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Among 70 hospitalists across three facilities, 47% of high prescribers of broad-spectrum hospital-onset (BSHO) agents remained high in the subsequent period versus 24% for initially high prescribers of anti-MRSA agents. Findings of persistence of high prescribing add credibility to our metric for BSHO agents but not anti-MRSA agents.
Most self-reported beta-lactam antibiotic (BLA) allergies are inaccurate. This study evaluated a digital tool designed to reassess beta-lactam allergies and enable the use of standard perioperative antibiotic prophylaxis (PAP) without the need for prior allergy testing.
Methods:
In this retrospective, observational single-center cohort study, a digital five-step questionnaire was utilized during preoperative anesthesia evaluations for surgical patients reporting beta-lactam allergies. The algorithm assessed the likelihood of a beta-lactam allergy and provided recommendations for either standard PAP or the use of an alternative agent. Adherence to the algorithm’s recommendations and the incidence of allergic reactions following PAP were analyzed.
Results:
Between September 2020 and October 2022, 983 surgical patients reported beta-lactam allergies. Of these, 322 patients (33%) either did not receive anesthesia or did not require PAP. Among the remaining 661 patients, the algorithm recommended standard prophylaxis for 420 (64%). Of these, 262 patients received BLA, resulting in 2 allergic reactions (0.8%; negative predictive value: 99.2%), while 158 received alternative antibiotics contrary to the recommendation, leading to 3 allergic reactions (1.9%). For the 241 patients (36%) in whom the algorithm indicated a high probability of beta-lactam allergy, 197 (82%) received alternative antibiotics with 4 allergic reactions (2%). Forty-four patients (18%) received BLA contrary to the algorithm’s recommendation, with no allergic reactions observed.
Conclusions:
The digital five-step algorithm was a simple and effective tool during preoperative assessment, enabling safe administration of standard PAP in 64% of surgical patients with reported beta-lactam allergies.
In the years immediately following World War II, California’s Santa Clara Valley was an agricultural breadbasket to the world. A mere 30 years later, the Santa Clara Valley would be known as ‘Silicon Valley’, and would be the most technologically productive region on the planet. This transition from an agricultural economy to an urbanized, technological economy came to be seen as curious, or even quaint. But in fact, this period of rapid suburban development out of an agricultural landscape laid the foundation for the housing and labour markets that came to characterize the contemporary Silicon Valley. This article reveals how the years following World War II set the stage for what Silicon Valley would become today. It argues that the roots of Silicon Valley’s current housing and labour system were based in the agricultural regime of the immediate post-World War II period and the subsequent Cold War economy.
The outbreak of the American Revolution thrust would-be revolutionaries into a paradoxical relationship with the law. As they overthrew colonial governments from New Hampshire to Georgia during the summer and fall of 1775, leaders of the resistance to Great Britain found themselves in the awkward position of having to justify rebellion against British authority while still professing to be law-abiding Britons. The revolutionaries’ mandate to govern rested on protecting rights to property and representation that many colonists believed had been violated by agents of the Empire, but the practicalities of war demanded extra-legal measures. The popular governments that replaced colonial administrations had to find a way to balance upholding many of the laws of the old regime while simultaneously organizing an armed insurrection against it. Much of this burden fell on revolutionary committees at the town and local level. As the Continental Congress and provincial elites vacillated between rebellion and reconciliation and struggled to assert control over the fast-growing revolutionary coalition, ad hoc governments comprised of ordinary citizens took on the tasks of governing their regions and organizing for armed struggle. For much of 1775 and early 1776, these popular regimes precariously balanced the need for extra-legal expediencies with the need to maintain at least a semblance of law to maintain their legitimacy.
Sam Issacharoff (NYU Law), a leading law professor and litigator, and Hon. Beverly Martin (NYU Law), formerly of the US Court of Appeals for the Eleventh Circuit, after sketching a bracing account of the origins of the current access-to-justice crisis, ask why changing legal services regulation won’t suffice to solve it. Focusing on debt collection lawsuits – currently the modal case in the entire American civil legal system – they show how much of the current crisis stems from adversarial asymmetries resulting from new species of institutional litigants that leverage scale economies and potent new technologies to assembly-line cases through the legal system. They outline a number of potential solutions to better way to contend with the stunning scale of the current access challenges.
While the field of European law scholarship has long maintained a form of ‘colonial amnesia’, this chapter considers the growing literature that has emerged over the past few years studying the entanglements between European law projects and (post)colonialism. The chapter first suggests a new analytical framework to assess these ‘entanglements’ and ‘continuities’ by looking at three ‘carriers of continuity’ in the law: biographies of multiple-positioned lawyers; forms of legal knowledge; institutions and professions in the European field of law. As it looks at European law projects from the margins and peripheries, this new stream of research can transform our understanding of European law which looks less like the ‘cathedral’ often praised by scholars and more like a complex ‘archipelago’, the legal borders and principles of which are uncertain and unequal.
Perspective-taking has been theorized to be a central psychological process in how people make punishment decisions. However, previous research has only tested theory in low-stakes or hypothetical contexts. The current research describes how jurors perspective-take in real capital punishment trials (N = 1,198) and tests a series of hypotheses from previous research in a high-stakes, naturalistic context. In examining the predictors of perspective-taking, we found that jurors are more likely to perspective-take for white victims than black victims, but not more likely to perspective-take if the trial participant is demographically similar to themselves. We further uncovered new findings that older jurors perspective-take less (regardless of whether it is for perpetrators or victims), and women perspective-take for victims more than men do. In examining how perspective-taking relates to capital punishment decisions, we found that jurors who take victims’ perspectives are more likely to vote for the death penalty. We found mixed support for the theory that jurors who take defendants’ perspectives are more lenient. We conclude by discussing the implications of our findings for legal arguments on the arbitrary and biased nature of capital punishment decisions.
Recent years have witnessed an extraordinarily swift advancement in the fields of artificial intelligence (AI) and the Internet of Things (IoT). AI applications like ChatGTP are gaining significant influence on various aspects of life and even ordinary households are nowadays highly digitalised, a trend that will only intensify with the growing proliferation of the Internet of Things.
This study aimed to evaluate school-age neurodevelopmental outcomes among children with single ventricle heart disease who underwent neonatal Norwood operation with regional cerebral perfusion compared to deep hypothermic circulatory arrest. Additionally, we aimed to identify predictors of school-age development, including early developmental measures.
Study design:
Patients enrolled in a prospective randomised trial of infants with single ventricle heart disease undergoing the Norwood operation with either regional cerebral perfusion or deep hypothermic circulatory arrest were included. For the same cohort of patients, this study performed neurodevelopmental testing at 5 years and 10 years of age. At 5 years, a comprehensive neuropsychological evaluation was performed. At 10 years, parent report instruments were used to measure participants’ behaviour and executive function.
Results:
Forty-one patients at 5 years of age and 33 patients at 10 years of age completed neurodevelopmental evaluation. There were no significant differences in neurodevelopmental scores between the regional cerebral perfusion and deep hypothermic circulatory arrest groups at either 5 or 10 years. At 5 years of age, the average full scale intelligence quotient (IQ) was 93.4 ± SD18.8. The Bayley Scale of Infant Development Psychomotor Developmental Index (r = 0.68, p < .0001) and mental developmental index (r = 0.64, p < .0001) at 1 year positively correlated with the full scale IQ at 5 years.
Conclusions:
Neurodevelopment is delayed in patients with single ventricle heart disease. Neurodevelopmental outcomes at school age did not differ based on the perfusion strategy for the Norwood operation. Mental and psychomotor developmental indices at 1 year are predictive of early school-age measures.
This article develops two logical arguments from evil that bypass Alvin Plantinga’s Free Will Defence through a critical examination of the relationship between freedom and value. The first argument assumes that morally innocent freedom is valuable, challenging the traditional emphasis on significant freedom. The second argument draws on an interpretation of J.L. Mackie’s underexplored ethical perspective, which highlights a form of evil that contrasts with the positive value of free will.
This article argues that a pervasive but confused theory of free will is driving unwarranted resistance to behavioral genetic research and undermining the concept of personal responsibility enshrined in our moral and legal conventions. We call this the theory of ‘free-will-by-subtraction’. A particularly explicit version of this theory has been propounded by the psychologist Eric Turkheimer, who has proposed that human agency can be scientifically quantified as the behavioral variation that remains unexplained after known genetic and environmental causes have been accounted for. This theory motivates resistance to research that suggests genetic differences substantially account for differences in human behavior because that is seen to reduce the scope of human freedom. In academic philosophy, free-will-by-subtraction theory corresponds to a position called ‘libertarian incompatibilism’, which holds that human beings are not responsible for behavior that has antecedent causes yet maintains that free will nonetheless exists because some fraction of human behavioral variation is self-caused. However, this position is rejected by most professional philosophers. We argue that libertarian incompatibilism is inconsistent with a secular materialist outlook in which all human behavior is understood to have antecedent causes whether those causes are known to science or not — an outlook Turkheimer shares. We show that Turkheimer sustains this contradiction by adopting an untenable position we call ‘epistemic libertarianism’, which holds that antecedent causes of our behavior only infringe on our freedom if we know about them. By contrast, the overwhelming majority of secular materialist philosophers support a position called ‘compatibilism’, which maintains that free will is compatible with the comprehensive causation of human behavior. We show that compatibilism neutralizes the threat that genetic explanation poses to human agency and rescues a generous conception of personal responsibility that aligns with our moral intuitions.
The legal services marketplace sits on the cusp of a revolution. For nearly a century, American lawyers have enjoyed a monopoly over the provision of legal services. Sweeping unauthorized practice of law (UPL) laws have prohibited (and in some cases, criminalized) the practice of law by anyone other than a licensed attorney – and these rules have further mandated that lawyers work as solo practitioners or in lawyer-owned law firms.1 This one-two punch has meant that only lawyers can provide legal advice and that even lawyers can’t practice law in nonlawyer-owned entities.2
Modern Slavery and the Governance of Global Value Chains provides an interdisciplinary analysis of the links between Global Value Chains (GVCs) governance, regulation, and vulnerability to severe forms of labour market exploitation by focusing on governance initiatives that seek to induce corporate action to end or mitigate modern slavery. The book brings together chapters by scholars from developed, developing, and emerging economies and from various disciplines to explore the complex relationship between global and local patterns of production and consumption, and severe forms of labour market exploitation. This title is also available as open access on Cambridge Core.
Antibiotics prescribed at hospital discharge are difficult to capture electronically for surveillance purposes unless patients are discharged to home with oral antibiotics. Our goal was to estimate the proportion of post-discharge antibiotics that are administered either in post-acute care facilities or via outpatient parenteral antibiotic therapy (OPAT) programs among patients discharged from Veterans Health Administration (VHA) hospitals.
Design:
We performed a retrospective study of all acute-care VHA admissions discharged during 2018–2021. The primary outcome was post-discharge antibiotic length of therapy, defined as the number of days of antibiotic exposure prescribed or recommended by inpatient providers at hospital discharge. Data on post-discharge antibiotic use was measured electronically for some discharge locations and estimated by performing manual chart reviews in randomly selected cases discharged to other locations.
Setting:
129 VHA hospitals.
Results:
There were 1,972,940 admissions, and 42.6% received inpatient antibiotics; 89.8% of patients were discharged to the community and 10.2% to post-acute care. The frequency of receiving post-discharge antibiotics varied by discharge location. Based on our calculations, 32.8% of all post-discharge days of antibiotic exposure occurred in post-acute care or via OPAT. Overall, 43.9% of all hospital-associated days of antibiotic exposure were administered during the hospital stay and the remaining 56.1% qualified as post-discharge.
Conclusions:
A third of all post-discharge antibiotics were dispensed in post-acute care facilities or by OPAT programs. These findings have implications for comparing hospitals on their post-discharge antibiotic use, because antibiotic data for patients discharged to these locations is often missing or difficult to collect.
Designating India as a ‘Union of States’ under Article 1, the Constitution of India does not adhere to a federal vocabulary. The perusal of the Constituent Assembly Debates establishes this verbiage to be a deliberate choice. Scholars such as Prof. Wheare (1963) have classified the Indian Federalism as ‘quasi-federal’, which remains a part of constitutional vocabulary to date. This scholarship undertakes an assessment of federal semantics and taxonomical choices under the Constitutions of the USA, Australia, Switzerland, Brazil and Canada, juxtaposing them with the ‘quasi-federal’ model of the Indian Constitution. Challenging rigid categorizations, the paper argues that the constitutions identified as ‘federal’ have also depicted centralizing tendencies in their working. Examining the legal and political intent behind the omission of ‘federal’ and its anti-federal fallouts, the scholarship explores that the lack of a uniform federal vocabulary and mis-categorization has allowed the Union government and the judiciary to reinforce the centralization of power that shapes the federal discourse, while sporadically identifying the federal features in the Indian Constitution.
We calculated the prevention potential of nosocomial bacteremia and compared it to qualitative assessments by treating departments and Infection Control Unit. Most cases had high preventability scores. Agreement with treating departments was low, highlighting a gap in recognition of preventable factors and the need to improve awareness and prevention practices.
Individuals with cerebral palsy (CP) experience significant impairments in lower limb mobility, which severely limit their daily activities and overall quality of life. Robotic exoskeletons have emerged as a cutting-edge solution to assist in the rehabilitation of individuals with CP by improving their motor functions. This systematic review, conducted following PRISMA guidelines, critically evaluates lower limb robotic exoskeletons specifically designed for individuals with CP, focusing on their design, rehabilitation interfaces, and clinical effectiveness. The review includes research papers published between 2010 and 2024, analyzing 30 lower limb exoskeletons reported in 57 papers. We analyze each exoskeleton, focusing on its technological features, user experience, and clinical outcomes. Notably, we identify a trend in which researchers are increasingly adapting exoskeleton functions to the specific needs of individual users, facilitating personalized rehabilitation approaches. Additionally, we highlight critical gaps in current research, such as the lack of sufficient long-term evaluations and studies assessing sustained therapeutic impacts. While ease of use remains crucial for these devices, there is a pressing need for user-friendly designs that promote prolonged engagement and adherence to therapy. This comprehensive review of existing gait rehabilitation exoskeleton technologies aimed to inform future design and application, ultimately contributing to the development of devices that better address the needs of individuals with CP and enhance their motor functions and quality of life.
In whales, extreme modifications to the ancestral mammalian feeding apparatus facilitate novel modes of aquatic feeding. These modifications manifest in morphological diversity across a suite of characters, including the mandibular symphysis. Cetaceans span a range of symphyseal morphologies, with one lineage (crown mysticetes) evolving a highly mobile condition unique among mammals. Here, we use phylogenetic comparative methods to examine the evolution of symphyseal fusion and elongation across 206 extant and fossil cetacean taxa. Ancestral state reconstructions corroborate observations from the fossil record that suggest the ancestral condition for Cetacea was a fused, moderately elongated symphysis. Shifts in symphyseal morphology coincided with ocean restructuring and diversification of feeding modes. Evolutionary rates peaked in the middle–late Eocene and at the Eocene/Oligocene boundary as whales evolved shorter, unfused symphyses. During the Eocene, ankylosed mandibles became less common with the appearance of increasingly pelagic whales. Mysticetes evolved decoupled, highly mobile mandibles near the Eocene/Oligocene boundary. Several odontocete lineages underwent a trait reversal and converged on fully fused, elongated mandibles in the Miocene. Analyses evaluating the influence of ecological variables indicate strong correlations in feeding strategy, dentition, and prey type. The loss of prey-processing behavior and changes to masticatory loading regimes may explain concurrent trends in symphyseal morphology and tooth simplification. We suggest that the functional and morphological diversity of the symphysis in whales is a consequence of aquatic feeding imposing different mechanical constraints than those associated with feeding on land.