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It has been proposed that second language (L2) learners differ from native speakers in processing due to either influence from their native language or an inability to integrate information from multiple linguistic domains in a second language. To shed new light on the underlying mechanism of L2 processing, we used an event-related potentials (ERP) paradigm to examine the processing of sentences with only in English by native speakers of English and advanced Dutch learners of English. Successful processing of sentences with only requires rapid integration of prosodic information with semantic and syntactic information. We found that L2 listeners showed native-like processing of the acoustics of contrastive pitch accents when adjacent to only. However, they needed more cues than L1 listeners to perform native-like in forming expectations for focus placement. Our results thus provide first ERP-based evidence for difficulty in the integration of information for focus expectation in difficult L2 constructs.
Disasters exacerbate inequities in health care. Health systems use the Hospital Incident Command System (HICS) to plan and coordinate their disaster response. This study examines how 2 health systems prioritized equity in implementing the Hospital Incident Command System (HICS) during the coronavirus disease 2019 (COVID-19) pandemic and identifies factors that influenced implementation.
Methods:
This is a qualitative case comparison study, involving semi-structured interviews with 29 individuals from 2 US academic health systems. Strategies for promoting health equity were categorized by social determinants of health. The Consolidated Framework for Implementation Research (CFIR) guided analysis using a hybrid inductive-deductive approach.
Results:
The health systems used various strategies to incorporate health equity throughout implementation, addressing all 5 social determinants of health domains. Facilitators included HICS principles, external partnerships, community relationships, senior leadership, health equity experts and networks, champions, equity-stratified data, teaming, and a culture of health equity. Barriers encompassed clarity of the equity representative role, role ambiguity for equity representatives, tokenism, competing priorities, insufficient resource allocation, and lack of preparedness.
Conclusions:
These findings elucidate how health systems centered equity during HICS implementation. Health systems and regulatory bodies can use these findings as a foundation to revise the HICS and move toward a more equitable disaster response.
Projected increases in human population suggest that 70% more food will be needed in the near future, this makes it imperative to search for alternative food and feed sources for human and animal nutrition to feed the exponentially growing human population. According to the FAO 2019 report, the immense challenge of achieving the Zero Hunger target by 2030 is persistent. Exploring the unexplored, refining unrefined traits, cultivating the uncultivated, and popularizing the unpopular remain the most adequate steps proposed by researchers to achieve the domestication of the undomesticated for food and nutrition security. In that line of thought, this study explored the proximate composition of 87 accessions of four wild unexplored Vigna species (V. racemosa, V. ambacensis, V. reticulata, V. vexillata) in order to reveal information leading to their future domestication and utilization. Standard procedures and methods approved by the Association of Official Analytical Chemists were used in carrying out the proximate composition (%protein, %lipid, %fibre, %ash and % moisture and % carbohydrate) of the wild Vigna legumes. The study revealed that the wild Vigna species possess a large variation range of nutrient characteristics which could be exploited in the improvement of domesticated species or guide their domestication. It was also found that some individual wild accessions have higher nutrient, content as compared with domesticated ones which could be advantageous for bio-fortification or domestication. Indications relating to the candidate accessions favourable for domestication, based on the nutrient characteristics were revealed.
There is substantial evidence that personality traits, in particular neuroticism and extraversions predict depressive and anxiety episodes as well as suicidal ideation. However, little research has examined whether these traits predict the first onset of depressive and anxiety disorders and suicidal ideation. Moreover, the few studies to date have not adjusted for pre-existing subthreshold symptoms, assessed dimensionally. In this study, 144 adolescents were assessed at baseline, 9-, and 18-month follow-ups. Neuroticism and extraversion were assessed via self-report, and depressive and anxiety disorders and suicidal ideation were assessed with diagnostic interviews. Adjusting for age, sex, and baseline symptoms, logistic regression analyses showed that neuroticism predicted the first onset of depressive disorders. However, neither neuroticism nor extraversion predicted first onsets of anxiety disorders, extraversion did not predict depressive disorders, and neither trait predicted suicidal ideation onset or severity after adjusting for baseline symptoms. Neuroticism and extraversion may respectively predispose youth to depressive or anxiety disorders but not to suicidal ideation over and above pre-existing symptoms. Results have implications for the early identification of at-risk youth and prevention of depressive and anxiety disorders and suicidal ideation.
Radiocarbon (F14C) and stable carbon (δ13C) values were measured in single grains of spring barley (Hordeum vulgare L.) from the sample archive from two adjacent sites of the Long-term Experiments (LTEs) Hoosfield Spring Barley at Rothamsted Research (Harpenden, Hertfordshire, UK), covering the growing periods (March to September) of 1852 to 2020. F14C data of the barley grain confirm that recent values are approaching and will decline below the “nominal” F14C value of 1, tracking a similar decrease reported in other studies. Importantly, the measured δ13C values reveal a different temporal decline over the pre-bomb and post-bomb timescale. Detailed statistical analysis of δ13C data along with δ13C analysis of independent, archived barley mash samples, verifies and quantifies the extent and rate of this decline. Evidence presented from the barley grain and barley mash samples suggests a clear breakpoint in δ13C data occurring in 1995, where the rate of change alters, in that the slope in δ13C data for the pre-1995 period is declining at 1.4‰ per century, and the slope in δ13C for the post-1995 period is declining at 3.6‰ per century. Such a consistent shift in δ13C data could be used with F14C values to extend the use of the bomb peak for forensic, ecological, and environmental applications.
In this paper, a novel tunable dual-band bandpass filter (BPF) with independently controlled passbands and constant absolute bandwidth (CABW) is proposed. The CABW passbands of designed dual-band BPF are obtained using manageable electric and magnetic mix coupling. Furthermore, the multiple transmission paths from the input port to the output port are extended for extra transmission zeros, which results in modified selectivity of the proposed dual-band BPF. The tunability and switchability of the developed filter can be implemented by introducing a single bias voltage of varactors for each band. For the tunable dual-band BPF, the simulated results show that the center frequency (CF) of the first passband varies from 2.38 to 2.68 GHz, and the CF of the second passband varies from 3.28 to 3.88 GHz, while 3-dB absolute bandwidths are 101 ± 7 MHz and 98 ± 4 MHz, respectively. Moreover, the two passbands of the filter can also be independently switched by removing the voltage imposed on the varactor CV1 and CV2. The measured results agree well with simulated results, which verify the design theory.
In the last few years, states have advanced various proposals for cooperation in the use of countermeasures. In this Article, we ask whether, and if so under what conditions, states may lawfully collaborate in the taking of countermeasures against other states. We distinguish five different types of collaboration: (1) independent but coordinated action; (2) secondment; (3) joint action; (4) aid and assistance; and (5) what we term “proxy countermeasures”—the idea of taking a measure at the request and on behalf of another state. We consider the permissibility of each, both where the acting state is itself entitled to resort to countermeasures and where it is not. We also draw attention to certain legal and policy considerations relating to, and to plausible avenues for, the development of international law.
We establish the exponential nonuniform Berry–Esseen bound for the maximum likelihood estimator of unknown drift parameter in an ultraspherical Jacobi process using the change of measure method and precise asymptotic analysis techniques. As applications, the optimal uniform Berry–Esseen bound and optimal Cramér-type moderate deviation for the corresponding maximum likelihood estimator are obtained.
This study explored the barriers and facilitators of mask-wearing behaviors during the pandemic in Taiwan, the United States, the Netherlands, and Haiti.
Methods:
Face-to-face interviews were conducted in Taiwan and online interviews were conducted with participants in the United States, the Netherlands, and Haiti.
Results:
In general, the habit of wearing a mask before coronavirus disease 2019 (COVID-19) was reported by Taiwanese participants. Additionally, Taiwanese participants perceived that wearing a mask was a social responsibility during the pandemic, suggesting that the collectivistic context might influence mask-wearing behavior. Unlike the Taiwanese population, some people in the United States and the Netherlands were reluctant to wear masks due to perceived restrictions on their freedom. Participants from Haiti mentioned that people who wore masks encountered violence, bullying, and discrimination. The results of this study suggest that political leadership and mask mandates have a strong impact on people’s mask-wearing behavior.
Conclusions:
These findings have valuable implications for the design of diverse behavioral interventions to enhance mask-wearing as part of infectious disease preparedness. Additionally, the findings from these countries offer valuable insights for the development of effective public health interventions to enhance society’s resilience during the current pandemic and future infectious disease outbreaks.
In the face of climate change, developing resilient crops is crucial for global food security in the 21st century to feed a growing population. Lentil (Lens culinaris Medikus) plays a vital role in ensuring global food and nutritional security. Traits like early flowering enable the crop to mature faster, thereby shortening the growing window and reducing yield losses caused by moisture and heat stresses during the reproductive phase. However, issues like limited genetic diversity in this trait remain unaddressed. To address this gap, our study aims to comprehensively assess genetic variability and trait associations in 158 lentil accessions. In the present study, we observed significant variations for days to 50% flowering (67–90 days), days to maturity (109–122 days) and 100 seed weight (1.69–2.68 g) throughout a period of two consecutive years (2020–2021 and 2021–2022). The observed variability in these traits offers a valuable avenue for the improvement of lentil yield through targeted selection and hybridization. Additionally, correlation analysis showed negative correlation between days to 50% flowering and grain yield per plant, while plant height had a significant (P < 0.01) positive correlation with all traits except yield per plant. Furthermore, we identified specific germplasm with exceptional traits that hold significant potential for future breeding programmes. The genotypes EC 223197-A and EC 267696 were identified for early flowering with high yield, and other genotypes that were identified for various traits would serve as breeding material for the introgression of these traits into elite cultivars.
In embracing corporate rescue, Malaysia introduced Judicial Management (JM) into its company law framework on 1 March 2018. The mechanism was modelled on Singapore's Judicial Management, which itself was based on the United Kingdom (UK) Administration Procedure. Despite its laudable objective of facilitating the rescue of financially distressed companies, the path to JM is paved with obstacles. This article identifies some of these obstacles and examines the issues that give rise to them. At the same time, the article proposes legislative reforms, drawing on comparative laws in Singapore and the UK. For the purposes of this article, three obstacles are examined: first, the power of a secured creditor or debenture holder to veto the JM application; second, the stringent and prohibitive burden imposed on an applicant company caused by the judicial interpretation, at times conflicting, of the provisions governing the application of a JM order; and third, the higher threshold imposed by legislative requirements on creditors’ meeting to approve the JM proposal. These obstacles are encountered at three stages of a JM application: first, at the initial stage of the application; second, in considering the merits of the JM; and third, when the creditors vote to approve the application.
To assess the prevalence of neuropsychiatric symptoms 2 years after the COVID-19 acute phase and to identify biobehavioral risk factors.
Methods:
This 2-year prospective study assessed adult individuals with COVID-19 via face-to-face interview and laboratory testing at onset, and via telephone interview at 2-year follow-up. Data collected included COVID-19 severity and management at onset, as well as depression, anxiety, insomnia, cognitive failure, and fatigue at follow-up using standardized assessment tools.
Results:
Out of 1,067 screened COVID-19 patients, 230 completed the 2-year follow-up (female, 53.5%; aged>40, 80.9%; native Italian, 94.9%; medical comorbidity, 53.5%; chronic medication, 46.3%; moderate to severe COVID-19, 24.9%; hospital admission, 28.7%; ICU, 5.2%). At follow-up, 9.1% had anxiety, 11.3% depression, 9.1% insomnia, 18.3% cognitive failure, and 39.1% fatigue, of clinical relevance. Headache (OR = 2.49, 95% CI = 1.01–6.16, p = 0.048), dyspnea (OR = 2.55, 95% CI = 1.03–6.31, p = 0.043), and number of symptoms (OR = 1.23, 95% CI = 1.01–1.51, p = 0.047) at onset were associated with anxiety at follow-up; dyspnea at onset was associated with depression at follow-up (OR = 2.80, 95% CI = 1.22–6.41, p = 0.015); number of comorbidities at onset was associated with insomnia at follow-up (OR = 1.48, 95% CI = 1.06–2.08, p = 0.022); female gender (OR = 2.39, 95% CI = 1.14–5.00, p = 0.020) and number of symptoms (OR = 1.20, 95% CI = 1.02–1.42, p = 0.026) at onset was associated with cognitive failure at follow-up; number of comorbidities (OR = 1.33, 95% CI = 1.03–1.73, p = 0.029) and symptoms (OR = 1.19, 95% CI = 1.04-1.37, p = 0.013) and raised interleukin 6 levels (OR = 4.02, 95% CI = 1.42–11.36, p = 0.009) at onset was associated with fatigue at follow-up.
Conclusions:
COVID-19 survivors, especially if female, with preexisting health problems, and with a more severe acute phase, may present with long-lasting neuropsychiatric sequalae, urging interventions to sustain recovery particularly in these higher risk individuals.
This article seeks to discover how this contemporary Finno-Ugric identity has been politically instrumentalized and negotiated in Estonia. First, we look at how the Estonian state engages with the concept of Finno-Ugric world and inscribes it into Estonia’s foreign policy goals. Then, we delve into the role of Finno-Ugric traditionalism in Estonian populist and far-right discourses. Third, we discuss how local identity constitutes and cements community building initiatives and projects in the Seto region known for its local specificity and cultural peculiarity.
The goal of this article is to show Russia’s civilizational turn in the broader context of imperial nationalism. The “turn” is a manifestation of imperial nationalism that today feeds not only on political ideas and history but also on geography. In the mass perception, geography is seen as an objective, non-ideologized scientific discipline less prone to political manipulation. Because of this, it can be employed to influence the Russian self-identification process in a much more subtle and efficient way than references to the more abstract notion of civilization. This article presents the Russian Geographical Society (RGS) as an identity entrepreneur managed by the ruling elite with a well-developed regional structure. It functions as a community of imperial practice. With its discursive and material practices, the RGS contributes to reproducing imperial nationalism, including in its civilizational version. The RGS is the keeper of the imperial body. By referring to the imperial body, I mean not just the physical territory but also the ways it is imagined in discourse and made material in numerous practices.
Industrial applications of flow through fractures such as geothermal energy or hydraulic stimulation involve forcing large flow rates through small fractures, thereby inducing inertial fluid behaviours and turbulence. The most common fracture flow model, Poiseuille flow (the cubic law), is incapable of capturing these phenomena and thus the impact of inertial and turbulent forces in fracture flow has remained relatively unexplored. The GG22 flow model is a newly derived fracture flow model that is capable of capturing inertial, transient and turbulent forces. In this article, we apply the GG22 flow model to hydraulic stimulation of radial fractures for the first time to determine how these phenomena manifest. We show that inertia and turbulence only manifest near the wellbore (within 30 radii) and lead to changes in fracture shape and injection pressure but have little impact on tip behaviour. Turbulence increases wellbore pressure and aperture while inertia decreases wellbore pressure and aperture. The majority of the pressure loss along the fracture occurs near the wellbore and is captured by turbulence where entrance correction factors would otherwise be needed. Using water, turbulence is the dominant mechanism that causes departures from Poiseuille flow at high $Re$. The solution departs immediately upon the manifestation of turbulence ($Re\geq 2\times 10^3$), while inertial effects manifest at higher flow rates ($Re\geq 2\times 10^4$). Using slickwater, the opposite trend is observed: inertial effects manifest first ($Re\geq 5\times 10^3$), while turbulent effects are delayed ($Re\geq 10^4$). In both cases, the threshold for departures from the Poiseuille flow solution are low and the differences are large.
To understand how healthcare facilities employ contact precautions for patients with multidrug-resistant organisms (MDROs) in the post–coronavirus disease 2019 (COVID-19) era and explore changes since 2014.
Design:
Cross-sectional survey.
Participants:
Emerging Infections Network (EIN) physicians involved in infection prevention or hospital epidemiology.
Methods:
In September 2022, we sent via email an 8-question survey on contact precautions and adjunctive measures to reduce MDRO transmission in inpatient facilities. We also asked about changes since the COVID-19 pandemic. We used descriptive statistics to summarize data and compared results to a similar survey administered in 2014.
Results:
Of 708 EIN members, 283 (40%) responded to the survey and 201 reported working in infection prevention. A majority of facilities (66% and 69%) routinely use contact precautions for methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE) respectively, compared to 93% and 92% in 2014. Nearly all (>90%) use contact precautions for Candida auris, carbapenem-resistant Enterobacterales (CRE), and carbapenem-resistant Acinetobacter baumannii. More variability was reported for carbapenem-resistant Pseudomonas aeruginosa and extended-spectrum β-lactamase–producing gram-negative organisms. Compared to 2014, fewer hospitals perform active surveillance for MRSA and VRE. Overall, 90% of facilities used chlorhexidine gluconate bathing in all or select inpatients, and 53% used ultraviolet light or hydrogen peroxide vapor disinfection at discharge. Many respondents (44%) reported changes to contact precautions since COVID-19 that remain in place.
Conclusions:
Heterogeneity exists in the use of transmission-based precautions and adjunctive infection prevention measures aimed at reducing MDRO transmission. This variation reflects a need for updated and specific guidance, as well as further research on the use of contact precautions in healthcare facilities.
Cell segregation caused by collective cell migration (CCM) is crucial for morphogenesis, functional development of tissue parts, and is an important aspect in other diseases such as cancer and its metastasis process. Efficiency of the cell segregation depends on the interplay between: (1) biochemical processes such as cell signaling and gene expression and (2) physical interactions between cells. Despite extensive research devoted to study the segregation of various co-cultured systems, we still do not understand the role of physical interactions in cell segregation. Cumulative effects of these physical interactions appear in the form of physical parameters such as: (1) tissue surface tension, (2) viscoelasticity caused by CCM, and (3) solid stress accumulated in multicellular systems. These parameters primarily depend on the interplay between the state of cell–cell adhesion contacts and cell contractility. The role of these physical parameters on the segregation efficiency is discussed on model systems such as co-cultured breast cell spheroids consisting of two subpopulations that are in contact. This review study aims to: (1) summarize biological aspects related to cell segregation, mechanical properties of cell collectives, effects along the biointerface between cell subpopulations and (2) describe from a biophysical/mathematical perspective the same biological aspects summarized before. So that overall it can illustrate the complexity of the biological systems that translate into very complex biophysical/mathematical equations. Moreover, by presenting in parallel these two seemingly different parts (biology vs. equations), this review aims to emphasize the need for experiments to estimate the variety of parameters entering the resulting complex biophysical/mathematical models.
Consistent with the idea that business ethics is a form of applied ethics, many virtue ethicists make use of an extant (pure) moral philosophy framework, namely, one developed by Alasdair MacIntyre. In doing so, these authors have refined MacIntyre’s work, but have never really challenged it. In here questioning, and developing an alternative to, the MacIntyrean orthdoxy, I illustrate the merit of business ethicists adopting a broader philosophical perspective focused on constructing (new) theory. More specifically—and in referring to action sports (e.g., mountain biking, snowboarding)—I propose that an external good motive is not only much more consistent with virtuous practical excellence than MacIntyreans acknowledge, but that such a motive is fundamental to identifying and explaining how practices can be deliberately created (by businesses). Consequently, and in stark contrast with MacIntyre’s deeply pessimistic outlook on modern business and society, I propose that those who value practices might celebrate our current era.