindsets aiming at closer collaboration among institutions, farmer involvement and capacity development and strengthening at all levels is suggested.
Leptin is thought to act as an important mediator in stress reactions. To date, no study has examined the association between psychological stress and leptin levels in children. This study aimed to assess the association between emotional symptoms and peer problems and serum leptin levels in children aged 10 years of the two population-based GINI-plus and LISA-plus birth cohorts.
Method
Cross-sectional data from 2827 children aged 10 years were assessed with regard to leptin concentrations in serum and behavioral problems using the parent-reported Strengths and Difficulties Questionnaire (SDQ). Linear regression modeling was applied to determine the likelihood of elevated leptin levels in children with emotional symptoms and peer problems, controlling for socio-economic status (SES), body mass index (BMI), fasting serum leptin levels, pubertal development and sex hormones.
Results
We found that increases in emotional symptoms (exp βadj = 1.03, s.e. = 0.02, p < 0.04) and peer problems (exp βadj = 1.05, s.e. = 0.01, p = 0.0001) were significantly associated with higher serum leptin levels controlled for BMI and sociodemographic factors. Similar results were found when the fasting serum leptin sample was examined (exp βadj = 1.08, s.e. = 0.04, p = 0.0294). Gender-stratified analyses showed a significant relationship between serum leptin and peer problems in girls (exp βadj = 1.05, s.e. = 0.02, p = 0.03), and a borderline significant association in boys (exp βadj = 1.04, s.e. = 0.02, p = 0.05).
Conclusions
Children with peer problems have higher stress and eat more, acquire a higher body fat mass and thus, through increased leptin resistance, exhibit higher leptin levels.
Pseudorabies virus (PrV) infections appear to be more widely distributed in the European wild boar (Sus scrofa) population than assumed. In Europe, attempts to isolate and characterize the causative agents have been limited so far. We therefore collected and examined a total of 35 PrV isolates obtained from wild boar or hunting dogs in Germany, France, Spain, Italy, Slovakia and Hungary between 1993 and 2008. Restriction enzyme analysis of genomic DNA using BamHI showed that all isolates, except one, belonged to genogroup I but different subtypes were evident. For further investigations of the phylogenetic relationships, a 732-bp fragment of the glycoprotein C (gC) gene was amplified by PCR. Sequence analysis revealed about 40 variant positions within this fragment. Comparison of the nucleotide sequences supported the separation into a clade containing isolates from North-Rhine Westphalia, Rhineland-Palatinate (Germany), France and Spain (clade B) and an apparently more variable clade comprising isolates from Brandenburg, Baden-Wurttemberg, Saxony, Saxony-Anhalt (Germany), Slovakia, Hungary, Italy and France (clade A).
The Global Plan of Action for Animal Genetic Resources was adopted by 109 countries in Interlaken, in September 2007. It aims to promote a pragmatic, systematic and efficient overall approach, which harmoniously addresses the development of institutions, human resources, cooperative frameworks, and resource mobilization for the sustainable use and conservation of animal genetic resources. The Global Plan of Action contains five Strategic Priorities for Action on conservation. Countries have thereby committed themselves to develop national conservation policies, to establish or strengthen in situ and ex situ conservation programmes, to develop and implement regional and global long-term conservation strategies and to develop approaches and technical standards for conservation.
Within avian breeds globally, 30% are at risk and 9% are extinct. The proportion of breeds at risk and extinct is highest in chickens. Fast structural change has been identified as one threat to genetic resources. Following the advent of highly pathogenic avian influenza (HPAI) H5N1, conservation of poultry genetic resources has been discussed. Although in situ conservation of poultry breeds is the preferred method, cryoconservation technology has advanced. Poultry genetic resources are under-conserved, and strategic approaches to conservation need to be developed and implemented.
Spectroscopic study of plasma produced through bombardment of the 1 × 3 mm2 area on the surface of a solid Mg target with Kr+ ions is carried out. Spectral lines of Mg I and Mg II ions were observed in the visible range (200–600 nm). The plasma parameters Ne = 1.4.1017 cm−3 and Te = 0.8 eV are calculated from electron impact broadening of the 4f–3d line of Mg II and from the ratio of intensities for the 4f–3d and 4s–3p lines of Mg II. The ionic composition of the plasma is determined. The detected X-ray emission is shown to be the characteristic emission of the target.
Demonstration of matching a laser ion source to the GSI RFQ-Maxilac linear accelerator and the acceleration of a 1.8-mA current beam of Ta10+ ions up to 45 keV/u energy is presented. A 10J/μs CO2 laser has been used to produce a hot plasma plume, emitting highly charged tantulum ions. The correct geometry and potential distribution of the matching section has been designed in accordance with the results of computer simulations by using the AXCEL code. Measurements of the charge state distribution of the accelerated beam indicate that it contains about 70% Ta10+ and 30% Ta11+ ions.
This paper presents numerical simulations of thermodynamic and hydrodynamic response for solid targets that are irradiated with strongly bunched, highly focused, intense beams of energetic uranium ions. The main purpose of this work is to study the behavior of thermal stress waves induced in such targets by the incident ion beam. These theoretical studies will complement the experimental investigations that will be carried out in the near future at the Gesellschaft für Schwerionenforschung (GSI) plasma physics experimental area. These experiments will be performed using the existing heavy ion synchrotron, SIS18, which delivers 4 × 109 uranium ions in a single bunch with a length of about 125 ns. Other time structures, for example, a pulse that consists of a series of bunches, are also possible. The particle energy is on the order of 400 MeV/u and the beam can be focused to sub millimeter radius. This information concerning material response under intense beam loading will have important implications on designing a viable production target for the superconducting fragment separator, Super-FRS, which is going to be constructed at the future facility for antiproton and ion research (FAIR), Darmstadt, Germany, for the production and separation of exotic nuclei.
With the aim of assessing how exchange practices regarding Animal Genetic Resources for Food and Agriculture (AnGR) affect the various stakeholders in the livestock sector and to identify policies and regulatory options that could guide the global exchange, use and conservation of AnGR, an exploration of future scenarios was used as a complementary approach to reviewing the current situation, as well as to identify stakeholders’ views on AnGR policy development.
Four 2050 future scenarios were developed and included:
1. Globalization and regionalization.
2. Biotechnology development.
3. Climate change and environmental degradation.
4. Diseases and disasters.
Having developed the scenarios, these were then used as an input point for a wide range of stakeholder consultations.
The findings show that such an approach has been a useful analytical tool. The ‘far’ future perspective appeared to make people less defensive, especially in a situation where current exchange problems were not yet particularly visible or well documented. Many interviewees broadly considered that it was not a question of ‘if’ the scenarios would happen, but rather a question of ‘when’. This implies that we might do well to consider the need to respond to future challenges through the proactive development of new policies or regulations. Such a finding is partly in contrast with the general perception of the current regulatory situation being broadly acceptable.
In light of the upcoming first International Technical Conference on Animal Genetic Resources (September 2007), experts have been interviewed to tell about their experiences in the management of animal genetic resources over the past fifty years. They identified three milestones in the history of Animal Genetic Resources (AnGR) management: the foundation of the Rare Breeds Survival Trust (1973), the FAO/UNEP 1980 Technical Consultation on AnGR, and the signing of the Convention on Biological Diversity (1992). Conservation of AnGR started at grassroot level and eventually led to policies at governmental level. The passion of civil society organizations remains vital to conserve local livestock breeds. Technical and financial support will be crucial for the future of AnGR conservation. The next milestone will be a Global Plan of Action that is expected as one outcome of the International Technical Conference.