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The electroosmotic flow (EOF) fields in the vicinity of solids with high dielectric permittivity are studied for the case of charge-asymmetric electrolyte solutions. Corresponding solutions of the coupled Poisson–Nernst–Planck and Navier–Stokes equations are obtained analytically and numerically. When a direct-current (DC) electric field is applied to a high-permittivity uncharged sphere, a net EOF develops that translates into a non-zero electrophoretic mobility of the sphere, although it does not carry any charge. Similarly, a DC field acting on a channel in a high-permittivity material results in a net flow through the channel, although the solid is uncharged. Such phenomena are expected to occur frequently whenever high-permittivity solids are immersed in charge-asymmetric electrolyte solutions and do not rely on special scenarios such as ion crowding. Also, the net flow velocities are very significant for realistic values of the electric field strength. The derived scaling relationships even predict giant net flow velocities through nanochannels of the order of metres per second for practically relevant scenarios.
It is a revealing exercise to search for variations of the word “colonial” in the indexes and tables of contents of these recent monographs in Anglophone literary studies. As the subdiscipline begins to chronicle contemporary cultural developments in which the British Empire’s legacies grow ever-less marked, it is perhaps inevitable that the terms and concepts that governed the preceding phase of scholarship—colonialism, imperialism, and postcolonialism—begin to recede into the background. The sudden and sharp recession of these terms, however, raises fundamental questions regarding the study of English-language texts from the Caribbean, South Asia, West, and East Africa (among other locales). Among the foremost of such questions may be: does the term “postcolonialism” now designate a mere literary period, as opposed to being what scholars over the last several decades seem to have agreed it also is, namely a critical method? What are the effects and implications of this shift, wherein not just literary works newly arrived to a world scene still marked and structured by colonial legacies, but older ones long identified as definitionally “postcolonial,” are increasingly treated without such concepts and terms? Suggestions of answers to such questions arise throughout these three books, all of which seek to reconsider one of the keystone concerns of postcolonial studies, namely the relationship between contemporary Anglophone writing and the authors and texts of the British literary canon.
For given positive integers $r\ge 3$, $n$ and $e\le \binom{n}{2}$, the famous Erdős–Rademacher problem asks for the minimum number of $r$-cliques in a graph with $n$ vertices and $e$ edges. A conjecture of Lovász and Simonovits from the 1970s states that, for every $r\ge 3$, if $n$ is sufficiently large then, for every $e\le \binom{n}{2}$, at least one extremal graph can be obtained from a complete partite graph by adding a triangle-free graph into one part.
In this note, we explicitly write the minimum number of $r$-cliques predicted by the above conjecture. Also, we describe what we believe to be the set of extremal graphs for any $r\ge 4$ and all large $n$, amending the previous conjecture of Pikhurko and Razborov.
The ability and knowledge to manage financial tasks may be compromised in old age, especially when the need to navigate the care and social benefit systems increases. Managing financial tasks may consist of a variety of actions of both the older people themselves and their representatives, often family members. This study explored how financial tasks related to the care and everyday life of older people who need long-term care are managed by using the ideas of modalities of agency and distributed agency. We analysed interviews of 19 older persons and their family members with a qualitative case analysis. All the older persons who participated in the study distributed the agency in financial tasks among their family members, but to different levels and for different reasons. We identified three types of distributed agency – inevitable, assimilated and minimal distributed agency – in which the older persons’ knowledge about financial tasks and their ability to manage financial tasks differed. Within these types, the cases differed in terms of the know-how of the family members and the reasons why the older people’s knowledge about financial tasks or their ability to manage their financial tasks were diminished. We conclude that older persons with long-term care needs require help in regard to financial tasks, and the older people’s and their family members’ ability to manage financial tasks could be enhanced by making the benefit systems and online banking more user-friendly and by improving the help from care staff.
Given increased survival for adults with CHD, we aim to determine outcome differences of infective endocarditis compared to patients with structurally normal hearts in the general population.
Methods:
We conducted a retrospective cross-sectional study identifying infective endocarditis hospitalisations in patients 18 years and older from the National Inpatient Sample database between 2001 and 2016 using International Classification of Disease diagnosis and procedure codes. Weighting was used to create national annual estimates indexed to the United States population, and multivariable logistic regression analysis determined variable associations. Outcome variables were mortality and surgery. The primary predictor variable was the presence or absence of CHD.
Results:
We identified 1,096,858 estimated infective endocarditis hospitalisations, of which 17,729 (1.6%) were adults with CHD. A 125% increase in infective endocarditis hospitalisations occurred for adult CHD patients during the studied time period (p < 0.001). Adults with CHD were significantly less likely to experience mortality (5.4% vs. 9.5%, OR 0.54, CI 0.47–0.63, p < 0.001) and more likely to undergo in-hospital surgery (31.6% vs. 6.7%, OR 6.49, CI 6.03–6.98, p < 0.001) compared to the general population. CHD severity was not associated with increased mortality (p = 0.53). Microbiologic aetiology of infective endocarditis varied between groups (p < 0.001) with Streptococcus identified more commonly in adults with CHD compared to patients with structurally normal hearts (36.2% vs. 14.4%).
Conclusions:
Adults with CHD hospitalised for infective endocarditis are less likely to experience mortality and more likely to undergo surgery than the general population.
This survey paper is concerned with vortex shedding from bodies in unsteady flow due either to time dependent motion of the body in a still fluid or unsteady motion of the fluid about a fixed body. The fluid is treated as incompressible, and the main emphasis is on starting flows and oscillatory flows. Much of the discussion describes 2D flow around sections of long or slender bodies. The first part of the paper covers the inviscid flow scaling of the forces induced by vortex shedding in time dependent flows which drive the shedding. This is followed by application of Wu’s impulse integral of the moment of vorticity to predict the forces induced by vortex shedding from a body in both inviscid and viscous flows. Vortex shedding phenomena involving small amplitude, high-frequency oscillatory flow such as vortex-induced vibration (VIV) and fluid-structure interaction (FSI) are not included in this discussion as in these cases the unsteady flow controls rather than drives the vortex shedding and they are well covered elsewhere.
The second part of the paper describes a vortex force mapping (VFM) method derived by considering the Lamb–Gromyko formulation for the pressure contribution which allows the integral of the vorticity field to be restricted to regions which are not far from the body. It is applied to both inviscid and viscous flows. The section finishes with discussion of application of the VFM to the calculation of forces induced on bodies from flow field measurements, such as particle image velocimetry (PIV).
Rates of youth suicidal thoughts and behaviors (STBs) are rising, and younger age at onset increases vulnerability to negative outcomes. However, few studies have investigated STBs in early adolescence (ages 10–13), and accurate prediction of youth STBs remains poor. Network analyses that can examine pairwise associations between many theoretically relevant variables may identify complex pathways of risk for early adolescent STBs. The present study applied longitudinal network analysis to examine interrelations between STBs and several previously identified risk and protective factors. Data came from 9,854 youth in the Adolescent Brain Cognitive Development Study cohort (Mage = 9.90 ± .62 years, 63% white, 53% female at baseline). Youth and their caregivers completed an annual measurement battery between ages 9–10 through 11–12 years. Panel Graphical Vector Autoregressive models evaluated associations between STBs and several mental health symptoms, socioenvironmental factors, life stressors, and substance use. In the contemporaneous and between-subjects networks, direct associations were observed between STBs and internalizing symptoms, substance use, family conflict, lower parental monitoring, and lower school protective factors. Potential indirect pathways of risk for STBs were also observed. Age-specific interventions may benefit from prioritizing internalizing symptoms and early substance use, as well as promoting positive school and family support.
Mobile health has been shown to improve quality, access, and efficiency of health care in select populations. We sought to evaluate the benefits of mobile health monitoring using the KidsHeart app in an infant CHD population.
Methods:
We reviewed data submitted to KidsHeart from parents of infants discharged following intervention for high-risk CHD lesions including subjects status post stage 1 single ventricle palliation, ductal stent or surgical shunt, pulmonary artery band, or right ventricular outflow tract stent. We report on the benefits of a novel mobile health red flag scoring system, mobile health growth/feed tracking, and longitudinal neurodevelopmental outcomes tracking.
Results:
A total of 69 CHD subjects (63% male, 41% non-white, median age 28 days [interquartile range 20, 75 days]) were included with median mobile health follow-up of 137 days (56, 190). During the analytic window, subjects submitted 5700 mobile health red flag notifications including 245 violations (mean [standard deviation] 3 ± 3.96 per participant) with 80% (55/69) of subjects submitting at least one violation. Violations precipitated 116 interventions including hospital admission in 34 (29%) with trans-catheter evaluation in 15 (13%) of those. Growth data (n = 2543 daily weights) were submitted by 63/69 (91%) subjects and precipitated 31 feed changes in 23 participants. Sixty-eight percent of subjects with age >2 months submitted at least one complete neurodevelopment questionnaire.
Conclusion:
In our initial experience, mobile health monitoring using the KidsHeart app enhanced interstage monitoring permitting earlier intervention, allowed for remote tracking of growth feeding, and provided a means for tracking longitudinal neurodevelopmental outcomes.
The terminal Ediacaran Period is signaled worldwide by the first appearance of skeletonizing tubular metazoan fossils, e.g., Cloudina Germs, 1972 and Sinotubulites Chen, Chen, and Qian, 1981. Although recent efforts have focused on evaluating the taxic composition and preservation of such assemblages from the southwestern United States, comparable forms reported in the 1980s from Mexico remain to be re-examined. Here, we reassess the latest Ediacaran skeletal materials from the La Ciénega Formation of the Caborca region in Sonora, Mexico, using a combination of analytical methods: optical microscopy of extracted fossils, thin-section petrography, scanning electron microscopy and energy dispersive X-ray spectroscopy, and X-ray tomographic microscopy. From our examination, we conclude that the La Ciénega hosts a polytaxic assemblage of latest Ediacaran tubular organisms that have been preserved through two taphonomic pathways: coarse silicification and calcareous recrystallization preserving finer details. Further, these fossils show signs that their shells might not have been inflexible or completely mineralized in vivo, and that they might also record tentatively interpreted predation traces in the form of drill holes or puncture marks. This work, along with ongoing efforts around the world, helps to provide a framework for biostratigraphic correlation and possible subdivision of the Ediacaran Period, and further shapes our view of metazoan evolution and ecology in the interval directly preceding the Cambrian explosion.
Let n be a positive integer and $\underline {n}=\{1,2,\ldots ,n\}$. A conjecture arising from certain polynomial near-ring codes states that if $k\geq 1$ and $a_{1},a_{2},\ldots ,a_{k}$ are distinct positive integers, then the symmetric difference $a_{1}\underline {n}\mathbin {\Delta }a_{2}\underline {n}\mathbin {\Delta }\cdots \mathbin {\Delta }a_{k}\underline {n}$ contains at least n elements. Here, $a_{i}\underline {n}=\{a_{i},2a_{i},\ldots ,na_{i}\}$ for each i. We prove this conjecture for arbitrary n and for $k=1,2,3$.
This study explores the implementation of an online control strategy based on dynamic mode decomposition in the context of flow control. The investigation is conducted mainly with a fixed Reynolds number of $Re = 100$, focusing on the flow past a circular cylinder constrained between two walls to mitigate vortex shedding. The control approach involves the activation of two synthetic jets on the cylinder through blowing and suction. Velocity fluctuations in the wake, specifically in the $x$-direction, are harnessed to ascertain the mass flow rate of the jets using the linear quadratic regulator and online dynamic mode decomposition. The study systematically assesses the control performance across various configurations, including different values of the input penalty factor ${\boldsymbol {R}}$, varying numbers of probes and distinct probe arrangement methods. The synthetic jets prove effective in stabilising the separation bubble, and their interaction with the unsteady wake leads to a notable reduction in drag force, its fluctuations and the amplitude of the lift force. Specifically, the mean and standard deviation of the drag coefficient witness reductions of $7.44\,\%$ and $96.67\,\%$, respectively, and the standard deviation of the lift coefficient experiences an impressive reduction of $85.18\,\%$. The robustness of the proposed control method has also been tested on two more complicated cases, involving unsteady incoming flows with multiple frequency components. Comparatively, the methodology employed in this paper yields results akin to those obtained through deep reinforcement learning in terms of control effectiveness. However, a noteworthy advantage lies in the substantial reduction of computational resource consumption, highlighting the efficiency of the proposed approach.
This paper argues that young people who claim state support in the UK are prone to accept the contemporary hegemonic conceptualisation within advanced capitalist societies, that individual behaviour and mindset are the key determinants of valorised labour market outcomes. The notion that the self is all encompassing and one can, and should, choose to overcome all challenges in life through self-improvement is particularly salient for recent generations of young people. Social policy reinforces this trend by encouraging changes in the individual to combat structural problems, and such ideology is present in the contemporary intensification of welfare conditionality. This paper draws upon secondary analysis of longitudinal qualitative data generated as part of the Welfare Conditionality Project (2013–2019) to demonstrate that young people who experience welfare conditionality are likely to individualise pathways to their future aspirations.
Many natural and industrial processes involve the flow of fluids made of solid particles suspended in non-Newtonian liquid matrices, which are challenging to control due to the fluid's nonlinear rheology. In the present work, a Taylor–Couette canonical system is used to investigate the flow of dilute to semi-dilute suspensions of neutrally buoyant spherical particles in highly elastic base polymer solutions. Friction measurement synchronized with direct flow visualization are combined to characterize the critical conditions for the onset of elasto-inertial instabilities, expected here as a direct transition to elasto-inertial turbulence (EIT). Adding a low particle volume fraction (${\leq }2\,\%$, dilute regime) does not affect the nature of the primary transition and reduces the critical Weissenberg number for the onset of EIT, despite a significant decrease in the apparent fluid elasticity. However, for particle volume fractions ${\geq }6\,\%$ (semi-dilute regime), EIT is no longer observed in the explored Reynolds range, suggesting an apparent relaminarization with yet not further decrease in fluid elasticity. Instead, a new regime, termed here elasto-inertial dissipative (EID), was uncovered. It originates from particle–particle interactions altering particle–polymer interactions and occurring under elasto-inertial conditions comparable to those of EIT. Increasing particle volume fraction in the semi-dilute regime and, in so, the particle contribution to the overall viscosity, delays the onset of EID similarly to what was observed previously for EIT in lower elasticity fluids. After this onset, a decrease in the pseudo-Nusselt number observed with increasing inertia and particle-to-polymer concentration ratio confirms a particle-induced alteration of energy transfer in the flow.
Staphylococcus aureus nasal carriers were randomized (1:1) to XF-73 or placebo nasal gel, administered 5x over ∼24hrs pre-cardiac surgery. S. aureus burden rapidly decreased after 2 doses (–2.2log10 CFU/mL; placebo –0.01log10 CFU/mL) and was maintained to 6 days post-surgery. Among XF-73 patients, 46.5% received post-operative anti-staphylococcal antibiotics versus 70% in placebo (P = 0.045).
This article contributes an account of a key moment in the development of venture capital. I argue the US Small Business Administration’s Task Force on Venture and Equity Capital for Small Business, established in 1976 and headed by William J. Casey, had an outsized impact on the development of modern venture capital and its close associations with the high technology sector. The Task Force’s 1977 report was influential in establishing both the figure of the venture capitalist and the business model of institutionally supported, limited partnership venture capital in the minds of policymakers, businesspeople, and the general public. This article traces the influence of one part of the Report: a prominently featured schematic model, entitled “Life Cycle of a New Enterprise: Model of a Growing and Successful Company, 1975-1976 Financial Market Conditions.” I trace the influence of the LCM as it spread through the developing high technology sector, as shown by its appearances in business publications, governmental reports, and congressional testimonies offered by industry leaders. The LCM was genericized away from its original authors and intentions, becoming part of the economic imaginary of the technology and innovation sector.