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From the bottom to the top of society, many white men are angry. This article provides a reputation-based rationale for this anger. Individuals care about their social status (elite vs. non-elite) and their social reputation (how they expect others to perceive them). Everyone is uncertain about how one becomes a member of the elite. When new information reveals that the system is biased in favor of white men, the social reputation of all white men decreases, causing a payoff loss. In contrast, policies meant to reduce inequalities in the access to the elite can be supported by some white men and opposed by others. The article highlights how the backlash from white men in recent years needs not be driven by racial animus or sexism and may instead be caused by a loss of status and/or reputation.
Several authors suggest that greater vegetation complexity provides more shelters, supporting higher parasitoid diversity. Additionally, it serves as visual cue in host searching. This study evaluates how visual stimuli and herbivore-induced vegetation changes affect parasitoid strategies and guilds in low deciduous forest [Yabucu], and Medium Semi-Evergreen forest [Noh-Bec]. We calculated the relative abundance of idiobiont and koinobiont life strategies for each vegetation type and constructed the range-abundance curves of these communities. Also, the relationship of guilds with the different types of damage from herbivory and leaf characteristics were described. The koinobiont:idiobiont (K:I) ratio was 6:1 (86.65% koinobionts and 13.35% idiobionts) in Yabucú and 1:2 (32.78% koinobionts and 67.22% idiobionts) in Noh-Bec. Some guilds were associated with vegetation: a negative correlation between fluctuating asymmetry seedlings (FAS) and parasitoids attacking larvae into the fruiting bodies of fungi was founded; the FAS is an indirect indicator of herbivory, nonetheless, the parasitoids found do not target phytophagous hosts, which makes an inverse relationship plausible and could potentially reduce intra-guild competition. Hyperparasitoids were positively associated with holes in adult plants (HA); with an association with herbivore parasitoids, which could be contributing to the recorded evidence of holes.
The prenatal and early-life periods pose a crucial neurodevelopmental window whereby disruptions to the intestinal microbiota and the developing brain may have adverse impacts. As antibiotics affect the human intestinal microbiome, it follows that early-life antibiotic exposure may be associated with later-life psychiatric or neurocognitive outcomes.
Aims
To explore the association between early-life (in utero and early childhood (age 0–2 years)) antibiotic exposure and the subsequent risk of psychiatric and neurocognitive outcomes.
Method
A search was conducted using Medline, PsychINFO and Excerpta Medica databases on 20 November 2023. Risk of bias was assessed using the Newcastle-Ottawa scale, and certainty was assessed using the grading of recommendations, assessment, development and evaluation (GRADE) certainty assessment.
Results
Thirty studies were included (n = 7 047 853 participants). Associations were observed between in utero antibiotic exposure and later development of autism spectrum disorder (ASD) (odds ratio 1.09, 95% CI: 1.02–1.16) and attention-deficit hyperactivity disorder (ADHD) (odds ratio 1.19, 95% CI: 1.11–1.27) and early-childhood exposure and later development of ASD (odds ratio 1.19, 95% CI: 1.01–1.40), ADHD (odds ratio 1.33, 95% CI: 1.20–1.48) and major depressive disorder (MDD) (odds ratio 1.29, 95% CI: 1.04–1.60). However, studies that used sibling control groups showed no significant association between early-life exposure and ASD or ADHD. No studies in MDD used sibling controls. Using the GRADE certainty assessment, all meta-analyses but one were rated very low certainty, largely owing to methodological and statistical heterogeneity.
Conclusions
While there was weak evidence for associations between antibiotic use in early-life and later neurodevelopmental outcomes, these were attenuated in sibling-controlled subgroup analyses. Thus, associations may be explained by genetic and familial confounding, and studies failing to utilise sibling-control groups must be interpreted with caution. PROSPERO ID: CRD42022304128
Monkeypox, a viral zoonotic disease, is currently spreading in Pakistan, raising serious public health concerns. Despite its rarity, the disease has the potential to spread rapidly, especially in areas with a limited health care infrastructure. This short communication overviews the current epidemiology of monkeypox in Pakistan, addressing diagnostic, surveillance, and control challenges, and aims to inform evidence-based prevention. We emphasize the need for enhanced surveillance, improved diagnostic capacity, and targeted public health interventions to prevent outbreaks and minimize the impact of the disease on public health.
This study analyses the current literature to evaluate the effectiveness of dabrafenib and trametinib in the multi-modal treatment of anaplastic thyroid cancer (ATC).
Method
A systematic review and meta-analysis of the literature were undertaken. The primary endpoint measured was overall response rate (ORR) defined by the RECIST v1.1 guidelines. Secondary endpoints were 12-month overall survival (OS), median OS and progression-free survival (PFS).
Results
Of 656 identified reports, 8 studies were included which featured 95 patients (median age 68.5 years, 46 per cent male). Median follow-up period was 11.8 months with a 12-month OS of 51 per cent. Median OS was 10.4 months. Progression-free survival (PFS) was 6.5 months. The ORR was 71 per cent. A total of 65 patients exhibited a partial or complete response in radiological tumour size. Side effects compared favourably to other kinase inhibitors.
Conclusion
Dabrafenib and trametinib exhibit a promising tumour response with a tolerable side profile. BRAF/MEK inhibitors continue to provide robust responses in BRAF-mutated ATC. The heterogeneity and lack of controls in included studies limits the confidence in the conclusions drawn.
Presidents possess vast authority to change policy unilaterally. But their power depends on the compliance of unelected officials, who typically have more information. We examine the conditions under which presidents invest in costly oversight of the bureaucracy. We identify an underlying political process—the polarization of an agent’s potential principals—and argue that because this increases the potential for future policy losses for presidents, they create new means of overseeing agency behavior. To test this argument, we examine abortion restrictions in foreign aid, leveraging archival records and interviews with former officials. Most importantly, this allows us to study prohibitions that were proposed but not adopted. We find that as abortion became an essential part of party competition for the presidency, Republican presidents increased their investment in oversight, which eroded bureaucrats ability to moderate presidential power over abortion abroad.
The motion of small non-spherical particles is often studied using the unsteady Stokes equations. Zhang & Stone (J. Fluid Mech., vol. 367, 1998, pp. 329–358) reported an asymptotic treatment for nearly spherical particles, to first order in particle non-sphericity, i.e. $O(\epsilon )$, where $\epsilon$ quantifies the shape deviation from a sphere. Importantly, key physical phenomena are absent at $O(\epsilon )$, including (1) coupling between the torque experienced by the particle and its linear translation, (2) coupling between the force the particle experiences and its rotation and (3) the effect of non-sphericity on the orientation averages of these forces and torques. We present an explicit asymptotic theory to second order in particle non-sphericity, i.e. $O(\epsilon ^2)$, for the force and torque acting on a particle in a general unsteady Stokes flow. The derived analytical formulae apply to particles of arbitrary shape, providing the leading-order asymptotic theory for the three above-mentioned phenomena. The theory is demonstrated for several example nearly spherical particles including a spheroid, a ‘pear-shaped’ particle and a simple model for a SARS-CoV-2 virion. This includes formulae for force and torque as a function of particle orientation and their corresponding orientation averages. Our study reveals that the orientation-averaged forces and torques experienced by a nearly spherical particle cannot be generally represented by a perfect sphere. The reported formulae are validated using finite-amplitude three-dimensional direct numerical simulations of the Navier–Stokes equations. A Mathematica notebook is also provided, facilitating implementation of the theory for particle shapes of the user's choosing.
And they will long to have heard Joachim's violin-playing as we long to have heard Bach at his organ: not from curiosity to verify an old record of technical prowess, but from the desire to recover the unrecorded manifestations of a creative mind.
The current unilateral and bilateral governance agreement cannot solve problems such as the large strength gap, loose organisation, and cultural diversity in cross-border data flow in Asia. Therefore, we are in urgent need of structuring a multilateral governance mechanism, that is, to build a mutual trust platform for cross-border data flow in Asia. From a digital technology perspective, the Asian Cross-Border Data Flow Trust Platform is a blockchain-based digital technology architecture. From the perspective of the organisational model, the Asian cross-border data flow governance based on the mutual trust platform can be understood as a cooperative network in which multiple Asian countries cooperate to make cross-border data decisions. As a necessary medium to eliminate the complexity of the cooperation network, legal procedures will transform the chaos on the Asian Cross-Border Data Flow Mutual Trust Platform into order by simplifying the communication between multiple agents.
We investigate the effect of three-dimensionality on the synchronisation characteristics of the wake behind an oscillating circular cylinder at ${\textit {Re}} = 300$. Cylinder oscillations in rotation, transverse translation and streamwise translation are considered. We utilise phase-reduction analysis, which quantifies the phase-sensitivity function of periodic flows, to examine the synchronisation properties. Here, we present an ensemble-based framework for phase-reduction analysis to handle three-dimensional wakes that are not perfectly time-periodic. Based on the phase-sensitivity functions, synchronisability to three types of cylinder oscillations is evaluated. In spite of similar trends, we find that phase-sensitivity functions involving three-dimensional wakes are lower in magnitude compared with those of two-dimensional wakes, which leads to narrower conditions for synchronisation to weak cylinder oscillations. We unveil that the difference between the phase-sensitivity functions of two- and three-dimensional flows is strongly correlated to the amplitude variation of the three-dimensional flow by the cylinder motions. This finding reveals that the cylinder motion modifies the three-dimensionality of the wake as well as the phase of vortex shedding, which leads to reduced phase modulation. The synchronisation conditions of three-dimensional wakes, predicted by phase-reduction analysis, agree with the identification by parametric studies using direct numerical simulations for forced oscillations with small amplitudes. This study presents the potential capability of phase-reduction to study synchronisation characteristics of complex flows.
To aid in prediction of turbulent boundary layer flows over rough surfaces, a new model is proposed to estimate hydrodynamic roughness based solely on geometric surface information. The model is based on a fluid-mechanics motivated geometric parameter called the wind-shade factor. Sheltering is included using a rapid algorithm adapted from the landscape shadow literature, while local pressure drag is estimated using a piecewise potential flow approximation. Similarly to evaluating traditional surface parameters such as skewness or average slope magnitude, the wind-shade factor is purely geometric and can be evaluated efficiently from knowing the surface elevation map and the mean flow direction. The wind-shade roughness model is applied to over 100 different surfaces available in a public roughness database and some others, and the predicted sandgrain-roughness heights are compared with measured values. Effects of various model ingredients are analysed, and transitionally rough surfaces are treated by adding a term representing the viscous stress component.
We establish a theoretical framework for predicting friction and heat transfer coefficients in variable-property forced air convection. Drawing from concepts in high-speed wall turbulence, which also involves significant temperature, viscosity and density variations, we utilize the mean momentum balance and mean thermal balance equations to develop integral transformations that account for the impact of variable fluid properties. These transformations are then applied inversely to predict the friction and heat transfer coefficients, leveraging the universality of passive scalars transport theory. Our proposed approach is validated using a comprehensive dataset from direct numerical simulations (DNS), covering both heating and cooling conditions up to a friction Reynolds number $\textit {Re}_\tau \approx 3200$. The predicted friction and heat transfer coefficients closely match the DNS data with accuracy margin 1–2 %, representing a significant improvement over the current state of the art.
Public health crises like Covid-19 profoundly influence informal care-givers of older adults with functional health limitations. This study deepens existing understanding of care-giving processes during the pandemic to uncover insights useful for developing effective care-giving interventions for the post-pandemic era and future public health crises. Specifically, it examined (1) how care-giving activities during the pandemic impacted care-giver psychological wellbeing by affecting caregiving burden and the positive aspects of caregiving and (2) the moderating effect of pandemic-specific factors (i.e., care recipients’ unmet health-care needs due to the pandemic). Multiple-group analyses were conducted on data on 906 informal care-givers of older adults with functional health limitations, obtained from the Covid-19 Supplement and Round 10 Survey of the National Health and Aging Trends Study conducted in the United States. The mean age of participants was approximately 60 years, and most were white women. Positive aspects of care-giving significantly mediated the relationships between providing assistance in activities of daily living (ADL), instrumental ADL, and emotional support and positive affect. Care-giving burden significantly mediated the relationship between assistance in ADL and positive and negative affect. Care recipients’ unmet health-care needs moderated the relationships between assistance in ADL and burden, assistance in ADL and negative affect, and emotional support and positive affect. In sum, this study underscores the positive aspects of care-giving as well as care-giving burden and demonstrates that greater attention should be paid to care-givers caring for individuals with unmet health-care needs during public health crises. The results suggest that more-effective responses to public health crises must be developed, especially within health-care systems.
To meet the development needs of aeroengines for high thrust-to-weight ratios and fuel-air ratios, a high temperature rise triple-swirler main combustor was designed with a total fuel-air ratio of 0.037, utilising advanced technologies including staged combustion, multi-point injection and multi-inclined hole cooling. Fluent software was used to conduct numerical simulations under both takeoff and idle conditions, thereby obtaining the distribution characteristics of the velocity and temperature fields within the combustor, as well as the generation of pollutants. The simulation results indicate that under takeoff conditions, the high temperature rise triple-swirler combustor achieves a total pressure loss coefficient of less than 6% and a combustion efficiency exceeding 99%. Under takeoff conditions, the OTDF and RTDF values are 0.144 and 0.0738, respectively. The mole fraction of NOx emissions is 3,700ppm, while the mole fraction of soot emissions is 2.55×10−5ppm. Under idle conditions, the triple-swirler combustor maintains a total pressure loss coefficient of less than 6% and a combustion efficiency greater than 99.9%. The OTDF and RTDF values are 0.131 and 0.0624, respectively. The mole fractions of CO and UHC emissions are both 0×10−32ppm at the calculation limit of Fluent software.