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Mohenjo-daro was a major city of the Indus Civilisation (c. 2600–1900 BC), with excavations revealing evidence for public infrastructure, civic amenities and hundreds of residences. Archaeologists traditionally assume that urbanism is accompanied by economic stratification, but, at Mohenjo-daro, qualitative evidence of inequality is absent. Drawing on early excavation data, the authors here calculate Gini coefficients of residence area, providing a quantitative proxy of economic inequality. Their results indicate that Gini coefficients, and thus inequality, declined over time, coinciding with increased prosperity and the development of the city’s street plan, indicating that governance likely helped limit economic inequality.
Colchester Museums has collected Roman-period medical instruments from the town since the late nineteenth century. Brought together here, along with items from the town housed in other institutions, their typological links or differences are explored, along with their wide range of uses. They are set in a variety of contexts, including a conquest-period British Doctor’s kit from Stanway, near Colchester, the alloys used in their manufacture, their distribution across the town and its suburbs, the diseases evident from late Romano-British human remains in the town’s cemeteries, and herbal remedies and other treatments. Interpretation of a previously enigmatic collyrium stamp attests to an eye infection not previously recorded in Roman Britain.
Historic accounts often cite mesquite gum as a component of O’odham material culture and medicinal practices. This study reevaluates these claims through chemical analysis of artifacts and reconsiders historical accounts in light of the chemistry of mesquite exudates. Museum artifacts previously identified as containing mesquite gum were instead identified as insect lac, consistent with its use in Hohokam artifacts and suggesting technological continuity. Mesquite polyphenolic exudate—distinct from polysaccharide gum—was identified as the base for carbonaceous black paints and, given its chemical properties, was likely used in traditional medicinal applications. Linguistic distinctions in O’odham terminology reflect a detailed understanding of mesquite resources. These findings highlight the importance of precise material identification in interpreting cultural and technological practices in the American Southwest, as well as the value of reevaluation of museum collections.
Many institutions today promote “Global Asia(s)” and “Global Asian Studies” as both a method and an initiative. As a growing field, these institutions are committed to reimagining the studies of Asia through transnational, comparative, and boundary-crossing approaches. To map its contemporary landscape and identify emerging challenges, this study draws on interviews with ten directors from diverse institutions around the world, each engaged in Global Asia(s)/Global Asian Studies in distinct and pioneering ways. Despite varied contexts, these institutions share strong commitments – particularly a collective dissatisfaction with traditional models of Asian Studies and a common drive to transcend geographic boundaries, the East–West divide, and disciplinary silos. At the same time, local histories, community needs, academic traditions, institutional structures, leadership visions, and available resources shape divergent interpretations and implementations of Global Asia(s). Rather than advancing a unified model, this study emphasizes the field’s plurality and reflexive knowledge production process, arguing that its strength lies in this diversity and ongoing dialogue.
We perform causal analysis on the low-dimensional Galerkin model for shear flow developed by Moehlis et al. (New J. Phys., vol. 6, 2004, 56). Our method integrates both equation-based analysis and the proposed Galerkin-based Granger causality (GGC) to investigate the effect of the nonlinear terms on the dynamics. Two types of quadratic interactions are identified: a fully triadic interaction and a modulated two-mode coupling. The propagation of these interactions through the nonlinear dynamics leads to a directed cause-and-effect network. Furthermore, the relative importance of each mode amplitude on the dynamics of the target mode is quantified. This analysis provides a deeper understanding of the nonlinear dynamics and distills control opportunities. To demonstrate the applicability of the proposed GGC to realistic flows where Galerkin projection is impractical, a turbulent lid-driven cavity flow is further studied. We foresee applications of the proposed causal analysis framework as valuable tools for Galerkin modelling – guiding investigations of modal causality, prediction uncertainty, model-order reduction and control design.
Venous thromboembolism prevalence amongst paediatric patients with CHD has increased over the years. Enoxaparin’s favourable pharmacokinetic and pharmacodynamic properties, paired with less intensive monitoring parameters, make it a desirable treatment option. Currently, reported enoxaparin dosing strategies and their correlation to therapeutic anti-Xa levels are variable for infants aged 2 to 12 months.
Methods:
This retrospective chart review evaluated the percentage of patients who achieved initial target anti-Xa levels on therapeutic enoxaparin. Patients were divided into standard-dose enoxaparin of 1 mg/kg every 12 hours and high-dose enoxaparin of 1.5 mg/kg every 12 hours.
Results:
Eighty-five patients were included in this study with similar demographics. More patients in the high-dose group achieved initial therapeutic levels of enoxaparin (36 (69%) vs 5 (15%); p < 0.001). The time between initial dose of enoxaparin and first therapeutic anti-Xa level was longer in the standard-dose group (87 hrs (IQR 41 to 112) vs 24 hrs (IQR 16 to 40; p < 0.001)), and there was no difference in the incidence of minor bleeding (6 (18%) vs 4 (7.7%); p = 0.18) or major bleeding (1 (3%) vs 0 (0%); p = 0.39), respectively.
Conclusions:
High-dose enoxaparin in infants with CHD resulted in a higher percentage of initial anti-Xa target attainment and a decreased time to target anti-Xa level, with no difference in bleeding. Our study suggests it may be safe and effective to dose enoxaparin higher in infants with CHD; however, further studies should confirm these findings.
This study aimed to adapt the Chronic Conditions Physician–Patient Relationship Scale (CC-PPR) into Turkish and to examine its validity and reliability among patients with chronic diseases receiving care from family physicians.
Methods:
A methodological study was conducted with 254 adult patients attending the Family Medicine Centers between May 01-October 01, 2025. The adaptation process followed World Health Organization guidelines. Construct validity was examined using confirmatory factor analysis (CFA), and reliability was assessed through internal consistency (Cronbach’s α, McDonald’s ω) and item–total correlations.
Results:
The CFA supported the original one-factor, 22-item structure with an excellent model fit (χ2[209] = 59.847, p = 1.000; comparative fit index [CFI] = 1.000; Tucker–Lewis index [TLI] = 1.016; root mean square error of approximation [RMSEA] = 0.000; standardized root mean square residual [SRMR] = 0.048). Sampling adequacy was good (Kaiser–Meyer–Olkin [KMO] = 0.970; Bartlett’s χ2[231] = 5934.429, p < 0.001). All standardized factor loadings were high (0.63–0.81, p < 0.001). Internal consistency was excellent (Cronbach’s α = 0.977; McDonald’s ω = 0.976), and corrected item–total correlations ranged from 0.74 to 0.86. Marital status, employment status, and type of health institution were significantly associated with relationship scores (p < 0.05).
Conclusion:
The Turkish version of the CC-PPR is a psychometrically robust, unidimensional, and reliable tool for evaluating the quality of family physician–patient relationships among individuals with chronic conditions. It can be used to assess communication and relational competencies of family physicians, support patient-centred care initiatives in chronic disease management.
We present a detailed characterisation of radio frequency interference (RFI) in the 2.4 GHz band around Murriyang, CSIRO’s Parkes radio telescope. The dominant sources of interference are Wi-Fi and Bluetooth transmissions. We quantify how the intensity and directionality of this RFI vary with time of day and document its evolution over several years. Although most observers currently discard data within this band, our analysis shows that the interference is confined in both time and frequency and can be effectively mitigated. Using 10 seconds of 16-bit voltage data recorded during observations of the Vela Pulsar (PSR J0835—4510), we demonstrate that the majority of the channelised data remain unaffected by RFI. We compare three RFI detection and mitigation algorithms and evaluate their relative performance. All methods perform effectively, and any could be implemented in real time to enable productive use of this observing band. A real time implementation would allow the scientific use of this 128MHz observing band to increase, from almost 70% of the band being completely unusable all of the time, to over 90% of becoming accessible for science. Given its simplicity and efficiency, a basic power-threshold approach offers a relatively straightforward solution.
Easy, universal, and cost-effective methods of gamete preservation for echinoids are required since echinoids are important model organisms for studying fertilization and early development, and at the same time, they are valuable fishery resources, and key components of marine ecosystems. In general, cryopreservation is the common method of animal sperm preservation, but we previously reported a simple method using a chilled condition as an alternative choice, using Hemicentrotus pulcherrimus. In this study, we applied this method to various echinoid species to test whether it was effective for them, and then we determined the features of the preserved sperm in detail. The fertilization capability of preserved sperm was maintained for several weeks, though higher sperm density was needed to obtain 100% fertilization in later periods. Eggs fertilized by the preserved sperm developed normally, and the morphology of the embryos was not affected. Sperm swimming in a stable, regular manner were observed even at the end of the preservation period, though the flagellar beat frequency was substantially decreased during preservation. There was almost no change of the flagellar beat form during preservation. Here, we showed that our simple method is basically applicable to various echinoid species and provides the opportunity for effective and immediate use of competent echinoid sperm by a wide variety of users, such as people in research, fisheries and education.
Recent advances in healthcare and rising life expectancy intensify longevity risk, motivating a deeper understanding of how cause-of-death (COD) rates interact. Using male COD data from 1978 to 2018 in the United States, we develop a copula-based hierarchical framework for seven major causes: cancer, diabetes, external causes, influenza, mental disorders, nephritis, and vascular disease. The framework integrates reconciliation, hierarchical dependence, and long-run equilibrium using a Lee–Carter (LC) setting. More specifically, the LC period indices are estimated under reconciliation penalties and are modeled through a sparse vector error correction model, with dependence captured by a hierarchical Archimedean copula. Two applications illustrate the value of our approach. In out-of-sample forecasting, the framework outperforms the standard LC model by improving the accuracy of aggregate mortality rates. In structural analysis, fitted connectedness reveals that diabetes and vascular disease act as net transmitters of mortality shocks, while cancer and external causes are net receivers. These insights help actuaries, demographers, clinicians, and policymakers enhance mortality forecasting to assess whether prioritizing government interventions for high-transmission causes could potentially maximize overall mortality improvements for society.
Cognitive reappraisal deficits are a transdiagnostic risk factor for major depressive disorder (MDD) and social anxiety disorder (SAD) and are observed in patients with these disorders at the neural level. Preliminary research suggests less activation of prefrontal regions during reappraisal (vs. viewing) of negative stimuli associates with overall symptom severity in patients with MDD or SAD, however, this is not reliably observed across studies. Consistent with research showing that reappraisal may only be adaptive when employed to cope with uncontrollable adversity, this study sought to examine whether neighborhood-level adversity (i.e. socioeconomic disadvantage, crime) moderated the relation between internalizing symptom severity and neural correlates of reappraisal.
Methods
This study included patients with a current diagnosis of MDD (n = 51) or SAD (n = 39). Patients completed measures of symptom severity as well as an emotion regulation task while in the scanner to assess neural activation during reappraisal. Patients’ addresses were geocoded to assess neighborhood socioeconomic disadvantage and crime.
Results
Results indicated that greater symptom severity was associated with decreased activation of key prefrontal regions underlying reappraisal, but only for patients living in neighborhoods characterized by high levels of personal (i.e. violent) crime. Unexpectedly, the opposite was found for patients living in low-crime neighborhoods, such that greater symptom severity was associated with increased neural activation during reappraisal (vs. viewing) of negative stimuli.
Conclusions
Findings highlight the critical importance of considering patients’ neighborhood contexts when evaluating associations between symptom severity and neural correlates of reappraisal in patients with internalizing disorders.
We study a nonlinear branching diffusion process in the sense of McKean, i.e. where particles are subjected to a mean-field interaction. We consider first a strong formulation of the problem and we provide an existence and uniqueness result by using contraction arguments. Then we consider the notion of weak solution and its equivalent martingale problem formulation. In this setting, we provide a general weak existence result, as well as a propagation of chaos property, i.e. the McKean–Vlasov branching diffusion is the limit of a large-population branching diffusion process with mean-field interaction.
This study evaluated the psychometric properties of the Turkish version of the Comprehensive Emotional Eating Scale (CEES) and examined its associations with emotion regulation, cognitive control, cognitive flexibility, and perceived stress in adults. A cross-sectional design was conducted with 1,521 adults aged 18–74 (68% female). The CEES was adapted following standard cross-cultural guidelines, including translation, back-translation, and approval by the original scale developer. Participants also completed the Emotional Appetite Questionnaire (EMAQ), Difficulties in Emotion Regulation Scale (DERS-16), Cognitive Control and Flexibility Questionnaire (CCFQ), and Perceived Stress Scale (PSS). Confirmatory factor analysis (CFA) assessed construct validity, while internal consistency, convergent validity, and multiple linear regression analyses explored predictors of emotional eating. CFA supported a four-factor structure representing Undereating–Positive Emotions, Undereating–Negative Emotions, Overeating–Positive Emotions, and Overeating–Negative Emotions, with item loadings of 0.48–0.77; one item was removed due to low loading. Internal consistency was high (α = .88–.91), and convergent validity was confirmed via EMAQ correlations. Multiple regression analyses indicated that greater difficulties in emotion regulation, higher perceived stress, lower cognitive control and flexibility, smoking, higher Body Mass Index (BMI), and chronic disease significantly increased emotional eating. Women showed higher undereating-negative emotion and total emotional eating scores, while smoking, higher BMI, and chronic disease elevated scores on specific subscales. The Turkish CEES demonstrates robust psychometric properties and reliably captures multidimensional emotional eating in adults. Psychological and demographic factors increase emotional eating subscales and total scores, supporting the scale’s use in research and clinical settings in Türkiye.