This study aimed to investigate the clinical characteristics and to analyse the epidemiological features of coronavirus disease 2019 (COVID-19) patients during convalescence. In this study, we enrolled 71 confirmed cases of COVID-19 who were discharged from hospital and transferred to isolation wards from 6 February to 26 March 2020. They were all employees of Zhongnan Hospital of Wuhan University or their family members of which three cases were <18 years of age. Clinical data were collected and analysed statistically. Forty-one cases (41/71, 57.7%) comprised medical faculty, young and middle-aged patients (aged ⩽60 years) accounted for 81.7% (58/71). The average isolation time period for all adult patients was 13.8 ± 6.1 days. During convalescence, RNA detection results of 35.2% patients (25/71) turned from negative to positive. The longest RNA reversed phase time was 7 days. In all, 52.9% of adult patients (36/68) had no obvious clinical symptoms, and the remaining ones had mild and non-specific clinical symptoms (e.g. cough, sputum, sore throat, disorders of the gastrointestinal tract etc.). Chest CT signs in 89.7% of adult patients (61/68) gradually improved, and in the others, the lesions were eventually absorbed and improved after short-term repeated progression. The main chest CT manifestations of adult patients were normal, GGO or fibre streak shadow, and six patients (8.8%) had extrapulmonary manifestations, but there was no significant correlation with RNA detection results (r = −0.008, P > 0.05). The drug treatment was mainly symptomatic support therapy, and antibiotics and antiviral drugs were ineffective. It is necessary to re-evaluate the isolation time and standard to terminate isolation for discharged COVID-19 patients.

In this paper, we review different definitions that multi-state k-out-of-n systems have received along the literature and study them in a unified way using the algebra of monomial ideals. We thus obtain formulas and algorithms to compute their reliability and bounds for it. We provide formulas and computer experiments for simple and generalized multi-state k-out-of-n systems and for binary k-out-of-n systems with multi-state components.

This paper studies the parameter estimation for Ornstein–Uhlenbeck stochastic volatility models driven by Lévy processes. We propose computationally efficient estimators based on the method of moments that are robust to model misspecification. We develop an analytical framework that enables closed-form representation of model parameters in terms of the moments and autocorrelations of observed underlying processes. Under moderate assumptions, which are typically much weaker than those for likelihood methods, we prove large-sample behaviors for our proposed estimators, including strong consistency and asymptotic normality. Our estimators obtain the canonical square-root convergence rate and are shown through numerical experiments to outperform likelihood-based methods.

As the field of modelling mortality has grown in recent years, the number and importance of identifiability issues within mortality models has grown in parallel. This has led both to robustness problems and to difficulties in making projections of future mortality rates. In this paper, we present a comprehensive analysis of the identifiability issues in age/period mortality models in order to first understand them better and then to resolve them. To achieve this, we discuss how these identification issues arise, how to choose identification schemes which aid our demographic interpretation of the models and how to project the models so that our forecasts of the future do not depend upon the arbitrary choices used to identify the historical parameters estimated from historical data.

We present a new robust bootstrap method for a test when there is a nuisance parameter under the alternative, and some parameters are possibly weakly or nonidentified. We focus on a Bierens (1990, Econometrica 58, 1443–1458)-type conditional moment test of omitted nonlinearity for convenience. Existing methods include the supremum p-value which promotes a conservative test that is generally not consistent, and test statistic transforms like the supremum and average for which bootstrap methods are not valid under weak identification. We propose a new wild bootstrap method for p-value computation by targeting specific identification cases. We then combine bootstrapped p-values across polar identification cases to form an asymptotically valid p-value approximation that is robust to any identification case. Our wild bootstrap procedure does not require knowledge of the covariance structure of the bootstrapped processes, whereas Andrews and Cheng’s (2012a, Econometrica 80, 2153–2211; 2013, Journal of Econometrics 173, 36–56; 2014, Econometric Theory 30, 287–333) simulation approach generally does. Our method allows for robust bootstrap critical value computation as well. Our bootstrap method (like conventional ones) does not lead to a consistent p-value approximation for test statistic functions like the supremum and average. Therefore, we smooth over the robust bootstrapped p-value as the basis for several tests which achieve the correct asymptotic level, and are consistent, for any degree of identification. They also achieve uniform size control. A simulation study reveals possibly large empirical size distortions in nonrobust tests when weak or nonidentification arises. One of our smoothed p-value tests, however, dominates all other tests by delivering accurate empirical size and comparatively high power.

The process of software testing usually involves the correction of a detected bug immediately upon detection. In this article, in contrast, we discuss continuous time testing of a software with periodic debugging in which bugs are corrected, instead of at the instants of their detection, at some pre-specified time points. Under the assumption of renewal distribution for the time between successive occurrence of a bug, maximum-likelihood estimation of the initial number of bugs in the software is considered, when the renewal distribution belongs to any general parametric family or is arbitrary. The asymptotic properties of the estimated model parameters are also discussed. Finally, we investigate the finite sample properties of the estimators, specially that of the number of initial number of bugs, through simulation.

The ruin probability in the classical Brownian risk model can be explicitly calculated for both finite and infinite time horizon. This is not the case for the simultaneous ruin probability in the two-dimensional Brownian risk model. Relying on asymptotic theory, we derive in this contribution approximations for both simultaneous ruin probability and simultaneous ruin time for the two-dimensional Brownian risk model when the initial capital increases to infinity.

This work proposes and analyzes a family of spatially inhomogeneous epidemic models. This is our first effort to use stochastic partial differential equations (SPDEs) to model epidemic dynamics with spatial variations and environmental noise. After setting up the problem, the existence and uniqueness of solutions of the underlying SPDEs are examined. Then, definitions of permanence and extinction are given, and certain sufficient conditions are provided for permanence and extinction. Our hope is that this paper will open up windows for investigation of epidemic models from a new angle.

We study the limit behaviour of a class of random walk models taking values in the standard d-dimensional ($d\ge 1$) simplex. From an interior point z, the process chooses one of the $d+1$ vertices of the simplex, with probabilities depending on z, and then the particle randomly jumps to a new location z′ on the segment connecting z to the chosen vertex. In some special cases, using properties of the Beta distribution, we prove that the limiting distributions of the Markov chain are Dirichlet. We also consider a related history-dependent random walk model in [0, 1] based on an urn-type scheme. We show that this random walk converges in distribution to an arcsine random variable.

The paper deals with prognosis estimation for industrial systems in a series configuration, modeled by superimposed renewal processes (SRP), when the cause of failures is not available. In the presence of missing information, an SRP is commonly approximated by a Poisson process or a virtual age model. The performance of the approximations was assessed in the ideal configuration where all parameters of the models are known. The current article adopts a practitioner's perspective by assuming that the parameters of the models are unknown and must be estimated. In addition to inference procedures, the assessment of the prognosis indicators, such as the remaining useful life, is discussed. Finally, we investigate a fleet of infrastructure components of the Norwegian railway network operated by Bane NOR.

For a one-dimensional smooth vector field in a neighborhood of an unstable equilibrium, we consider the associated dynamics perturbed by small noise. We give a revealing elementary proof of a result proved earlier using heavy machinery from Malliavin calculus. In particular, we obtain precise vanishing noise asymptotics for the tail of the exit time and for the exit distribution conditioned on atypically long exits. We also discuss our program on rare transitions in noisy heteroclinic networks.

We study failure rate monotonicity and generalised convex transform stochastic ordering properties of random variables, with an emphasis on applications. We are especially interested in the effect of a tail-weight iteration procedure to define distributions, which is equivalent to the characterisation of moments of the residual lifetime at a given instant. For the monotonicity properties, we are mainly concerned with hereditary properties with respect to the iteration procedure providing counterexamples showing either that the hereditary property does not hold or that inverse implications are not true. For the stochastic ordering, we introduce a new criterion, based on the analysis of the sign variation of a suitable function. This criterion is then applied to prove ageing properties of parallel systems formed with components that have exponentially distributed lifetimes.

The signature representation shows that the reliability of the system is a mixture of the reliability functions of the k-out-of-n systems. The first representation was obtained for systems with independent and identically distributed (IID) components and after it was extended to exchangeable (EXC) components. The purpose of the present paper is to extend it to the class of systems with identically distributed (ID) components which have a diagonal-dependent copula. We prove that this class is much larger than the class with EXC components. This extension is used to compare systems with non-EXC components.

Two definitions of Birnbaum’s importance measure for coherent systems are studied in the case of exchangeable components. Representations of these measures in terms of distribution functions of the ordered component lifetimes are given. As an example, coherent systems with failure-dependent component lifetimes based on the notion of sequential order statistics are considered. Furthermore, it is shown that the two measures are ordered in the case of associated component lifetimes. Finally, the limiting behavior of the measures with respect to time is examined.

We investigate the probability that an insurance portfolio gets ruined within a finite time period under the assumption that the r largest claims are (partly) reinsured. We show that for regularly varying claim sizes the probability of ruin after reinsurance is also regularly varying in terms of the initial capital, and derive an explicit asymptotic expression for the latter. We establish this result by leveraging recent developments on sample-path large deviations for heavy tails. Our results allow, on the asymptotic level, for an explicit comparison between two well-known large-claim reinsurance contracts, namely LCR and ECOMOR. Finally, we assess the accuracy of the resulting approximations using state-of-the-art rare event simulation techniques.

Recent work studying triadic closure in undirected graphs has drawn attention to the distinction between measures that focus on the “center” node of a wedge (i.e., length-2 path) versus measures that focus on the “initiator,” a distinction with considerable consequences. Existing measures in directed graphs, meanwhile, have all been center-focused. In this work, we propose a family of eight directed closure coefficients that measure the frequency of triadic closure in directed graphs from the perspective of the node initiating closure. The eight coefficients correspond to different labeled wedges, where the initiator and center nodes are labeled, and we observe dramatic empirical variation in these coefficients on real-world networks, even in cases when the induced directed triangles are isomorphic. To understand this phenomenon, we examine the theoretical behavior of our closure coefficients under a directed configuration model. Our analysis illustrates an underlying connection between the closure coefficients and moments of the joint in- and out-degree distributions of the network, offering an explanation of the observed asymmetries. We also use our directed closure coefficients as predictors in two machine learning tasks. We find interpretable models with AUC scores above 0.92 in class-balanced binary prediction, substantially outperforming models that use traditional center-focused measures.

We introduce two general classes of reflected autoregressive processes, INGAR+ and GAR+. Here, INGAR+ can be seen as the counterpart of INAR(1) with general thinning and reflection being imposed to keep the process non-negative; GAR+ relates to AR(1) in an analogous manner. The two processes INGAR+ and GAR+ are shown to be connected via a duality relation. We proceed by presenting a detailed analysis of the time-dependent and stationary behavior of the INGAR+ process, and then exploit the duality relation to obtain the time-dependent and stationary behavior of the GAR+ process.