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This chapter focusses on diseases and states that are linked to reduced or absent hunger. The largest part of the chapter is devoted to anorexia nervosa, and the abnormalities in hunger that occur in this disease, both as a cause (e.g., gut disorders in childhood impairing learning of interoceptive hunger) and consequence (extinction of hunger). A section on constitutional thinness follows, where a person is healthy and does not restrict food intake yet remains unusually thin. Certain chronic diseases, as well as old age, are linked to loss of hunger, and wasting. The final section explores several other sources of restriction. These include orthorexia (attempts to achieve dietary purity), meat-free diets, and the effects of stress, anxiety, and melancholic depression. The chapter ends with the most theoretically interesting topic, avoidant and restrictive feeding disorder and its related entity, paediatric feeding disorder. These conditions may reflect dysfunctional acquisition of hunger, and so provide further evidence for a learning perspective on human hunger.
The relationship between frailty, self-efficacy, and advance care planning (ACP) remains unclear in Asia. This study examined how frailty status relates to decisional self-efficacy, ACP engagement, and advance directive completion among older adults receiving home healthcare in Taiwan.
Methods
A cross-sectional analysis was conducted using baseline data from a nationwide cohort in Taiwan. Participants (N = 358) were categorized by Clinical Frailty Scale (CFS): mildly frail (CFS 4–5, n = 60), moderately frail (CFS 6, n = 83), severely frail (CFS 7, n = 147), and very severely frail (CFS 8–9, n = 68). ACP engagement and decision-making self-efficacy were assessed using Likert scales.
Results
Patients with greater frailty had lower odds of high decisional self-efficacy (CFS: 8–9: odds ratio [OR] = 0.38, 95% confidence interval [CI] = 0.14–1.07) but higher odds of ACP engagement (CFS: 6: OR = 3.38, 95% CI = 1.40–8.17; CFS: 7: OR = 2.52, 95% CI = 1.08–5.89) compared with mildly frail individuals. However, this increase did not extend linearly to the very severely frail group. Advance directive completion remained low across all frailty levels (4.8–10.0%) and was not significantly associated with frailty status.
Conclusions
Frailty was associated with lower decisional self-efficacy but higher readiness for ACP, revealing a divergence between perceived confidence and planning motivation. Despite greater engagement, advance directive completion remained low. Stage-sensitive, values-based approaches may help bridge the gap between intention and documentation across the frailty spectrum.
Individuals with severe mental illness (SMI) have increased risk of physical comorbidities, linked to worse outcomes such as greater psychopathology, frailty, and neurocognitive impairment. Mechanisms underlying this burden remain unclear. This study examined whether frailty and psychopathology predict evening chronotype, especially in SMI with comorbidities.
Methods
A longitudinal study assessed 165 participants at two time points over one year: schizophrenia (n = 30), bipolar disorder (n = 42), major depressive disorder (n = 35), and healthy controls (n = 58). The SMI group (n = 107) was divided into SMI with comorbidities (SMI-C; n = 47) and without (SMI; n = 60). Measures included psychopathology, frailty, chronotype, neurocognitive and functional performance, and hematological biomarkers.
Results
Neurocognitive and functional impairments were greater in SMI groups than controls (F = 10.3–31.4; p < 0.0001; η²p = 0.12–0.34). The SMI-C group showed worse frailty than controls at T1 (F = 4.3; p < 0.01; η²p = 0.05) and than SMI at T2 (F = 8.5; p < 0.0001; η²p = 0.12), and elevated MCV/MCH (F = 3.8–9.4; p < 0.05–0.0001; η²p = 0.04–0.11). Chronotype distribution did not differ. Frailty and psychopathology predicted chronotype in SMI (p < 0.05–0.01); in controls, frailty and performance did so (p < 0.05).
Conclusions
Psychopathological and hematological profiles are associated with chronotype and may help identify subgroups for chronobiology-informed interventions. These findings support more personalized treatment approaches.
Creatine monohydrate (CrM) is a widely used supplement to improve physical performance and strength. Recent studies suggest it may also benefit cognitive function and depression treatment. However, data on its effects in older adults are scarce, highlighting the need for further research in this population. This study is a randomised, double-blind, placebo-controlled trial assessing 5 weeks of CrM supplementation combined with physical training in older adults (≥ 75 years). Participants will be divided into four groups: placebo (PL), placebo with multicomponent training (PL + MT), creatine monohydrate supplementation (CrM) and creatine monohydrate with multicomponent training (CrM + MT). Evaluations will be conducted before, during and after the intervention and again after a 5-week washout period. The training programme includes supervised sessions twice a week over 4 weeks, focusing on resistance, cardiovascular, balance, reaction and agility exercises. Functional capacity and fall risk will be measured, alongside physical tests such as handgrip strength and one-repetition maximum (1RM) tests for leg press, bench press, seated row and leg extension. Cognitive and emotional assessments will also be conducted during the intervention. The results of this study aim to increase our understanding of the effects of CrM supplementation in older adults. This study is expected to generate valuable information on the impact and safety of this nutrition and exercise strategy, and its application can be extended to a variety of health conditions. CLINICAL TRIALS: https://clinicaltrials.gov/study/NCT06677359.
A study using a waitlist control group pre–post design evaluated a new 13-week, peer-delivered Frailty Coach Program that was adapted from two prior self-management interventions involving persons with type 2 diabetes (2019) and other chronic conditions (2022). The intervention included teaching participants to use three Self-Management support strategies and providing education and encouragement to incorporate the Canadian Frailty Network AVOID (Activity, Vaccinate, Optimize medication, Interact, and Diet & nutrition) strategies into their lives. Results showed that over half the study participants made significant changes and had returned to lower levels of frailty as measured by the Clinical Frailty Scale. Other self-reported outcome measures that included eight subscales of the RAND 36-item Health Survey showed improved physical functioning, improved emotional well-being, and improved their impression of general health. At the end of the project, the program was approved for ongoing funding by the provincial Ministry of Health.
Community-dwelling older women (age >50) with lived experience of incarceration (LEI) are an increasing yet mostly unacknowledged group with long-term health challenges. Research addressing aging-related health in older women with LEI is rare, and almost none engages collaboratively and equitably with older women to understand their aging-related health needs, preferences, and priorities. To foster awareness and readiness for engagement in outcomes research, we co-planned, implemented, and evaluated a sequence of interlinked activities and outputs with older women, clinicians and researchers, and community advocates. The Older Women Leading Healthy Aging Research Together (OWLHART) network met monthly from November 2024 to June 2025. Four to six women, two clinician-researchers, two community advocates, and a project team shared aging-related health beliefs, concerns, and outcome priorities; learned the basics of research and benefits of patient-centered outcomes research; created tools to teach about older women’s health after incarceration and the role of research; and developed outreach to disseminate the work. OWLHART models an equity-focused capacity-building approach for research engagement outside the clinical setting and with a patient group that has been overlooked as patients and as research partners.
Millions of Americans survive critical illness each year, only to be faced with new life-altering impairments in physical, cognitive, and mental health function that alter their ability to live independently. The mechanisms underlying these sequelae of critical illness are incompletely understood but are believed to develop as a function of the severity of the critical illness and the patient’s underlying vulnerability. Clinically, a patient’s underlying vulnerability can be understood as the syndrome of frailty.
Frailty affects 30% of those with critical illness and over 40% of survivors of critical illness. The presence of frailty at ICU admission confers a greater risk of death and, among survivors, disability in activities of daily living. Validated tools including the Clinical Frailty Scale, the frailty index, and the frailty phenotype can be used to identify frailty in those affected by critical illness. While effective interventions such as physical activity, nutritional support, and palliative care can reduce age-related frailty among community-dwelling older adults, the efficacy of these interventions in those along the continuum of critical illness is an area of ongoing study.
Understanding the characteristics of older patients in primary care is important to develop appropriate and targeted programs.
Objective
We describe the characteristics of older adults (aged 70+) accessing primary care in three Canadian provinces.
Methods
Participants (n = 594) completed a survey package comprising demographics, health system usage, presence of chronic conditions, and a quality-of-life measure, the EQ-5D-5L. Frailty was assessed using a deficit accumulation frailty index (FI).
Findings
The most common chronic conditions reported were high blood pressure (51.1%), osteoarthritis (37.2%), diabetes (22.8%), and heart disease (21.8%). Mean FI was .153; 22.9 per cent were frail (FI > 0.21). Females reported higher levels of pain/discomfort and anxiety/depression than males; females also reported lower levels of education and income. Mean self-rated health was similar for males and females, but a higher proportion of men reported optimal health across the EQ-5D-5L dimensions.
Discussion
Our study provides benchmark and baseline data helpful to others planning primary care for older adults.
Frailty is associated with adverse outcomes among patients with head and neck cancers. We evaluated the awareness of frailty among Irish head and neck healthcare professionals.
Methods
A cross-sectional survey was distributed to Irish multidisciplinary head and neck healthcare professionals.
Results
Eighty responses were received with varying clinical experience. Seventy-nine (99 per cent) participants believed frailty could influence: post-treatment functional outcomes (77 [96 per cent]), overall survival (72 [90 per cent]) and treatment related toxicity among head and neck cancer patients. Eighteen (23 per cent) participants had used frailty in practice. A lack of awareness / training (68 [85 per cent]) and time / practical constraints (62 [78 per cent]) were the main barriers identified to the utilisation of frailty in practice.
Conclusion
Irish head and neck healthcare professionals are aware of frailty and believe it may be of benefit in clinical practice. Barriers to incorporation of frailty in head and neck care included a lack of training, time or resources.
The concept of precarity is increasingly being applied in social gerontology to understand risks and uncertainties faced by older adults. However, existing research has not captured precarity quantitatively nor has it modelled its effect on older adults’ health. We therefore develop a Later Life Precarity Index and model its association with frailty. Using longitudinal data on 15,733 older adults from the English Longitudinal Study of Ageing, we examine the association between frailty and risks across the domains of finances, pensions, employment, housing, relationship and unpaid care-giving. We then develop the Later Life Precarity Index and model its longitudinal association with a Frailty Index using hybrid panel regression. The results indicate that multiple social risks are strongly and independently associated with frailty, particularly around finances, housing, fuel poverty and food insecurity. In longitudinal models, the precarity index explains both between-individual differences and within-individual changes in frailty and performs substantially better than standard measures of socio-economic status (wealth and education). The strong longitudinal association of the precarity index with frailty suggests that social gerontology’s growing focus on precarity is a useful lens for understanding the diverse, changing and new forms of social risk that impact frailty. By developing, testing and sharing this novel measure of later life precarity, this study brings potential for new understandings of the evolving drivers of inequalities in the health of older adults.
This study describes the management and outcomes of temporal bone fractures resulting from falls.
Methods
We retrospectively reviewed patients with traumatic temporal bone fractures from 2018 through 2022.
Results
We analysed 171 patients with temporal bone fractures, 62 (36.3 per cent) of which occurred secondary to falls. Fall patients were significantly older than non-fall patients (mean age 46 vs. 38 years; p = 0.0079) and had higher Modified Frailty Index-5 scores (0.63 vs. 0.20; p = 0.0003). Fall patients had shorter hospital stays (10.1 vs. 15.8 days; p = 0.015), were more frequently discharged home (66.1 vs. 44.0 per cent; p = 0.007) and were less likely to experience non-resolving facial nerve weakness (6.5 vs. 21.1 per cent; p = 0.030).
Conclusion
Patients with temporal bone fractures from falls are older and frailer than non-fall patients and have unique preventative and rehabilitation needs.
This study analyzed medium-to-long-term trends in long-term care insurance expenditures in Katsurao Village, which underwent complete evacuation following the Fukushima Daiichi Nuclear Power Plant accident, to elucidate the disaster’s impact on care needs. Long-term care insurance expenditure data of Katsurao Village from 2010 to 2023 were analyzed. Per capita long-term care expenditure was calculated by dividing the total long-term care insurance benefits by the population aged ≥65 years and compared to national averages. In 2016, when evacuation orders were largely lifted, per capita long-term care insurance expenditure reached JPY 562,970, approximately three times pre-disaster levels (JPY 197,461 in 2010). Although expenditures gradually decreased thereafter, they remained high at JPY 415,884 in 2023. Evacuation due to nuclear disaster leads to sustained increases in long-term care burden.
Due to frailty, chronic health issues, limited mobility, dependence on assistive devices, and polypharmacy, the geriatric population is more susceptible to the adverse effects of earthquakes. The aim of this study was to determine the factors affecting the quality of life of older adults who experienced the Kahramanmaraş-centered earthquakes in Türkiye on February 6, 2023.
Methods
This cross-sectional interview-based study was conducted with 340 older adults who experienced the earthquakes on February 6, 2023, and visited outpatient departments in Gaziantep. Data were gathered using a demographic form, Modified Fried Frailty Index, and WHO Quality of Life Instrument for Older Adults.
Results
Participants’ average age was 71.37 ± 6.56 years, and 56.6% were women. Among them, 20.9% lost a first-degree relative, 15.3% were injured, and 45.3% were displaced. WHOQOL-OLD scores differed significantly by age, marital status, education, chronic illness, polypharmacy, living arrangements, and frailty.
Conclusions
This study highlights the factors influencing the quality of life of older adults in Türkiye after an earthquake. Living with a spouse and having primary or secondary education improved quality of life, while chronic illnesses and displacement had negative impacts. These findings emphasize the importance of considering the specific needs of older adults in disaster preparedness and response.
Frailty is an ageing-related syndrome of physiological decline, heightening vulnerability and increasing risk of adverse health outcomes. Nutritional deficiencies, particularly in vitamins B9, B12 and D, are prevalent among the elderly owing to physiological changes and reduced food intake. Research suggests a correlation between low levels of these vitamins and an elevated risk of frailty. Vitamin B9, crucial for DNA synthesis and cell division, shows potential in frailty prevention, although evidence regarding supplementation remains inconclusive. Similarly, vitamin B12, essential for nerve function and red blood cell formation, presents conflicting findings regarding its impact on frailty prevention. Vitamin D, essential for bone health and muscle function, is linked to frailty risk, yet studies on the efficacy of supplementation yielded mixed results. The mechanisms involving these vitamins, including their roles in DNA methylation and inflammation regulation, highlight the need for further research to clarify their direct impact on frailty prevention. Maintaining optimal levels of vitamins B9, B12 and D may reduce frailty, but older individuals need a complete approach that includes proper nutrition, physical activity and other preventive measures.
We developed a clinical care pathway for the detection and management of frailty for older adults living in long-term care (LTC) homes.
Methods
We utilized a modified Delphi with residents of LTC homes experiencing frailty, their caregivers, and care providers. The pathway was created using existing literature and input from key LTC experts.
Findings
Fifty-two panelists completed round one of the Delphi, and 55.8% of these respondents completed round two. Both rounds had high agreement and ratings. We added six new statements following analysis of round two, and 15 statements were modified/updated to reflect panelist feedback. The final pathway included 28 statements and promotes a resident-centered approach that highlights caregiver involvement and inter-professional teamwork to identify and manage frailty, as well as initiate palliative care earlier.
Conclusion
Implementing this pathway will allow health care providers to adopt screening measures and adapt care to a resident’s frailty severity.
The overall objective of this study is to shed light on the disaster preparedness status of geriatric patients visiting tertiary hospitals in Istanbul while assessing the relationship between frailty scores, self-efficacy, and independence among geriatric patients.
Methods
This prospective cross-sectional study was conducted in the Emergency Medicine Departments of 2 tertiary centers in Istanbul. In the survey, health and frailty status, demographics, and earthquake preparedness and planning were assessed. The Clinical Frailty Scale (CFS), Tilburg Frailty Indicator (TFI), and PRISMA-7 score were administered. Contingency tables were constructed to examine the associations between frailty categories and categorical outcomes related to disaster preparedness, self-efficacy, and independence.
Results
A small portion (5.4%) of patients had received earthquake preparedness training. Regarding emergency preparedness, 32.4% had easy access to a list of emergency contacts, and 32.1% knew the location of the emergency kit. A relationship was found between the presence of an earthquake preparedness kit and the CFS and TFI (P<0.005). All the self-efficacy and independence parameters needed during disasters were found to be significantly higher among frailer patients (P<0.005).
Conclusions
Inadequate disaster preparedness, characterized by low self-efficacy and high external dependence, are influenced by frailty. Enhancing disaster preparedness requires identifying and supporting frail individuals.
Frailty in older adults with cancer is complex, evolving, and often overlooked in care. This qualitative study explored how frailty is experienced and reported using patient-reported outcome measures (PROMs) and visualized over time through journey maps. Eleven participants (65+) completed the Comprehensive Frailty Assessment Instrument (CFAI) and semi-structured interviews. Individual journey maps combined CFAI scores with personal narratives to track changes in physical, mental, and social aspects of frailty over time. While PROMs showed variability in frailty severity, narratives revealed discrepancies, such as low frailty scores despite significant treatment-related challenges. Fatigue, emotional distress, and isolation were common during treatment, with lasting impacts post-treatment. Findings suggest PROMs alone may not fully capture lived experience. Integrating narrative dialogue provides a more person-centred approach to frailty assessment and care planning.
Electronic medical record (EMR) systems in primary care present an opportunity to address frailty, a significant health concern for older adults. Researchers in the UK used Read codes to develop a 36-factor electronic frailty index (eFI), which produces frailty scores for patients in primary care settings.
Aim:
We aimed to translate the 36-factor eFI to a Canadian context.
Methods:
We used manual and automatic mapping to develop a coding set based on standardized terminologies used in Canada to reflect the 36 factors of the eFI. Manual mapping was completed independently by two coders, followed by group consensus among the research team. Automatic mapping was completed using Apelon TermWorks. We then used EMR data from the British Columbia Canadian Primary Care Sentinel Surveillance Network. We searched structured data fields related to diagnoses and reasons for patient visits to develop a list of free text terms associated with any of the 36 factors.
Results and conclusions:
A total of 3768 terms were identified; 3021 were codes. A total of 747 free text terms were identified from 527,521 reviewed data entries. Of the 36 frailty factors, 24 were captured mostly by codes; 7 mostly by free text; and 4 approximately equally by codes and free text. Three key findings emerged from this study: (1) It is difficult to capture frailty using only standardized terminologies currently used in Canada and a combination of standardized codes and free text terms better captures the complexity of frailty; (2) EMRs in primary care can be better optimized; (3) Output from this study allows for the development of a frailty screening algorithm that could be implemented in primary care settings to improve individual and system level outcomes related to frailty.
This study aimed to assess whether frailty (measured using the 5-Item Modified Frailty Index) was associated with increased morbidity following surgical tracheostomy.
Methods
A single-centre retrospective cohort study analysed a prospectively maintained database between 2022 and 2023. Univariable and multivariable regressions were used to determine factors (including frailty) associated with increased morbidity.
Results
A total of 174 patients underwent surgical tracheostomy in the study period with 28 patients determined as frail (16.1 per cent). Overall, 21 patients (12.1 per cent) suffered a tracheostomy-specific complication. Multivariable regression found an association between frail patient status and increased tracheostomy-specific complications (odds ratio 4.09, 95 per cent confidence interval 1.51–11.11; p = 0.006) and longer hospital length of stay (β 15.76 days, 95 per cent confidence interval 1.06–30.44; p = 0.036).
Conclusion
Frailty was associated with increased morbidity and longer hospital stay following tracheostomy. Assessment of frailty may guide decision making and patient discussions when planning tracheostomy.
A version of the discrete proportional hazards model is developed for psychometrical applications. In such applications, a primary covariate that influences failure times is a latent variable representing a psychological construct. The Metropolis-Hastings algorithm is studied as a method for performing marginal likelihood inference on the item parameters. The model is illustrated with a real data example that relates the age at which teenagers first experience various substances to the latent ability to avoid the onset of such behaviors.