We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.
To save content items to your account,
please confirm that you agree to abide by our usage policies.
If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account.
Find out more about saving content to .
To save content items to your Kindle, first ensure no-reply@cambridge.org
is added to your Approved Personal Document E-mail List under your Personal Document Settings
on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part
of your Kindle email address below.
Find out more about saving to your Kindle.
Note you can select to save to either the @free.kindle.com or @kindle.com variations.
‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi.
‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.
Childhood maltreatment is a key risk factor for conduct disorder (CD), and the “ecophenotype hypothesis” suggests that maltreatment-related versus non-maltreatment-related CD are neurobiologically distinct. This may explain inconsistent findings in previous structural connectivity studies of CD. We tested this hypothesis by comparing youth with CD with (CD/+) versus without (CD/−) childhood physical or sexual abuse in white-matter microstructure. Diffusion tensor imaging data were collected from 100 CD and 169 control participants aged 9–18 years. Using Tract-Based Spatial Statistics, we compared the CD and control groups in fractional anisotropy, and axial, radial and mean diffusivity, then compared the CD/+ (n = 39) and CD/− (n = 61) subgroups and controls. The combined CD group had higher fractional anisotropy in the corpus callosum than controls. When divided by abuse history, only the CD/− subgroup exhibited higher corpus callosum fractional anisotropy than controls; the CD/+ subgroup did not differ from controls. Comparing the CD subgroups, the CD/+ subgroup displayed higher superior longitudinal fasciculus axial diffusivity than the CD/− subgroup. Notably, sex-stratified analyses yielded different findings in all-male and all-female samples. Findings support the ecophenotype hypothesis, demonstrating microstructural differences between the CD/+ and CD/− subgroups and emphasizing the importance of considering abuse/maltreatment (and sex) in future studies.
Less is known about the relationship between conduct disorder (CD), callous–unemotional (CU) traits, and positive and negative parenting in youth compared to early childhood. We combined traditional univariate analyses with a novel machine learning classifier (Angle-based Generalized Matrix Learning Vector Quantization) to classify youth (N = 756; 9–18 years) into typically developing (TD) or CD groups with or without elevated CU traits (CD/HCU, CD/LCU, respectively) using youth- and parent-reports of parenting behavior. At the group level, both CD/HCU and CD/LCU were associated with high negative and low positive parenting relative to TD. However, only positive parenting differed between the CD/HCU and CD/LCU groups. In classification analyses, performance was best when distinguishing CD/HCU from TD groups and poorest when distinguishing CD/HCU from CD/LCU groups. Positive and negative parenting were both relevant when distinguishing CD/HCU from TD, negative parenting was most relevant when distinguishing between CD/LCU and TD, and positive parenting was most relevant when distinguishing CD/HCU from CD/LCU groups. These findings suggest that while positive parenting distinguishes between CD/HCU and CD/LCU, negative parenting is associated with both CD subtypes. These results highlight the importance of considering multiple parenting behaviors in CD with varying levels of CU traits in late childhood/adolescence.
We introduce the concept of social sustainability, intertwined with ecological and economic aspects, to the field of service robots and comparable automation technology. It takes a first step towards a comprehensive guideline that operationalizes and applies social sustainability. By applying this guideline to the project MURMEL we offer a concept that collects and rates social key issues to visualize their individual importance. Social sustainability is an important and often overlooked aspect of sustainable technology development which should be considered in the early development phase.
This research communication describes the influence of diet, mammary quarter position and milking process on the temperature of teats and udder of cows fed diets containing different lipid sources. Five primiparous cows were fed diets containing cottonseed, sunflower seed, soybeans or soybean oil as a source of lipids and a reference diet without the inclusion of lipid sources in a 5 × 5 Latin Square design. Milk yield was determined in the last five days of each period. Milk samples were collected for SCC analysis on the last two days of each experimental period. The images of the mammary gland were obtained using an infrared camera and were analyzed with appropriate computer software. Milk yield was 14.8% higher for cows fed soybeans as a source of lipids. Diets and somatic cell counts did not influence the temperature of teats and udder. The milking process reduced the temperature of teats and udder by 0.79°C. Rear teats and rear quarters had higher surface temperatures than front teats and fore quarters. Changes in temperature of teats and mammary quarters occurred as a function of the milking process and quarter position. However, the diet and the SCC did not influence the temperature of teats and mammary quarters in this experiment.
Functional magnetic resonance imaging (fMRI) studies in schizophrenia found altered brain activation patterns during Theory of Mind (ToM) task performance in the so-called ToM-network, recently focusing on over- rather than under-activation. Even though most fMRI-studies applied tasks that might gradually activate the ToM-network, no study so far has investigated the time-course of ToM-performance. Some of the varying activation results might thus be due to time-course of performance.
Aim
Our aim was to investigate neural activation over time in schizophrenia compared with a healthy control sample.
Methods
Using a block design in fMRI, we presented a sophisticated paradigm that depicts moving geometrical shapes interacting in social patterns. 14 patients with schizophrenia and 15 healthy controls participated in the study. Functional activation patterns were investigated for the first and second half of the videos separately.
Results
Both groups activated brain areas related to the ToM-network during performance of ToM videos as compared to a baseline condition. Most importanly, schizophrenia patients showed activation in ToM-related brain areas only in the second part, while healthy controls activated the ToM-network in the first part of the video presentation.
Conclusions
Results confirm recent findings of an increased activation in ToM-related brain areas in schizophrenia. Moreover, patients activated ToM-related brain areas later than healthy controls. This delay might be due to a general cognitive slowing, symptom-related inhibition of cognition-associated processes or specific delay in task processing. As this is the first study to investigate this time-course of ToM, more research is needed to classify results.
Previous studies of conduct disorder (CD) have reported structural and functional alterations in the limbic system. However, the white matter tracts that connect limbic regions have not been comprehensively studied. The uncinate fasciculus (UF), a tract connecting limbic to prefrontal regions, has been implicated in CD. However, CD-related alterations in other limbic tracts, such as the cingulum and the fornix, have not been investigated. Furthermore, few studies have examined the influence of sex and none have been adequately powered to test whether the relationship between CD and structural connectivity differs by sex. We examined whether adolescent males and females with CD exhibit differences in structural connectivity compared with typically developing controls.
Methods
We acquired diffusion-weighted magnetic resonance imaging data from 101 adolescents with CD (52 females) and 99 controls (50 females). Data were processed for deterministic spherical deconvolution tractography. Virtual dissections of the UF, the three subdivisions of the cingulum [retrosplenial cingulum (RSC), parahippocampal and subgenual cingulum], and the fornix were performed and measures of fractional anisotropy (FA) and hindrance-modulated orientational anisotropy (HMOA) were analysed.
Results
The CD group had lower FA and HMOA in the right RSC tract relative to controls. Importantly, these effects were moderated by sex – males with CD significantly lower FA compared to male controls, whereas CD and control females did not differ.
Conclusions
Our results highlight the importance of considering sex when studying the neurobiological basis of CD. Sex differences in RSC connectivity may contribute to sex differences in the clinical presentation of CD.
To understand how foraging decisions impact individual fitness of herbivores, nutritional ecologists must consider the complex in vivo dynamics of nutrient–nutrient interactions and nutrient–toxin interactions associated with foraging. Mathematical modeling has long been used to make foraging predictions (e.g. optimal foraging theory) but has largely been restricted to a single currency (e.g. energy) or using simple indices of nutrition (e.g. fecal nitrogen) without full consideration of physiologically based interactions among numerous co-ingested phytochemicals. Here, we describe a physiologically based model (PBM) that provides a mechanistic link between foraging decisions and demographic consequences. Including physiological mechanisms of absorption, digestion and metabolism of phytochemicals in PBMs allows us to estimate concentrations of ingested and interacting phytochemicals in the body. Estimated phytochemical concentrations more accurately link intake of phytochemicals to changes in individual fitness than measures of intake alone. Further, we illustrate how estimated physiological parameters can be integrated with the geometric framework of nutrition and into integral projection models and agent-based models to predict fitness and population responses of vertebrate herbivores to ingested phytochemicals. The PBMs will improve our ability to understand the foraging decisions of vertebrate herbivores and consequences of those decisions and may help identify key physiological mechanisms that underlie diet-based ecological adaptations.
We performed a new series of measurements on samples that were part of early measurements on radiocarbon (14C) dating made in 1948–1949. Our results show generally good agreement to the data published in 1949–1951, despite vast changes in technology, with only two exceptions where there was a discrepancy in the original studies. Our new measurements give calibrated ages that overlap with the known ages. We dated several samples at four different laboratories, and so we were also able to make a small intercomparison at the same time. In addition, new measurements on samples from other Egyptian materials used by Libby and co-workers were made at UC Irvine. Samples of tree rings used in the original studies (from Broken Flute Cave and Centennial Stump) were obtained from the University of Arizona Laboratory of Tree-Ring Research archive and remeasured. New data were compared to the original studies and other records.
Heavy rain on snow often leads to disastrous damages in torrent watersheds. In January 1998 a project was started to investigate “runoff and infiltration characteristics of different alpine soil/vegetation units under snow cover”. One aim was to determine the runoff rates from snow-covered, differently cultivated soil/vegetation units (pastures, dwarf-shrub stands, forests), especially under conditions of sparse snow cover and frozen soil. Differences in runoff formation between artificially snowed skiing areas and plots with natural snow cover were also of interest. Heavy rain (intensity 100 mm h–1) was simulated on four plots by using a transportable spray irrigation installation. The investigations showed runoff coefficients of 0.4–0.7. The lowest runoff values were found where the soil under snow cover was not frozen, but even on these stands the runoff coefficient exceeded 0.4. Snow depth and runoff delay are strongly correlated (R2 = 0.8). An increment in snow of 10 cm is followed by a runoff delay of 3.6 min. Divergences from this coherence are due to the composition of the snowpack, especially in case of artificial snow. This result is encouraged by runoff simulations performed for the irrigated plots by use of a hydrological model.
Salmonella is a leading cause of bacterial foodborne illness. We report the collaborative investigative efforts of US and Canadian public health officials during the 2013–2014 international outbreak of multiple Salmonella serotype infections linked to sprouted chia seed powder. The investigation included open-ended interviews of ill persons, traceback, product testing, facility inspections, and trace forward. Ninety-four persons infected with outbreak strains from 16 states and four provinces were identified; 21% were hospitalized and none died. Fifty-four (96%) of 56 persons who consumed chia seed powder, reported 13 different brands that traced back to a single Canadian firm, distributed by four US and eight Canadian companies. Laboratory testing yielded outbreak strains from leftover and intact product. Contaminated product was recalled. Although chia seed powder is a novel outbreak vehicle, sprouted seeds are recognized as an important cause of foodborne illness; firms should follow available guidance to reduce the risk of bacterial contamination during sprouting.
This case of a 65-year-old male with dermatillomania, diffuse anxiety symptoms, and avoidant personality disorder (PD) illustrates the interference of attention-deficit hyperactivity disorder (ADHD) in the diagnostic process and during schema-focused therapy. In conclusion, ADHD in older adults and interference with PD is a subject of clinical importance and worth further investigation.
The male of Ixodes soricis Gregson was discovered at Silver Creek, BritishColumbia, in 1948 (Gregson, 1949). The tick was found with its hypostome fully inserted into the lateral body wall of a partially engorged female of the same species. It was not described because the specimen in situ represented an interesting example of either accidental parasitism (Anastos, 1948), or more likely an unsuccessful attempt at copulation, since it is questionable whether the males, like those of some other species of Ixodes, ever feed. The recent discovery, however, by the junior author, of another specimen, in a collection of ticks from a shrew taken at Seattle, Washington, permits the following description of the male of this species.
By way of commentary on Jeannerod (1994), we propose that (1) intention, response imagery, and actual response processes carry equal weight in inferring from one process to another, (2) memory networks control intention, which interacts with imagery-based processing to control response imagery, and (3) response imagery will demonstrate learning effects better when imagery reconstruction and elaboration are emphasized and neutral retention tests are utilized.
Microvalves are a promising field of application for shape memory alloy (SMA) microactuators as they require a large force and stroke in a restricted space. The performance of SMA-actuated microvalves does not only depend on SMA material properties, but also requires a mechanically and thermally optimized design as well as a batch fabrication technology that is compatible with existing microsystems technologies. This chapter gives an overview of the different engineering aspects of SMA microvalves and describes the ongoing progress in related fields. Different valve types based on various design-material-technology combinations are highlighted. The examples also demonstrate the opportunities for emerging new applications.
Introduction
Shape memory alloys (SMAs) belong to the category of smart materials as they exhibit multi-functional properties, which can be used simultaneously to generate actuation, sensing and adaptive functions. The high energy density and favorable scaling behavior of their mechanical properties upon miniaturization make these materials particularly attractive for actuator applications in micro-dimensions.
In this realm, however, the close neighborhood of functional parts as well as fabrication constraints have a strong impact on physical properties and overall performance. In addition, the related research fields of materials development, design engineering and microtechnology are strongly interlinked and cannot be considered separately. Currently, each of these research fields faces a number of obstacles and constraints.
Despite the tremendous success in the development of SMA thin films and foils, considerable limitations due to temperature range, hysteresis and fatigue exist.
SMA microactuators usually consist of a monolithic structure with quasi-two- dimensional shape. In order to make an optimum use of the shape memory effect, homogeneous stress distributions should be generated upon loading, which requires some kind of shape optimization.
In this work, we present simulations of the thermo-magneto-mechanical performance of a ferromagnetic SMA microactuator in the inhomogeneous field of a CoSm permanent magnet and compare it with experimental results. For the simulations, a combination of different finite element (FEM) programs is used allowing the coupling of electrical, thermal, magnetic and mechanical properties. The field of a permanent magnet is calculated along the trajectory of the microactuator, from which the magnetic forces Fmag and their gradients are derived. Shape memory forces FSME are calculated based on a two-phase macromodel. Both forces, Fmag and FSME, determine the quasi-static behavior of a NiMnGa microscanner, which has been proposed recently.