We investigated the interactive effects of bilingualism and sleep on executive functioning at the behavioral level. We conducted two experiments using two independent samples of bilingual young adults, the Flanker task to assess executive performance, the Pittsburg Sleep Quality Index to measure retrospective sleep quality over a one-month period and the Insomnia Severity Index to assess insomnia-related symptoms. In Experiment 1, we registered bilingualism effects on executive performance in poor, but not in good sleepers. In Experiment 2, the magnitude of bilingual effects increased with increasing severity of insomnia symptoms. We conclude that when poor sleep quality and insomnia negatively affect cognitive resources, bilingualism-related cognitive effects emerge more prominently. This suggests higher degrees of bilingualism may compensate detrimental effects of poor sleep quality and insomnia on executive functioning. We suggest that cognitive research in bilingualism and sleep could benefit from controlling for interindividual variability in sleep quality and vice versa.

This study examines geographic origins of basketry, animal and human grave offerings (including a feline trophy head, camelid bone instruments and human trophy heads) interred as grave goods at the cemetery of Uraca in the Majes Valley, Arequipa, Peru during the Early Intermediate Period to Middle Horizon (c. 100 bce–750 ce). We aim to identify whether any of these human or non-human beings or artifacts were non-local to the Majes Valley and explore the ontologically informed meanings underlying the incorporation of geographically distant beings and things into mortuary landscapes. We report new grave good 87Sr/86Sr (n = 36) relative to published data from Uraca human trophy heads and non-trophy individuals (n = 55). Defining the local 87Sr/86Sr range as the mean ±2σ of the non-trophy and non-camelid or small home-range fauna, we compare the proportions of non-local outliers between plant, animal and human grave-offering types. The 87Sr/86Sr range of all new samples is 0.70609–0.70954, encompassing the 87Sr/86Sr variability of much of southern Peru from the coast to the highlands. Nearly half of camelids, the feline trophy, most camelid whistles and one basketry sample were non-local, suggesting that assembling beings and things from both local and distant geographies was an important aspect of making the mortuary landscape.

To provide a useful contextual backdrop to an exhibition at the Royal College of Psychiatrists this summer, we used a question and answer format to summarise the thoughts of its curator, Gavin Miller. Gavin has chosen 12 books published by Penguin between 1949 and 1975 to illuminate the relationship between psychiatrists, psychologists, psychotherapists and the British media. He reflects on the opportunities and pitfalls that come with the association, the motivations of previous writers and provides practical advice for any media psychiatrists considering such a role in the future. The exhibition is open to visitors to the College building in London.

The silent patent ductus arteriosus is currently considered a benign lesion with some practitioners dismissing these patients from cardiac follow-up. We present a 5-year-old male with no known cardiac history who presented with endarteritis in a silent patent ductus arteriosus and underwent successful antibiotic treatment and transcatheter device occlusion.

Since the mid-2010s, conflicts at UNESCO over the interpretation of Japanese colonial rule and wartime actions in the first half of the twentieth century in Japan, South Korea, and China have been fierce. Contested nominations include the Meiji Industrial Revolution Sites for the World Heritage List (Japan), the Documents of Nanjing Massacre for the Memory of the World (MoW) Register (China), and two still pending applications on the Documents on the Comfort Women (South Korean and Japanese NGOs). This paper examines the recent “heritage war” negotiations at UNESCO as they unfolded in a changing political, economic, and security environment. Linking World Heritage and MoW nominations together for a holistic analysis, this paper clarifies the interests of State actors and of various non-State actors, such as NGOs, experts, and the UNESCO secretariat. We discuss the prospects for these contested nominations and recommend further involvement of non-State actors to ensure more constructive and inclusive heritage interpretation to enable a more comprehensive understanding of history.

Background: The complement C5 inhibitor (C5IT), ravulizumab, is approved in Canada for the treatment of anti-acetylcholine receptor antibody-positive (AChR-Ab+) generalized myasthenia gravis (gMG). Updated effectiveness and safety results from the ongoing MG SPOTLIGHT Registry (NCT04202341) are reported. Methods: MGFA classification and MG-ADL total scores were assessed in patients who received ravulizumab only (ravu-only) or transitioned from eculizumab to ravulizumab (ecu-to-ravu), with data available prior to C5IT initiation (“pre-C5IT”) and ≥1 assessment post-initiation (“post-ravu”). Results: Of 52 patients with 2 post-ravu assessments, average treatment duration was 10.4 months at last assessment (LA). Mean±SD MG-ADL scores improved (pre-C5IT: 7.6±3.6; LA: 3.4±3.3), as did the proportions of patients with minimal symptom expression (MSE, MG-ADL≤1) (pre-C5IT: 1/52 [2%]; LA: 17/52 [33%]) and MGFA classification 0-II (pre-C5IT: 18/45 [40%]; LA: 40/45 [89%]). In the ravu-only subgroup, outcomes improved (pre-C5IT vs LA): MG-ADL, 6.3±3.0 vs 4.0±3.4; MGFA 0-II, 9/14 [64%] vs 12/14 [86%]. The ecu-to-ravu subgroup sustained continued gradual improvement from last eculizumab assessment to LA: MG-ADL, 4.4±4.2 vs 3.0±2.8; MGFA 0-II, 19/21 [90%] vs 20/21 [95%]. Ravulizumab was well tolerated; no meningococcal infections were reported. Conclusions: These results demonstrate the long-term effectiveness and safety of ravulizumab in routine clinical practice in patients with gMG.

We present the first radio–continuum detection of the circumstellar shell around the well-known WN8 type Wolf-Rayet star WR16 at 943.5 MHz using the Australian Square Kilometre Array Pathfinder (ASKAP) Evolutionary Map of the Universe (EMU) survey. At this frequency, the shell has a measured flux density of 72.2$\pm$7.2 mJy. Using previous Australia Telescope Compact Array (ATCA) measurements at 2.4, 4.8, and 8.64 GHz, as well as the Evolutionary Map of the Universe (EMU) observations of the star itself, we determine a spectral index of $\alpha\,=\,+0.74\pm0.02$, indicating thermal emission. We propose that the shell and star both exhibit thermal emission, supported by the its appearance in near-infrared and H$\alpha$ observations. The latest Gaia parallax is used to determine a distance of 2.28$\pm$0.09 kpc. This star is well known for its surrounding circular nebulosity, and using the distance and an angular diameter of $8.^{\prime}42$, we determine the shell size to be 5.57$\pm$0.22 pc. We use the Gaia proper motion (PM) of WR16 to determine peculiar velocities of the star as $V_{\alpha}(pec) =$ –45.3$\pm$5.4 km s$^{-1}$ and $V_{\delta}(pec) =$ 22.8$\pm$4.7 km s$^{-1}$, which indicates that the star is moving in a north-west direction, and translates to a peculiar tangential velocity to be 50.7$\pm$6.9 km s$^{-1}$. We also use these proper motion (PM) to determine the shell’s origin, estimate an age of $\sim 9500\pm 1300$ yr, and determine its average expansion velocity to be $280\pm40$ km s$^{-1}$. This average expansion velocity suggests that the previous transitional phase is a Luminous Blue Variable (LBV) phase, rather than a Red Super Giant (RSG) phase. We also use the measured flux at 943.5 MHz to determine a mass-loss rate of $1.753\times 10^{-5}\,{\rm M}_\odot\,$yr$^{-1}$, and use this to determine a lower-limit on ionising photons of $N_{UV} \gt 1.406\times 10^{47}\,\textit{s}^{-1}$.

The Mazon Creek Lagerstätte (Moscovian Stage, late Carboniferous Period; Illinois, USA) captures a diverse view of ecosystems in delta-influenced coastal settings through exceptional preservation of soft tissues in siderite concretions. The generally accepted paradigm of the Mazon Creek biota has been that of an inferred paleoenvironmental divide between what have been termed the Braidwood and Essex assemblages, wherein the former represents a freshwater ecosystem with terrestrial input and the latter a marine-influenced prodelta setting with abundant cnidarians, bivalves, worm phyla, and diverse arthropods. Here, we revisit the paleoecology of the Mazon Creek biota by analyzing data from nearly 300,000 concretions from more than 270 locations with complementary multivariate ordinations. Our results show the Braidwood assemblage as a legitimate shoreward community and provide evidence for further subdivision of the Essex assemblage into two distinct subassemblages, termed here the Will-Essex and Kankakee-Essex. The Will-Essex represents a benthos dominated by clams and trace fossils along the transition between nearshore and offshore deposits. The Kankakee-Essex is dominated by cnidarians, presenting an ecosystem approaching the geographic margin of this taphonomic window. These new insights also allow a refined taphonomic model, wherein recalcitrant tissues of Braidwood organisms were subject to rapid burial rates, while organisms of the Essex assemblage typically had more labile tissues and were subject to slower burial rates. Consequently, we hypothesize that the Braidwood fossils should record more complete preservation than the Essex, which was exposed for longer periods of aerobic decomposition. This is supported by a higher proportion of non-fossiliferous concretions in the Essex than in the Braidwood.

Dog relinquishment has been a persistent issue in Taiwan. The commercialisation of companion animals, inadequate regulation of pet shops and unethical breeding, and the cultural opposition to euthanasia have contributed to rising stray populations and overwhelmed shelters. However, current measures in Taiwan have focused predominantly on post-relinquishment management, with insufficient attention paid to the sources of relinquished dogs. This study examines the pathway of dog relinquishment by tracing acquisition motivation, choice of purchase channel, ownership experience, and potential relinquishment. Using an online survey of 444 Taiwanese dog owners, this study explores the interplay between these factors. While several factors relate to relinquishment, owners’ knowledge and motivations are the strongest predictors of successful ownership, as better-prepared owners tend to choose more appropriate acquisition channels, apply more effective training methods, and report fewer problem behaviours. Strengthening pre-acquisition education and tightening channel regulations may be key to reducing dog relinquishment and improving animal welfare in Taiwan.

In this article, we argue that Brazilian tan lines constitute a new site of race and class struggle on and over women’s bodies. Popular in Rio’s socially and geographically marginalized periphery, fita (electrical tape) bikinis leave sharp and shocking tan lines that call attention to the contrast between lighter and darker skin. Brazil’s funk music sensation Anitta brings this aesthetic practice to the global stage as part of her brand, disrupting hegemonic beauty norms and attracting attention for herself and her fans. Through the public display of their bronzed sensuality, Brazilian women accrue “visibility capital” as they create new forms of bodily value and self-esteem in what we call a look economy. While global beauty hierarchies continue to promote and glorify whiteness, Anitta and fita tanners simultaneously turn heads (in person), attract eyeballs (online), and lay claim to the right to represent Brazil.

Multicenter clinical trials are essential for evaluating interventions but often face significant challenges in study design, site coordination, participant recruitment, and regulatory compliance. To address these issues, the National Institutes of Health’s National Center for Advancing Translational Sciences established the Trial Innovation Network (TIN). The TIN offers a scientific consultation process, providing access to clinical trial and disease experts who provide input and recommendations throughout the trial’s duration, at no cost to investigators. This approach aims to improve trial design, accelerate implementation, foster interdisciplinary teamwork, and spur innovations that enhance multicenter trial quality and efficiency. The TIN leverages resources of the Clinical and Translational Science Awards (CTSA) program, complementing local capabilities at the investigator’s institution. The Initial Consultation process focuses on the study’s scientific premise, design, site development, recruitment and retention strategies, funding feasibility, and other support areas. As of 6/1/2024, the TIN has provided 431 Initial Consultations to increase efficiency and accelerate trial implementation by delivering customized support and tailored recommendations. Across a range of clinical trials, the TIN has developed standardized, streamlined, and adaptable processes. We describe these processes, provide operational metrics, and include a set of lessons learned for consideration by other trial support and innovation networks.

Aims: Suicide remains one of the leading causes of death worldwide, with rates among older adults increasing steadily. Older people face higher suicide completion rates, especially in 45–49 and 90+ age group. The impact of suicide on society is profound, underlining the need for targeted interventions for this demographic.

This project follows the Triple Aim framework to improve overall health system by:

Enhancing suicide prevention in older populations through mental well-being promotion.

Increasing awareness and improving patients’ experience by creating a supportive, responsive environment.

Developing a replicable model across healthcare settings, contributing to broader suicide prevention efforts.

Methods: Focus groups were conducted with 3 cohorts: patients, families and staff. 4–8 participants were recruited for each group using purposive sampling method. Semi-structured interview was conducted to explore their views on suicide prevention, their challenges, and expectations.

Results: Many patients identified negative emotions: stress and overthinking are contributing factors. Many find feelings of guilt/hopelessness, bereavement particularly challenging. Additionally, social isolation, physical health problems and poor sleep also lead to suicide.

According to staff, many patients lack access to service due to language barrier, immobility/disabilities, socio-economic deprivation and limited access to technologies. Cultural beliefs and stigma play a major role. Staff also highlighted that role transition to retirement results loneliness/isolation.

Preventive strategies include normalisation and promoting awareness in public. Having representation in peer support group can improve stigma in minority. Social interventions can aid role transition and provide sense of belonging. Integrated care with multiple touchpoints from emergency care to community/GP follow-ups alongside with multidisciplinary approach with occupational therapist and psychologist are crucial in providing patient-centred care.

Conclusion: These focus groups underscore the importance of suicide prevention for older people. The insight gained will inform future strategies and prioritise change ideas in our service.

We analyze generating functions for trees and for connected subgraphs on the complete graph, and identify a single scaling profile which applies for both generating functions in a critical window. Our motivation comes from the analysis of the finite-size scaling of lattice trees and lattice animals on a high-dimensional discrete torus, for which we conjecture that the identical profile applies in dimensions $d \ge 8$.

The First Large Absorption Survey in H i (FLASH) is a large-area radio survey for neutral hydrogen in and around galaxies in the intermediate redshift range $0.4\lt z\lt1.0$, using the 21-cm H i absorption line as a probe of cold neutral gas. The survey uses the ASKAP radio telescope and will cover 24,000 deg$^2$ of sky over the next five years. FLASH breaks new ground in two ways – it is the first large H i absorption survey to be carried out without any optical preselection of targets, and we use an automated Bayesian line-finding tool to search through large datasets and assign a statistical significance to potential line detections. Two Pilot Surveys, covering around 3000 deg$^2$ of sky, were carried out in 2019-22 to test and verify the strategy for the full FLASH survey. The processed data products from these Pilot Surveys (spectral-line cubes, continuum images, and catalogues) are public and available online. In this paper, we describe the FLASH spectral-line and continuum data products and discuss the quality of the H i spectra and the completeness of our automated line search. Finally, we present a set of 30 new H i absorption lines that were robustly detected in the Pilot Surveys, almost doubling the number of known H i absorption systems at $0.4\lt z\lt1$. The detected lines span a wide range in H i optical depth, including three lines with a peak optical depth $\tau\gt1$, and appear to be a mixture of intervening and associated systems. Interestingly, around two-thirds of the lines found in this untargeted sample are detected against sources with a peaked-spectrum radio continuum, which are only a minor (5–20%) fraction of the overall radio-source population. The detection rate for H i absorption lines in the Pilot Surveys (0.3 to 0.5 lines per 40 deg$^2$ ASKAP field) is a factor of two below the expected value. One possible reason for this is the presence of a range of spectral-line artefacts in the Pilot Survey data that have now been mitigated and are not expected to recur in the full FLASH survey. A future paper in this series will discuss the host galaxies of the H i absorption systems identified here.