“Actionability” is a key concept in precision oncology. Its precise definition, however, remains contested. This article undertakes a philosophical analysis of “actionability” to aid in conceptual clarification. We map distinct concepts of actionability, arguing that each is best understood as a contextually objective category articulated to mitigate risk of “conceptual slippage.” We defend “interactive pluralism,” acknowledging the need for distinct concepts but also for conceptual interaction in practice. This article thus offers insights for both practitioners and philosophers, clarifying approaches to actionability for scientists and clinicians and serving as a case study to test competing views on scientific pluralism.

How may elites experience a symbolic fall from grace? Elite scholarship has typically described how symbolic structures contribute to consecrate and reinforce existing power relations. Processes of deconsecration are, however, less well described. Deconsecration as a social process is distinct from déclassement, as well as from cultural or juridical processes of exclusion. It is the loss of the very status as “elite.” We address the question of deconsecration through a historical case study of the exclusion of elite groups from the Danish Who’s Who and professional bodies in the wake of the liberation after the German occupation of Denmark 1940–1945.

Mary Midgley challenges the dominant conceptions of human nature, ethics, community and ecology taught at A-Level. This article considers some of the key themes of her thinking.

Let $p$ be a prime number, $k$ a finite field of characteristic $p>0$ and $K/k$ a finitely generated extension of fields. Let $A$ be a $K$-abelian variety such that all the isogeny factors are neither isotrivial nor of $p$-rank zero. We give a necessary and sufficient condition for the finite generation of $A(K^{\mathrm {perf}})$ in terms of the action of $\mathrm {End}(A)\otimes \mathbb {Q}_p$ on the $p$-divisible group $A[p^{\infty }]$ of $A$. In particular, we prove that if $\mathrm {End}(A)\otimes \mathbb {Q}_p$ is a division algebra, then $A(K^{\mathrm {perf}})$ is finitely generated. This implies the ‘full’ Mordell–Lang conjecture for these abelian varieties. In addition, we prove that all the infinitely $p$-divisible elements in $A(K^{\mathrm {perf}})$ are torsion. These reprove and extend previous results to the non-ordinary case.

Carrot is an important vegetable crop worldwide valued for its fleshy edible roots of varied colours. Owing to its highly cross-pollinated nature and small flower size, cytoplasmic male sterility (CMS) is being utilized for hybrid development. Among different types of male sterility, petaloid CMS is widely used for hybrid carrot breeding globally. This study aimed to develop selection criteria for parents in developing heterotic F1 hybrids using CMS lines. A large number of agro-morphological traits and Simple Sequence Repeats (genomic-SSRs) were used to assess the diversity among parental lines. We developed 60 F1 hybrids by crossing four petaloid CMS lines and 15 testers in line × tester mating design and evaluated them in replicated randomized block design trial for four vegetative and 11 economic traits. The mean squares of all the traits in line × tester interactions were significant. The estimates of genetic components of variance indicated predominance of non-additive gene action except for root maturity, root length and core diameter. The hybrids with highest per se performance also had significant positive specific combining ability effects. The root yield and root weight showed highest heterosis percentage (33%). The best performing heterotic hybrids were DCatH-5392, DCatH-700 and DCatH-9892. Correlation between genetic distance and relative heterosis of economic traits indicated no significant association and thus genetic distance could not be used to predict heterosis. As most of the yield-related traits were controlled by non-additive gene action, heterosis breeding could be potentially used along with combining ability analysis to reduce time in selection of best parents and crosses in tropical carrot.

The sharpnose shark (Rhizoprionodon longurio) is among the top three shark species captured by artisanal fisheries of the Gulf of California. This study includes information regarding the feeding habits of this species using the stomach contents of 70 individuals ranged from 54 to 109 cm in total length (TL). Out of the 16 prey items identified, fish of the families Scombridae (Scomber japonicus; prey-specific relative importance index [%PSIRI] = 6.3) and Batrachoididae (%PSIRI = 5.5), the cephalopod Lolliguncula spp. (%PSIRI = 6.3), and the crustacean Pleuroncodes planipes (%PSIRI = 4.3) were the most important prey. Only female stomachs were obtained (N = 19) in the central area of the gulf, and the PSIRI indicated that the preferred prey were the cephalopod Lolliguncula spp. (%PSIRI = 10.5) and fish of the Sparidae family (Calamus brachysomus; %PSIRI = 5.8). The number of stomachs was not sufficient to analyse differences by sex. Regarding its trophic position, R. longurio was a tertiary consumer (TLK = 4.4). A TLK = 4.4 was calculated for the central area, and a TLK = 4.3 for the southern area. According to Levin's index (Bi), this shark is a specialist predator in the whole study area (Bi = 0.19), including the centre (Bi = 0.29). Conversely, it was considered a generalist predator in the southern area (Bi = 0.63). The high quantity of empty stomachs could relate to the time the sharks were caught in fishing a gear.

The interpretation of administrative policies is of great importance in contemporary public law. The correct approach to policy interpretation has, however, been subject to insufficient academic scrutiny. The effect of policies is to provide guidance: not only to decision-makers, but also to stakeholders in the decision. Obvious stakeholders include the applicant or the individual who is the subject of the administrative decision, but the scope of potential legitimate stakeholders may go far beyond this. In matters of general interest, the broader public may be guided by policy (for instance, whether to object to a proposal during a consultation exercise, or on what basis to object). When considering how policy should be interpreted, the court should have regard to the extent of the appropriate audience of the policy, specifically considering how the least expert reader of the policy would interpret it. This ‘least expert reader principle’ will assist in answering difficult questions, such as whether the court should have regard to the underlying evidence base when interpreting a policy. The courts should rely upon, and express their reasoning by reference to, the least expert reader principle, in order to increase the transparency of judgments in the field of policy interpretation.

Chemosensory proteins (CSPs) were necessary for insect sensory system to perform important processes such as feeding, mating, spawning, and avoiding natural enemies. However, their functions in non-olfactory organs have been poorly studied. To clarify the function of CSPs in the development of Mythimna separata (Walker) larvae, two CSP genes, MsCSP17 and MsCSP18, were identified from larval integument transcriptome dataset. Both of MsCSP17 and MsCSP18 contained four conserved cysteine sites (C × (6)-C × (18)-C × (2)-C), with a signal peptide at the N-terminal. RT-qPCR analysis showed that MsCSP17 and MsCSP18 have different expression patterns among different developmental stages and tissues. MsCSP17 was highly expressed in 1st–4th instar larvae, and MsCSP18 had high expression in adults. Both genes were expressed highly in larval head, thorax, integument and mandible. Moreover, both of MsCSP17 and MsCSP18 were lowly expressed in larval integuments when larvae molted for 6 h and 9 h from 3rd to 4th instar, but highly at the beginning and end phase during molting. After injection of dsMsCSP17 and dsMsCSP18, the expression levels of two genes decreased significantly, with the body weight of larvae decreased, the mortality increased, and the eclosion rate decreased. It was suggested that MsCSP17 and MsCSP18 contributed to the development of M. separata larvae.

Social, political, and economic institutions covary with one another in heterogenous ways across space and time. Social Network Analysis (SNA) offers a set of analytical tools and conceptual frameworks that have allowed for formal comparisons of interactions, affiliations, and relationships in reconstructing historical trajectories of institutional change. Although archaeologists have made full use of a range of metrics that describe the structural variation of social networks, formal approaches to analyzing the covariance of networks, and the institutions that structured networks in the past, remain undertheorized. In most cases, descriptive metrics are compared between networks built from different datasets or networks separated in time. Using quadratic assignment procedure (QAP) correlations to compare matrices of archaeological data, I draw on a ceramic dataset of approximately 350,000 sherds from the Southern Appalachian region to investigate how decisions related to manufacture choice and to stylistic design covaried with one another between roughly AD 800 and 1650. I explore how material attributes may or may not vary independently of one another and what that means for our analyses of the institutions they reflect. The results contribute to broader comparative analyses of institutional change and perennial discussions of social evolution.

Trans identities are increasingly subjected to contentious public and political debate in the UK, and this has resulted in resource to the law across various contexts. Against that background, this paper considers trans legal parenthood after the decision in R (McConnell and YY) v Registrar General for England and Wales. This judgment held that a trans man who gave birth was the legal ‘mother’ of his child. The wider consequence is that trans legal parenthood will not reflect trans identities, but birth-assigned sex/gender, regardless of whether the parent holds a gender recognition certificate. Separate from this underlying social and political context concerning trans identities, the paper argues that legal parenthood is a flexible and pragmatic concept, which lacks inherent normative content, and which has previously proved capable of accommodating a variety of different familial and reproductive circumstances. The paper argues that the gendered descriptors of ‘mother’ and ‘father’, while remaining the law's default, are not inherent to legal parenthood. Thus, the paper concludes that, despite the ongoing political and cultural debates concerning trans identities, the existing concept of legal parenthood is capable of properly recognising trans parenthood, without requiring any fundamental changes to the concept itself.