Indigenous Peoples in Canada are comprised of First Nations, Inuit and Métis and are the youngest and fastest growing population in the country. However, there is limited knowledge of how they are affected by multiple sclerosis (MS), the most common nontraumatic neurological disease of young adults, with Canada having one of the highest prevalences in the world. In this narrative review, we outline the limited studies conducted with Indigenous Peoples living with MS in Canada and the gaps in the literature. From the limited data we have, the prevalence of MS in Indigenous Peoples is lower, but the disease appears to be more aggressive. Given the dearth of Canadian data, we explore the worldwide MS studies of Indigenous populations. Lastly, we explore ways in which we can improve our understanding of MS among Indigenous Peoples in Canada, which entails building trust and meaningful relationships with these communities and acknowledging past and ongoing injustices. Furthermore, healthcare professionals conducting research with Indigenous Peoples should undergo training in cultural safety and data sovereignty, including principles of ownership, control, access and possession to have greater engagement with Indigenous communities to conduct more relevant research. With joint efforts between healthcare professionals and Indigenous communities, the scientific research community can be positioned to conduct better, more appropriate and desperately needed research, ultimately with improvements in the delivery of care to Indigenous Peoples living with MS in Canada.

Recent years have witnessed growing attention to popular culture’s role in the reproduction, negotiation, and contestation of global political life. This article extends this work by focusing on games targeted at young children as a neglected, yet rich site in which global politics is constituted. Drawing specifically on the Heroes of History card game in the Top Trumps franchise, I offer three original contributions. First, I demonstrate how children’s games contribute to the everyday (re)production of international relations through the contingent storying of global politics. Heroes of History’s narrative, visual organisation, and gameplay mechanics, I argue, construct world politics as an unchanging realm of conflict through their shared reproduction of a valorised, masculinised figure of the warrior hero. This construction, moreover, does important political work in insulating young players from the realities and generative structures of violence. Second, the polysemy of children’s games means they also provide opportunity for counter-hegemonic ‘readings’ of the world even in seemingly straightforward examples of the genre such as this. Third, engaging with such games as meaningful objects of analysis opens important new space for dialogue across International Relations literatures on children, popular culture, gender, the everyday, and heroism in world politics.

This article serves as the introduction to a Special Issue of the European Journal of International Security titled ‘What the War on Terror Leaves Behind’. In it, we seek to contextualise and summarise the diverse contributions of this collection, which is animated by four overarching questions: (i) More than 20 years after the attacks of 11 September 2001, is the War on Terror now, finally, over? (ii) What, if any, legacies remain from the post-9/11 way of thinking and doing counterterrorism? (iii) What is the significance of the War on Terror’s legacies or absence thereof? and, (iv) How do the War on Terror’s impacts and effects sit within other historical contexts and (dis)continuities? The article begins with a brief overview of some of the conceptual and political ambiguities of the War on Terror itself, before situating the issue in relation to issues of continuity and change anticipated by the four questions above. A second section then explores the urgency of these questions for academic debate, and in the ‘real world’ of international security as experienced by states, communities, and other subjects. A third section then summarises the argument and contributions of the articles in the issue –highlighting the lack of agreement on key issues within these debates.

Contemporary reckoning with the catastrophic outcomes of the post-9/11 era opens important questions for the future of counterterrorism policy. It also raises significant issues for thinking through the future priorities and purposes of security scholarship. In this article we make two core claims. First, recent years have seen considerable mainstreaming of ostensibly critical ideas on (counter)terrorism within political debate, media commentary, and – crucially – security policy. Second, such ideas – including around the futility of ‘war’ on terror; the ineffectiveness of torture; the unstable framing of threats such as radicalisation; and the inefficiency of excessive counterterrorism expenditure – were widely dismissed as lacking in policy relevance, even being utopian, when articulated by critically oriented scholars. This development, we argue, raises important ontological questions around the ending of security paradigms such as the war on terror. It also prompts vital political, epistemological, and normative questions around the status of overtly critical scholarship when its ideas and recommendations achieve wider currency.

Opportunistic use of limited resources is often attributed to invasive species, and as a mature vine, old man’s beard (Clematis vitalba L.) is known to have devastating negative impacts on the trees it colonizes. No previous experimental studies have been published on how easily C. vitalba seedlings can colonize ground covered by other established vegetation. This species has had an increasing presence in forestry blocks and riparian zones in New Zealand, both of which usually maintain some grass cover. To determine the importance of vegetative ground cover for preventing ingress of new C. vitalba plants, this study looked at seedling emergence through the soil and establishment of C. vitalba within four different levels of grassy cover at three sites: (1) ground kept bare after vegetation removal; (2) ground bare at C. vitalba seed sowing, but thereafter allowed to recover; (3) vegetative cover trimmed to 4 cm high at C. vitalba sowing, and then allowed to recover; and (4) unmanaged vegetation. At the highest level of vegetation density (unmanaged vegetation), no C. vitalba seedlings were ever detected throughout a 1-yr monitoring period. At lower ground cover densities, poor seedling emergence was observed, with a maximum of 36% of seeds sown in bare plots producing a seedling. Also, seedlings did not survive past 1 yr, except in bare plots or in plots where vegetation grew sparsely. However, seedlings that did survive began producing multiple stems within 6 mo of emergence. These results indicate that obstacles to seedling emergence and poor development at the young seedling stage when vegetative cover is dense severely limit C. vitalba’s chances to invade new sites via seed. Yet some successful seedling recruitment does occur due to the magnitude of the propagule pressure on the landscape and the difficulty of maintaining high-density ground cover across large areas throughout the year.

The Pliensbachian–Toarcian succession of North Yorkshire provides a global reference for the interval incorporating the Toarcian Oceanic Anoxic Event (T-OAE, ∼183 Ma). Major and trace element, carbon stable-isotope (δ13Corg) and total organic carbon (TOC) data for the Dove’s Nest core, drilled close to the classic outcrop sections of the Yorkshire coast, demonstrate geochemical, mineralogical and grain-size trends linked to sea level and climate change in the Cleveland Basin. High-resolution correlation between the core and outcrop enables the integration of data to generate a comprehensive chemostratigraphic record. Palaeoredox proxies (Mo, U, V, TOC/P, DOP and Fe speciation) show a progressive shift from oxic bottom waters in the late Pliensbachian through dysoxic–anoxic conditions in the earliest Toarcian to euxinia during the T-OAE. Anoxia–dysoxia persisted into the middle Toarcian. Elemental and isotope data (Re, Re/Mo, δ34SCAS, δ98Mo and ε205Tl) from the coastal sections evidence global expansion of anoxic and euxinic seafloor area driving drawdown of redox-sensitive metals and sulfate from seawater leading to severe depletion in early Toarcian ocean water. The record of anoxia–euxinia in the Cleveland Basin largely reflects global-scale changes in ocean oxygenation, although metal depletion was temporarily enhanced by periods of local basin restriction. Osmium and Sr isotopes demonstrate a pulse of accelerated weathering accompanying the early Toarcian hyperthermal, coincident with the T-OAE. The combined core and outcrop records evidence local and global environmental change accompanying one of the largest perturbations in the global carbon cycle during the last 200 Ma and a period of major biotic turnover.

OBJECTIVES/GOALS: Racial discrimination and its associated stress are well-documented contributors to health disparities among African Americans (AA).This feasibility study aimed to acquire methodological insights and build the infrastructure for a subsequent mindfulness interventional study to reduce the effects of racism-based stress. METHODS/STUDY POPULATION: 20 AA participants ( female 12, male 8 )ages 18-50 were enrolled, and clinical data (blood pressure, waist/hip, BMI, lipids, HbA1c, creatinine) for Allostatic Index were collected. Racism-based stress was measured using RBTSSS and the Everyday Discrimination Scale (EDS). Psychometric measures (Coping, resilience, mindfulness, social connection) and sleep (PSQI) were included. Bivariate analysis explored associations between psychological measures and stress biomarkers, supported by Spearman’s correlation analysis. RESULTS/ANTICIPATED RESULTS: Low discrimination (EDS) was associated with a lower Total cholesterol/HDL ratio (2.99 vs. 4.20, p=0.009) and higher HDL (62 vs. 52, p=0.001). Low EDS participants also had better sleep (mean=3, SD=1.33, vs. mean=5.8, SD=3.99, p=0.05*) but reported less coping through drugs and alcohol (p=0.022*) and higher resilience (p=0.047*). Mindfulness negatively correlated to sleep disturbance (r=-0.477 to r=-0.62), coping and resilience. . EDS correlated with overall life stress and drug and alcohol use. Sleep disturbance was negatively associated with social connection (r=-0.569**) and mindfulness. Sleep disturbance and discrimination correlated positively with drug and alcohol use and overall life stress (r=0.52 and r=0.0.59, respectively), while resilience was negatively correlated with sleep (r=-0.45). DISCUSSION/SIGNIFICANCE: Discrimination was associated with increased stress and unfavorable coping, while mindfulness may offer potential benefits for sleep, coping, and resilience. These preliminary findings provide a foundation for further exploring the potential of mindfulness interventions to address the biopsychological impacts of racism-induced stress.

While mentors can learn general strategies for effective mentoring, existing mentorship curricula do not comprehensively address how to support marginalized mentees, including LGBTQIA+ mentees. After identifying best mentoring practices and existing evidence-based curricula, we adapted these to create the Harvard Sexual and Gender Minority Health Mentoring Program. The primary goal was to address the needs of underrepresented health professionals in two overlapping groups: (1) LGBTQIA+ mentees and (2) any mentees focused on LGBTQIA+ health. An inaugural cohort (N = 12) of early-, mid-, and late-career faculty piloted this curriculum in spring 2022 during six 90-minute sessions. We evaluated the program using confidential surveys after each session and at the program’s conclusion as well as with focus groups. Faculty were highly satisfied with the program and reported skill gains and behavioral changes. Our findings suggest this novel curriculum can effectively prepare mentors to support mentees with identities different from their own; the whole curriculum, or parts, could be integrated into other trainings to enhance inclusive mentoring. Our adaptations are also a model for how mentorship curricula can be tailored to a particular focus (i.e., LGBTQIA+ health). Ideally, such mentor trainings can help create more inclusive environments throughout academic medicine.

From 1923 to the present day, various studies have increasingly analysed the beginnings of the cult of Thomas Aquinas, as well as the authenticity of his works. Over the last century, the reception of Thomas Aquinas between these two poles of sanctity and the authority accorded to his works has shown itself to be a significant pairing, of which this article unpacks some important stages.

Old man’s beard is a woody liana that has become an invasive weed in many areas of its introduction, through its vigorous spread and negative impacts on the tree hosts it climbs. Control techniques that improve precision and reduce non-target damage are increasingly preferred for weed control yet have not been compared in published research for use against old man’s beard. Field experiments in New Zealand were conducted to: (i) assess targeted herbicide techniques for control of this weed’s climbing stems when growing among trees and (ii) assess foliar herbicides for control of creeping stems in ruderal sites. For climbing stems, triclopyr in oil was applied around the circumference of woody stems near their base, which was compared with cutting the stems and applying concentrated glyphosate gel (45% ai) to each cut end. Herbicides were applied in autumn directly to individual stem bases of the weed, thereby protecting tree hosts and other non-target vegetation. The basal application of triclopyr to intact stems was highly effective (>95% mortality) with no damage to nearby trees noted. The glyphosate gel applications to cut stems were less effective (56% mortality by 2 yr after treatment). For creeping stems in grass-dominated ruderal sites, selective foliar herbicide sprays had not been previously juxtaposed to compare control of old man’s beard. Three selective sprays that do not damage existing grass cover were applied in autumn at their recommended rates: (i) metsulfuron; (ii) triclopyr; and (iii) a mixture of triclopyr, picloram, and aminopyralid. All herbicide treatments provided effective control, although metsulfuron had a negative effect on grass vigor, which might allow new establishment of old man’s beard seedlings by competitive release. These results provide effective options that reduce non-target damage for control of both climbing and creeping old man’s beard stems.

The article explores the complicity of children’s picturebooks in the construction and critique of world politics. Focusing on The Gruffalo, it argues that this spectacularly successful book: (1) stories the international as a pessimistic, anarchical world populated by self-interested, survival-seekers; (2) disrupts this reading and its assumptions through evocation of the social production of threat; and, (3) provides a more fundamental decolonial critique of the international through parochial privileging of its protagonist’s journey through a ‘deep dark wood’. In doing this, we argue, the book vividly demonstrates the world’s susceptibility to multiple incompatible readings, while rendering visible the assumptions, framing, and occlusions of competing understandings of the international. As such, it theorises both world politics and knowledge thereof as contingent and unstable. In making this argument, three contributions are made. First, empirically, we expand research on popular culture and world politics through investigating a surprisingly neglected example of the former. Second, theoretically, we demonstrate the work such texts perform in (re)creating and (de)stabilising (knowledge of) global politics. Third, we offer a composite methodological framework for future research into the context, content, and framing of complex texts like The Gruffalo.