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We calculate the hydrodynamic force on a small spherical, unsteady squirmer moving with a time-dependent velocity in a fluid at rest, taking into account convective and unsteady fluid inertia effects in perturbation theory. Our results generalise those of Lovalenti & Brady (J. Fluid Mech., vol. 256, 1993, pp. 561–605) from passive to active spherical particles. We find that convective inertia changes the history contribution to the hydrodynamic force, as it does for passive particles. We determine how the hydrodynamic force depends on the swimming gait of the unsteady squirmer. Since swimming breaks the spherical symmetry of the problem, the force is not determined completely by the outer solution of the asymptotic matching problem, as it is for passive spheres. There are additional contributions due to the inhomogeneous solution of the inner problem. We also compute the disturbance flow, illustrating convective and unsteady effects when the particle experiences a sudden start followed by a sudden stop.
This study offers a diachronic look (1840-today) into the direct partial interrogation system in Quebec French. The main goals are to provide empirical evidence of the rise of the in situ variant within the Quebec French system, and to understand how the system evolved over centuries, independently from Hexagonal French. The data (based on more than 1600 tokens) show that the emergence of the in situ variant seems to depend on the wh word itself, but its usage seems to be more important in Montreal. There are a few examples of in situ found before the 1970s, but this variant was never publicly condemned nor associated to “bad usage”. This article, inspired by a historical sociolinguistics approach, provides much needed original data from five different corpora, both (written) historical and (oral) contemporary, and shows that the partial interrogative system in Quebec is not stable over time. The Montreal data suggests a system evolving differently in this city than in other regions of the province, and the data from each wh word show that interrogatives with comment still only marginally allow the in situ variant.
Cette étude offre un portrait diachronique (1840 à aujourd’hui) global de la variation à l’intérieur du système d’interrogation partielle directe en français québécois. L’objectif principal est de contribuer de façon empirique à la compréhension du développement de la variante in situ en français du Québec, et d’en arriver à montrer l’évolution, indépendante de celle ayant lieu en France, sur plus d’un siècle. Nos données (plus de 1600 occurrences) montrent que l’émergence de la variante in situ dépend du mot wh utilisé, et qu’elle semble plus avancée à Montréal qu’ailleurs. Nous avons trouvé quelques traces de la variante in situ avant 1970 dans les documents métalinguistiques, et montrons que cette variante n’a jamais été condamnée. Le présent article s’inscrit dans une approche de sociolinguistique historique et fournit des données originales, tirées de corpus historique (écrit) et contemporains (oraux). Ce portrait quantitatif montre à quel point le système d’interrogation directe partielle n’est pas stable dans le temps, et suggère une évolution dans la communauté montréalaise qui se distingue des autres communautés étudiées. Le mot interrogatif comment résiste encore à la variante in situ, mais les taux globaux d’utilisation nous permettent de considérer la variante in situ comme faisant partie intégrante de l’interrogation en français québécois oral.
In two cases decided on October 18, 2022, the European Court of Human Rights issued judgments for the first time in complaints alleging racial profiling in police identity checks. The applicants in both cases alleged that the police had selected them for a check due to racial discrimination, and both argued that the state had failed to conduct an effective investigation in response to their complaints. In one case, a unanimous court found a violation of the European Convention on Human Rights, but in the other case, a sharply divided court decided 4–3 that there was no violation. The cases raise serious questions about proof and evidence in racial profiling cases, as well as what policies and procedures would meet the state obligation to ensure an adequate legal framework to protect against racial discrimination.
To evaluate the impact of Hurricanes Irma and Maria on 3 major chronic diseases in Puerto Rico.
Methods:
San Juan Overweight Adults Longitudinal study participants were re-evaluated after Hurricanes Irma and Maria (May 2019–July 2020) for the Preparedness to Reduce Exposures and Diseases Post-hurricanes and Augment Resilience study. This study compared the prevalence and incidence of asthma, depression, and hypertension within the same 364 individuals over time.
Results:
Asthma and depression prevalence and incidence did not change significantly after the hurricanes. The prevalence of hypertension increased significantly after the hurricanes (OR = 2.2, 95% CI: 1.2, 3.9). The incidence of hypertension after the hurricanes (IR = 9.0, 95% CI: 6.5, 12.4) increased significantly compared to before the hurricanes (IR = 6.1, 95% CI: 4.5, 8.0) (age-adjusted incidence rate ratio [aIRR] = 1.4, 95% CI: 4.5, 8.0) for similar time periods.
Conclusion:
Hurricanes Irma and Maria were associated with a significant increase in the prevalence and incidence of hypertension in this study population. Contrary to expectations, no significant increases were observed in depression and asthma prevalence after the hurricanes. Results from this study can inform better strategies to prevent and manage hypertension in the population affected by a hurricane.
In the context of China's rising global role, the question of where its academia is moving to becomes a matter of concern. Embedded in the literature on academic (de)colonization and intellectual pluralism, research was conducted by Chinese educational scholars on the status quo of educational studies on and in mainland China within the world system of knowledge production. We report its major findings in order to respond to continuing struggles within the contemporary Chinese academic society and between global “centres” and “peripheries.” Drawing on semi-structured interviews conducted with both overseas ethnic Chinese and non-Chinese education researchers, as well as bibliographic and content analyses among relevant academic publications, its findings indicate the growing but still limited global impact of educational studies on/in China especially theoretically and epistemologically, tensions between “centres” and “peripheries” within the world knowledge system, as well as tensions between internationalization and local knowledge. Suggestions for future directions have been concluded based on empirical data.
The paper examines the introduction of trained female nurses for the British army men in colonial India between 1888 and 1920. It discusses the genesis of the Indian Nursing Service (INS), including the background and negotiations leading up to its formation, terms of employment, duties and working conditions of the nursing sisters. The memoir of Catharine Grace Loch, who served as the first Chief Lady Superintendent of the service is used extensively to trace the early experiences and challenges of the nursing sisters. The paper primarily argues that the INS being a new service, the colonial government maintained tight control over its functioning, and extreme conservatism in spending, thus retarding the growth of professional army nursing in India. Secondly, in examining the relations between the sisters and the (male) nursing orderlies, sub-medical and medical officers, the paper argues that the inadequate delineation of the nursing sisters’ position in the military medical hierarchy was an important reason for the undermining of their expertise and status. Thirdly, the paper contends that as an all-women service, nursing constituted an important avenue of female agency within the patriarchal colonial establishment, which subjected the sisters to scrutiny both professionally and socially. The paper analyses the resultant conditions and regulations imposed on the sisters – most of them determined by gender and class notions. Finally, the paper discusses the gradual establishment and recognition of the service as an important cornerstone for the health of the army, while highlighting the shortcomings that yet persisted up until 1920.
As the population ages and the prevalence of dementia increases, caring for a relative living at home with dementia has become a reality for many families worldwide. Studies have shown that families are confronted with diverse difficulties as they try to address the challenges involved in providing care. By understanding how they manage daily life, formal service providers become better equipped to meet the diverse needs of these families. Learning how families live with memory loss and cognitive changes calls for an understanding of the shared context surrounding the person, including the collective of people, and their connections. With the research method of ethnographic case study, we followed eight families living at home with dementia for two years. All participants had been placed on a waiting list for a specialised dementia day care programme. The analysis presented here is based on three cases which reflect widely different experiences and situations. We describe how these families dealt with their daily living at home, if and how they made use of the formal support available and what approaches they found helpful for improving their lives. The results show how the persons living with dementia and their care-givers drew on the collective of their backgrounds, surroundings and available support. With diverse arrangements, families tried to find ways to make their daily lives work out. But constant re-arrangement was necessary. This knowledge could be a central learning point for formal service to build on. While systematic or routine procedures in service provision can be helpful, time and space must be provided for professionals to understand families' different practices, so that they can provide family-centred support.
Transposition of the great arteries is a severe CHD that affects term neonates. The presence of major aortopulmonary collateral arteries in neonatal transposition of the great arteries patients is rare. This study investigated the clinical and haemodynamic implications of the presence of major aortopulmonary collateral arteries in neonatal transposition of the great arteries patients who underwent an arterial switch operation.
Materials and Methods:
The study was a retrospective analysis conducted on neonates diagnosed with transposition of the great arteries who underwent arterial switch operation within the period from 1 May 2020 to 1 January 2023 at two high-patient-volume paediatric cardiac surgery centres in Turkey. The patients’ demographic characteristics, echocardiographic features, and clinical data were analysed. Additionally, the possible clinical effects of the presence of major aortopulmonary collateral arteries were statistically evaluated.
Results:
Two hundred cases of neonatal transposition of the great arteries were included in this study, with 55% of the cases male. All the patients underwent arterial switch operation. The median age at the time of arterial switch operation was 5 days (interquartile range 3–7), with a median weight of 3,100 g (interquartile range 2,900–3,400). The median pre-operative saturation level was 76% (interquartile range 70–82%). Prior to arterial switch operation, 32 patients underwent balloon atrial septostomy.
In all the patients, the interatrial septum was checked to determine if the atrial septum was intact. A patent foramen ovale (≤ 3 mm) was found in 112 patients, and a non-restrictive atrial septal defect (> 3 mm) was found in 88. Forty-eight patients had ventricular septal defects, and 72 had coronary anomalies. Major aortopulmonary collateral arteries were found in 4 patients pre-operatively and in 12 patients after arterial switch operation (echocardiography, n = 8; angiography, n = 4). Of the patients with post-operative detection of cumulative number of major aortopulmonary collateral arteries were on post-operative day 1 in 2 patients, on post-operative day 3 in 5 patients, on post-operative day 7 in 6 patients, and on post-operative day 14 in 11 patients.
Transcatheter closure was performed in 3 cases due to recurrent extubation failure. Major aortopulmonary collateral artery shrinkage was observed in one case under medical treatment. The length of paediatric cardiac intensive care unit stay (10 days versus 8 days; p < 0.005), mechanical ventilator time (4 days versus 2 days; p = 0.02), and inotrope use time (5 days versus 3 days; p = 0.04) were higher in the major aortopulmonary collateral artery cases than patients without major aortopulmonary collateral artery.
Conclusion:
Major aortopulmonary collateral arteries are frequent in transposition of the great arteries patients and may have clinical effects. The presence of major aortopulmonary collateral arteries should be investigated in patients who do not have a favourable post-operative course after arterial switch operation.
In 2009, Guangdong province initiated a programme of regenerating its blighted urban neighbourhoods, outdated industrial plants and dilapidated villages (also known as “three-old redevelopment”), which continues today. While the academic attention focuses mainly on the city and project levels, few studies give a full and up-to-date account of the overall programme. This paper documents the background, purpose, scope, policy framework, project types, implementation modalities and initial outcomes of the programme. Unlike most urban regeneration projects around the world, the Guangdong programme – the largest coordinated effort in the global history of urban regeneration – is primarily driven not by the potential increases of land value but by an urgent need to find solutions to the conflict between the local demand for urban land and the rigid national land use control. The expected land value increases are harnessed to attract the participation of market players at the project level. The Guangdong experience opens up a new way for urban spatial development in China, especially at a time when China further strengthens national land use control under the newly established national territorial planning system.
The most frequent abnormality of the valves involved in rheumatic heart disease is mitral regurgitation. A promising supportive diagnostic tool for rheumatic heart disease is the N-terminal pro-brain natriuretic peptide, which can identify mitral valve damage.
Objective:
To prove a positive correlation between N-terminal pro-brain natriuretic peptide levels and the severity of mitral regurgitation or accompanied by mild aortic valve dysfunction in children with rheumatic heart disease.
Material and method:
Children aged 1–18 years who had been identified as having rheumatic heart disease with a single mitral regurgitation or accompanied by mild aortic issues at Sanglah General Hospital, Denpasar, met the inclusion criteria for this cross-sectional study. Mitral regurgitation severity was determined using the parameters of vena contracta width, effective regurgitation orifice area, regurgitant jet area, and regurgitation volume. Bivariate analysis using the Spearman correlation test.
Results:
From 36 research subjects, the mean age was 11.32 years. In this study, there was a moderate positive correlation between the levels of N-terminal pro-brain natriuretic peptide and the regurgitation jet area. N-terminal pro-brain natriuretic peptide levels also had a moderately positive correlation with the vena contracta width and a weakly positive correlation with the regurgitation volume. Effective regurgitation orifice area and N-terminal pro-brain natriuretic peptide levels did not significantly correlate.
Conclusion:
There was a moderately positive correlation between N-terminal pro-brain natriuretic peptide levels and the severity of mitral regurgitation on regurgitation jet area, a moderately positive correlation with the vena contracta width, and a weakly positive correlation with regurgitation volume in rheumatic heart disease patients.
Elite conferences, such as the Nobel Symposia organized by the Nobel Foundation since 1965, have often put a premium on the uninhibited exchange of ideas rather than the broad exchange of information. Nobel Symposium 14, The Place of Value in a World of Fact (1969), combined this ethos with the ambition to engage with ‘world problems’ that were thought by many at the time to constitute a global crisis. This paper examines the relationship between the Nobel Foundation's ideal of scientific neutrality/objectivity and the ‘neutral activism’ in Swedish 1960s foreign policy. Furthermore, it investigates the social networking that preceded and followed the symposium, arguing that these processes were more important for the symposium's impact than the actual meeting. They formed channels through which it was able to influence other larger meetings, like the 1972 UN conference on the human environment, and contributed to the creation of international organizations, most importantly the International Federation of Institutes for Advanced Study. This suggests that the common historiographic focus on science meetings as events should be complemented by analytical perspectives that also view them as processes.
Cardiac arrhythmias are a major concern in patients with CHD. The purpose of this study was to evaluate the long-term outcomes in patients with CHD submitted to catheter ablation.
Materials and Methods:
Observational retrospective study of patients with CHD referred for catheter ablation from January 2016 to December 2021 in a tertiary referral centre. Acute procedural endpoints and long-term outcomes were assessed.
Results:
A total of 44 ablation procedures were performed in 36 CHD patients (55% male, mean age 43 ±3 years). Fifty-four arrhythmias were ablated: 23 cavotricuspid isthmus atrial flutters, 10 atrial re-entrant tachycardias, eight focal atrial tachycardias, eight atrial fibrillations, three atrioventricular re-entrant tachycardias, and two ventricular tachycardias. During a median follow-up time of 37 months (interquartile range 12–51), freedom from arrhythmia recurrence was achieved in 93%, with 1.2 procedures per patient (18% with anti-arrhythmic drugs). There were no adverse events related to catheter ablation. No predictors of recurrence were identified.
Conclusion:
In patients with CHD, catheter ablation presents a high mid-term efficacy while maintaining a safe profile.
Competition policy is one important aspect of trade liberalization. However, when examining preferential trade agreements (PTAs), a major type of policy tools to liberalize trade, competition provisions are revealed not to be uniformly distributed across these treaties. What explains the variation in the design of competition clauses in PTAs? Borrowing insights from the rational design of international institutions and combining them with those from treaty ratification and policy diffusion literatures, I identify five major causal mechanisms through which competition provisions are incorporated into PTAs. In evaluating them, I employ a range of operationalization techniques to capture the proposed mechanisms. A treaty-level analysis of 319 PTAs over the period 1960–2015 lends strong and robust support to most of the hypothesized relationships. By integrating theoretical frameworks across international political economy literatures with that from law and economics scholarship, this study demonstrates the utility of political science thinking to the real-world international law-making.
Optogenetics, the use of microbial rhodopsins to make the electrical activity of targeted neurons controllable by light, has swept through neuroscience, enabling thousands of scientists to study how specific neuron types contribute to behaviors and pathologies, and how they might serve as novel therapeutic targets. By activating a set of neurons, one can probe what functions they can initiate or sustain, and by silencing a set of neurons, one can probe the functions they are necessary for. We here review the biophysics of these molecules, asking why they became so useful in neuroscience for the study of brain circuitry. We review the history of the field, including early thinking, early experiments, applications of optogenetics, pre-optogenetics targeted neural control tools, and the history of discovering and characterizing microbial rhodopsins. We then review the biophysical attributes of rhodopsins that make them so useful to neuroscience – their classes and structure, their photocycles, their photocurrent magnitudes and kinetics, their action spectra, and their ion selectivity. Our hope is to convey to the reader how specific biophysical properties of these molecules made them especially useful to neuroscientists for a difficult problem – the control of high-speed electrical activity, with great precision and ease, in the brain.