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Supersonic impinging tones have been attracting significant interest because high-intensity discrete-frequency tones pose substantial risks to structural safety in applications such as rocket launch and recovery, and space vehicle attitude adjustment. However, various issues remain to be addressed regarding the jet oscillation and tone generation mechanism. In this study, a numerical simulation of the supersonic impinging jet with a nozzle pressure ratio of 4.03 and an impingement distance of 2.08 times the nozzle exit diameter is conducted. The results show good consistency with the reference data by other researchers. A phase-locked averaging analysis of 2960 flow field snapshots is employed to investigate jet structure oscillation dynamics and the tone generation mechanism. The phase-locked averaged images reveal that the pressure variation induced by Kelvin–Helmholtz vortices as they pass through the reflected shock results in the periodic motions of the reflected shock and Mach disk. The periodically oscillating Mach disk generates high-pressure fluid masses driving recirculation bubbles through a cyclic ‘compression–generation–merging’ oscillation. The streamline oscillation and sound-ray analyses reveal there are two distinct tone source regions: the impinging zone and the wall jet region. Consequently, it is proposed that vortex collapse in conjunction with wall jet oscillations coexist to generate the tone. According to the directivity, the tone emitted from the wall jet source region is believed to contribute to the feedback loop. These findings collectively contribute to an improved understanding of the jet plume oscillation and tone generation mechanisms of the supersonic impinging jet.
Climate change is increasingly recognized as a significant driver of emerging infectious diseases, with the potential to catalyze the next global pandemic. This paper explores the complex interplay between climate change and the emergence of novel pathogens, emphasizing the environmental, ecological, and socio-economic factors that contribute to disease transmission. Rising temperatures, altered precipitation patterns, and habitat destruction are reshaping ecosystems, bringing humans into closer contact with zoonotic reservoirs and vectors. These changes amplify the risk of spillover events, as seen in recent outbreaks. The study identifies key challenges, including inadequate surveillance systems, limited global cooperation, and the disproportionate impact on vulnerable populations. Furthermore, it proposes adaptive measures such as enhanced early warning systems, integrated One Health approaches, and climate-resilient public health infrastructure. By addressing these challenges and implementing proactive strategies, the global community can mitigate the risk of a climate-driven pandemic and strengthen preparedness for future health crises. This paper underscores the urgent need for interdisciplinary collaboration and policy innovation to safeguard global health in the face of a changing climate
The dynamics of a stratified fluid in which the rotation vector is slanted at an angle with respect to the local vertical (determined by gravity) is considered for the case where the aspect ratio of the characteristic vertical scale of the motion D to the horizontal scale L is not small. In cases where the Rossby number of the flow is small the natural coordinate system is non-orthogonal and modifications to the dynamics are significant. Two regimes are examined in this paper. The first is the case in which the horizontal length scale of the motion, L, is sub-planetary where the quasi-geostrophic approximation is valid. The second is the case where the horizontal scale is commensurate with the planetary radius and so the dynamics must be formulated in spherical coordinates with imposing a full variation on the relevant components of rotation. In the quasi-geostrophic case the rotation axis replaces the direction of gravity as the axis along which the geostrophic flow varies in response to horizontal density gradients. The quasi-geostrophic potential vorticity equation is most naturally written in a non-orthogonal coordinate system with fundamental alterations in the dynamics. Examples such as the reformulation of the classical Eady problem are presented to illustrate the changes in the nature of the dynamics. For the second case where the horizontal scale is of the order of R, the planetary radius, more fundamental changes occur leading to more fundamental and difficult changes in the dynamical model.
We study nonlinear resonant triad interactions among flexural-gravity waves generated by a steadily moving load on a floating ice sheet. Of the many possible triad interactions involving at least one load-produced wave, we focus on the double-frequency case where the wavenumber of the leading wave is double that of the trailing wave. This case stands out because resonant interactions can occur with or without the presence of an ambient wave. Using multiple-scale perturbation analysis, we obtain amplitude evolution equations governing the leading-order, steady-state response. We complement the theoretical predictions with direct numerical simulations of the initial–boundary value problem using a high-order spectral method accurate to arbitrary order. Our results show that the double-frequency interaction can cause the trailing wave amplitude to decay with distance from the load, with its energy transferred to its second harmonic which radiates forwards to coherently interfere with the leading wave. Depending on the length and orientation of the load, the resonant interaction can in some cases cause the wave drag to become vanishingly small, or in other cases nearly double the maximum bending strain compared to the linear prediction. We also consider the effect of a small ambient wave that can initiate a resonant interaction in the leading wave field in addition to the trailing wave field interaction. This can result in a steady, localised wave packet containing two mutually trapped wave components, leading to vanishing wave drag. This work has potential implications for defining safe operating profiles for vehicles travelling on floating ice.
The thermocapillary flows generated by an inclined temperature gradient in and around a floating droplet are studied in the framework of the lubrication approximation. Numerical simulations of nonlinear flow regimes are fulfilled. It is shown that under the action of Marangoni stresses, a droplet typically moves as a whole. It is found that an inclined temperature gradient can lead to the excitation of periodic oscillations. With an increase of the inclination of the temperature gradient, temporally quasi-periodic oscillations have been obtained. In a definite region of parameters, an inclined temperature gradient can suppress oscillations, changing the droplet’s shape. The diagram of regimes in the plane of longitudinal and transverse Marangoni numbers has been constructed. Bistability has been found.
Despite advances in the development of systemic anticoagulants, there remain few agents approved for utilisation in patients with mechanical heart valves. Currently, recommendations for periprocedural and long-term anticoagulation in mechanical heart valves include unfractionated heparin or vitamin K antagonists, and there are some reports for off-label use of low-molecular-weight heparins. Emerging data on parenteral direct thrombin inhibitors, such as bivalirudin, have led to increased utilisation in both extracorporeal membrane oxygenation and ventricular assist devices. We present the case of a paediatric patient with rheumatic heart disease who had significant bleeding on unfractionated heparin who successfully received prolonged bivalirudin therapy in the setting of mechanical aortic and mitral heart valves.
Non-word repetition (NWR) is often utilized for the assessment of phonological short-term memory (PSTM) and as a clinical marker for language-related disorders. In this study, associations between children's language competence and their performance in language-specific NWR tasks as well as the relevance of NWR for the prediction of language development were scrutinized. German preschoolers (N = 1,801) were compared regarding their performance in NWR, German vocabulary, and articulation. For 141 children, results of a school enrolment test were available. Multilingual children performed as well as monolingual German-speaking children in NWR only under the condition of comparable German language skills. NWR performance depended on item length, children's vocabulary and articulation skills and was weakly associated with language-related medical issues. The predictive power of NWR for children's performance in the school enrolment test was minimal. To conclude, chosen German-based NWR tasks did not deliver convincing results as a clinical marker or predictor of language development.
Being deeply embedded in the mythological framework of old-school Christian angelology, the theodicy presented in this article outlines a thoroughgoing and unexpectedly simple solution to the problem of evil. Unlike other Satan-oriented theodicies, whose central idea is that natural evil is reducible to moral evil by taking the malevolent actions of demons into consideration, it accounts for both natural and moral evil in perfectly familiar deal-making terms. Of particular interest is that it makes no appeal to the overriding importance of free will nor to the inscrutability of God’s ways. Instead it envisions a primordial agreement on which everything depends. If it stands up to scrutiny, it offers an intriguing explanation for why God permits such an awful lot of badness.
Next of kin play a vital role in the informal care of older relatives in long-term-care facilities (LTCFs). However, finding a sustainable balance between everyday commitments and caring for their loved ones can be demanding, and there is a need to explore new ways to support their caregiving efforts while prioritising their wellbeing. Digital communication technologies have shown promise in enabling meaningful social interactions between older adults and their families, yet their potential to foster connections in LTCFs remains understudied. This study explores the efficacy of a communication technology called Komp in facilitating meaningful connections between next of kin and older relatives in LTCFs. It utilises Norwegian data from all public nursing homes in Oslo municipality to assess whether Komp can facilitate social contact between nursing home residents and their next of kin, and if the use of Komp impacts the next of kin’s experience of satisfaction with this contact. Based on 238 next of kin, this study uses two data sources: (1) survey data collected from all next of kin, in three waves, and (2) a highly detailed weekly data stream from each Komp device. These sources are combined and analysed using multiple regression analysis. The results generally show a positive and significant relationship between use of Komp and increased social satisfaction, indicating that Komp can serve as a valuable tool to help next of kin maintain social bonds with older relatives in LTCFs.
Spin coating is the process of generating a uniform coating film on a substrate by centrifugal forces during rotation. In the framework of lubrication theory, we investigate the axisymmetric film evolution and contact-line dynamics in spin coating on a partially wetting substrate. The contact-line singularity is regularized by imposing a Navier slip model. The interface morphology and the contact-line movement are obtained by numerical solution and asymptotic analysis of the lubrication equation. The results show that the evolution of the liquid film can be classified into two modes, depending on the rotational speed. At lower speeds, the film eventually reaches an equilibrium state, and we provide a theoretical description of how the equilibrium state can be approached through matched asymptotic expansions. At higher speeds, the film exhibits two or three distinct regions: a uniform thinning film in the central region, an annular ridge near the contact line, and a possible Landau–Levich–Derjaguin-type (LLD-type) film in between that has not been reported previously. In particular, the LLD-type film occurs only at speeds slightly higher than the critical value for the existence of the equilibrium state, and leads to the decoupling of the uniform film and the ridge. It is found that the evolution of the ridge can be well described by a two-dimensional quasi-steady analysis. As a result, the ridge volume approaches a constant and cannot be neglected to predict the variation of the contact-line radius. The long-time behaviours of the film thickness and the contact radius agree with derived asymptotic solutions.
Dean’s approximation for curved pipe flow, valid under loose coiling and high Reynolds numbers, is extended to study three-dimensional travelling waves. Two distinct types of solutions bifurcate from the Dean’s classic two-vortex solution. The first type arises through a supercritical bifurcation from inviscid linear instability, and the corresponding self-consistent asymptotic structure aligns with the vortex–wave interaction theory. The second type emerges from a subcritical bifurcation by curvature-induced instabilities and satisfies the boundary region equations. A connection to the zero-curvature limit was not found. However, by continuing from known self-sustained exact coherent structures in the straight pipe flow problem, another family of three-dimensional travelling waves can be shown to exist across all Dean numbers. The self-sustained solutions also possess the two high-Reynolds-number limits. While the vortex–wave interaction type of solutions can be computed at large Dean numbers, their branch remains unconnected to the Dean vortex solution branch.
While the majority of 2021 Capitol insurrection participants were white men, the media prominently highlighted the involvement of male conservative activists of color. However, we still know little about the perspectives of men in the general public regarding this event in our nation’s history, particularly across racial/ethnic and other identity groups. This project examines the influence of racialized anger and racial efficacy on self-identified male views toward the 2021 Capitol insurrection across racial/ethnic groups. We utilize the 2020 Collaborative Multiracial Post-Election Survey (CMPS), which was the only national, post-election dataset to yield responses on the Capitol insurrection across a large number of identity groups like men of color. Using the CMPS, we hypothesize that the level of racialized anger and racial efficacy will impact attitudes toward the 2021 Capitol insurrection for men across racial groups comparing men of color and their white male counterparts. We find racial anger has a negative effect on political attitudes about the 2021 Capitol insurrection across all groups of men, while racial efficacy has varied effects on certain men of color groups in comparison to white men. This paper underscores the importance of intersectionality in the study of public opinion formation and the effect of political attitudes like racial efficacy and racialized anger on non-traditional political engagement.
Grandparent childcare is important to support parents’ work/care reconciliation. Research has begun to identify relationships between grandparent childcare patterns and policy settings. However, this work is disparate and focused on childcare policy, with little engagement with the broader range of policies that shape grandparent childcare. A holistic approach to understanding the relationship between policies and grandparent childcare is important to capture the intergenerational dynamics of family decisions about childcare and the complementarities (or not) of policies in different domains. This scoping review identifies policies that directly aim to shape grandparents’ involvement in childcare and that indirectly shape configurations of care. Most literature focuses on childcare and parental leave policies’ impact on parental demand for grandparent childcare. But a wider, intergenerational, policy lens reveals that policies (such as retirement income policies) affect parents’ demand for, and grandparents’ supply of childcare, and that policies in different domains are not always aligned.
Patent ductus arteriosus is a common condition in preterm neonates, often necessitating medical or surgical intervention. This report presents a case of a preterm neonate born at 27 gestational weeks and who experienced patent ductus arteriosus rupture during a device closure procedure. Patent ductus arteriosus rupturing during device closure is rare and life threatening but can be successfully managed with prompt recognition and intervention.
The proto-oncogene tyrosine kinase receptor encoded by the W locus (CD-117) has been confirmed to be critical to the processes of germ cell proliferation, migration and survival in the rodent. The purpose of the present study was to examine the expression of germ cell-specific CD-117 marker in testis and germ line stem cells (GSCs). The aim of this study was analysis of CD-117 expression as germ cell marker in the seminiferous tubule of mice.
Materials and Methods:
In this experimental study, we employed a comprehensive array of techniques to scrutinize the expression of CD-117. Our analysis encompassed the utilization of immunocytochemistry, immunohistochemistry, Fluidigm real-time Reverse Transcription Polymerase Chain Reaction (RT-PCR), and flow cytometry methodologies.
Results:
The Immuno-history-fluorescent analysis revealed the distribution of the germ cell marker CD-117 in the differentiated compartment of seminiferous tubules. High-magnification of confocal microscopy analysis showed surface expression of CD-117 in testis section. Whereas isolated GSCs colonies clearly express the germ-specific protein CD-117, TSCs (testicular stromal cells) were negative for this marker. Fluidigm real-time RT-PCR result demonstrated a significant expression (P < 0.001) of CD-117 in the neonate and adult GSCs compared to TSCs cells. Similarly, flow cytometry analysis confirmed expression of CD-117 in the GSCs colonies and testis cells.
Conclusion:
These results discriminate in spite of stage-specific ectopic, expression of CD-117 is a specific germ cell marker for proliferation and differentiation of GSCs into sperm, and can be beneficial for understanding of the signalling pathways related to differentiation of GSCs.
Gravity-driven film flow in circular pipes with isolated topography was examined with fluorescence imaging for three flow rates, two angles of inclination, and four topography shapes. The time-averaged free surface response in the vicinity of the topography depended on flow rate, inclination angle and topography shape. For some flow conditions, the time-averaged free surface included a capillary ridge, and for a subset of those conditions, a series of capillary waves developed upstream with a spacing often approximated by half the capillary length. In contrast to film flow over planar topography, the capillary ridge often formed downstream of the topography, and for the lowest flow rate over rectangular step down topography, the free surface developed a steady overhang along the downstream face of the topography. Possible dynamic causes of the unique film flow behaviour in circular pipes are discussed. Transient free surface fluctuations were observed at half the magnitude reported in film flow over corrugated circular pipes, and local maxima in transient magnitude corresponded to axial locations of inflection points in the time-averaged free surface. Local maxima are related to low surface pressure regions that vary in location and amplitude. Rectangular step down topography generated an extra ridge of fluid that formed on top of the capillary ridge for flow conditions, resulting in a capillary ridge downstream of the step. The extra ridge varied in temporal duration and spatial extent, and finds no comparison in planar film flow. No evidence of periodic behaviour was detected in the transient film response.