The Middle Dnieper region, situated within a transitional glacial–periglacial zone, preserves complex loess–palaeosol archives. This study reconstructs the environmental evolution of the Velyka Andrusivka sequence using a multiproxy approach integrating sedimentological, geochemical, mineralogical, magnetic, and palynological data supported by luminescence dating. The succession rests on Dnieper glacial till and comprises loess units from the last and penultimate glacial cycles, palaeosols, and an upper chernozem formed after loess deposition had ceased. Optically stimulated luminescence ages range from ∼22 to 187 ka, revealing hiatuses and diachronous boundaries relative to Marine Isotope Stage divisions. The older loess is more heterogeneous and enriched in Zr-Hf-REE with mixed provenance, whereas the younger loess is more homogeneous and dominated by distal dust. These contrasts demonstrate how local sediment recycling and regional dust supply jointly shaped the environmental signal. Palaeosols record phases of weathering, while the upper chernozem largely retains the parent-loess texture within a sequence overprinted by postdepositional alterations in colour, geochemistry, and magnetic properties. Comparison along the 50°N transect shows that robust interpretation of the sequence requires integration with neighbouring loess–palaeosol records, as only multi-site correlation captures shared stratigraphic patterns and site-specific deviations, enabling reconstruction of environmental processes across multiple spatial scales.