Background: Efgartigimod, a human immunoglobulin G (IgG)1 antibody Fc fragment, blocks the neonatal Fc receptor, decreasing IgG recycling and reducing pathogenic IgG autoantibody levels. ADHERE assessed the efficacy and safety of efgartigimod PH20 subcutaneous (SC; co-formulated with recombinant human hyaluronidase PH20) in chronic inflammatory demyelinating polyneuropathy (CIDP). Methods: ADHERE enrolled participants with CIDP (treatment naive or on standard treatments withdrawn during run-in period) and consisted of open-label Stage A (efgartigimod PH20 SC once weekly [QW]), and randomized (1:1) Stage B (efgartigimod or placebo QW). Primary outcomes were clinical improvement (assessed with aINCAT, I-RODS, or mean grip strength; Stage A) and time to first aINCAT score deterioration (relapse; Stage B). Secondary outcomes included treatment-emergent adverse events (TEAEs) incidence. Results: 322 participants entered Stage A. 214 (66.5%) were considered responders, randomized, and treated in Stage B. Efgartigimod significantly reduced the risk of relapse (HR: 0.394; 95% CI: 0.25–0.61) versus placebo (p=0.000039). Reduced risk of relapse occurred in participants receiving corticosteroids, intravenous or SC immunoglobulin, or no treatment before study entry. Most TEAEs were mild to moderate; 3 deaths occurred, none related to efgartigimod. Conclusions: Participants treated with efgartigimod PH20 SC maintained a clinical response and remained relapse-free longer than those treated with placebo.

Recent scholarship on affective polarization documents partisan animosity in people's everyday lives. But does partisan dislike go so far as to deny fundamental rights? We study this question through a moral dilemma that gained notoriety during the COVID-19 pandemic: triage decisions on the allocation of intensive medical care. Using a conjoint experiment in five countries we analyze the influence of patients’ partisanship next to commonly discussed factors determining access to intensive medical care. We find that while participants’ choices are consistent with a utilitarian heuristic, revealed partisanship influences decisions across most countries. Supporters of left or right political camps are more likely to withhold support from partisan opponents. Our findings offer comparative evidence on affective polarization in non-political contexts.

The polar mesopause region (80-100 km) is the coldest region of the Earth's atmosphere and is expected to be sensitive to global change. Reported increases in observations of polar mesospheric clouds over the last 100 years have been postulated to be related to decreased temperatures (associated with tropospheric warming) and increased water vapour at mesospheric altitudes (a result of increased methane concentrations in the troposphere). The temperature of this region can be monitored by spectroscopic techniques utilising hydroxyl (OH) emissions which originate near 87 km. The Australian Antarctic Division, Atmospheric and Space Physics group has been analyzing OH (6-2) band spectra recorded with a Czerny—Turner scanning spectrometer at Davis Station, Antarctica (68.6° S, 78.0° E) to optimise temperature determinations for climate change studies. A number of difficulties were encountered, some of which have been overcome and all of which can be overcome. The mid-winter average temperature of the OH layer for May-July 1990 has been measured as 224 ±2 K. The equivalent value for 1996 is 215±2 K. Possible reasons for the difference are discussed.

The Millimetre Astronomy Legacy Team 90 GHz (MALT90) survey aims to characterise the physical and chemical evolution of high-mass star-forming clumps. Exploiting the unique broad frequency range and on-the-fly mapping capabilities of the Australia Telescope National Facility Mopra 22 m single-dish telescope1 , MALT90 has obtained 3′ × 3′ maps towards ~2 000 dense molecular clumps identified in the ATLASGAL 870 μm Galactic plane survey. The clumps were selected to host the early stages of high-mass star formation and to span the complete range in their evolutionary states (from prestellar, to protostellar, and on to $\mathrm{H\,{\scriptstyle {II}}}$ regions and photodissociation regions). Because MALT90 mapped 16 lines simultaneously with excellent spatial (38 arcsec) and spectral (0.11 km s−1) resolution, the data reveal a wealth of information about the clumps’ morphologies, chemistry, and kinematics. In this paper we outline the survey strategy, observing mode, data reduction procedure, and highlight some early science results. All MALT90 raw and processed data products are available to the community. With its unprecedented large sample of clumps, MALT90 is the largest survey of its type ever conducted and an excellent resource for identifying interesting candidates for high-resolution studies with ALMA.

Suboptimal vitamin D status among the South Asian UK population is widely reported; however, its impact on bone health is unclear. The aim of the present study was to conduct a comparative investigation of vitamin D status in postmenopausal South Asian (SA) and Caucasian (C) women and its relationship to parathyroid hormone (PTH) concentration, biochemical markers of bone turnover and bone quality. A cross-sectional study of community-dwelling women aged 50–66 years was carried out. A total of sixty-six SA women of Pakistani origin and forty-two C women living in the same community were recruited. Fasting blood was taken for the measurement of vitamin D, PTH and biochemical markers of bone turnover, including type-1 collagen β C-telopeptide (βCTX), procollagen type-1 amino-terminal propeptide (P1NP), and bone-specific alkaline phosphatase (BAP) activity. Bone quality was assessed using broadband ultrasound attenuation (BUA). Total serum 25-hydroxyvitamin D (25(OH)D) was significantly lower in the SA women than the C women (medians: SA 10·5 v. C 47·1 nmol/l; P < 0·001) This was associated with a significantly elevated serum PTH concentration in the SA group (medians: SA 7·3 v. C 4·5 pmol/l; P < 0·01). BAP activity was also significantly higher in the SA group, indicating elevated osteoblast activity and bone turnover (medians: SA 23·0 v. C 20·0 U/l; P < 0·05). No significant differences were observed between the two groups for P1NP, βCTX or BUA. Although the SA women had significantly higher serum PTH and lower 25(OH)D concentrations than C women, this was not associated with significantly higher markers of bone resorption, or reduced bone quality in the SA women.

The effects of supplements of protein meal or sorghum grain given to young cattle for 140 days during their first winter and spring post-weaning, were recorded over 560 days for cattle grazing on low quality pastures in subtropical Australia. The supplements were offered to steers in four treatment groups, replicated three times, at the following rates per head to late spring: (a) mineral mix (M) + cotton-seed hulls, 90g/day (control), (b) M + protein meal, 600 g/day (protein daily), (c) as for (b) but at 2·1 kg/3·5 days (protein twice-weekly), or (d) M + sorghum grain, 560 g/day (sorghum). For the next 130 days, to late summer, only supplement (c) was continued while the remaining three groups were not supplemented. None of the supplements was offered for the final 290 days of the experiment when the steers grazed an improved pasture.

At the end of the first spring, the live weight of the steers supplemented daily and twice-weekly with protein was respectively 229 and 216 kg. These were significantly (p < 0·01) heavier than the sorghum-supplemented (174 kg) or control steers (160 kg). At the end of the first summer, the steers given supplements of protein meal twiceweekly, or daily, remained significantly heavier (265, 250 kg respectively) than sorghum-supplemented or control steers (209, 198 kg). By the second summer, the steers previously given protein supplements were still heavier than the steers from the control group (357 v. 317 kg, respectively).

In steers which were offered the protein supplement during winter and spring, samples of blood taken at the end of spring had lower (P < 0·01) plasma ratios of glycine to branched-chain amino acids (valine, leucine and isoleucine) and a lower ratio of methionine: valine, than in the steers which were not offered the supplement. These ratios were significantly (P < 0·05) correlated with live-weight change over the preceding 140 days. On this basis it was considered that the improved growth of the steers offered the protein supplements was associated with an increased availability of specific essential amino acids, which may have initiated in the steers an increased appetite for pasture D.M.