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The objective of this study was to investigate the gene-breastfeeding interaction on BMI based on the Chinese National Twin Register (CNTR). The study included 4,573 pairs of same-sex twins aged 2–18 from CNTR. Data were collected using a self-reported questionnaire, and a structural equation model was used to analyze the gene-environment interaction of breastfeeding with BMI in six age groups. Our findings indicate that as age increases, the heritability of BMI shows an increasing trend, being the lowest (h2: 0.08; 95% CI [0.00, 0.19]) in the 6- to 8-year age group and the highest (h2: 0.57, 95% CI [0.44, 0.72]) in the 12- to 14-year age group. Additionally, breastfeeding significantly modified the additive genetic component of BMI in the 6- to 8-year age group and 12- to 14-year age group. In the 6- to 8-year age group, breastfeeding decreased the impact of genes on BMI, with a genetic effect modification coefficient (βa) of −0.19 (−0.25, −0.13). In the 12- to 14-year age group, breastfeeding increased the impact of genes on BMI, with a genetic effect modification coefficient (βa) of 0.08 (0.02, 0.15). In conclusion, as age increases, the genetic influence on children’s BMI becomes more pronounced. Breastfeeding may modulate genetic effects at the ages of 6–8 and 12–14. Given the metabolic diversity of obesity, our findings offer insight into how breastfeeding interacts with genetic background, helping to unravel the complex gene–environment interplay influencing obesity.
Located in the central part of the Western Antarctic Peninsula, the Argentine Islands-Kyiv Peninsula region is a hotspot of moss diversity, with 51 species and one variety currently known. However, no studies have specifically addressed the distribution of rare mosses in this region. Applying the only definition of moss rarity currently available for Antarctica, we identify very rare (one to two unique occurrences) and rare (three to five unique occurrences) moss species in the region and present a biogeographical analysis of their spatial distribution with corresponding maps, based on a comprehensive synthesis of archival published occurrence data. Of the 51 recorded species, 23 were classified as locally very rare or rare. Cape Tuxen, Galindez Island, Darboux Island and Cape Pérez hosted the highest concentrations of rare moss diversity, with eight, seven, seven and six species, respectively. Five rare species were recorded at Petermann Island, four at Booth and Lahille islands and three each at Diorite, ‘Eight’ and Uruguay islands. Additionally, several locations hosted species with unique characteristics, including their only known occurrence in the Antarctic Peninsula or at their known range edge. Very rare and rare species assemblages showed only partial overlap among sites: the four most species-rich sites shared several taxa, but no species occurred at all sites. Uruguay, Diorite and ‘Eight’ islands together represented a full moss species pool of the four most species-rich sites. In addition, some sites supported distinct species not recorded elsewhere in the region. Notwithstanding the limitations of the available survey data, these findings highlight the regional significance of the Argentine Islands-Kyiv Peninsula region within the Western Antarctic Peninsula for moss diversity in terms of the recognized criteria required for developing proposals for formal protection under the Antarctic Treaty.
This article tests theories of verb stress in the Northwest Caucasian language Abkhaz using a new database corpus of 3,115 inflected forms of 445 verbs. I describe the creation of the corpus and show how it can be used to gain new insights into principles of Abkhaz stress assignment, which depend on complex interactions between phonology and polysynthetic verbal morphology. I implement a previous theory of Abkhaz stress assignment (Dybo 1977) in a computer program and use the corpus to assess empirically how well it accounts for stress patterns across the lexicon of eventive verbs in Abkhaz. I show how this empirical evaluation identifies both strengths and weaknesses of the theory, and use these to propose a revised theory of Abkhaz stress assignment. The revised theory ties with or outperforms the original in all verb categories, accounting for the stress alternations in 40 additional verbs, which comprise almost 10% of the corpus. This shows that corpora, combined with computational implementations of phonological theories, can be used to further our understanding of highly complex phonological data sets.
Indigenous identity politics in South America increasingly mobilize language as a resource for political visibility, cultural continuity, and resistance to homogenizing state agendas. While many Indigenous movements pursue linguistic standardization, the Murui-Muina people of the Colombian Amazon advance an inverse project: they emphasize internal differentiation, maintaining four ethnolinguistic groups (Murui, Mɨka, Mɨnɨka, Nɨpode). Drawing on long-term ethnographic and linguistic fieldwork, this article examines how Murui-Muina speakers construct and sustain these distinctions through ideologically charged lexical contrasts (‘flag words’) that function as shibboleths of subgroup identity. Situated within histories of violence, Indigenous language politics, and Northwest Amazonian multilingual ecologies, the analysis shows how minimal linguistic differences become imbued with cosmological significance, social meaning, and political value. The Murui-Muina case challenges structuralist definitions of ‘language’, demonstrating that what ultimately counts as a language depends on local approaches to language itself, offering a broader insight into how linguistic diversity is lived, valued, and reproduced. (Indigenous identity, linguistic diversity, language standardization, Murui-Muina, Northwest Amazonia, Colombia)
Meta-analysis is a cornerstone of evidence synthesis, yet challenges arise when studies report heterogeneous summary statistics, such as means and standard deviations (SDs) versus medians, interquartile ranges (IQRs), or other percentiles. Excluding studies that report only medians and IQRs can introduce bias and reduce precision, particularly when outcomes are skewed, which is common in clinical research. Although several methods exist to estimate means and SDs from alternative summaries, many rely on strong normality assumptions, exhibit computational burden, or fail to adequately account for the precision of reported quantiles (e.g., extreme values versus medians). To address these limitations, we propose two flexible weighted estimators for estimating the mean and SD from reported quantiles. The methods leverage inverse-variance and inverse–variance–covariance weighting, respectively, to enhance both accuracy and precision. Additionally, our methods are flexible enough to accommodate any set of reported quantiles and various underlying distributions, and they can be readily implemented using standard statistical software. Simulation studies demonstrate that the weighted estimators provide nearly unbiased estimates of the mean and SD with high precision in most cases, especially for large sample sizes. In a real-world meta-analysis, the estimates obtained using the proposed estimators closely aligned with those derived from true sample statistics. These approaches are particularly valuable for skewed outcomes and offer a practical and user-friendly solution for researchers seeking to integrate heterogeneous data while improving accuracy and precision.
The Middle Persian Nāmagīhā ī Manuščihr “Epistles of Manuščihr”, the Zoroastrian high priest of Pārs and Kermān, written in 881 ce, are an important testimony of an inner-Zoroastrian dispute on orthopraxy in early Islamic Iran. They reflect Manuščihr’s efforts to preserve the extensive purification ritual Baršnūm against being substituted with a simplified ritual by his brother, the teacher-priest (Hērbed) Zādspram. Manuščihr wrote three letters to make his position clear. His second letter, addressed to Zādspram, is interesting not only for its theological debate but also for the personal relationship it reveals between two priest-brothers. Manuščihr argues on an elaborate scholarly level by quoting from the religious authoritative texts, and expresses his brotherly love and responsibility for leading his younger brother back to the correct path. This article focuses on his theological argumentation but also on the debate, how the family ties may have affected it and how he used linguistic expressions and style in this context.
Prevention of child maltreatment – incorporating physical abuse, sexual abuse, emotional abuse, neglect and exposure to domestic violence – is a clearly defined global policy priority. Global Burden of Disease studies have focused on estimating burden attributable to childhood sexual abuse omitting other forms of child maltreatment. This study aims to estimate burden attributable to child maltreatment using data from the first comprehensive national study, the Australian Child Maltreatment Study (ACMS), accounting for the co-occurrence of multiple forms, the complex impact of multi-type maltreatment and the contribution of interrelated factors.
Methods
We estimated burden attributable to child maltreatment by age and gender for Australia in 2021. Risk–outcome pairs that met criteria for sufficient evidence for a causal relationship were included. Relative risks were estimated as a function of exposure based on data from the ACMS incorporating increased risk with multi-type maltreatment and adjustment for confounding. Levels of exposure in each of the 32 mutually exclusive combinations or patterns of child maltreatment were estimated based on ACMS data by age and gender. The theoretical minimum risk exposure level was determined as no exposure to child maltreatment in the population and population attributable fractions (PAFs) were calculated. Attributable mortality, years of life lost, years lived with disability and disability-adjusted life years (DALYs) were estimated by multiplying PAFs by the relevant burden of disease estimates by age and gender for Australia in 2021. Sensitivity analyses were conducted to assess the robustness of the results. Uncertainty was propagated into attributable burden estimates using Monte Carlo simulation methods.
Results
Overall, child maltreatment accounted for 6.6% (95% uncertainty interval (UI), 6.2–6.9%) of all DALYs for women and 6.4% (95% UI, 6.0–6.7%) of all DALYs for men in Australia in 2021. An estimated 71.2% of self-harm, 57.1% of anxiety disorders and 49.3% of major depressive disorder (MDD) DALYs in women, and 63.8% of self-harm, 55.9% of anxiety disorders and 42.9% of MDD DALYs in men were attributable to child maltreatment.
Conclusions
Child maltreatment contributes to a substantial proportion of burden of disease in Australia, equivalent to leading lifestyle-related risk factors such as high body mass index, high blood pressure and smoking. This research significantly advances knowledge of the disease burden attributable to child maltreatment and provides novel methodology for measuring the impact of all five forms of child maltreatment combined on mental health and health risk behaviours nationally and globally.
The Women, Peace, and Security Policy Advisor at the United States Agency for International Development (USAID) served as the agency’s lead responsible for implementing the Women, Peace, and Security (WPS) Act of 2017 and the 2023 U.S. Strategy on Women, Peace, and Security. Tazreen Hussain (TH) served as the USAID Women, Peace, and Security Policy Advisor from 2024 to 2025. In early 2025, the Donald Trump administration officially shut down USAID, including the women, peace, and security portfolio. This is a slightly edited version of an interview that took place with Mona Lena Krook (MLK) via Zoom on December 12, 2025.
In various organizational settings, a team member is given the authority to make an investment decision that influences the value of the jointly produced surplus. We experimentally investigate the effect of asymmetric status, investment decisions, and the outcome of these decisions on bargaining behavior and outcomes. Agents’ initial contributions to the surplus are determined by their relative performances in a real-effort task. Three treatments vary in how the final surplus value is determined. We observe that when low-contributors take a risk, they are punished (rewarded) for failure (success), whereas high-contributors receive a fixed share independent of the outcome. Analysis of bargaining process variables, subjects’ communication during bargaining, and third parties’ normative judgments provides further insights into the possible mechanism behind this observation.
Archaeologists often designate certain anthropogenic structures as ‘monumental’, creating an architectural dichotomy that has an ascribed implicit value. This article challenges the usefulness of such differentiation, which, the author argues, does not describe objective characteristics of buildings but rather reflects a social construct rooted in the origins of the modern discipline of architecture. By exploring the assumptions inherent in current three-dimensional views and evolutionary models of architectural development, and employing ancient Egyptian architecture as a pertinent case study, this article aims to open our eyes to fundamental aspects of past architectural practices that are veiled by these frameworks.
In a recent article, Michael Rea has argued that hope for universalism to be true is incompatible with a lack of belief in its truth, so that hopeful universalists should become believing universalists. His reasoning, in short, is that hope for universalism involves belief that universalism is good, and such belief conflicts with a recognition of what might be God’s perfect will – that universalism is false. In response, I defend hopeful universalism by arguing that at least in some cases, we should align our hopes (or what Eleonore Stump terms our ‘desires of the heart’) with what we take to be not God’s consequent will, but only God’s antecedent will – and it may be only God’s antecedent will, and not God’s consequent will, that universalism be true.
The COVID-19 pandemic has illustrated the importance of public support for non-pharmaceutical public health interventions and the perils of rampant spread of misinformed and conspiratorial beliefs. Open-minded epistemic attitudes may be associated with adherence to public health recommendations and protect against holding false beliefs. In a large (N = 46,745 from 68 countries) global sample collected during the first months of the COVID-19 pandemic, we find that a six-item self-report measure of open-mindedness predicts decreased belief in COVID-19 conspiracy theories, increased physical distancing, increased engagement in recommended hygienic behaviors, and increased support for public health policies that aimed at decreasing COVID-19 transmission. In fact, out of 17 individual difference measures that we examined, open-mindedness proved to be the strongest or among the strongest predictors of rejecting conspiracy beliefs, of supporting physical distancing and public health policies, and of engaging in physical hygiene behaviors. In exploratory analyses of the open-mindedness measure, we found that public health support is associated with a learning-orientedfactor while conspiratorial beliefs were associated with a threat-oriented factor. These results suggest that it will be important to investigate whether open-mindedness can be cultivated or encouraged through educational or other interventions to ensure that public health is protected and that conspiracy theories do not spread.
This article reconsiders late Qing state building through the underexamined lens of ecological governance, moving beyond teleological narratives of imperial decline to reassess the regime’s resilience and institutional adaptability under conditions of mounting environmental, fiscal, and geopolitical strain. Drawing on a transregional synthesis of ecological, social, political, and economic historiography, it argues that the crises confronting the Qing in the nineteenth century stemmed less from institutional stagnation or state decay than from a profound mismatch between inherited governing capacities and intensifying socio-ecological pressures generated by population growth, commercialization, and environmental degradation. Employing R. Bin Wong’s analytical framework of Challenges, Capacities, Commitments, and Claims, the article traces how the Qing state recalibrated its governing priorities in response to these challenges and constraints. Through six case studies spanning agrarian cores and imperial borderlands, it shows how ecological governance took multiple, regionally differentiated forms. Across these settings, the state selectively retreated from labour-intensive, resource-consuming paternalistic commitments while expanding extractive, coercive, and territorial strategies aimed at dynastic survival. Rather than signalling simple state decline, these uneven and survival-oriented adaptations constituted a process of governing recalibration shaped by negotiation among state authorities, local actors, and non-human forces such as water, soil, and forests. By foregrounding the agency of ecological dynamics, this article situates the late Qing within broader debates on empire, sustainability, and state capacity, offering a comparative framework for understanding how premodern and modern states confronted environmental limits in moments of systemic crisis.
External injuries and morphological deformities may serve as useful indicators when assessing the welfare of wild animals, as they can be easily observed, be scored in a non-disruptive manner, and likely correlate with reductions in welfare in many contexts. However, the welfare effects of injuries and deformities have so far been mostly examined for animals in captivity. In contrast, the many fish living in the wild have received considerably less attention, especially in relation to naturally occurring causes, such as parasitism, predation attempts, and intra-specific conflict. Here, I attempt to quantify the prevalence of injuries and deformities in wild fish by conducting a targeted review of six relevant journals, and suggest areas where future research would be particularly useful. The results indicate that both anthropogenic and non-anthropogenic factors can cause injuries and deformities in wild fish, and that many of the focal species (i.e. the species studied in the reviewed papers) are closely related. The average prevalence of injuries and/or deformities was 15% across studies. Despite the existence of potential confounding factors (e.g. a selection bias in terms of focal populations and species), these results highlight the potential importance of injuries and deformities as determinants and indicators of fish welfare in the wild.
This article introduces the heuristic of epistemic inertia to complicate narratives of radical rupture in global sites of expertise. In 2006, the United Nations adopted the Convention on the Rights of Persons with Disabilities (CRPD), widely celebrated as a radical break from the medical model, which had long framed disability as an individual impairment to be treated by medical doctors. Through the heuristic of epistemic inertia, we examine how, despite adopting a more pluralised expert repertoire, the CRPD Committee retains some deep-seated (neo)liberal assumptions of the medical model. Through an analysis of General Comment No. 8, we identify three main manifestations of this persistence across both models: first, an understanding of dignity as tied to productivity and autonomy; second, the idea that individuals must ‘adapt’ to existing societal arrangements through merit; and third, the portrayal of market participation as the privileged moral horizon. What falls out of view are alternative imaginaries grounded in interdependence or collective forms of care, which exist outside prevailing economic logics. In this configuration, the figure of the rights-bearer is not a radical alternative to the medical patient, insofar as rights are still articulated through expectations of optimisation and self-reliance within prevailing market logics.