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Infants born at high altitudes, such as in the Puno region, typically exhibit higher birthweights than those born at low altitudes; however, the influence of ethnicity on childhood anthropometric patterns in high-altitude settings remains poorly understood. This study aimed to characterise the nutritional status, body composition and indices, and somatotype of Quechua and Aymara children aged 6–10 years. A cross-sectional, descriptive, and comparative design was employed, with a simple random sampling of children from six provinces representative of the Puno region, including 1,289 children of both sexes. Twenty-nine anthropometric measurements were taken, and fat, muscle, and bone components were assessed using bioelectrical impedance analysis. Standardised equations were applied to determine body indices. Among the findings, most children presented normal nutritional status according to BMI-for-age and height-for-age Z-scores. However, high rates of overweight and obesity were observed in Aymara (39%) and Quechua (28.4%) children, with differences in fat content between ethnic groups at the 5th, 10th, 50th, and 75th percentiles. Both groups were characterised by brachytypy and brachybrachial proportions; Quechua children were mesoskelic and Aymara brachyskelic, with macrocormic proportions, rectangular trunks, and broad backs. The predominant somatotype was mesomorphic, with a stronger endomorphic tendency among Aymara. It is concluded that both groups exhibit normal nutritional status; however, Aymara children show a greater tendency towards fat accumulation and notable morphological differences. Differences were also observed in limb proportions, particularly a relatively shorter lower limb.
Prolonged childhood and adolescent loneliness (CAL) is linked to various adverse mental health outcomes, yet its impact on schizophrenia spectrum disorders (SSD) has been understudied. While loneliness is associated with psychosis and worsens symptoms in SSD, few studies have explored the long-term effects of early loneliness on SSD risk. Understanding how CAL interacts with genetic liability to schizophrenia is essential for identification of high-risk individuals.
Aims
This study evaluated whether prolonged CAL is associated with increased SSD risk and examined the interaction between CAL and genetic liability for schizophrenia. Gender differences in these associations were also explored.
Method
Data from the European Gene–Environment Interactions in Schizophrenia (EU-GEI) study were analysed, including 1261 individuals with SSD, 1282 unaffected siblings and 1525 healthy controls. CAL was retrospectively assessed for periods before age 12 years and age 12–16 years. Genetic risk was measured using polygenic risk scores for schizophrenia. Logistic regression models and the Relative Excess Risk due to Interaction (RERI) method were used to examine gene–environment interactions, with stratification by gender.
Results
Prolonged CAL was associated with higher odds of SSD (odds ratio [95% CI] = 5.20 [3.85−7.01] for loneliness before age 12; odds ratio [95% CI] = 7.26 [5.63−9.38] for loneliness during adolescence). The interaction between CAL and genetic risk was strongest during adolescence (RERI [95% CI] = 23.46 [10.75−53.53]). Females showed a greater effect (odds ratio [95 %CI] = 10.04 [6.80−14.94]) than males (odds ratio [95% CI] = 5.50 [3.95−7.66]). Incorporating CAL and genetic interaction increased predictive values to 17% for SSD risk − rising to 22.5% in females − compared with 2.6 and 2.8%, respectively, for genetic risk alone.
Conclusions
Prolonged CAL significantly increases SSD risk, particularly in females. The inclusion of CAL alongside genetic risk substantially enhances predictive accuracy. Early identification of CAL could inform preventive strategies, especially in genetically vulnerable populations.
There is interest in exploring biodegradable chemicals, e.g. sex pheromones, in behaviour manipulation to control the polyphagous mirid species Helopeltis bakeri Poppius. Understanding this insect pest’s reproductive behaviour is critical for identifying and isolating semiochemicals. H. bakeri rate of sexual maturation was determined by identifying the time the winged adult changed colour after the 5th and final nymphal form. We verified that there was no significant difference in the rate of colour change for both sexes. Copulation lasted an average of 167.0 ± 77.1 min and was observed on mating pairs >72 h old from the time of final molt. Close-range copulation behaviour of H. bakeri was recorded using the Behavioral Observation Research Interactive Software, and sequential behaviour analysis was performed by creating adjacency matrices. The ethograms revealed the absence of specific calling behaviour from either of the sexes. However, the male’s active pursuit of the female may indicate the latter’s role in releasing sex attractants. Using a wind tunnel, it was observed that the number of male visitations of 96-h to 120-h-old females significantly differed from the attraction in younger females (p < 0.05) and peaked from 2:00 PM to 12:00 AM. This supports the crepuscular nature of this mirid species. The difference in the sex maturation age and maximum male attraction implies that the secretion of sex attractant could happen after the completion of development, i.e. the exhibition of colour dimorphism.
The Nasrid emirate of southern Iberia emanated power through architecture; this project aims to better understand how this was made possible, via an interdisciplinary exploration of the Alhambra monument and other Al-Andalus constructions. Initial results of archaeological campaigns, structure chronologies and communication plans undertaken in 2021 and 2022 are presented.
Species’ declines are caused by a combination of factors that affect survival and/or breeding success. We studied the effects of a set of environmental and anthropogenic variables on the disappearance of Canarian Houbara Bustards Chlamydotis undulata fuertaventurae on Fuerteventura (Canary Islands), once the main stronghold of this endangered bird. Of 83 male display sites detected in 1997–1998, only 29 remained occupied in 2020–2021 (a 65% decrease in only 23 years). We compared habitat quality, density of conspecifics, other steppe birds and crows, presence of human infrastructure, and degree of environmental protection between these 29 extant sites and the 54 extinct sites using univariate analyses and generalised linear models (GLMs). The most influential variable in the abandonment of display sites was the Normalised Difference Vegetation Index (NDVI), an indicator of green vegetation productivity, which suggests a strong effect of habitat aridification due to climate change on the population’s extinction process. Powerline density was the second most important factor. This suggests that houbaras have survived where a greater abundance of food resources has enabled a higher breeding success, and where powerline fatalities have caused lower mortality over the years. Higher densities of houbaras, and other steppe birds and crows at extant display sites confirmed the better habitat quality in these areas. Extant display sites, located generally in protected areas, also had lower densities of human infrastructure (e.g. buildings, roads). We discuss the conservation implications of these results and provide management recommendations for this endangered subspecies.
The first insights on habitat and phylogenetic origin of a newly found population of Solen marginatus are provided in the mid-North Atlantic Azores archipelago, in the bay of Praia da Vitória, Terceira Island. Distribution is confined to the northern portion and most sheltered part of the bay down to 14.2 m depth. Densities with an average of 12.69 individuals/m2 were found at 8.4 m depth, using 4 × 20 sqm visual transects. Sizes of shell length between 10 and 12 cm comprised 60% of collected specimens (n = 118), ranging between 8.79 and 15.4 cm and averaging 11.28 cm. Considering shell length, the high densities and dispersion area, a settlement period above 20 years is estimated. Greater genetic affinity was found in the Ria de Aveiro (North of Portugal) and the Asturias populations (North of Spain). The source origin remains undetermined, with intentional or non-intentional anthropogenic introduction, as well as natural dispersion remaining possible, although more unlikely. Due to the commercial value of this species, a new clam fishery is likely to develop in the area, requiring further studies and immediate conservation measures.
This paper presents XeraWord, an innovative tool for automatically generating nominal phrases. XeraWord can be used for different tasks, ranging from teaching languages to the creation of examples in lexicography, or even for the development of resources for natural language processing. In this area, Xera was the first experiment, allowing the automatic generation of nominal phrases in three languages: German, French and Spanish. This tool was extended to support other languages, namely, Portuguese and Galician.
We start by presenting the theory behind the development of Xera and its new version, XeraWord, namely, the applied base methodology, and the natural language processing resources used to support it. Then, TraduWord, a tool specifically developed to construct resources for new languages, is presented. This tool allows the semi-automatic translation of the data required for the nominal phrase generation. For this, we discuss its advantages and disadvantages, analysing the quality of the translated resources, as well as the amount of manual work required to validate and correct these resources.
Alumina is produced from bauxite, which contains a mixture of various oxides, such as aluminum (Al), iron (Fe), silicon (Si), and titanium (Ti). Bauxite can also be considered a source of several other valuable metals, such as scandium (Sc), vanadium (V), and gallium (Ga). The composition and mineralogy of alumina determine their economic value, but their characteristics vary by locality. The physicochemical characteristics of bauxites can also be influenced largely by weathering processes, even within the same locality. For this reason, the present study was undertaken with the objective of comparing the characterization data of three bauxite samples collected, which will be referred to as D, E, and F, from the Cruz Alta do Pará plateau in northern Brazil. The samples were solubilized by multi-acid digestion and fusion with lithium metaborate to quantify their metal compositions by inductively coupled plasma optical emission spectrometry (ICP-OES). The mineralogical characterization was conducted by X-ray diffraction (XRD), and the phase changes of minerals in bauxite were detected by thermogravimetric analysis (TGA/DTG). The total organic carbon (TOC) technique was used to quantify the C in the samples, and the moisture content was also measured. Alumina was 30 wt.% on average for all samples, good for producing high-purity alumina by hydrometallurgical processes. The results, however, showed high (~20 at.%) silica concentrations in two samples and ~3 wt.% Fe in one sample, which can pose a challenge in the Bayer process. The X-ray diffraction (XRD) analysis showed that gibbsite (Gbs), kaolinite (Kln), anatase (Ant), and hematite (Hem) were the major mineral phases in these samples. The study showed that the samples from the same mine vary in their metal content, especially with regard to Si, and they, thus, need to be processed selectively to maximize their economic value.
The objective of this work was to study mortality increase in Spain during the first and second academic semesters of 2020, coinciding with the first 2 waves of the Covid-19 pandemic; by sex, age, and education.
Methods:
An observational study was carried out, using linked populations and deaths’ data from 2017 to 2020. The mortality rates from all causes and leading causes other than Covid-19 during each semester of 2020, compared to the 2017–2019 averages for the same semester, was also estimated. Mortality rate ratios (MRR) and differences were used for comparison.
Results:
All-cause mortality rates increased in 2020 compared to pre-covid, except among working-age, (25–64 years) highly-educated women. Such increases were larger in lower-educated people between the working age range, in both 2020 semesters, but not at other ages. In the elderly, the MMR in the first semester in women and men were respectively, 1.14, and 1.25 among lower-educated people, and 1.28 and 1.23 among highly-educated people. In the second semester, the MMR were 1.12 in both sexes among lower-educated people and 1.13 in women and 1.16 in men among highly-educated people.
Conclusion:
Lower-educated people within working age and highly-educated people at older ages showed the greatest increase in all-cause mortality in 2020, compared to the pre-pandemic period.
Image-processing pipelines require the design of complex workflows combining many different steps that bring the raw acquired data to a final result with biological meaning. In the image-processing domain of cryo-electron microscopy single-particle analysis (cryo-EM SPA), hundreds of steps must be performed to obtain the three-dimensional structure of a biological macromolecule by integrating data spread over thousands of micrographs containing millions of copies of allegedly the same macromolecule. The execution of such complicated workflows demands a specific tool to keep track of all these steps performed. Additionally, due to the extremely low signal-to-noise ratio (SNR), the estimation of any image parameter is heavily affected by noise resulting in a significant fraction of incorrect estimates. Although low SNR and processing millions of images by hundreds of sequential steps requiring substantial computational resources are specific to cryo-EM, these characteristics may be shared by other biological imaging domains. Here, we present Scipion, a Python generic open-source workflow engine specifically adapted for image processing. Its main characteristics are: (a) interoperability, (b) smart object model, (c) gluing operations, (d) comparison operations, (e) wide set of domain-specific operations, (f) execution in streaming, (g) smooth integration in high-performance computing environments, (h) execution with and without graphical capabilities, (i) flexible visualization, (j) user authentication and private access to private data, (k) scripting capabilities, (l) high performance, (m) traceability, (n) reproducibility, (o) self-reporting, (p) reusability, (q) extensibility, (r) software updates, and (s) non-restrictive software licensing.
El estudio del parentesco permite comprender mejor las sociedades antiguas porque está relacionado con el comportamiento social, económico, político y reproductivo de la población. Es posible conocer la magnitud de la endogamia y hacer inferencias sobre la movilidad de ambos sexos. Una mayor similitud genética promedio dentro de muestras femeninas sugiere mayor migración masculina (modelo de residencia posmarital matrilocal). A la inversa se deduce un modelo de residencia patrilocal y si no hay diferencias se infiere un modelo bilocal. Nuestro objetivo es conocer la divergencia genética entre grupos incas del altiplano del noroeste de Cusco utilizando caracteres cuantitativos del cráneo para estimar el parentesco, el número de migrantes por generación y el patrón de residencia posmarital. Los restos óseos empleados (99 cráneos masculinos y 75 femeninos) proviene de los sitios Paucarcancha, Patallacta y Torontoy. Se aplicaron técnicas de análisis multivariado y modelos derivados de la genética de poblaciones. Existen diferencias morfológicas entre los sitios a pesar de la escasa distancia geográfica. La divergencia genética fue de 0,035 (siete individuos migrantes por generación). La varianza dentro de grupos es similar en ambos sexos (modelo posmarital bilocal). Se discute la evidencia obtenida con otras localidades y subregiones del Área Andina Centro Meridional.
This work studies quantitative measures for ranking judicial decisions by the Brazilian Supreme Court [Supremo Tribunal Federal (STF)] and selecting leading cases, which are understood as those with broadness of influence on different legal fields. The measures are based on a network built over decisions whose cases were finalized in the Brazilian Supreme Court between 01/2001 and 12/2019, which were obtained by crawling publicly available STF records. Three ranking measures are proposed; two are adaptations of the PageRank algorithm, and one adapts Kleinberg’s algorithm. Such measures are compared with respect to agreement on top 100 rankings; we also analyze each robustness measure based on self-agreement under perturbation.
We examine whether the resulting quantitative ranking is congenial to a qualitative intuition of what the legal community usually considers as relevant precedents. We also discuss some possible criteria of relevance in the seek for patterns that suggest how quantitative and qualitative measures would better align. The ranking of leading cases and relevant decisions improved after building decision networks without irrelevant appeals and decisions that overflow the court offers a starting point to discuss the role of STF in the Brazilian judicial system.
In our last work, both versions of PageRank and Kleinberg algorithms produced different rankings and all of them were robust with respect to 10% and 20%-perturbation levels, but none of them retrieved leading cases at the top of these rankings. Then, we took a further step in the studies of the STF decision network and we introduced better filtering of network nodes guided by legal expertise on the works of the Supreme Court. We also introduced more fine-grained perturbance levels to understand the impact of such filters in the STF decision network. We concluded that after filtering low-relevance decision types, the STF decision network is still robust under 10%-perturbation, but it presents higher degradation by increasing perturbation levels. The two versions of PageRank still produce different rankings. Kleinberg’s algorithm provides a different ranking, with many relevant criminal cases. Although we improved algorithms rankings filtering decisions from the network, which represents an important methodological step, there is still room for improvement. Given that relevant decisions are well ranked after filtering out a large amount of irrelevant decisions, the results set a starting point to discuss the role of STF in the Brazilian judicial system.
This systematic literature review aimed to provide an overview of the characteristics and methods used in studies applying the disability-adjusted life years (DALY) concept for infectious diseases within European Union (EU)/European Economic Area (EEA)/European Free Trade Association (EFTA) countries and the United Kingdom. Electronic databases and grey literature were searched for articles reporting the assessment of DALY and its components. We considered studies in which researchers performed DALY calculations using primary epidemiological data input sources. We screened 3053 studies of which 2948 were excluded and 105 studies met our inclusion criteria. Of these studies, 22 were multi-country and 83 were single-country studies, of which 46 were from the Netherlands. Food- and water-borne diseases were the most frequently studied infectious diseases. Between 2015 and 2022, the number of burden of infectious disease studies was 1.6 times higher compared to that published between 2000 and 2014. Almost all studies (97%) estimated DALYs based on the incidence- and pathogen-based approach and without social weighting functions; however, there was less methodological consensus with regards to the disability weights and life tables that were applied. The number of burden of infectious disease studies undertaken across Europe has increased over time. Development and use of guidelines will promote performing burden of infectious disease studies and facilitate comparability of the results.
Social spending by central governments in Latin America has, in recent decades, become increasingly insulated from political manipulation. Focusing on the 3×1 Program in Mexico in 2002-2007, we show that social spending by local government is, in contrast, highly politicized. The 3×1 Program funds municipal public works, with each level of government—municipal, state, and central—matching collective remittances. Our analysis shows that 3×1 municipal spending is shaped by political criteria. First, municipalities time disbursements according to the electoral cycle. Second, when matching collective remittances, municipalities protect salaries of personnel, instead adjusting budget items that are less visible to the public, such as debt. Third, municipalities spend more on 3×1 projects when their partisanship matches that of the state government. Beyond the 3×1 Program, our findings highlight the considerable influence that increasing political and economic decentralization can have on local government incentives and spending choices, in Mexico and beyond.
Now that racism has been officially recognized in Brazil, and some universities have adopted affirmative-action admission policies, measures of the magnitude of racial inequality and analyses that identify the factors associated with changes in racial disparities over time assume particular relevance to the conduct of public debate. This study uses census data from 1950 to 2000 to estimate the probability of death in the early years of life, a robust indicator of the standard of living among the white and Afro-Brazilian populations. Associated estimates of the average number of years of life expectancy at birth show that the 6.6-year advantage that the white population enjoyed in the 1950s remained virtually unchanged throughout the second half of the twentieth century, despite the significant improvements that accrued to both racial groups. The application of multivariate techniques to samples selected from the 1960, 1980, and 2000 census enumerations further shows that, controlling for key determinants of child survival, the white mortality advantage persisted and even increased somewhat in 2000. The article discusses evidence of continued racial inequality during an era of deep transformation in social structure, with reference to the challenges of skin color classification in a multiracial society and the evolution of debates about color, class, and discrimination in Brazil.
In intensive livestock production systems, estimating forage production and its nutritive value can assist farmers in optimizing pasture management, stocking rate, and feed supplementation to animals. In this study, we aimed to use vegetation indices, determined using a proximal canopy reflectance sensor, to estimate the forage mass, crude protein content, and nitrogen in live forage of Marandu palisadegrass (Urochloa brizantha). Pasture canopy reflectance was measured at three wavelengths (670, 720, and 760 nm) using a Crop Circle device equipped with an ACS-430 sensor. Total forage mass, plant-part composition, leaf area index (LAI), and crude protein content were assessed during 14 growth cycles in a pasture under four management regimes, comprising different combinations of two N fertilization rates and two irrigation schedules. For each forage assessment, pasture canopy reflectance data were used to calculate the following vegetation indices: normalized difference vegetation index, normalized difference red edge, simple ratio index (SRI), modified simple ratio, and chlorophyll index. In addition, we also performed analyses of the linear and exponential regressions between vegetation indices and total forage mass, leaf + stem mass, leaf mass, LAI, crude protein content, and nitrogen in live forage. The best estimates were achieved for total forage mass, leaf + stem mass, leaf mass, and nitrogen in live forage using SRI (R2 values between 0.72 and 0.79). When estimating pasture productive variables (total forage mass, leaf + stem mass, leaf mass, and LAI) from SRI, the equations showed R2 values between 0.69 (leaf mass) and 0.74 (LAI) and relative errors ranging from 19% to 21%. For each of the water and nitrogen supply conditions evaluated, this index facilitated the monitoring of forage mass time series and nitrogen in live forage and the extraction of this nutrient by the pasture.
Sierra Leone is a country highly prone to disasters, still recovering from the catastrophic 2014 Ebola epidemic. In 2018, the country launched its first National Emergency Medical Service (NEMS) aiming to strengthen the provision of essential health services to the population with the long-term goal of creating a resilient health system able to effectively respond to and recover from emergencies. The Center for Research and Training in Disaster Medicine, Humanitarian Aid, and Global Health (CRIMEDIM), together with the Italian NGO Doctors with Africa (CUAMM), under the direct supervision of the Ministry of Health and Sanitation (MoHS), developed a prehospital Disaster Training Package (DTP) to be delivered to all NEMS personnel to boost the prehospital management of mass-casualty incidents (MCIs) and outbreaks. The DTP included a first phase in which NEMS local trainers underwent a training-of-trainers (ToT) course, enabling them to deliver cascade trainings to 16 district ambulance supervisors, 441 paramedics, 441 ambulance drivers, and 36 operators working in the NEMS operation center. This on-going training package represents the first Disaster Medicine training course for prehospital health professionals in Sierra Leone.
The early clinical predictors of respiratory failure in Latin Americans with Guillain–Barré syndrome (GBS) have scarcely been studied. This is of particular importance since Latin America has a high frequency of axonal GBS variants that may imply a worse prognosis.
Methods:
We studied 86 Mexican patients with GBS admitted to the Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, a referral center of Mexico City, to describe predictors of invasive mechanical ventilation (IMV).
Results:
The median age was 40 years (interquartile range: 26–53.5), with 60.5% men (male-to-female ratio: 1.53). Most patients (65%) had an infectious antecedent (40.6% gastrointestinal). At admission, 38% of patients had a Medical Research Council (MRC) sum score <30. Axonal subtypes predominated (60.5%), with acute motor axonal neuropathy being the most prevalent (34.9%), followed by acute inflammatory demyelinating polyneuropathy (32.6%), acute motor sensory axonal neuropathy (AMSAN) (25.6%), and Fisher syndrome (7%). Notably, 15.1% had onset in upper limbs, 75.6% dysautonomia, and 73.3% pain. In all, 86% received either IVIg (9.3%) or plasma exchange (74.4%). IMV was required in 39.5% patients (72.7% in AMSAN). A multivariate model without including published prognostic scores yielded the time since onset to admission <15 days, axonal variants, MRC sum score <30, and bulbar weakness as independent predictors of IMV. The model including grading scales yielded lower limbs onset, Erasmus GBS respiratory insufficiency score (EGRIS) >4, and dysautonomia as predictors.
Conclusion:
These results suggest that EGRIS is a good prognosticator of IMV in GBS patients with a predominance of axonal electrophysiological subtypes, but other early clinical data should also be considered.
Land-use change is a major driver of biodiversity loss. Large-scale disturbances such as habitat loss, fragmentation and degradation are known to have negative consequences for native biota, but the effects of small-scale disturbances such as selective logging are less well known. We compared three sites with different regimes of selective logging performed by Indigenous communities in the South American temperate rainforest, to assess effects on the density and habitat selection patterns of the Near Threatened endemic arboreal marsupial Dromiciops gliroides. We used structured interviews to identify patterns of wood extraction, which was 0.22–2.55 m3 per ha per year. In the less disturbed site only two tree species were logged, in the intermediately disturbed sites eight species were logged at low intensity, and in the most disturbed site seven species were logged intensively. The site with intermediate disturbance had the highest fleshy-fruited plant diversity and fruit biomass values as a result of the proliferation of shade-intolerant plants. This site also had the highest density of D. gliroides. These findings are consistent with Connell's intermediate disturbance hypothesis, suggesting that coexistence of people with nature is possible if wood extraction volumes are moderate, increasing plant diversity. Indigenous communities have sustainably used natural resources for centuries, but current rates of land-use change are becoming a significant threat to both them and their natural resources.
Clearfield™ (CL) rice (Oryza sativa L.) is a weedy rice (Oryza spp.; synonym = red rice) control tool that has been used in Brazil since 2003. This system includes the use of an imidazolinone (IMI)-tolerant cultivar and the application of IMI herbicides. In this review article, Brazilian weed scientists evaluate the challenges and lessons learned over 18 yr of CL use. CL system benefits include selective weedy rice control, better crop establishment during the most advantageous period of the year, and more efficient fertilizer use. In Rio Grande do Sul state, the CL system, in conjunction with other improvements, has contributed to rice grain yield gains from 5,500 kg ha−1 before 2002 to around 8,400 kg ha−1 currently. In contrast, the main problem that has arisen over this period is the rapid evolution of IMI-resistant weedy rice, caused by gene flow from CL rice cultivars. The off-label use (rate and continuous use) of IMI herbicides has contributed to the evolution of resistance in Echinochloa spp. and other weeds. IMI herbicide carryover has also affected susceptible crops grown after CL rice. Crop rotation with soybean [Glycine max (L.) Merr.] is increasing, ensuring system sustainability. The importance of minimum tillage has also become apparent. Such cultivation includes applying nonselective herbicides before sowing or just before crop emergence (at the spiking stage to eliminate as much weedy rice as possible and other weeds at an early growth stage). It also includes the use of certified seeds free of weedy rice, following label instructions for IMI herbicides, applying the herbicide PRE followed by POST, and complementary weedy rice management practices, such as roguing of surviving weedy rice plants.