Drosophila melanogaster has given enormous contributions to Space Biology Research. This organism is an important tool to be manipulated in genetic engineering and molecular experiments in order to understand different biological processes homologous to other multicellular systems, including humans. Their milestone contribution in microgravity conditions and radiation, the two most important variables in space, have allowed new knowledge and perspectives on the positive and negative effects on cellular, molecular and genetic levels. In this review, we expose the historical contribution of Drosophila melanogaster in Astrobiology.

Fast radio bursts (FRBs) are short-duration radio transients that occur at random times in host galaxies distributed all over the sky. Large field of view instruments can play a critical role in the blind search for rare FRBs. We present a concept for an all-sky FRB monitor using a compact all-sky phased array (CASPA), which can efficiently achieve an extremely large field of view of $\sim10^4$ square degrees. Such a system would allow us to conduct a continuous, blind FRB search covering the entire southern sky. Using the measured FRB luminosity function, we investigate the detection rate for this all-sky phased array and compare the result to a number of other proposed large field-of-view instruments. We predict a rate of a few FRB detections per week and determine the dispersion measure and redshift distributions of these detectable FRBs. This instrument is optimal for detecting FRBs in the nearby Universe and for extending the high-end of the FRB luminosity function through finding ultraluminous events. Additionally, this instrument can be used to shadow the new gravitational-wave observing runs, detect high-energy events triggered from Galactic magnetars and search for other bright, but currently unknown transient signals.

A new approach for constructing polar-like boundary-conforming coordinates inside a toroid with strongly shaped cross-sections is presented. A coordinate mapping is obtained through a variational approach, which involves identifying extremal points of a proposed action in the mapping space from $[0, 2{\rm \pi} ]^2 \times [0, 1]$ to a toroidal domain in $\mathbb {R}^3$. This approach employs an action built on the squared Jacobian and radial length. Extensive testing is conducted on general toroidal boundaries using a global Fourier–Zernike basis via action minimisation. The results demonstrate successful coordinate construction capable of accurately describing strongly shaped toroidal domains. The coordinate construction is successfully applied to the computation of three-dimensional magnetohydrodynamic equilibria in the GVEC code where the use of traditional coordinate construction by interpolation from the boundary failed.

The TRiC/CCT complex assists in the folding of approximately 10% of cytosolic proteins through an ATP-driven conformational cycle, playing a crucial role in maintaining protein homeostasis. Despite our understanding of ATP-driven TRiC ring closing and substrate folding, the process and mechanisms underlying TRiC ring-opening and substrate release remain largely unexplored. In this study, by determining an ensemble of cryo-EM structures of yeast TRiC in the presence of ADP, including three intermediate transition states, we present a comprehensive picture of the TRiC ring-opening process. During this process, CCT3 detects the loss of γ-phosphate and initiates with the dynamics of its apical protrusion, and expands to the outward leaning of the consecutive CCT6/8/7/5 subunits. This is followed by significant movements of CCT2, CCT4, and especially CCT1 subunits, resulting in the opening of the TRiC rings. We also observed an unforeseen temporary separation between the two rings in the CCT2 side, coordinating the release of the originally locked CCT4 N-terminus, which potentially participates in the ring-opening process. Collectively, our study reveals a stepwise TRiC ring-opening mechanism, provides a comprehensive view of the TRiC conformational landscape, and sheds lights on its subunit specificity in sensing nucleotide status and substrate release. Our findings deepen our understanding of protein folding assisted by TRiC and may inspire new strategies for the diagnosis and treatment of related diseases.

This study demonstrates a kilowatt-level, spectrum-programmable, multi-wavelength fiber laser (MWFL) with wavelength, interval and intensity tunability. The central wavelength tuning range is 1060–1095 nm and the tunable number is controllable from 1 to 5. The wavelength interval can be tuned from 6 to 32 nm and the intensity of each channel can be adjusted independently. Maximum output power up to approximately 1100 W has been achieved by master oscillator power amplifier structures. We also investigate the wavelength evolution experimentally considering the difference of gain competition, which may give a primary reference for kW-level high-power MWFL spectral manipulation. To the best of our knowledge, this is the highest output power ever reported for a programmable MWFL. Benefiting from its high power and flexible spectral manipulability, the proposed MWFL has great potential in versatile applications such as nonlinear frequency conversion and spectroscopy.

Large-aperture gratings have significant applications in inertial confinement fusion, immersion lithography manufacturing and astronomical observation. Currently, it is challenging and expensive to manufacture sizable monolithic gratings. Therefore, tiled multiple small-aperture gratings are preferred. In this study, the impact of seam phase discontinuity on the modulation of the laser beam field was explored based on the measurement results of the Shenguang-II laser large-aperture multi-exposure-tiled grating. An innovative method for accurately calculating the phase jump of multi-exposure-tiled grating seams was proposed. An intensive electromagnetic field analysis was performed by applying rigorous coupled-wave analysis to a reasonably constructed micrometer-level periodic grating seam structure, and the phase jump appearing in millimeter-scale seams of large-aperture tiled gratings was obtained accurately.

A key objective for upcoming surveys, and when re-analysing archival data, is the identification of variable stellar sources. However, the selection of these sources is often complicated by the unavailability of light curve data. Utilising a self-organising map (SOM), we demonstrate the selection of diverse variable source types from a catalogue of variable and non-variable SDSS Stripe 82 sources whilst employing only the median $u-g$, $g-r$, $r-i$, and $i-z$ photometric colours for each source as input, without using source magnitudes. This includes the separation of main sequence variable stars that are otherwise degenerate with non-variable sources ($u-g$,$g-r$) and ($r-i$,$i-z$) colour-spaces. We separate variable sources on the main sequence from all other variable and non-variable sources with a purity of $80.0\%$ and completeness of $25.1\%$, figures which can be modified depending on the application. We also explore the varying ability of the same method to simultaneously select other types of variable sources from the heterogeneous sample, including variable quasars and RR-Lyrae stars. The demonstrated ability of this method to select variable main sequence stars in colour-space holds promise for application in future survey reduction pipelines and for the analysis of archival data, where light curves may not be available or may be prohibitively expensive to obtain.

Dispersion relations of electrostatic surface waves propagating in magnetized plasmas contained in an infinite duct and in an infinite cylindrical column surrounded by vacuum are derived by means of a Vlasov equation and fluid equations, respectively. The kinematic boundary condition imposed on the distribution function, the specular reflection conditions on the four sides of a duct, can be satisfied by placing infinite number of fictitious surface charge sheets spaced by the duct widths. The Vlasov equation that includes these surface charge sheets is solved by summing up the contribution due to the infinite charge sheets. The method of placing appropriate fictitious surface charge sheets enables one to treat the surface waves in bounded plasmas of Cartesian structure with mathematical efficiency, kinetically. The kinetic duct dispersion relation is compared with the dispersion relation for the magnetized cylindrical plasma column. When the square duct cross-sectional area as well as the cylinder radius become infinity, both dispersion relations become the dispersion relation of the upper-hybrid wave.

A high-energy pulsed vacuum ultraviolet (VUV) solid-state laser at 177 nm with high peak power by the sixth harmonic of a neodymium-doped yttrium aluminum garnet (Nd:YAG) amplifier in a KBe2BO3F2 prism-coupled device was demonstrated. The ultraviolet (UV) pump laser is a 352 ps pulsed, spatial top-hat super-Gaussian beam at 355 nm. A high energy of a 7.12 mJ VUV laser at 177 nm is obtained with a pulse width of 255 ps, indicating a peak power of 28 MW, and the conversion efficiency is 9.42% from 355 to 177 nm. The measured results fitted well with the theoretical prediction. It is the highest pulse energy and highest peak power ever reported in the VUV range for any solid-state lasers. The high-energy, high-peak-power, and high-spatial-uniformity VUV laser is of great interest for ultra-fine machining and particle-size measurements using UV in-line Fraunhofer holography diagnostics.

Fiber Bragg grating-based Raman oscillators are capable of achieving targeted frequency conversion and brightness enhancement through the provision of gain via stimulated Raman scattering across a broad gain spectrum. This capability renders them an exemplary solution for the acquisition of high-brightness, specialized-wavelength lasers. Nonetheless, the output power of all-fiber Raman oscillators is typically limited to several hundred watts, primarily due to limitations in injectable pump power and the influence of higher-order Raman effects, which is inadequate for certain application demands. In this study, we introduce an innovative approach by employing a graded-index fiber with a core diameter of up to 150 μm as the Raman gain medium. This strategy not only enhances the injectable pump power but also mitigates higher-order Raman effects. Consequently, we have successfully attained an output power of 1780 W for the all-fiber Raman laser at 1130 nm, representing the highest output power in Raman fiber oscillators with any configuration reported to date.

We report a novel pilot project to characterise intra-night optical variability (INOV) of an extremely rare type of quasar, which has recently been caught in the act of transiting from a radio-quiet to radio-loud state, on a decadal time scale. Such rare transitions may signify a recurrence, or conceivably the first switch-on of jet activity in optically luminous quasars. The newly formed jet could well be jittery and unsteady, both in power and direction. The optically brightest among such radio-state transition candidates, the quasar J0950+5128 ($z = 0.2142$), was monitored by us with dense sampling in the R-band, during 2020-21 in 6 sessions, each lasting $ \gt $ 4 hours. This is the first attempt to characterise the INOV properties associated with this recently discovered, extremely rarely observed phenomenon of quasar radio-state transition. The non-detection of INOV in any of the 6 sessions, down to the 1-2% level, amounts to a lack of evidence for a blazar-like optical activity, $\sim$ 2 years after its transition to radio-loud state was found. The only INOV feature detected in J0950+5128 during our observational campaign was a $\sim$ 0.15-mag spike lasting < 6 minutes, seen at 13.97 UT on 18-March-2021. We also report the available optical light curves of this quasar from the Zwicky Transient Facility survey, which indicate that it had experienced a phase of INOV activity around the time its transition to the radio-loud state was detected, however that phase did not sustain until the launch of our INOV campaign $\sim$ 2 years later.

Continuum kinetic simulations are increasingly capable of resolving high-dimensional phase space with advances in computing. These capabilities can be more fully explored by using linear kinetic theory to initialize the self-consistent field and phase space perturbations of kinetic instabilities. The phase space perturbation of a kinetic eigenfunction in unmagnetized plasma has a simple analytic form, and in magnetized plasma may be well approximated by truncation of a cyclotron-harmonic expansion. We catalogue the most common use cases with a historical discussion of kinetic eigenfunctions and by conducting nonlinear Vlasov–Poisson and Vlasov–Maxwell simulations of singlemode and multimode two-stream, loss-cone and Weibel instabilities in unmagnetized and magnetized plasmas with one- and two-dimensional geometries. Applications to quasilinear kinetic theory are discussed and applied to the bump-on-tail instability. In order to compute eigenvalues we present novel representations of the dielectric function for ring distributions in magnetized plasmas with power series, hypergeometric and trigonometric integral forms. Eigenfunction phase space fluctuations are visualized for prototypical cases such as the Bernstein modes to build intuition. In addition, phase portraits are presented for the magnetic well associated with nonlinear saturation of the Weibel instability, distinguishing current-density-generating trapping structures from charge-density-generating ones.