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On July 19, 2024, the International Court of Justice (ICJ) rendered an advisory opinion on Legal Consequences Arising from the Policies and Practices of Israel in the Occupied Palestinian Territory, Including East Jerusalem. By votes of 11–4, the Court found that Israel's continued presence in the Occupied Palestinian Territory (OPT) was unlawful and needed to be ended as rapidly as possible. By a 14–1 majority, the Court also found that Israel was obligated to cease all new settlement activities, evacuate existing settlers from the OPT, and make reparation. The ICJ further opined by votes of 12–3 that all states and international organizations were obliged not to recognize as legal the situation arising from Israel's unlawful presence in the OPT, that all states must refrain from giving aid or assistance to the maintenance of that situation, and that the United Nations “should consider the precise modalities” required to bring Israel's unlawful presence in the OPT to an end.
Which additional epistemic skills or attributes must a competent journalist possess in order to produce competent science journalism? I aim to answer this question by bringing together insights from journalism, science communication, and epistemology. In Section 2, I outline the Epistemic Challenge for Science Journalism. In Section 3, I present the dominant answer in the literature, the Knowledge-Based Solution, and argue against it. In Section 4, I propose an alternative, the Confirmation-Based Solution. In Section 5, I argue that this solution can address recent concerns regarding journalistic objectivity. Section 6 discusses my proposal in the context of epistemological debates about norms of assertion. Section 7 concludes.
We describe a geometric, stable pair compactification of the moduli space of Enriques surfaces with a numerical polarization of degree $2$, and identify it with a semitoroidal compactification of the period space.
This study aims to examine the surgical outcome of Kabuki syndrome patients after neonatal congenital heart surgery.
Methods:
This was a single-centre retrospective study of Kabuki syndrome patients undergoing neonatal congenital heart surgery from 2018 to 2023. Primary outcome was survival to discharge after index surgery. Secondary outcomes were morbidities and complications. Survival and hospital length of stay were compared to neonates with non-Kabuki genetic anomalies undergoing congenital heart surgery in the same time period.
Results:
A total of seven patients were reviewed. All Kabuki syndrome patients had left-sided lesions including three with hypoplastic left heart syndrome, three with aortic stenosis and/or aortic arch hypoplasia, and one with an isolated coarctation of aorta. Hospital survival was 5/7 (71% compared to 88% for neonates with non-Kabuki genetic anomalies). To date, four remain alive, including one with hypoplastic left heart syndrome. A higher percentage of Kabuki syndrome patients had unplanned interventions (43% vs 15% in non-Kabuki), abnormal brain imaging (29% vs 5%), and bacteremia (29% vs 9%). Median total ventilator days for Kabuki patients were also longer (16 days vs 6 days in non-Kabuki) as was hospital length of stay (66 days vs 41 days).
Conclusions:
Despite survival to discharge after index operation, Kabuki syndrome patients with single ventricle physiology remain at high risk of mortality and morbidity after cardiac surgery. However, they may be discharged without ventilator dependency and survive to toddler years.
Liouville-type theorems for the steady incompressible Navier–Stokes system are investigated for solutions in a three-dimensional (3-D) slab with either no-slip boundary conditions or periodic boundary conditions. When the no-slip boundary conditions are prescribed, we prove that any bounded solution is trivial if it is axisymmetric or $ru^r$ is bounded, and that general 3-D solutions must be Poiseuille flows when the velocity is not big in $L^\infty$ space. When the periodic boundary conditions are imposed on the slab boundaries, we prove that the bounded solutions must be constant vectors if either the swirl or radial velocity is independent of the angular variable, or $ru^r$ decays to zero as $r$ tends to infinity. The proofs are based on the fundamental structure of the equations and energy estimates. The key technique is to establish a Saint-Venant type estimate that characterizes the growth of the Dirichlet integral of non-trivial solutions.
We say that a Kripke model is a GL-model (Gödel and Löb model) if the accessibility relation $\prec $ is transitive and converse well-founded. We say that a Kripke model is a D-model if it is obtained by attaching infinitely many worlds $t_1, t_2, \ldots $, and $t_\omega $ to a world $t_0$ of a GL-model so that $t_0 \succ t_1 \succ t_2 \succ \cdots \succ t_\omega $. A non-normal modal logic $\mathbf {D}$, which was studied by Beklemishev [3], is characterized as follows. A formula $\varphi $ is a theorem of $\mathbf {D}$ if and only if $\varphi $ is true at $t_\omega $ in any D-model. $\mathbf {D}$ is an intermediate logic between the provability logics $\mathbf {GL}$ and $\mathbf {S}$. A Hilbert-style proof system for $\mathbf {D}$ is known, but there has been no sequent calculus. In this paper, we establish two sequent calculi for $\mathbf {D}$, and show the cut-elimination theorem. We also introduce new Hilbert-style systems for $\mathbf {D}$ by interpreting the sequent calculi. Moreover, we show that D-models can be defined using an arbitrary limit ordinal as well as $\omega $. Finally, we show a general result as follows. Let X and $X^+$ be arbitrary modal logics. If the relationship between semantics of X and semantics of $X^+$ is equal to that of $\mathbf {GL}$ and $\mathbf {D}$, then $X^+$ can be axiomatized based on X in the same way as the new axiomatization of $\mathbf {D}$ based on $\mathbf {GL}$.
This review aimed to assess the impact of okra (Abelmoschus esculentus L.) consumption on CVD risk factors. Relevant studies were identified through electronic searches of databases, including PubMed, Scopus, Web of Science, CENTRAL and EMBASE, up to January 2025. Twelve trials involving 770 participants with interventions ranging from 2 to 12 weeks and doses varying from 125 to 40 000 mg/d were included. Okra supplementation significantly reduced BMI (standardised mean difference (SMD) = −0·70; 95 % CI −1·23, −0·16; P = 0·011), fat mass (SMD = −0·74; 95 % CI −1·13, −0·36; P < 0·001), hip circumference (SMD = −0·85; 95 % CI −1·41, −0·28; P = 0·003), weight (SMD = −0·77; 95 % CI −1·42, −0·11; P = 0·022), fasting insulin (SMD = −0·35; 95 % CI −0·63, −0·07; P = 0·013), fasting plasma glucose (SMD = −1·07; 95 % CI −1·75, −0·38; P = 0·002), HbA1c (SMD = −0·38; 95 % CI −0·71, −0·05; P = 0·023), homeostatic model assessment of insulin resistance (SMD = −0·56; 95 % CI −0·84, −0·29; P < 0·001), LDL-cholesterol (SMD = −0·32; 95 % CI −0·52, −0·11; P = 0·003), total cholesterol (SMD = −0·45; 95 % CI −0·74, −0·16; P = 0·003) and aspartate aminotransferase (SMD = −0·45; 95 % CI −0·73, −0·17; P = 0·002). Okra supplementation demonstrated significant benefits in improving anthropometric measures, glycaemic control, lipid profiles and liver function tests, suggesting its potential as an adjunct therapy for improving CVD risk factors.
Small-scale shear layers arising from the turbulent motion of viscoelastic fluids are investigated through direct numerical simulations of statistically steady, homogeneous isotropic turbulence in a fluid described by the FENE-P model. These shear layers are identified via a triple decomposition of the velocity gradient tensor. The viscoelastic effects are examined through the Weissenberg number ($\textit{Wi}$), representing the ratio of the longest polymer relaxation time scale to the Kolmogorov time scale. The mean flow around these shear layers is analysed within a local reference frame that characterises shear orientation. In both Newtonian and viscoelastic turbulence, shear layers appear in a straining flow, featuring stretching in the shear vorticity direction and compression in the layer normal direction. Polymer stresses are markedly influenced by the shear and strain, which enhance kinetic energy dissipation due to the polymers. The shear layers in viscoelastic turbulence exhibit a high aspect ratio, undergoing significant characteristic changes once $\textit{Wi}$ exceeds approximately 2. As $\textit{Wi}$ increases, the extensive strain weakens, diminishing vortex stretching. This change coincides with an imbalance between extension and compression in the straining flow. In the shear layer, the interaction between vorticity and polymer stress causes the destruction and production of enstrophy at low and high $\textit{Wi}$ values, respectively. Enstrophy production at high $\textit{Wi}$ is induced by normal polymer stress oriented along the shear flow, associated with the diminished extensive strain. The $\textit{Wi}$-dependent behaviour of these shear layers aligns with the overall flow characteristics, underscoring their pivotal roles in vorticity dynamics and kinetic energy dissipation in viscoelastic turbulence.
Sodium-glucose cotransporter-2 inhibitors reduce cardiovascular outcomes in patients with congestive heart failure and a biventricular circulation. Congestive heart failure in Fontan univentricular circulation is distinctly different. Experience with sodium-glucose cotransporter-2 inhibitors in this group has not yet been well described.
Objectives:
This work describes safety and tolerability of sodium-glucose cotransporter-2 inhibitors in patients with Fontan circulation.
Methods:
Single-centre review of patients with Fontan circulation prescribed a sodium-glucose cotransporter-2 inhibitors for congestive heart failure. Primary outcome was tolerability or need for discontinuation. Secondary outcomes were changes in New York Heart Association class, congestive heart failure hospitalisation, ventricular function, exercise performance, and laboratory values.
Results:
We identified 25 patients with Fontan circulation prescribed an sodium-glucose cotransporter-2 inhibitors, most with a systemic right ventricle. Over a third of subjects had at least moderately reduced baseline ventricular function. Baseline catheterisation showed a mean Fontan pressure of 17.1 ± 3.7 mmHg and pulmonary capillary wedge pressure 11.7 ± 3.2 mmHg at rest; 59% had occult diastolic dysfunction with abnormal pulmonary capillary wedge pressure elevation following volume expansion. Most were on congestive heart failure medications and/or a pulmonary vasodilator prior to sodium-glucose cotransporter-2 inhibitors addition, and three had a congestive heart failure hospitalisation within the previous year. All reported good medication tolerance except one patient was nonadherent to medications and two discontinued sodium-glucose cotransporter-2 inhibitors for perceived side effects. There were no significant differences in secondary outcomes. There was, however, a downward trend of serum brain natriuretic peptide (n = 13) and improved peak VO2 (n = 6), though neither statistically significant (p > 0.05).
Conclusion:
This series, the largest published to date, suggests that sodium-glucose cotransporter-2 inhibitors are safe and tolerable congestive heart failure therapy in Fontan circulation. Further research is warranted to explore therapy in this unique population.
This article explores the potential of 3,4-methylenedioxymethamphetamine (MDMA)-assisted therapy to enhance exposure and response prevention in obsessive–compulsive disorder treatment. We discuss the mechanisms of MDMA, including fear extinction, psychological flexibility, and empathogenic effects that may improve adherence and efficacy, as well as highlighting important safety considerations for further research.
wh-fronting questions (as in English) are analyzed as wh-movement while wh-in-situ questions (as in Chinese) are analyzed as LF movement or unselective binding. Optionality between the two types of questions is observed in many languages, however, upon closer inspection, a stream of previous literature argues that only one strategy is truly available in any given language. Cheng (1991) and Faure & Palasis (2021) argue that wh-fronting languages in Indonesian and Colloquial French are not derived by wh-movement, while Chang (2016) argues that wh-in-situ questions in Colloquial Singapore English (CSE) are not derived from unselective binding or LF movement but are declarative syntax questions. Bobaljik & Wurmbrand (2015) explicitly propose that a language can either have the true wh-in-situ or the wh-movement strategy, but not both.
This paper uses CSE as a case study and argues that it allows true wh-movement and true wh-in-situ questions. CSE has been argued to only allow wh-movement by some (Chang 2016) and to only allow wh-in-situ by others (Lan 2016). This study experimentally tests the predictions made by these analyses and shows that the patterns are best accounted for if both ‘true’ wh-movement and ‘true’ wh-in-situ questions exist in CSE (see also Sato & Ngui 2017), thus challenging the previous analyses for CSE, and the cross-linguistic generalization in Bobaljik & Wurmbrand 2015.
Hospital-onset bacteremia and fungemia (HOB) has been suggested as a suitable and automatable surveillance target to include in surveillance programs, however differences in definitions across studies limit interpretation and large-scale implementation. We aimed to apply an automated surveillance system for HOB in multiple hospitals using a consensus definition, and describe HOB rates.
Design and setting:
Retrospective cohort study in four Dutch hospitals: 1 tertiary hospital and 3 secondary hospitals.
Patients:
All patients admitted for at least one overnight stay between 2017 and 2021 were included, except patients in psychiatry wards.
Methods:
Data from the electronic health records and laboratory information system were used to identify HOBs based on the PRAISE consensus definition. HOB rates were calculated at ward and micro-organism-level.
Results:
Hospital-wide HOB rates varied from 1.0 to 1.9, and ICU rates varied from of 8.2 to 12.5 episodes per 1000 patient days. The median time between admission and HOB was 8–13 days. HOBs were predominantly caused by Enterobacterales, Enterococci, S. aureus and coagulase-negative staphylococci. Longitudinal HOB surveillance detected differences over time at ward and micro-organism level; for example increased HOB rates were observed during the COVID-19 pandemic. Sensitivity analyses demonstrated the impact of assumptions regarding the collection of confirmatory blood cultures for common commensals.
Conclusions:
Applying a fully automated definition for HOB surveillance was feasible in multiple centers with different data infrastructures, and enabled detection of differences over time at ward and micro-organism-level. HOB surveillance may lead to prevention initiatives in the future.
In this research, we examine redistricting plan review by state supreme courts to determine what factors influence party-aligned voting in judicial decisions. We analyze whether judicial selection systems matter, as well as the ideological extremism of judges. Our judge-level data includes votes on redistricting cases heard across the American states from 1961 to 2022. We find that judges who are ideologically extreme are more likely to cast party-aligned votes, but only when selected by appointment with life tenure or by partisan elections.
The paleopedology of the world’s largest retrogressive thaw slump, Batagay, is understudied. Micromorphological and geochemical analysis reveal the properties of th host sediments and major pedogenic features. Epigenetic soil profiles of Marine Oxygen Isotope Stage (MIS) 7 (or older) and 5e are clearly distinguished and well developed due to favorable bioclimatic conditions for pedogenesis, probably similar to modern ones. The oldest unit contains a paleosol similar to a Histic Reductaquic Cryosol, indicating a peat-covered, boggy environment. The MIS 5e unit contains organic-rich Histic Spodic Cryosol with well-developed structure, formed during the interglacial optimum, which was relatively warm and presumably resembled modern bioclimatic conditions. MIS 4–3 deposits contains soil-like bodies enriched in coarse organogenic material resembling incipient Histic Reductaquic Cryosols. Interglacial/interstadial units contain micromorphological evidence of aggregate and pore formation, Fe-oxide and organic matter redistribution and clay accumulation. Stadial deposits show weakly expressed soil structure with uneven aggregates, cryogenic disintegration of plant detritus and rare evidence of accumulation of humic substances. Major elemental ratios indicate intensification of biochemical weathering in paleosols and soil-like bodies. Pedogenically reworked material of stadial sedimentary units with sporadic and incipient soil-like bodies provide a significant source for paleoenvironmental reconstruction of harsh Late Pleistocene environments.