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We present a new way to control the unfolding of definitions in dependent type theory. Traditionally, proof assistants require users to fix whether each definition will or will not be unfolded in the remainder of a development; unfolding definitions is often necessary in order to reason about them, but an excess of unfolding can result in brittle proofs and intractably large proof goals. In our system, definitions are by default not unfolded, but users can selectively unfold them in a local manner. We justify our mechanism by means of elaboration to a core theory with extension types – a connective first introduced in the context of homotopy type theory – and by establishing a normalization theorem for our core calculus. We have implemented controlled unfolding in the proof assistant, inspiring an independent implementation in Agda.
This paper documents a new, unique annual database of global wine markets covering 1835–2023. The database expands enormously the opportunities for conducting studies on national and global wine production, consumption and trade from an historical and comparative perspective for the world as a whole and for most relevant countries. The combination of this basic information with other economic variables such as real GDP, population, total merchandise trade, total crop area, and the consumption of other alcoholic drinks has enabled us to generate myriad derived variables that are helpful for comparative analyses as well as for studying the two waves of globalization.
We present three-dimensional velocity gradient statistics from turbulent Rayleigh–Bénard convection experiments in a horizontally extended cell of aspect ratio 25, a paradigm for mesoscale convection with its organisation into large-scale patterns. The Rayleigh number ${\textit{Ra}}$ ranges from $3.7 \times 10^5$ to $4.8 \times 10^6$, the Prandtl number ${\textit{Pr}}$ from 5 to 7.1. Spatio-temporally resolved volumetric data are reconstructed from moderately dense Lagrangian particle tracking measurements. All nine components of the velocity gradient tensor from the experiments show good agreement with those from direct numerical simulations, both conducted at ${\textit{Ra}} = 1 \times 10^6$ and ${\textit{Pr}} = 6.6$. As expected, with increasing ${\textit{Ra}}$, the flow in the bulk approaches isotropic conditions in the horizontal plane. The focus of our analysis is on non-Gaussian velocity gradient statistics. We demonstrate that statistical convergence of derivative moments up to the sixth order is achieved. Specifically, we examine the probability density functions (PDFs) of components of the velocity gradient tensor, vorticity components, kinetic energy dissipation and local enstrophy at different heights in the bottom half of the cell. The probability of high-amplitude derivatives increases from the bulk to the bottom plate. A similar trend is observed with increasing ${\textit{Ra}}$ at fixed height. Both indicate enhanced small-scale intermittency of the velocity field. We also determine derivative skewness and flatness. The PDFs of the derivatives with respect to the horizontal coordinates are found to be more symmetric than the ones with respect to the vertical coordinate. The conditional statistical analysis of the velocity derivatives with respect to up-/down-welling regions and the rest did not display significant difference, most probably due to the moderate Rayleigh numbers. Furthermore, doubly logarithmic plots of the PDFs of normalised energy dissipation and local enstrophy at all heights show that the left tails follow slopes of 3 / 2 and 1 / 2, respectively, in agreement with numerical results. In general, the left tails of the dissipation and local enstrophy distributions show higher probability values with increasing proximity towards the plate, in comparison with those in the bulk.
We determine unsteady time-periodic flow perturbations that are optimal for enhancing the time-averaged rate of heat transfer between hot and cold walls (i.e. the Nusselt number Nu), under the constraint of fixed flow power (Pe$^2$, where Pe is the Péclet number). The unsteady flows are perturbations of previously computed optimal steady flows and are given by eigenmodes of the Hessian matrix of Nu, the matrix of second derivatives with respect to amplitudes of flow mode coefficients. Positive eigenvalues of the Hessian correspond to increases in Nu by unsteady flows, and occur at $Pe\geqslant 10^{3.5}$ and within a band of flow periods $\tau \sim Pe^{-1}$. For $\tau {\textit{Pe}}\leqslant 10^{0.5}$, the optimal flows are chains of vortices that move along the walls or along eddies enclosed by flow branches near the walls. At larger $\tau {\textit{Pe}}$, the vorticity distributions are often more complex and extend farther from the walls. The heat flux is enhanced at locations on the walls near the unsteady vorticity. We construct an iterative time-spectral solver for the unsteady temperature field, and find increases in Nu of up to 7 % at moderate-to-large perturbation amplitudes.
Given a nonzero integer n, Gupta and Saha [‘Integer solutions of the generalised polynomial Pell equations and their finiteness: the quadratic case’, Canad. Math. Bull., to appear] classified all polynomials $x^2+ax+b\in {\mathbb {Z}}[x]$ for which the polynomial Pell equation $P^2-(x^2+ax+b)Q^2=n$ has solutions ${P,Q\in {\mathbb {Z}}[x]}$ with $Q\neq 0$. We generalise their work to the equation $P^2-(f^2+af+b)Q^2=nR$, where f is a fixed polynomial in ${\mathbb {Z}}[x]$. As an application of our results, we study the equation $P^2-D(f)Q^2=n$, where D is a monic, quartic and non square-free polynomial in ${\mathbb {Z}}[x]$. This extends Theorem 1.4 of Scherr and Thompson [‘Quartic integral polynomial Pell equations’, J. Number Theory259 (2024), 38–56].
This study aims to evaluate patient outcomes related to mitral valve disease (stenosis, regurgitation, or mixed) who benefited from mitral repair or replacement under one year of age.
Methods:
Monocentric retrospective study including all children with mitral valve repair or replacement under 1 year of age over a period of 22 years (2001–2023).
The outcomes assessed were:
early mortality (at 30 days), late mortality, and need for re-intervention.
Results:
A total of 56 patients were identified, with a median age of 147 days and median weight of 5.1 kg. Of these, 39 underwent mitral valve repair and 17 underwent replacement. The median follow-up duration was 2.9 years (interquartile range 0.3–8.1). Patients who underwent replacement had longer ICU stays, hospital stays, and assisted ventilation times (p = 0.005, p = 0.01, p = 0.019), with higher early mortality (12% vs. 0%). Survival was significantly higher in the repair group (p = 0.039). Re-intervention was required in 23 patients (41.1%): 16 had replacement, 6 had re-repair, and 2 needed pacemaker implantation. Seven patients (12.5%) needed more than one re-intervention. Re-intervention-free survival rates after repair were 81%, 65%, and 46% at 1, 5, and 10 years, respectively. After replacement, rates were 74% at 1 year and 55% at 5 and 10 years. Conclusion Mitral valve surgery in infants is particularly high risk and is associated with high rate of re-intervention. While mitral repair demonstrates superior outcomes in mortality, it often delays but does not always prevent the need for valve replacement.
Gaming disorder (GD) is increasingly recognized as a clinically significant condition, yet its implications in first-episode psychosis (FEP) remain largely unexplored. This perspective article focuses on the intersection of GD and FEP, highlighting key diagnostic and treatment challenges, including symptom overlap that complicates differential diagnosis, the absence of validated screening tools, and difficulties in sustained patient engagement. Drawing insights from substance use disorder management in FEP, we propose a preliminary clinical framework for integrating GD assessment and intervention into early intervention in psychosis programs. This approach prioritizes comprehensive evaluation, patient-centered care, and a harm-reduction model that supports digital well-being. Addressing GD inFEP populations is crucial for optimizing functional recovery and promoting a holistic, recovery-oriented approach to psychiatric care. Further research is needed to refine screening tools and validate tailored interventions in this population.
This study aimed to determine the prevalence of undiagnosed diabetes and prediabetes in patients presenting with recurrent otomycosis and to evaluate associated risk factors, fungal profiles and cerumen pH variations.
Methods
This cross-sectional study included 213 adults with greater than or equal to two episodes of otomycosis. Glycaemic status was assessed using fasting blood sugar, post-prandial blood sugar and glycated haemoglobin. Fungal identification and cerumen pH measurement were performed. Multivariate analysis identified predictors of recurrence.
Results
Undiagnosed diabetes and prediabetes were found in 30 per cent and 13 per cent of patients, respectively. Candida albicans predominated in diabetics, while Aspergillus niger was common in normoglycaemics. Cerumen pH was significantly higher in diabetics (6.6) compared to normoglycaemics (5.3). Glycated haemoglobin greater than or equal to 6.5 per cent, Candida infection and steroid ear drop use were independent predictors of recurrence.
Conclusion
A substantial proportion of patients with recurrent otomycosis harbour unrecognised glycaemic abnormalities. Routine diabetes screening in ENT clinics may aid in early metabolic disease detection and reduce recurrence rates.
The spatial and temporal distribution of species is influenced by multiple processes operating at various scales. Beta diversity, which describes variation in species composition among sites, helps to understand community assembly mechanisms in spatial dimensions. Taxonomic beta diversity reflects differences in species composition, while functional beta diversity accounts for variations in ecological roles and traits among species. Both provide insights into the processes influencing the patterns of composition of communities. Accordingly, this study explores taxonomic and functional beta diversity patterns in anuran communities across different vegetation types in the Atlantic Forest of southeastern Brazil, focusing on two components of variation in species composition: turnover and nestedness. Field surveys were conducted in 16 sites in northern Rio de Janeiro state, covering five vegetation types. Our findings show that species turnover predominantly drives beta diversity, both taxonomically and functionally. Montane and Submontane Ombrophilous Forests contribute significantly to both taxonomic and functional beta diversity by hosting unique assemblages of species, including microendemic taxa and rare functional traits not found in other vegetation types. Nevertheless, other vegetation types also harbour exclusive species and contribute to overall diversity. Rather than focusing solely on conservation recommendations, these findings provide novel insights into how turnover and nestedness contribute differently to taxonomic and functional beta diversity, revealing the distinct ecological processes and habitat characteristics that shape anuran community composition across the Atlantic Forest.
Flower colour is a key trait shaping pollination, reproduction and plant–environment interactions. In arid ecosystems, it may also signal adaptations to heat and (Ultraviolet) UV stress. Tecomella undulata, a threatened keystone tree of the Indian Desert, exhibits striking flower colour polymorphism with yellow, orange and red morphs. This study tested whether artificial intelligence (AI) can reliably classify these morphs, thereby supporting conservation efforts. Field surveys were conducted across natural populations in the Thar Desert. An accessible no-code AI platform (Google Teachable Machine) was used for supervised classification of flower and tree images, with unsupervised clustering applied for validation. The AI classifier achieved high accuracy in distinguishing morphs at both flower and tree scales. Morphs showed consistent separation, with orange functioning as an intermediate form. Despite red morphs being more frequent, the presence of yellow and orange morphs contributes essential functional diversity important for pollinator interactions and reproductive resilience. This study demonstrates that no-code AI provides an effective, scalable approach to documenting intraspecific variation in threatened species. By enabling rapid and reliable identification of flower colour morphs, the approach offers practical applications for ex situ conservation, restoration and morph-aware biodiversity management in T. undulata and other arid-zone trees.
Shock-tube experiments are conducted to investigate the Atwood-number dependence of hydrodynamic instability induced by a strong shock with a Mach number exceeding 3.0. The compressible linear theory performs reliably under varying compressibility conditions. In contrast, the impulsive model significantly loses predictive accuracy at high shock intensities and Atwood numbers ($A_t$), particularly when specific heat ratio differences across the interface are pronounced. To address this limitation, we propose a modified impulsive model that offers favourable predictions over a wide range of compressibility conditions while retaining practical simplicity. In the nonlinear regime, increasing $A_t$ enhances both the shock-proximity and secondary-compression effects, which suppress bubble growth at early and late stages, respectively. Meanwhile, spike growth is promoted by the spike-acceleration and shock-proximity mechanisms. Several models reproduce spike growth across a wide range of $A_t$, whether physical or incidental. In contrast, no models reliably describe bubble evolution under all $A_t$ conditions, primarily due to neglecting compressibility effects that persist into the nonlinear regime. Building on these insights, we develop an empirical model that effectively captures bubble evolution over a wide $A_t$ range. Modal evolution is further shown to be strongly affected by compressibility-induced variations in interface morphology. The effect is particularly pronounced at moderate to high $A_t$, where it suppresses the fundamental mode growth while promoting higher-order harmonic generation.