Signal transducers and activators of transcription (STAT) genes are involved in signal mediation of various hormones and cytokines. STAT1 located on chromosome number 2 is involved in mammary gland development and is associated with milk composition traits in bovines. This study aimed to find any relationship and impact of STAT1/BspHI gene with milk fat and protein yields in a herd of Holstein Friesian (HF) crossbred cattle of sub-tropical climate of Northern India. Milk composition data of 535 adult HF crossbred cows for a period of 12 years was collected from the records maintained at Livestock Farm, Guru Angad Dev Veterinary and Animal Sciences University. First lactation data of 222 animals was chosen for further analysis. After data correction for non-genetic factors (season of calving, period of calving, interaction effect of season and period of calving and age at first calving) these animals were categorised into two groups based on corrected high and low milk fat and protein yields. Forty animals were then selected for blood collection and further laboratory analysis. Amplified using PCR-RFLP technique, the 314 bp STAT1 gene was digested using BspHI restriction enzyme. C-T polymorphism at nucleotide position 201 and 260 of the STAT1 amplicon was observed. At 201, for genotype AA and Aa, the genotypic frequencies were 0.80 and 0.20%. At 260, for genotype BB and Bb, the genotypic frequencies were 0.25 and 0.75%. Least square analysis showed a significant association of all genotypes with milk fat and protein yields. Hence, STAT1 can be used as a potential candidate gene to aid in better animal selection in breeding programmes.

This article aims to analyse how the intertwining of politics and religion, economic transformation due to industrialisation, and family influence each contributed to the abandonment of the traditional, religious marriage calendar during the eighteenth and nineteenth centuries in the Barcelona Area or the Oficialitat de Barcelona, the most populated deanery among the four that comprised the Diocese of Barcelona. We make use of the Barcelona Historical Marriage Database, covering the period 1715–1880, to calculate descriptive statistics and linear probability models. Our main findings indicate a progressive change in marriage seasonality; with an increasing number of marriages taking place during Lent across the nineteenth century, as well as the emergence of a December peak in marriages in the first third of that century. Although the primary occupational sector was declining, farmers tended to adhere to the traditional marriage calendar, while the upper classes and artisans were increasingly likely to marry during Lent. During periods of Liberal political influence, which were marked by steps toward secularization, the proportion of marriages taking place during Lent increased. However, independent of the political period, Lenten marriages tended to be passed from one generation to the next, confirming the continuing influence of the family on the timing of marriages in Spain.

The anthropology of sport literature, and literature on neoliberalism in Africa more broadly, has often been predicated on the notion that neoliberalism forces a conversion from seeing the self as collectively produced towards the development of an individualistic and competitive ‘entrepreneurship of self’. While global long-distance running is increasingly competitive, with the odds against success stacked ever higher, this is not a dynamic that can be traced in Ethiopia. Rather, there is a sense that the individualism and competitiveness that are acknowledged to already be at the heart of Amhara society must be tempered in order for athletes to survive within this system. Increasing competition is understood to require people to work together more closely, rather than forcing them apart. In this article, I explore the paradox that bodily acts of trust can coexist with the discursive insistence on the impossibility of trust in competitive environments. By focusing on the warm-up as a key site of trust work, I show how an awareness of the challenges inherent in enacting trusting relations in close proximity with others necessitates deliberate work over a number of years to render such behaviour as unspoken as possible.

This article explores the Musical Design course offered at McGill University by Mario Bertoncini in 1975–6 in a collaboration between the music department and the department of mechanical engineering. Some of the students independently created a collective named Sonde (originally named MuD from the name of the course). This unique pedagogical experience, influenced by Bertoncini’s understanding of craftmanship in Renaissance workshops, will be presented as an antecedent of research-creation or artistic practice as research, a ubiquitous and vastly recognised modality of research that has been gaining more and more traction since the early 2000s.

In this paper, we consider a joint drift rate control and two-sided impulse control problem in which the system manager adjusts the drift rate as well as the instantaneous relocation for a Brownian motion, with the objective of minimizing the total average state-related cost and control cost. The system state can be negative. Assuming that instantaneous upward and downward relocations take a different cost structure, which consists of both a setup cost and a variable cost, we prove that the optimal control policy takes an $\left\{ {\!\left( {{s^{\ast}},{q^{\ast}},{Q^{\ast}},{S^{\ast}}} \right),\!\left\{ {{\mu ^{\ast}}(x)\,:\,x \in [ {{s^{\ast}},{S^{\ast}}}]} \right\}} \right\}$ form. Specifically, the optimal impulse control policy is characterized by a quadruple $\left( {{s^{\ast}},{q^{\ast}},{Q^{\ast}},{S^{\ast}}} \right)$, under which the system state will be immediately relocated upwardly to ${q^{\ast}}$ once it drops to ${s^{\ast}}$ and be immediately relocated downwardly to ${Q^{\ast}}$ once it rises to ${S^{\ast}}$; the optimal drift rate control policy will depend solely on the current system state, which is characterized by a function ${\mu ^{\ast}}\!\left( \cdot \right)$ for the system state staying in $[ {{s^{\ast}},{S^{\ast}}}]$. By analyzing an associated free boundary problem consisting of an ordinary differential equation and several free boundary conditions, we obtain these optimal policy parameters and show the optimality of the proposed policy using a lower-bound approach. Finally, we investigate the effect of the system parameters on the optimal policy parameters as well as the optimal system’s long-run average cost numerically.

Governments across the Global South have decentralized a degree of power to municipal authorities. Are local officials sufficiently knowledgeable about how to execute their expanded portfolio of responsibilities? Past studies have focused on whether citizens lack the requisite information to hold local officials accountable. We instead draw on extensive fieldwork and a novel survey of small-town politicians in India to show that local officials themselves have distressingly low levels of procedural knowledge on how to govern. We further show that procedural knowledge shapes the capabilities of officials to represent their constituents and that asymmetries in knowledge may blunt the representative potential of these bodies. Finally, we show that winning office does not provide an institutionalized pathway to knowledge acquisition, highlighting the need for policy-based solutions. Our findings demonstrate the importance of assessing knowledge deficits among politicians, and not only citizens, to make local governance work.

Applications of moral foundations theory in political science have revealed differences in the degree to which liberals and conservatives explicitly endorse five core moral foundations of care, fairness, authority, loyalty, and sanctity. We argue that differences between liberals and conservatives in their explicit ratings of abstract and generalized moral principles do not imply that citizens with different political orientations have fundamentally different moral intuitions. We introduce a new approach for measuring the importance of the five moral foundations by asking U.K. and U.S. survey respondents to compare pairs of vignettes describing violations relevant to each foundation. We analyze responses to these comparisons using a hierarchical Bradley–Terry model which allows us to evaluate the relative importance of each foundation to individuals with different political perspectives. Our results suggest that, despite prominent claims to the contrary, voters on the left and the right of politics share broadly similar moral intuitions.

Saccular otoliths (sagittae) have long been shown to be species-specific and exhibit inland geospatial intra- and interpopulation morphological differences with variations in environmental conditions. Here, we analysed inland and outland geospatial variations in sagittae shape, length (Lo), width (Wo), perimeter (Po), and area (Ao), and fluctuating asymmetry (FA) in Chelon auratus males and females collected from Ghar El Melh (Tunisia) and Etoile Bay (Mauritania) stations to assess whether sagittae shape and morphometry differ between these two niches having different environmental conditions. At the intrapopulation level, a significant otolith shape asymmetry was observed between left and right and left–left and right–right otoliths among males and females of the Ghar El Melh (Tunisia) population and a significant symmetry among those of the Etoile Bay (Mauritania) population. At the interpopulation level, a significant asymmetry was found between left and right otoliths' shape among males and females of the two populations. Besides, a discriminant function analysis of otoliths' contour shape separated left and right otoliths among males and females at the intra- and interpopulation levels and also separated those of the two populations. Moreover, differential significant asymmetry in Lo, Wo, Po, and Ao between left and right otoliths was observed among males and females at the intra- and interpopulation levels. Therefore, the geospatial variations in environmental conditions between the two ecological niches effectively induced differences in otolith morphology. These significant asymmetries were discussed in terms of FA caused by environmental stress conditions resulting from variations in abiotic factors between the two ecological niches.

Leaching and volatilization of N from urea, and precipitation and fixing of Zn by commercial fertilizers, has led to excessive costs for farmers and problems for the environment. Incorporating fertilizers in a porous material such as diatomite can prevent these losses by slowing the nutrient release. A new fertilizer formulation, based on the urea-zinc (UZn) complex in the eutectic solution of salt-urea was prepared. In the following, UZn was incorporated into diatomite and nano-diatomite by using hydroxypropyl methylcellulose (HPMC) as a binder. The treatments included the following: U: urea; UZn: urea-Zn; UZn-D: urea-Zn-diatomite; UZn-ND: urea-Zn-nano-diatomite; UZn-D-B: urea-Zn-diatomite-binder; and UZn-ND-B: urea-Zn-nano-diatomite-binder. The slow-release urea fertilizers (SRUFs) were characterized using FESEM/EDS, FTIR, CHN, XRD, DLS, and zeta potential techniques. Urea slow-release behavior, kinetics in water, and available Zn and N-forms leaching in the soil column were evaluated compared with conventional urea and zinc fertilizers. The pattern of release of urea in water was sigmoidal and after 12 h, only 20% of urea was released from fertilizers containing diatomite and HPMC. The NO3– release pattern in the soil started with a 12-day delay, and after that, the rate of NO3– leaching decreased by two to three times in the application of fertilizers containing HPMC compared with urea. The Zn concentration in the leachates of columns supplied with SRUFs was 35% less than for those supplied with ZnSO4. The results showed that the SRUFs make N and Zn available in the soil and but reduce the rate of their release.

Measurement is the weak link between theory and empirical test. Complex concepts such as ideology, identity, and legitimacy are difficult to measure; yet, without measurement that matches theoretical constructs, careful empirical studies may not be testing that which they had intended. Item response theory (IRT) models offer promise by producing transparent and improvable measures of latent factors thought to underlie behavior. Unfortunately, those factors have no intrinsic substantive interpretations. Prior solutions to the substantive interpretation problem require exogenous information about the units, such as legislators or survey respondents, which make up the data; limit analysis to one latent factor; and/or are difficult to generalize. We propose and validate a solution, IRT-M, that produces multiple, potentially correlated, generalizable, latent dimensions, each with substantive meaning that the analyst specifies before analysis to match theoretical concepts. We offer an R package and step-by-step instructions in its use, via an application to survey data.