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Chapter 29 - Neuronal Death

from Cellular Responses

Published online by Cambridge University Press:  07 August 2021

Mirna Lechpammer ,
Marc Del Bigio  and
Rebecca Folkerth
By
Marc Del Bigio
Mirna Lechpammer
Affiliation:
New York University School of Medicine
Marc Del Bigio
Affiliation:
University of Manitoba, Canada
Rebecca Folkerth
Affiliation:
New York University School of Medicine
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Summary

The idea that loss of neurons could be associated with disease states and that certain microscopic appearances could be indicative of these arose in the mid to late 1800s. If neurons die, become dysfunctional, or are disconnected following a challenge, functionality of the affected neural circuit is compromised. Depending on the magnitude and localization, this may have relatively mild consequences (such as a learning deficit) or major consequences (such as developmental delay, epilepsy, cerebral palsy, or death). We are interested in selective or regional neuron death because they can help to explain the neurologic dysfunction experienced by an individual or give insight into the pathologic process that preceded death.

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Perinatal Neuropathology , pp. 145 - 154
Publisher: Cambridge University Press
Print publication year: 2021

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