We present the Cosmological Double Radio Active Galactic Nuclei (CosmoDRAGoN) project: a large suite of simulated AGN jets in cosmological environments. These environments sample the intra-cluster media of galaxy clusters that form in cosmological smooth particle hydrodynamics (SPH) simulations, which we then use as inputs for grid-based hydrodynamic simulations of radio jets. Initially conical jets are injected with a range of jet powers, speeds (both relativistic and non-relativistic), and opening angles; we follow their collimation and propagation on scales of tens to hundreds of kiloparsecs, and calculate spatially resolved synthetic radio spectra in post-processing. In this paper, we present a technical overview of the project, and key early science results from six representative simulations which produce radio sources with both core- (Fanaroff-Riley Type I) and edge-brightened (Fanaroff-Riley Type II) radio morphologies. Our simulations highlight the importance of accurate representation of both jets and environments for radio morphology, radio spectra, and feedback the jets provide to their surroundings.

Non-technical summary. As we consider a transition to a low-carbon future, there is a need to examine the mineral needs for this transformation at a scale reminiscent of the Green Revolution. The efficiency gains of the agrarian transition came at ecological and social costs that should provide important lessons about future metal sourcing. We present three options for a Mineral Revolution: status quo, incremental adaption and revolutionary change. We argue that a sustainable Mineral Revolution requires a paradigm shift that considers wellbeing as a purpose and focuses on preserving natural capital.

Technical summary. As we consider a transition to a low-carbon future, there is a need to examine the mineral needs for this transformation at a scale reminiscent of the Green Revolution. The efficiency gains of the agrarian transition came at ecological and social costs that can also provide important lessons about the Mineral Revolution. We lay out some of the key ways in which such a mineral revolution can be delineated over temporal scales in a paradigm shift that considers wellbeing as a purpose and focuses on preserving natural capital. These prospects are conceptually presented as three pathways that consider the status quo, incremental adaption and revolutionary change as a means of planning more effectively for a low-carbon transition.

Social media summary. Sourcing metals sustainably will require to consider wellbeing as a purpose and to preserve natural capital.

Viral pneumonia is an important cause of death and morbidity among infants worldwide. Transmission of non-influenza respiratory viruses in households can inform preventative interventions and has not been well-characterised in South Asia. From April 2011 to April 2012, household members of pregnant women enrolled in a randomised trial of influenza vaccine in rural Nepal were surveyed weekly for respiratory illness until 180 days after birth. Nasal swabs were tested by polymerase chain reaction for respiratory viruses in symptomatic individuals. A transmission event was defined as a secondary case of the same virus within 14 days of initial infection within a household. From 555 households, 825 initial viral illness episodes occurred, resulting in 79 transmission events. The overall incidence of transmission was 1.14 events per 100 person-weeks. Risk of transmission incidence was associated with an index case age 1–4 years (incidence rate ratio (IRR) 2.35; 95% confidence interval (CI) 1.40–3.96), coinfection as initial infection (IRR 1.94; 95% CI 1.05–3.61) and no electricity in household (IRR 2.70; 95% CI 1.41–5.00). Preventive interventions targeting preschool-age children in households in resource-limited settings may decrease the risk of transmission to vulnerable household members, such as young infants.

Moral reasoning and decision making help guide behavior and facilitate interpersonal relationships. Accounts of morality that position commonsense psychology as the foundation of moral development, (i.e., rationalist theories) have dominated research in morality in autism spectrum disorder (ASD). Given the well-documented differences in commonsense psychology among autistic individuals, researchers have investigated whether the development and execution of moral judgement and reasoning differs in this population compared with neurotypical individuals. In light of the diverse findings of investigations of moral development and reasoning in ASD, a summation and critical evaluation of the literature could help make sense of what is known about this important social-cognitive skill in ASD. To that end, we conducted a systematic review of the literature investigating moral decision making among autistic children and adults. Our search identified 29 studies. In this review, we synthesize the research in the area and provide suggestions for future research. Such research could include the application of an alternative theoretical framework to studying morality in autism spectrum disorder that does not assume a deficits-based perspective.

The evolution of glyphosate resistance in weedy species places an environmentally benign herbicide in peril. The first report of a dicot plant with evolved glyphosate resistance was horseweed, which occurred in 2001. Since then, several species have evolved glyphosate resistance and genomic information about nontarget resistance mechanisms in any of them ranges from none to little. Here, we report a study combining iGentifier transcriptome analysis, cDNA sequencing, and a heterologous microarray analysis to explore potential molecular and transcriptomic mechanisms of nontarget glyphosate resistance of horseweed. The results indicate that similar molecular mechanisms might exist for nontarget herbicide resistance across multiple resistant plants from different locations, even though resistance among these resistant plants likely evolved independently and available evidence suggests resistance has evolved at least four separate times. In addition, both the microarray and sequence analyses identified non–target-site resistance candidate genes for follow-on functional genomics analysis.

Deciding on the most efficacious PRE and POST herbicide options and their ideal application timing can be challenging for soybean producers. Climatic events during the 14 d before and after herbicide application can further complicate decisions because of their influence on herbicide effectiveness. Nine field trials were conducted at three locations in southwestern Ontario from 2003 to 2006, to determine the most effective PRE and POST soybean herbicides for control of common lambsquarters, common ragweed, green foxtail, and redroot pigweed. When precipitation was low at least 7 d before and after herbicide application weed control was reduced in treatments that included imazethapyr (PRE or POST) or flumetsulam/S-metolachlor (a premix formulation) (PRE). Cumulative precipitation during the 12 d after PRE application that exceeded the monthly average by at least 60% reduced common lambsquarters control when metribuzin was applied and green foxtail control when imazethapyr was applied. Delaying application of imazethapyr + bentazon to a later soybean growth stage decreased control of common lambsquarters and green foxtail; however, environmental conditions appeared to influence these results. Precipitation on the day of application decreased control of common ragweed and redroot pigweed more with quizalofop-p-ethyl + thifensulfuron-methyl + bentazon compared with imazethapyr + bentazon. Soybean yield varied among POST herbicide treatments because of reduced weed control. This research confirms that environmental conditions pre- and postapplication, as well as application timing, influence herbicide efficacy and should be considered by growers when selecting an herbicide program.

We examine the fracture of a quasi-two-dimensional surfactant-laden aqueous foam under an applied driving pressure, using a network modelling approach developed for metallic foams by Stewart & Davis (J. Rheol., vol. 56, 2012, p. 543). In agreement with experiments, we observe two distinct mechanisms of failure analogous to those observed in a crystalline solid: a slow ductile mode when the driving pressure is applied slowly, where the void propagates as bubbles interchange neighbours through the T1 process; and a rapid brittle mode for faster application of pressures, where the void advances by successive rupture of liquid films driven by Rayleigh–Taylor instability. The simulations allow detailed insight into the mechanics of the fracturing medium and the role of its microstructure. In particular, we examine the stress distribution around the crack tip and investigate how brittle fracture localizes into a single line of breakages. We also confirm that pre-existing microstructural defects can alter the course of fracture.

To determine if total lifetime physical activity (PA) is associated with better cognitive functioning with aging and if cerebrovascular function mediates this association. A sample of 226 (52.2% female) community dwelling middle-aged and older adults (66.5±6.4 years) in the Brain in Motion Study, completed the Lifetime Total Physical Activity Questionnaire and underwent neuropsychological and cerebrovascular blood flow testing. Multiple robust linear regressions were used to model the associations between lifetime PA and global cognition after adjusting for age, sex, North American Adult Reading Test results (i.e., an estimate of premorbid intellectual ability), maximal aerobic capacity, body mass index and interactions between age, sex, and lifetime PA. Mediation analysis assessed the effect of cerebrovascular measures on the association between lifetime PA and global cognition. Post hoc analyses assessed past year PA and current fitness levels relation to global cognition and cerebrovascular measures. Better global cognitive performance was associated with higher lifetime PA (p=.045), recreational PA (p=.021), and vigorous intensity PA (p=.004), PA between the ages of 0 and 20 years (p=.036), and between the ages of 21 and 35 years (p<.0001). Cerebrovascular measures did not mediate the association between PA and global cognition scores (p>.5), but partially mediated the relation between current fitness and global cognition. This study revealed significant associations between higher levels of PA (i.e., total lifetime, recreational, vigorous PA, and past year) and better cognitive function in later life. Current fitness levels relation to cognitive function may be partially mediated through current cerebrovascular function. (JINS, 2015, 21, 816–830)

The aim of this study was to examine delay discounting in girls and boys with ADHD-Combined type (ADHD-C) relative to typically developing (TD) children on two tasks that differ in the extent to which the rewards and delays were experienced by participants. Children ages 8–12 years with ADHD-C (n=65; 19 girls) and TD controls (n=55; 15 girls) completed two delay discounting tasks involving a series of choices between smaller, immediate and larger, delayed rewards. The classic delay discounting task involved choices about money at delays of 1–90 days and only some of the outcomes were actually experienced by the participants. The novel real-time discounting task involved choices about an immediately consumable reward (playing a preferred game) at delays of 25–100 s, all of which were actually experienced by participants. Participants also provided subjective ratings of how much they liked playing the game and waiting to play. Girls with ADHD-C displayed greater delay discounting compared to boys with ADHD-C and TD girls and boys on the real-time discounting task. Diagnostic group differences were not evident on the classic discounting task. In addition, children with ADHD-C reported wanting to play the game more and liking waiting to play the game less than TD children. This novel demonstration of greater delay discounting among girls with ADHD-C on a discounting task in which the rewards are immediately consumable and the delays are experienced in real-time informs our understanding of sex differences and motivational processes in children with ADHD. (JINS, 2016, 22, 12–23)

This double blind cross-over study, involving 9 chronic spinal cord injured (SCI) patients (6 paraplegic and 3 paretic), was a first attempt to investigate the effects of the noradrenergic agonist, clonidine, on the modulation of the locomotor pattern and spasticity in patients with spinal cord lesions. Electromyographic (EMG), footswitch and video recordings were made as the patients walked on a treadmill with the support of an overhead harness if needed. Overground locomotion was also assessed in the paretic patients. All 3 spastic paretic patients had kinematic deviations and abnormal EMG recruitment profiles during the premedication or placebo sessions. With clonidine therapy one patient demonstrated a marked improvement in locomotor function. This patient progressed from non-ambulation to limited independent ambulation as the extent of coactivation in antogonist muscles decreased. The other 2 paretics who presented limited spasticity showed minimal changes while on clonidine. In the paraplegic patients, clonidine did not elicit locomotor activity, although there were marked reductions in stretch reactions and clonus during assisted locomotion. They remained incapable of locomotion, either during the control period or during the clonidine therapy. These results indicate that clonidine may be a potentially useful medication for both locomotion and certain manifestations of spasticity in SCI patients but further investigation is warranted.