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The ICH E9(R1) addendum provides guidelines on accounting for intercurrent events in clinical trials using the estimands framework. However, there has been limited attention to the estimands framework for meta-analysis. Using treatment switching, a well-known intercurrent event that occurs frequently in oncology, we conducted a simulation study to explore the bias introduced by pooling together estimates targeting different estimands in a meta-analysis of randomized clinical trials (RCTs) that allowed treatment switching. We simulated overall survival data of a collection of RCTs that allowed patients in the control group to switch to the intervention treatment after disease progression under fixed effects and random effects models. For each RCT, we calculated effect estimates for a treatment policy estimand that ignored treatment switching, and a hypothetical estimand that accounted for treatment switching either by fitting rank-preserving structural failure time models or by censoring switchers. Then, we performed random effects and fixed effects meta-analyses to pool together RCT effect estimates while varying the proportions of trials providing treatment policy and hypothetical effect estimates. We compared the results of meta-analyses that pooled different types of effect estimates with those that pooled only treatment policy or hypothetical estimates. We found that pooling estimates targeting different estimands results in pooled estimators that do not target any estimand of interest, and that pooling estimates of varying estimands can generate misleading results, even under a random effects model. Adopting the estimands framework for meta-analysis may improve alignment between meta-analytic results and the clinical research question of interest.
During the second and third centuries AD, recruitment in the Roman army brought many Palmyrenes from their home city to various parts of the Roman Mediterranean and its hinterland. Military recruitment brought them to Dacia and Numidia in particular, but a famously well-documented unit of Palmyrenes was stationed at Dura-Europos on the Middle Euphrates. Most Palmyrene soldiers served in units of the auxilia or numeri, and many of these then settled in the regions in which they had served. Their descendants could be found in the same regions generations later. As Palmyrene soldiers and their descendants faced varied degrees of dispersal and isolation from their compatriots, they endured diverse pressures to assimilate. They also witnessed their ancestral divinities being adopted by fellow soldiers, military collectives or networks and local populations. Did Palmyrenes maintain social or cognitive links to their ancestral homeland under such circumstances? Did they conceive of themselves as part of a broader, dispersed Palmyrene community even as they became enmeshed in local ones? This chapter address such questions.
This article reflects on the emergence of volumetric capture as a means to render human experience in three dimensions and how its applications in medicine, performance, and digital archiving are reshaping our relationship to documentation and embodiment. From 360-degree imagery to the advanced rendering techniques of Gaussian Splatting, these tools raise questions about the ethics of visualisation and the power to represent. This article draws on the work of scholars such as Taylor, Schneider, Kenderdine, Holling, and DeNora to challenge the notion of archives as neutral or static repositories and asks: in an age where our movements can be stored and repurposed, how do we navigate the tension between visibility and consent, between preservation and autonomy?
9.1 [603] So then, by taking up our shield a longside the doctrines of the truth with the utmost endurance, so it seems to me, we have held our own against the nonsensical words of those who know only how to disparage our doctrines.1 But because our opponent bears down upon the ineffable glory with all his sails unfurled and dares, as it were, to lead forth his profane ideas in unbearable assaults, expending his most effective resources on the task of stripping the nature of God the Father of his progeny and stripping the true Son, who came from his nature, of his hypostasis2 (for he does away with his existence and engages in such extremely perilous undertakings), come now, “putting on the breastplate of justice,” while also lifting up “the shield of faith” and whetting against him “the sword of the Spirit, which is the word of God,”3 let us show that he is a liar and in his extreme arrogance all but kicks against the goads4 and leaps down into the deep pit of destruction.5 [604]
How have preventive and curative medical breakthroughs shaped life expectancy and the dispersion of age at death in the United States over the past century? We address this question by developing a life-cycle model in which both health and lifespan are endogenous. The model distinguishes between preventive innovations, which reduce the incidence of disease, and curative advances, which lower mortality risks associated with existing health conditions. Our quantitative analysis shows that while both types of medical innovation have contributed to increased life expectancy since 1935, curative advances have been the primary driver of the decline in the dispersion of age at death. Medical innovations have also improved welfare – measured in terms of a consumption-equivalent metric – by an average of 0.11% per year, with curative advances representing the most significant contribution. These findings are robust across different scenarios and parametrization strategies.
Edited by
Martin Nedbal, University of Kansas,Kelly St. Pierre, Wichita State University and Institute for Theoretical Studies, Prague,,Hana Vlhová-Wörner, University of Basel and Masaryk Institute, Prague
Czech-language music criticism first became prominent in the 1860s, and its authors often used their musical discussions to explore then-emerging political conversations, especially ethnocentric concepts of identity. Still, they drew their models from earlier, predominantly Germanophone music critics, historiographers, and aestheticians – writers who did not yet subscribe to such ethnocentric views. This chapter focuses on Germanophone writers, specifically Franz Xaver Niemetschek, Anton Müller, and August Wilhelm Ambros examining their perspectives on canonic composers of the past – particularly Mozart and Gluck – to illustrate the ideological underpinnings of Bohemian music criticism. Compounding the complexity of these critics’ ideas, twentieth-century scholars like Mirko Očadlík and Tomislav Volek reinterpreted both their writings and identities once again to reflect still new political goals.
Chaucer’s works were written during the late fourteenth century, a period which saw considerable changes in the functions of the English language as it came to replace French and Latin as the languages of written record. As well as being an important source for the scholarly understanding of late Middle English, Chaucer’s works shed light on the status of English and its variety of registers and dialects, enabling scholars to gain a deeper awareness of the sociolinguistic connotations of its different forms and usages. The Canterbury Tales, with its array of pilgrims drawn from a variety of professions, social classes and geographical regions narrating a series of tales reflecting a wide range of genres, is a valuable source of evidence for historical pragmatics. This chapter shows the way in which Chaucer’s text offers insights into the conventions of social interaction, including forms of address, politeness and verbal aggression, and the use of discourse markers.
1 The successes of your holy empire are noteworthy, remarkable, and cannot be expressed in words, and the incomparability of your piety, which is like an inheritance come to you from above, you have successfully defended from the arrows of envy, thanks to the skill in all things excellent that you received from your father and also your grandfather,1 as is obvious in this instance.2
We prove that determining the weak saturation number of a host graph $F$ with respect to a pattern graph $H$ is computationally hard, even when $H$ is the triangle. Our main tool establishes a connection between weak saturation and the shellability of simplicial complexes.
In the 1890s and 1900s, theologian and activist Jabez T. Sunderland became a keen follower of the Brāhmos, conceding that the Brāhmo movement and the Unitarian movement to which he belonged form parallel tracks in the reconstruction of religion. These parallel tracks manifest in both the rise of Indian religious reformers in the USA from the second half of the nineteenth century as well as North American religious reformers and theorists deepening their interest, and commitment, to, Indian religion. One of these Indian reformers who visited the United States was none other than the Brāhmo missionary and intellectual P.C. Mozoomdar, who lectured and wrote a great deal about Jesus, social service as a form of service to God, as inspirations for the new, Brāhmo religion. Mozoomdar argued that this new religion, keeping in faith and standards of worship, born out by the comparative method. The linkages between the USA and India in the realm of religion continued through the end of the century, with the rise of one Narendra Nath Datta, known from the 1890s as Swami Vivekananda in the USA in 1893. This final chapter includes a variety of critical engagements after the death of Keshab Chandra Sen and the appreciation of his ideas by the American parallel to the Brāhmo Samaj, the Free Religious Association, which began in the 1870s. These new conceptions of Indian religion preceded and paralleled the rise of Vivekananda by the 1890s. This chapter ends with a consideration of Vivekananda, a figure whose definitions of religion become dominant by the end of the century.
Edited by
Martin Nedbal, University of Kansas,Kelly St. Pierre, Wichita State University and Institute for Theoretical Studies, Prague,,Hana Vlhová-Wörner, University of Basel and Masaryk Institute, Prague
This chapter explores the role of central aspects of cognition in historical linguistics. After describing and discussing the cognitive commitment and its theoretical background, this chapter highlights the relation to cognitive archaeology as well as historical psychology and explores the methodological prerequisites for cognitive approaches to the history of English, particularly the quantitative turn in cognitive linguistics. Case studies from different periods of English illustrate how cognitive factors can shed light on synchronic historical language stages and diachronic developments, and how these in turn can help us to further explore the cognitive commitment. Finally, we argue for a feedback loop, where modern cognitive linguistic theories feed into and guide historical enquiries, but are also checked and modified, if necessary, on the basis of historical findings.
This chapter lays out the ways in which Hans Christian Ørsted (1777–1851) influenced the development of the concept of thought experiment. Ernst Mach (1838–1916) is currently more often credited with laying the foundations of contemporary views, and he is sometimes thought to have been little (if at all) influenced by Ørsted. Against these standard accounts, I will show that Ørsted’s and Mach’s descriptions have key features in common. Both thinkers hold that thought experiments: (1) are a method of variation, (2) require the experimenter’s free activity, and (3) are useful in educational contexts for guiding students to arrive at certain conclusions on their own (i.e., to genuinely appropriate new concepts). The process of variation is guided by the search for invariants, some of which do not directly appear in experience. Since it is important that teachers and students be able to bring the same ideal objects to mind, thought experiments play a key role for both Ørsted and Mach in math education. While Ørsted’s emphasis on the role of thought experiments in math has been proposed as a reason why his descriptions are not relevant for contemporary use of thought experiments, I will show how their role in mathematical thinking – stemming from Kant’s descriptions of the method of construction in geometry – are part of a wider account of thought experiments that encompasses their role in the sciences and also philosophy.
Edited by
Martin Nedbal, University of Kansas,Kelly St. Pierre, Wichita State University and Institute for Theoretical Studies, Prague,,Hana Vlhová-Wörner, University of Basel and Masaryk Institute, Prague
Drawing on postcolonial and decolonial theory developed since the 1990s for the study of socialist and post-socialist East Central Europe, this chapter approaches opera as a crucial cultural site for (re)negotiating the relationship with “the West,” Soviet hegemony, and the Global South after 1948. It focuses on the ambivalence in representations of the racialized Other in Czech opera, which highlights the specific, lateral relationship between what was formally known as the Second and Third worlds. The chapter offers a close reading of the opera JezeroUkereve (“Lake Ukerewe”) by Otmar Mácha, premiered in 1966. Featuring Black and mixed-race characters, the opera generally expresses empathy for and solidarity with the colonized populations, informed by the Czechs’ experience with German oppression, yet it unavoidably reproduces the colonial ideology of a civilizational mission. The opera is interpreted in relation to Czechoslovakia’s official Africa policy and the aesthetic debates about Czech New Music.