The first “R” from animal research ethics prescribes the replacement of animal experiments with animal-free alternatives. However, the question of when an animal-free method qualifies as an alternative to animal experiments remains unresolved.

Drawing lessons from another debate in which the word “alternative” is central, the ethical debate on alternatives to germline genome editing, this paper develops a general account of when something qualifies as an alternative to something. It proposes three ethically significant conditions that technique, method, or approach X must meet to qualify as an alternative to Y: (1) X must address the same problem as Y, under an appropriate description of that problem; (2) X must have a reasonable chance of success, compared to Y, in solving the problem; and (3) X must not be ethically unacceptable as a solution. If X meets all these conditions, its relative advantages and disadvantages determine whether it is preferable, indifferent, or dispreferable as an alternative to Y.

This account is then applied to the question of whether animal-free research methods qualify as alternatives to animal research. Doing so breaks down the debate around this question into more focused (ethical and other) issues and illustrates the potential of the account.

This research note assesses participatory health governance practices for HIV and AIDS in Brazil. By extension, we also evaluate municipal democratic governance to public health outcomes. We draw from a unique dataset on municipal HIV/AIDS prevalence and participatory health governance from 2006–17 for all 5,570 Brazilian municipalities. We use negative binomial regression and coarsened exact matching with treatment effects to estimate the influence of community health governance institutions on HIV/AIDS prevalence. Municipalities with participatory health councils experience 14% lower HIV/AIDS prevalence than other municipalities, all else equal. Family Health Program coverage, municipal state capacity, and municipal per capita health spending are also associated with systematically lower HIV/AIDS prevalence. We conclude that participatory health governance may combat HIV and AIDS through municipal spending, education, and community mobilization. Municipal health councils can facilitate these strategies and offer opportunities for improving well-being around the world.

We investigate the feasibility of cyber risk transfer through insurance-linked securities (ILS). On the investor side, we elicit the preferred characteristics of cyber ILS and the corresponding return expectations. We then estimate the cost of equity of insurers and compare it to the Rate on Line expected by investors to match demand and supply in the cyber ILS market. Our results show that cyber ILS will work for both cedents and investors if the cyber risk is sufficiently well understood. Thus, challenges related to cyber risk modeling need to be overcome before a meaningful cyber ILS market may emerge.

This paper focuses on the little-known but important cave-sanctuary of Zar Trypa on Mount Ossa (modern Kissavos) in north-eastern Thessaly. In 1910, research conducted at the site uncovered remains of votives from the Classical, Hellenistic and Roman periods, including a group of eight inscriptions dedicated to the Nymphs. Despite this remarkable epigraphic assemblage, the site was not investigated beyond a single excavation season and today is largely unknown. Consequently, the Zar Trypa cave and its finds have never featured prominently in the discussion of Thessalian religion or of Greek ‘natural’ sanctuaries. Combining archival studies, on-site observations and GIS-based methods of landscape archaeology, this paper sets out to re-assess the surviving archaeological evidence from the Zar Trypa cave, to examine the spatial setting of ritual activity at the site, and to place the cave in the context of Mount Ossa's natural environment and ancient settlement pattern. Drawing on the methodological framework of ‘lived religion’, this assessment not only contributes towards our understanding of ancient religious experiences at the Zar Trypa cave, but also addresses broader questions such as the significance and meaning of ‘sacred travel’ in pre-Christian antiquity.

In addition to interest in undergraduate research, political science increasingly recognizes the value of civically engaged research for various educational, professional, and civic outcomes. With limited time and steep tradeoffs, instructors must find ways to cleverly combine undergraduate research experiences with the broader normative civic-education responsibilities of political science and higher education. This article presents a course design that allows instructors to leverage their classroom for both civic education and undergraduate research without the need for previously developed community partnerships that are common to most engaged research and learning. Our approach brings together undergraduate research and community engagement through course design.

As Nigeria grew as an independent nation, the role of the Church Missionary Society (CMS) began to evolve, reflecting the needs of a burgeoning multi-ethnic society. This transformation is particularly evident in the Diocese on the Niger – the first indigenous Anglican diocese in Western Africa – a topic of debate within various factions of the Church of Nigeria, Anglican Communion. These contentions – centred on historical accuracy, heritage and primacy – mirror broader socio-political disputes concerning the Igbo people’s history and reveal postwar ethnocentric trends in Nigeria. We propose that the strategic positioning of the Diocese on the Niger was part of the CMS mission’s expansion plan into Islamic-dominated Western and Northern Nigeria. Igboland, with its geographical significance and potential as a fertile ground for the gospel, was a deliberate choice. The debates around these contested viewpoints and legacies epitomize the societal disputes over historical interpretation and its theological implications – extending beyond the events themselves and prompting reflection on the embodiment of Christ’s teachings in navigating socio-political complexities. These discussions go beyond religious or geographical disagreements – they symbolize a broader struggle to understand and interpret the past.

We introduce a category of filtered F-isocrystals and construct a symbol map from Milnor K-theory to the group of 1-extensions of filtered F-isocrystals. We show that our symbol map is compatible with the syntomic symbol map to the log syntomic cohomology by Kato and Tsuji. These are fundamental materials in our computations of syntomic regulators which we work in other papers.

Assisted reproductive technology is a crucial factor that increases the incidence of monozygotic twinning in humans. This article discusses the impact of various indicators in assisted reproductive technology studies on pregnancy outcomes, especially studies with a large number of clinical cases. Furthermore, three rare cases in multiples pregnancy are discussed: fetus papyraceous of a pair of male monozygotic twins in a set of triplets, two pairs of sesquizygotic twins with sex-discordance, and rare conjoined triplets.

The year 2022 marks 15 years since the entry into force of the United Nations Educational, Scientific and Cultural Organization’s 2005 Convention on the Protection and Promotion of the Diversity of Cultural Expressions. Among its objectives, this treaty aims at acknowledging the specific nature – economic and cultural – of cultural activities, goods, and services, reaffirming the sovereign right of states to adopt or implement measures they deem appropriate for the protection and the promotion of the diversity of cultural expressions as well as reinforcing international cooperation for more balanced cultural exchanges. Since its adoption, this treaty has been criticized for its low level of constraint. However, data collected over the years show that parties rely extensively on the Convention to undertake diverse initiatives to achieve the treaty’s objectives. Based on concrete examples, this article aims to show that the effectivity of a legal instrument does not only rely on its degree of constraint but also on other factors, including monitoring mechanisms put in place in the context of its implementation.

In this paper we develop a new technique for showing that a nonlinear algebraic differential equation is strongly minimal based on the recently developed notion of the degree of non-minimality of Freitag and Moosa. Our techniques are sufficient to show that generic order $h$ differential equations with non-constant coefficients are strongly minimal, answering a question of Poizat (1980).

This study is part of a growing wave of interest in foreign language (FL) learners’ emotions, their sources, and their effects. Previous studies have confirmed that there is a clear relationship between the emotions of foreign language enjoyment (FLE), foreign language classroom anxiety (FLCA), foreign language boredom (FLB), and foreign language performance. However, the relative importance of each emotion as a predictor of FL performance has yet to be examined, and as different teaching and learning strategies can elicit different emotions, it is difficult to determine whether FL teachers and learners should prioritize a specific emotion in course design and study. We, therefore, utilized structural equation modeling and latent dominance analysis on a sample of 502 Moroccan EFL learners in order to examine the relative importance of each emotion in predicting FL performance. We argue that it is crucial to use sophisticated statistical analyses and to collect samples from outside Western, educated, industrialized, rich, and democratic (WEIRD) countries. The latent dominance analysis revealed that FLCA had the strongest (negative) effect on English test scores. FLB had a significant—but slightly weaker—negative effect and FLE had a significant—but weaker still—positive effect. As such, it is vital that FL teachers and learners not underestimate the impact of anxiety on language learning.