The maternal metabolic environment can be detrimental to the health of the offspring. In a previous work, we showed that maternal high-fat (HH) feeding in rabbit induced sex-dependent metabolic adaptation in the fetus and led to metabolic syndrome in adult offspring. As early development representing a critical window of susceptibility, in the present work we aimed to explore the effects of the HH diet on the oocyte, preimplantation embryo and its microenvironment. In oocytes from females on HH diet, transcriptomic analysis revealed a weak modification in the content of transcripts mainly involved in meiosis and translational control. The effect of maternal HH diet on the embryonic microenvironment was investigated by identifying the metabolite composition of uterine and embryonic fluids collected in vivo by biomicroscopy. Metabolomic analysis revealed differences in the HH uterine fluid surrounding the embryo, with increased pyruvate concentration. Within the blastocoelic fluid, metabolomic profiles showed decreased glucose and alanine concentrations. In addition, the blastocyst transcriptome showed under-expression of genes and pathways involved in lipid, glucose and amino acid transport and metabolism, most pronounced in female embryos. This work demonstrates that the maternal HH diet disrupts the in vivo composition of the embryonic microenvironment, where the presence of nutrients is increased. In contrast to this nutrient-rich environment, the embryo presents a decrease in nutrient sensing and metabolism suggesting a potential protective process. In addition, this work identifies a very early sex-specific response to the maternal HH diet, from the blastocyst stage.

Non-judicial remedies for corporate human rights abuses have a viable and complementary role to judicial remedies in mature jurisdictions, although in Ukraine the ‘bouquet’ of effective remedies is more of a still-life. The national mediation community is gaining momentum and the authors argue that mediation may take place within state-based non-judicial remedies when institutionalized by the office of the Ombudsman. The objective of this article is to scrutinize the rule of law, access to justice, and the effectiveness criteria of the UNGPs with regard to mediation. The authors conclude that mediation can meet all of the effectiveness criteria requirements and special effort should be devoted to addressing the challenges of power imbalances between parties, the confidential nature of mediation and the public demand for transparency, to ensure that mediation outcomes are in accord with internationally recognized human rights. Based on the findings, the authors suggest that a state-based business and human rights mediation scheme, in line with the UNGPs’ effectiveness criteria, should have its own three pillars, namely, accessibility, availability and awareness, with quality assurance as its cornerstone.

The aims of the present study were to assess secular trends in breast-feeding and to explore associations between age at introduction of solid foods and breast-feeding duration. Data from three national dietary surveys in Norway were used, including infants born in 1998 (Spedkost 1, n 1537), 2006 (Spedkost 2, n 1490) and 2018 (Spedkost 3, n 1831). In all surveys, around 80 % of the infants were breastfed at 6 months of age. At 12 months of age, breast-feeding rate was 41 % in Spedkost 1, increasing to 48 % in Spedkost 2 and 51 % in Spedkost 3. Compared with earlier introduction, introduction of solid foods at ≥ 5 months of age was associated with a lower risk of breast-feeding cessation during the first year of life in the two most recent Spedkost surveys. In Spedkost 2, the adjusted hazard ratio for breast-feeding cessation during the first year of life for those introduced to solid foods at ≥ 5 months of age was 0·43 (95 % CI (0·31, 0·60)), P < 0·001, while the corresponding number in Spedkost 3 was 0·44 (95 % CI (0·29, 0·67)), P < 0·001. In conclusion, breast-feeding at infant age 12 months increased over time. Introduction of solid foods at ≥ 5 months of age was positively associated with breast-feeding duration in the two most recent Spedkost surveys. As breast-feeding contributes to numerous health benefits for infant and mother, and possibly improved dietary sustainability in infancy, findings point to the importance of continued protection, support and promotion of breast-feeding.

The northern Adriatic Sea is an important foraging ground for the loggerhead sea turtle Caretta caretta (Linnaeus, 1758) within the Mediterranean Sea. Here, stranding patterns of loggerhead sea turtles were examined over a four-year period (2019–2022) along a short (17 km) stretch of the Italian coast south of the Po River delta. A total of 355 records (alive, n = 24; dead, n = 331) were analysed, and the curved carapace lengths (CCL, notch to tip, cm) mainly reflected large juveniles and sub-adults (average CCL = 57.2 cm; 95% CI = 55.6–58.7). The month of July was identified as the critical month with the highest number of strandings, mirroring migratory processes towards this area during warmer months. The number of stranded turtles•km−1 as well as the absolute number of strandings along the short stretch of the coast might suggest this area as the most impacted in the Mediterranean Sea. This research emphasizes that human activities in the waters south of the Po River delta, particularly trawl fishing, are the primary cause of loggerhead sea turtle strandings and that tracking stranding patterns can offer valuable information about the geographic ranges, seasonal movements, and life cycles of this species.

My aim in this article is to provide an account of practical judgement, for Kant, that situates it within his theory of judgement as a whole – particularly, with regards to the distinction between the determining and reflecting use of judgement. I argue that practical judgement is a kind of determining judgement, but also one in which reflecting judgement plays a significant role. More specifically, I claim that practical judgement arises from the cooperation of the reflecting power of judgement with the faculty of reason – the former assisting the latter in the application of its principle. I conclude by considering a possible role for feeling in practical judgement.

Because economic outcomes depend on private-sector expectations, central banks might be tempted to guide these by publishing projections of key macroeconomic variables. We find that optimal projections require misleading the public. Optimal non-misleading projections are time-inconsistent. Non-misleading time-consistent projections can only improve policy outcomes if the public’s forecasts are noisier, or inconsistent with implemented policy. Since the public only has incentives to be guided by policymakers’ projections when most vulnerable to being mislead, these cannot be trusted blindly. Consistent with this, we find statistically significant systematic deviations between FOMC projections and professional forecasts for US inflation and GDP growth.

In this article, I argue that Du Bois’s Japan—despite displaying his myopic failure to critique non-Western imperialism—served as a potential model for his reimagining transnational democratic leadership beyond Western-centric models and their legacies of White supremacy and democratic despotism. Du Bois’s reflections from the 1890s to the 1960s generally demonstrate a sustained, seven decade-long fluid commitment to realizing a vision of transnational leadership that was accountable to the democratic masses, whether in Asia, Africa, the United States, or elsewhere. Such reflections hold importance now (even as they did in Du Bois’s time) as we continue to grapple with the legacies of Western “democratic” dominance, especially in international institutions designed to facilitate global governance.

Gramsch and Lay [8] gave spectral mapping theorems for the Dunford-Taylor calculus of a closed linear operator $T$,

\[ \widetilde{\sigma}_i(f(T)) = f(\widetilde{\sigma}_i(T)), \]

$\widetilde {\sigma }_i$

$f$

$f$

$\widetilde \sigma$

Photographs of a single shark specimen (1040 mm in total length) caught in the Oyodo River estuary, Miyazaki Prefecture, Kyushu, Japan, by a recreational angler and uploaded to the social networking service Facebook, were identified as a juvenile specimen of the bull shark Carcharhinus leucas. The photographic record, now deposited in the Kanagawa Prefectural Museum of Natural History collection, represents the northernmost record of this species in the western Pacific Ocean. Although C. leucas is known to utilize primarily tropical estuarine habitats as nursery grounds, a few reports exist regarding the utilization of subtropical and warm-temperate latitude estuaries, as in this case. From the perspectives of species conservation and shark-bite mitigation in warm-temperate latitudes, further information on C. leucas occurrence around its northern distribution limit is required.

Post-operative pulmonary venous stenosis is a poor prognostic factor in single-ventricle haemodynamics. Implantation of a drug-eluting stent is a therapeutic option. However, due to their small size, they inevitably become inadequate as the patient grows. We present the first case, to the best of our knowledge, of the replacement of a small-diameter stent with a large-diameter stent during Fontan surgery.