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We derive large-sample and other limiting distributions of components of the allele frequency spectrum vector, $\mathbf{M}_n$, joint with the number of alleles, $K_n$, from a sample of n genes. Models analysed include those constructed from gamma and $\alpha$-stable subordinators by Kingman (thus including the Ewens model), the two-parameter extension by Pitman and Yor, and a two-parameter version constructed by omitting large jumps from an $\alpha$-stable subordinator. In each case the limiting distribution of a finite number of components of $\mathbf{M}_n$ is derived, joint with $K_n$. New results include that in the Poisson–Dirichlet case, $\mathbf{M}_n$ and $K_n$ are asymptotically independent after centering and norming for $K_n$, and it is notable, especially for statistical applications, that in other cases the limiting distribution of a finite number of components of $\mathbf{M}_n$, after centering and an unusual $n^{\alpha/2}$ norming, conditional on that of $K_n$, is normal.
The Hobbesian problem of order has been central to international relations (IR) pedagogy. What are the political implications of this pedagogy? Giving students conceptual tools to understand world politics feels vital in this moment of anxiety about the erosion of the current international order. But some of the deepest threats to international order are rooted in a multiplicity of justice claims. IR's explanatory orientation, and the many biases underlying its anchoring concepts, limit our ability as educators to make sense of those threats in the language of the discipline. How do we teach IR, then, without socializing students into a problematic discipline that only reproduces the existing order? I propose that rather than jettison our disciplinary concepts and frames with their baked-in injustices, we can reorient our teaching about them. Drawing on history and mythology, I focus on the Westphalian myth that anchors IR's central question: Given states, how can international order be produced? I suggest another version of the myth that foregrounds how order and justice, the explanatory and the normative, are entangled all the way down. This revised Westphalian myth urges us to think of recognition of political units—a justice claim—as intrinsic to ordering decisions.
Understanding the origins of policy ideas can be crucial when trying to explain dynamics of political change and continuity. Paradigmatic changes in the German pension system have been attributed to the import of “foreign” neoliberal policy ideas from transnational organizations and other countries. The literature describes such processes as policy diffusion, transfer, or translation. In contrast, this article argues that foreign pension ideas did not have a substantive influence on local policy innovations and preference-formation processes. Instead, pension policy pioneers developed their ideas predominantly “from within” through bricolage by reconfiguring long-standing domestic schools of thought. Drawing on a wide range of primary and secondary sources, the analysis combines a broad historical perspective with case studies of individual policy makers. This sheds new light on the careers of ideas and why significant actors pick them up at certain points.
Droplet impingement on a heated substrate is the fundamental process underlying various technologies, ranging from spray cooling to inkjet printing. Understanding the coupled effects of fluid dynamics and heat transfer patterns during droplet jumping, boiling and evaporation, which determine the outcomes of the impingement process, is essential. Here, we developed two-colour planar laser-induced fluorescence and micro-particle image velocimetry technologies to measure quantitatively the velocity and temperature distributions inside the droplet during an impingement process with high temporal and spatial resolution. With our novel measuring system, the hot spots at the solid–liquid interface are discovered for the first time. The influence of contact boiling on the droplet internal mixing, which impedes droplet recoiling and reduces the rebounding velocity, is discussed. A significant enhancement in heat absorption for partially rebounding droplets is discovered, where the impingement heat transfer rate is doubled compared to other vapour-layer-covered droplets. The scaling correlations of viscous dissipation rate and contact time of rebounding droplets, as well as the time variation of droplet temperature rise, are proposed. More detailed patterns inside droplets can be captured by these experimental methods, which will help to reveal more intrinsic mechanisms lying in thermally induced flow, complex fluids and droplet-impacting-based technologies.
In Iberia, ditched enclosures appeared during the Copper Age (late fourth to third millennium bc). These sites are linked by their circular organization, communal labour investment, and complex temporality, but vary markedly in their distribution, function, and scale. Though archaeological attention has focused on ‘mega-sites’, an assessment of small-scale enclosures in marginal environments is key to understanding the social dynamics that facilitated their emergence. Here, the authors present results from Los Melgarejos (Getafe, Spain), the first Iberian Chalcolithic enclosure (3 ha) to be extensively documented, with all structures and seven per cent of the enclosure ditches excavated. Bioarchaeology, mortuary archaeology, isotope analyses (δ13Cco, δ13Cap, δ15N), and radiocarbon dating are employed to compare lived experiences of diet, stress, trauma, and funerary ritual at small- and large-scale enclosures. Comparisons with the mega-site of Marroquíes reveal similarities in lived experience and ritual practice, as well as regional differences in dietary isotopes, highlighting the utility of multiscalar comparisons for understanding prehistoric lifeways.
We report a unique case of an adolescent patient with Fontan physiology presenting with unconjugated hyperbilirubinemia due to dehiscence of a tricuspid valve annuloplasty ring.
Historically, the higher education curriculum in business degrees has contained little or no Aboriginal and Torres Strait Islander (herein ‘Indigenous’) content. With the increase in awareness at the societal level, Australian university business schools need to change and design the curriculum, so that students graduate with the capability to engage with Indigenous businesses, individuals, and communities while understanding contemporary policy and business including sustainability, Human Resources, supply chain, and governance. First, secondary data from Australian Department of Education, Skills, and Employment were collected on Indigenous and non-Indigenous higher education students is presented to establish the current levels of student’s access and completion rates in management, commerce and business areas. Secondly, focus groups were held to gain the views of educators who have taught Indigenous curriculum in Foundation business and commerce curriculum and share their perceptions of the impact of this on students and themselves. The secondary data presented show the imperative of providing strategies to support and opportunities to Indigenous students and that by embedding Indigenous knowledge students can build awareness and connection leading to short and long term improvements. Information gathered from the research can be used to support the largely positive impact teaching Indigenous curriculum thereby addressing government policies in closing the gap of education and employment.
This article scrutinizes public contestations over Black history during 1963's Emancipation Centennial. Specifically, it investigates how the Kennedy administration censored the historian John Hope Franklin's drafts for the chief commemorative effort Freedom to the Free, a history of civil rights since 1863. Reflecting the hubris of mid-twentieth-century racial liberalism, these edits excised white supremacy from American history, instead celebrating a confining definition of racial progress that prioritized Black equalization, adjustment, and incorporation into a deracialized liberal nationhood. The censoring of Franklin's dissident Americanism therefore highlights how racial liberalism simultaneously promoted and suppressed Black history, historians, and public figures more generally.
Why did the human brain evolve? This study develops a Malthusian growth model with heterogeneous agents and natural selection to explore the evolution of human brain size. We find that if the cognitive advantage of a larger brain dominates its higher metabolic costs, then the average brain size increases over time, which is consistent with the rising trend in human brain size that started over 2 million years ago. Furthermore, an improvement in hunting-gathering productivity (e.g., the discovery of using stone tools and fire in hunting animals and cooking food) helps to trigger this human brain size evolution. As the average brain size increases, the average level of hunting-gathering productivity also rises over time. Quantitatively, our model is able to replicate the trend in hominin brain evolution over the last 10 million years.
Let G be a split connected reductive group defined over $\mathbb {Z}$. Let F and $F'$ be two non-Archimedean m-close local fields, where m is a positive integer. D. Kazhdan gave an isomorphism between the Hecke algebras $\mathrm {Kaz}_m^F :\mathcal {H}\big (G(F),K_F\big ) \rightarrow \mathcal {H}\big (G(F'),K_{F'}\big )$, where $K_F$ and $K_{F'}$ are the mth usual congruence subgroups of $G(F)$ and $G(F')$, respectively. On the other hand, if $\sigma $ is an automorphism of G of prime order l, then we have Brauer homomorphism $\mathrm {Br}:\mathcal {H}(G(F),U(F))\rightarrow \mathcal {H}(G^\sigma (F),U^\sigma (F))$, where $U(F)$ and $U^\sigma (F)$ are compact open subgroups of $G(F)$ and $G^\sigma (F),$ respectively. In this article, we study the compatibility between these two maps in the local base change setting. Further, an application of this compatibility is given in the context of linkage – which is the representation theoretic version of Brauer homomorphism.
The field of developmental psychopathology has grown broadly. Here, I draw upon lessons learned from Dante Cicchetti to highlight areas that show promise for continued disciplinary advancement. These include attention to equifinality and multifinality in the conceptualization of initial study designs, and more emphasis on specificity in accounting for developmental change. A shift from reliance on external events and towards greater diversity of research approaches will allow researchers to devote attention to the variety of ways that individuals come to understand and then respond to their own life experiences. The field of developmental psychopathology holds tremendous promise for advancing basic science about human development that can be applied to create interventions that improve the well-being of individuals and address significant societal issues.
The incidence of obesity-related glomerulopathy (ORG) is rising worldwide with very limited treatment methods. Paralleled with the gut–kidney axis theory, the beneficial effects of butyrate, one of the short-chain fatty acids (SCFA) produced by gut microbiota, on metabolism and certain kidney diseases have gained growing attention. However, the effects of butyrate on ORG and its underlying mechanism are largely unexplored. In this study, a mice model of ORG was established with a high-fat diet feeding for 16 weeks, and sodium butyrate treatment was initiated at the 8th week. Podocyte injury, oxidative stress and mitochondria function were evaluated in mice kidney and validated in vitro in palmitic acid-treated-mouse podocyte cell lines. Further, the molecular mechanisms of butyrate on podocytes were explored. Compared with controls, sodium butyrate treatment alleviated kidney injuries and renal oxidative stress in high-fat diet-fed mice. In mouse podocyte cell lines, butyrate ameliorated palmitic acid-induced podocyte damage and helped maintain the structure and function of the mitochondria. Moreover, the effects of butyrate on podocytes were mediated via the GPR43-Sirt3 signal pathway, as evidenced by the diminished effects of butyrate with the intervention of GPR43 or Sirt3 inhibitors. In summary, we conclude that butyrate has therapeutic potential for the treatment of ORG. It attenuates high-fat diet-induced ORG and podocyte injuries through the activation of the GPR43-Sirt3 signalling pathway.
The paper by Castaing et al. (J. Fluid Mech., vol. 204, 1989, pp. 1–30) on turbulent Rayleigh–Bénard convection has been one of the most impactful papers on the subject – not by giving the right and complete answers but by developing versatile concepts and by asking the right questions, namely: (i) What is the overall flow organization? (ii) What is the dependence of the Nusselt number ${\textit {Nu}}$ (the dimensionless heat transport) on the Rayleigh number ${\textit {Ra}}$ (the thermal driving strength)? (iii) What is the ultimate state of turbulence for extremely large ${\textit {Ra}}$? Thanks to Castaing et al. having asked the right questions, the field has made tremendous progress over the last 35 years.
We sought to examine the relative importance of surgical lesion complexity versus the presence of genetic/syndromic/extracardiac anomalies (GSAs) in determining survival, morbidity or need for reinterventions following repair for aortic arch hypoplasia.
Methods:
A single-centre, retrospective cohort study of infants undergoing biventricular aortic arch repair via sternotomy from 2010 to 2021 was conducted. Survival analysis was performed using Kaplan–Meier methods, with additional Bayesian survival modelling for subgroups. Composite morbidity comprised respiratory, renal, neurologic, or sepsis-related complications.
Results:
Of 83 included infants, n = 13/83 (15.7%) had complex repairs; 27/83 (32.5%) were GSA+. Operative mortality was significantly higher in GSA+ versus GSA− patients (18.5% vs. 1.8%; p = 0.01), though not for complex versus non-complex repairs. Overall 10-year Kaplan–Meier survival was 86.7%. Bayesian modelling suggested equivalent post-discharge attrition in non-complex/GSA+ and complex/GSA− patients, with the poorest outcomes in complex/GSA+ patients; non-complex/GSA− patients had 100% survival. GSA+ patients exhibited higher composite morbidity (44.4% vs. 7.1% in GSA− p < 0.001), with their mode of death seemingly related to a high incidence of respiratory and neurological morbidity, notably in Dandy–Walker syndrome. The 10-year freedom from arch reinterventions was 87.7%; neither complexity, GSA status, nor post-repair peak arch velocity predicted the need for arch reinterventions.
Conclusions:
Whilst anatomic complexity may have been somewhat neutralised as a risk factor for operative mortality, in contrast to GSA+ status, there is further post-discharge attrition attributable to complexity or GSA+ status, with additive risk effects. Morbidity directly related to certain syndromes underlies some of this risk. Non-anatomic substrates represent a persistent limitation to outcomes of surgical aortic arch repair in infants.
In a two-dimensional plane, entire solutions of the Allen–Cahn type equation with a finite Morse index necessarily have finite ends. In the case that the nonlinearity is a sine function, all the finite-end solutions have been classified. However, for the classical Allen–Cahn nonlinearity, the structure of the moduli space of these solutions remains unknown. We construct in this paper new finite-end solutions to the Allen–Cahn equation, which will be called fence of saddle solutions, by gluing saddle solutions together. Our construction can be generalized to the case of gluing multiple four-end solutions, with some of their ends being almost parallel.
A long-standing issue in pipe flow physics is whether the friction of the fluid follows a logarithmic or an algebraic decay. In 2005, McKeon et al. (J. Fluid Mech., vol. 538, 2005, pp. 429–443) published a detailed analysis of new measurements in the Princeton facility, and apparently settled the debate by showing that ‘the log is the law’. Almost 20 years later, no better data are presently available to reinforce their statement. Still, the story may not be totally over, and this is bad news for mathematicians who were hoping to get a long awaited final answer to one of their most elusive questions.
The nanoscale is the new frontier of fluid dynamics and its phenomenology can echo at the macroscale as in the canonical example of drop impact on a planar substrate. Unprecedented advances in measurement technology have recently equipped fluid dynamicists with the ability to probe nanoscale effects. The paper by Li et al. (J. Fluid Mech., vol. 785, 2015, R2) uses ultrafast imaging at the hundreds of nanoseconds scale to resolve the first contact between the drop and the substrate and thereby reveal the effect of prescribed nano-roughness on contact line motion.
This article looks again at the history of British migration policy in the 1940s and 1950s by centering international and imperial politics, and by drawing on archives related to shipping. These sources suggest that the British government sought to reactivate a system of race-segregated mobility across the Empire-Commonwealth after the Second World War. This involved subsidizing fares for emigrants bound for Australia, transporting migrants from Europe to the UK, and withdrawing shipping from routes that connected the Caribbean to the UK. Very soon, however, these policies came under strain. There were not enough deep-sea ships to meet demand for berths to Australia or to bring over recruited European migrants. Then the Australian government found new ways to ship migrants from continental Europe by signing a deal with the International Refugee Organization, challenging UK policy to keep Australian immigration British. Meanwhile, new routes were opened up from the Caribbean and South Asia to the UK. These trends raised a host of dilemmas for policymakers and all related to transport infrastructure. Thinking about transport can deepen our understanding of migration history, and the article's conclusion suggests some of the ways that taking such an approach can contribute to existing explanations for the government's fateful decision to amend the UK's nationality and citizenship legislation during the 1960s.