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This study examined data from 20 national genebanks in Latin America and the Caribbean, Africa, the Near East and Asia to identify similarities and differences in genebank operations and processes, funding and facilities, as well as opportunities to strengthen their contributions to the global system of crop conservation and use. Data on genebank performance metrics were collected and used to assess compliance with FAO Genebank Standards. This enabled the analysis of trends in ex situ conservation of major food crops, locally important crops and crop wild relatives across national genebanks and the identification of shared challenges and opportunities to improve genebank operations and address funding gaps. All genebanks in the study failed to meet quality management standards and performance goals for the effective management of crop collections. The most pressing challenge for all national genebanks was the management and safety duplication of highly diverse collections in both seed and field genebanks, often with limited information available to guide best conservation practices. A further critical constraint was the fluctuating and often insufficient funding to support the wide range of tasks needed to secure and use this valuable national crop germplasm.
Production of seafood has received relatively little attention in agri-food debates despite the fact that, since the 1960s, seafood production has been transformed through the industrialization of fisheries and globalization of seafood commodity chains. Intensive aquaculture emerged as a new industry in response to declining fish catches. Global commodity chains of seafood and capital accumulation processes changed tremendously, leading to complex international trade dynamics and rising inequalities. The Turkish aquaculture sector has also been transformed via government subsidies, and a few vertically integrated aquaculture companies started to produce farmed sea bass and sea bream (SBSB) in Turkish waters, while organizing their operations both upstream (processing of fish feed in Africa) and downstream (sales and distribution in Europe) in the global SBSB value chain. We adopted a single commodity approach to uncover how seafood production has been transformed via expanding commodity frontiers of capital-intensive SBSB production by focusing on the strategies of Turkish aquaculture enterprises, trade dynamics, and socio-ecological implications of SBSB production via in-depth interviews with key stakeholders and a review of legislative documents and trade data. Our analysis offers critical insights into the agrarian-change debate in Turkey by analyzing the global and regional socio-ecological inequalities created by Turkish SBSB production.
Compliance with court decisions is essential for the rule of law. Generally, regimes comply with decisions that serve their interests; however, compliance with decisions against government interests is less certain. In 1947–2005 and 2014–2023, the Supreme Court of Pakistan (SCP) decided many politically important cases in favour of the prevailing authoritarian and hybrid regimes. However, between 2005 and 2013, although the SCP reached decisions against the government’s interests in politically important cases, the government still complied. Why would authoritarian and hybrid regimes, such as those in Pakistan between 2005 and 2013, comply with decisions in politically important cases that were against their interests instead of disobeying or ignoring them? Very few studies have addressed this puzzling phenomenon. This article argues that increasing public support for courts coupled with reinforcement mechanisms—supported by both the judiciary and external actors—contributes to such compliance. The article concludes that a combination of social, political, and legal factors is essential for compliance by authoritarian and hybrid regimes in politically important cases.
A classical theorem of Jordan asserts that if a group G acts transitively on a finite set of size at least $2$, then G contains a derangement (a fixed-point free element). Generalisations of Jordan’s theorem have been studied extensively, due in part to their applications in graph theory, number theory and topology. We address a generalisation conjectured recently by Ellis and Harper [‘Orbits of permutation groups with no derangements’, Preprint, 2024, arXiv:2408.16064], which says that if G has exactly two orbits and those orbits have equal length $n \geq 2$, then G contains a derangement. We prove this conjecture in the case where n is a product of two primes, and in the case where $n=bp$ with p a prime and $2b\leq p$. We also verify the conjecture computationally for $n \leq 30$.
Women entrepreneurs face distinct gender-specific challenges, including restricted access to venture capital, work–life conflicts driven by stereotypes, and competing demands from their roles as business owners, caregivers, and community leaders. These pressures often foster polychronicity – a temporal orientation favoring simultaneous task management. Grounded in role accumulation theory, we conduct a two-stage survey of 129 Chinese women entrepreneurs to investigate the relationship between polychronicity and resilience. We further examine three moderators – frequent interruptions, entrepreneurial experience, and emotional intelligence – that amplify polychronicity’ s resilience-building effects. This study highlights the positive association between polychronicity and women entrepreneurs’ resilience, offering new insights into temporal dynamics in entrepreneurship. It also provides women entrepreneurs with practical strategies to help them navigate multiple role challenges and thrive amid adversity by leveraging their preference for multitasking.
With the passing of Richard Van Praagh in September of 2025, paediatric cardiology has lost one of its giants. With one of his greatest contributions, namely the segmental approach, he revolutionised the practice of paediatric cardiology. He and Stella, his wife and closest collaborator, developed the Cardiac Registry at Boston Children’s Hospital and published more than 300 articles. Together, they trained many fellows, with endless generosity and dedication, and gave conferences all over the world, spreading their ideas and concepts. Richard will be sorely missed, but he has transmitted to us the desire and the tools to continue to build on his firm foundations.
It is widely assumed that English law adopts a restrictive approach towards tort actions for “wrongful life”. This article reveals the true legal position to be much more complex. A broad distinction exists between cases where the wrong occurred before or at conception and those where it occurred during pregnancy, with claims usually being permitted in the former scenario but not in the latter. In this article, I expose this bifurcation as arbitrary before examining potential solutions for remedying it.
This article explores how AI-generated music challenges traditional theological understandings of creativity, spirituality, and the soul. By engaging the theological traditions of analogy and participation developed by Thomas Aquinas, Thomas de Vio Cajetan, and Francisco Suárez, this article reconsiders whether AI-generated music generates emotions and spiritual significances in listeners and whether it might disclose something meaningful about the nature of divine creativity. Rather than arguing AI music is either a technological innovation or artistic threat, this article suggests various frameworks of analogy, participation, and pneumatology to create a better theological discernment on how divine creativity works through secondary causes within creation. The exploration concludes in proposing a ‘theology of digital transcendence’ – a framework for understanding how computational creativity participates in the broader economy of divine creation.
There is limited knowledge on titration, optimal dosing, and efficacy of angiotensin-converting enzyme inhibitors in paediatric patients following cardiac surgery.
Methods:
Patients after cardiac surgery to repair ventricular septal defect or coarctation of the aorta from 01/2017 to 12/2019 were eligible for a retrospective single-centre study. Medical records were reviewed for patient characteristics and outcomes. Mean arterial pressure response and angiotensin-converting enzyme inhibitor dosage were collected. Controls were patients not receiving angiotensin-converting enzyme inhibitor postoperatively. Appropriate statistics were used for analysis.
Results:
Among a total of 286 patients [n = 188 (66%) ventricular septal defect; n = 98 (34%) coarctation of the aorta], 170 (59%) received angiotensin-converting enzyme inhibitor on any postoperative day 1 to 5. The median age was 4.9 months (IQR 1.2–14.4) and weight 5.5 kg (IQR 3.7–9.2). The most common angiotensin-converting enzyme inhibitor was captopril on day 1 [n = 117 (69%)] and lisinopril at discharge [n = 86 (51%)]. Patients in treatment group were shown to have higher median mean arterial pressure at baseline and at time 1, compared with controls (mean difference 3.57 (95% CI: 1.85, 5.35) and 3.46 (95% CI: 1.41, 5.50), respectively. Median mean arterial pressure among controls significantly increased over time with a slope of 0.97 (95% CI: 0.2, 1.74), while median mean arterial pressure among treatment group decreased with a slope of −0.31 (−0.93,0.31). Patients who received high and medium doses of angiotensin-converting enzyme inhibitor showed significantly decreasing median mean arterial pressure over time with a slope of −2.85 (−5.14, −0.56) and −1.25 (−2.4, −0.11), respectively.
Conclusion:
High and medium dose angiotensin-converting enzyme inhibitor therapy had a greater effect in decreasing mean arterial pressure when compared to low dose.
This article explores the impact of LM Radio—Rádio Clube de Moçambique’s B-Station, broadcasting in English and Afrikaans—in colonial southern Mozambique. Drawing on 441 issues of Rádio Moçambique magazine (1935–1973) and interviews with announcers, directors, and musicians, it reconstructs the station’s history and production practices and examines its reception among Mozambican musicians through the lenses of modernity and cosmopolitanism. Often regarded as apolitical, LM Radio’s trajectory reveals a complex engagement with the Portuguese colonial project and urban youth culture. The article also considers how these dynamics inform postcolonial memory, highlighting media’s role in shaping colonial modernity in southern Africa.
The flow in a rapidly rotating cylinder forced by the harmonic oscillations of a small sphere along the rotation axis is explored numerically. For oscillation frequencies less than twice the cylinder rotation frequency, the forced response flows feature conical shear layers emitted from the critical latitudes of the sphere. These latitudes are where the characteristics of the hyperbolic system, arrived at by ignoring nonlinear, viscous and forcing terms in the governing equations, are tangential to the sphere. These conical shear layers vary continuously with the forcing frequency so long as it remains inertial. At certain values of the forcing frequency, linear inviscid inertial modes of the cylinder are resonated. Of all possible inertial modes, only those whose symmetries are compatible with the symmetry of the forced system are resonated. This all occurs even in the linear limit of vanishingly small forcing amplitude. As the forcing amplitude is increased, nonlinearity leads to non-harmonic oscillations and a non-zero mean flow which features a Taylor columnar structure extending from the sphere to the two endwalls in an axially invariant fashion.
Mediante el concepto de archivo sonoro global proponemos una perspectiva holística para abordar el estudio del universo sonoro al que se accede a través de Internet. Dicho concepto hace referencia a un reservorio de fijaciones sonoras en extremo heterogéneo, expansivo e inestable que alberga expresiones musicales, paisajes sonoros, sonidos del cuerpo humano, mensajes de voz generados con aplicaciones de mensajería instantánea, podcasts y muchos otros fenómenos sonoros. En el desarrollo del artículo describimos cómo y qué agentes alimentan ese archivo, dónde se encuentran alojadas las fijaciones que lo integran y cuáles son sus atributos centrales sobre la base de los conceptos de diversidad, expansividad, inestabilidad, modularidad e intermedialidad.1
We aimed to investigate the association of chrono-nutrition components with anthropometric measures and body composition in adults living in Tehran. This cross-sectional study was conducted on 450 healthy adults. The exposures of the study were meal frequency, meal timing, meal irregularity, breakfast skipping, night fasting duration, time of the first and last eating occasion and the time interval from the last meal to bed. The outcomes were BMI, waist circumference, neck circumference (NC), waist:hip ratio, waist:height ratio (WHtR), body adiposity index (BAI), body roundness index (BRI), a body shape index, percentage of body fat (PBF), fat mass (FM), fat-free mass and muscle mass. Bonferroni correction was applied, and the significance level was less than 0·004. Using ANCOVA, after adjusting for confounders, late lunch eating was associated with a lower PBF. There was a positive trend across the tertiles of dinner time with greater WHtR (mean difference = 0·019; Ptrend = 0·025) and BRI (mean difference = 0·24; Ptrend = 0·022). Moreover, increased irregularity at dinner time was associated with higher levels of PBF (Ptrend = 0·026) and FM (Ptrend = 0·025). Also, longer overnight fasting was associated with lower NC (Ptrend = 0·049) and a greater BRI (Ptrend = 0·050). We found differences across the time interval from the last meal to bed with greater means of BAI (Ptrend = 0·026), PBF (Ptrend = 0·014) and FM (Ptrend = 0·020). However, after applying the Bonferroni correction, we found no significant association between chrono-nutrition components and anthropometric measures and body composition in adults living in Tehran. Further studies are necessary to confirm the results.
This study aimed to update normative data and establish cut-off scores for a fruit-based semantic verbal fluency (SVF) task among older Taiwanese adults as a method for detecting mild cognitive impairment (MCI). The task was chosen due to its familiarity and cultural neutrality for Mandarin-speaking populations.
Method:
SVF performance was evaluated in 245 healthy control participants and 360 individuals diagnosed with MCI. The influence of demographic variables was examined, and regression-based correction formulas were developed. Receiver operating characteristic (ROC) analyses determined optimal cut-off values according to established clinical classifications of MCI.
Results:
Age, education, and sex significantly influenced SVF performance. A demographically corrected 15th percentile threshold of 10 words was proposed for community screening. An optimal ROC-derived cut-off of 11.5 words yielded an AUC of .716 (95% CI: .68–.76), with sensitivity of 57.8% and specificity of 73.9%. SVF scores were significantly correlated with global cognition, memory, and processing speed.
Conclusions:
The fruit-based SVF task is a quick, culturally relevant tool for detecting early cognitive impairment. Revised norms and cut-off scores can improve MCI identification in Mandarin-speaking seniors.
Unlike existing studies on labour and income in the digital era, this paper argues not only that the impact of the digital economy’s intervention in the labour process is fragmented rather than comprehensive, but also that the transformation of job demand and labour supply behaviours is simultaneous and related to the attributes of the industries in which they operate. Drawing on the conventional biased technological progress hypothesis and labour process theory, we argue that the digital economy has generally increased the labour income inequality for migrant workers in China. Using geospatially matched China Labour Dynamics Survey 2018 microdata and provincial digitalisation indices, we uncover a digital ‘upgrading trap’: the development of the digital economy hides the process of inequality formation in the hedging relationship between objective labour demand ‘upgrading’ and subjective labour supply ‘expanding’. The former can be summarised as the risk of ‘no job’ and the latter as the risk of ‘no way back’. Counterintuitively, consumer Internet development demonstrates a greater role in both reducing workers’ inequality in secondary labour markets and promoting a fair primary distribution. These findings reconceptualise digital inequality as coevolutionary outcomes, and offer a tripartite governance way for inclusive growth through portable skill certification, algorithmic accountability mechanisms, and interoperable social security systems.
Centromeres are chromosomal loci essential for the correct segregation of genetic material during cell division. Defects in centromere function can lead to aneuploidy and cancer. During early embryonic development in mammals, prior to the first cell division, male and female genomes are separated in pronuclei located at the centre of the zygote. Parental chromatin clusters at the interface between the two pronuclei and this clustering step is critical to avoid aneuploidy in human and bovine zygotes. Yet, despite their essential function in chromosome segregation, the position and spatial organization of centromeres during the first cell cycle in mammals is mostly unknown. Previous studies conducted in bovine embryos derived from in vitro fertilization (IVF) showed that cell cycle progression impacts on the success rate of blastocyst formation. Specifically, embryos that entered earliest into S-phase or the earliest cleaving embryos were more likely to develop into blastocysts. To determine the precise timing of these events we performed a detailed characterization of key phases of the first cell cycle in bovine zygotes derived from IVF. In parallel we examined the spatial positioning of centromeres. We identify 20 h post insemination (hpi) as the timepoint when male and female pronuclei are juxtaposed and are completing S-phase. At this timepoint, we show that centromeres are positioned distal to the pronuclear interface and use super resolution microscopy to demonstrate extensive centromere clustering into chromocentres. Our results identify distinct nuclear features observed at 20 hpi, which may serve as cell cycle markers in determining successful bovine IVF.
The traditional ant colony optimisation (ACO) algorithm, when applied to mobile robot path planning, faces several challenges: slow convergence, susceptibility to local optima, and the generation of paths with excessive turning points, all of which reduce the robot’s operational efficiency. To overcome these shortcomings, this paper proposes a targeted set of improvements designed to enhance algorithm performance and increase the practicality and efficiency of path planning. First, we introduce an initial pheromone enhancement mechanism based on the Bresenham algorithm. By augmenting pheromone concentration along the approximate straight-line path from the start to the goal, ants are guided to explore in the optimal direction, thereby significantly accelerating convergence. Second, we integrate a directional continuity factor into the path selection probability: by using vector dot products to strengthen the bias toward consistent directions and by coupling this with a curvature-based pheromone reward that favours straighter segments, we ensure smoother, more direct paths. Finally, we apply a spring-model-based smoothing strategy as a post-processing step to the paths generated by the ant colony, reducing path complexity and the number of turns to guarantee efficient and reliable robot motion. To validate the performance of the improved algorithm, we conduct comparative experiments on a MATLAB platform against other enhanced ACO variants reported in the literature. The results demonstrate that our proposed algorithm significantly outperforms these existing methods across all performance metrics, exhibiting superior path planning capabilities.