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International security is an ambiguous concept – it has many meanings to many people. Without an idea of how the world works, or how security is defined and achieved, it is impossible to create effective policies to provide security. This textbook clarifies the concept of security, the debates around it, how it is defined, and how it is pursued. Tracking scholarly approaches within security studies against empirical developments in international affairs, historical and contemporary security issues are examined through various theoretical and conceptual models. Chapters cover a wide range of topics, including war and warfare, political violence and terrorism, cyber security, environmental security, energy security, economic security, and global public health. Students are supported by illustrative vignettes, bolded key terms and an end-of-book glossary, maps, box features, discussion questions, and further reading suggestions, and instructors have access to adaptable lecture slides.
This study assesses the validity and reliability of empirical strategies derived from the study of European populisms by applying them to the case of Canada. Using a dataset of 5,845 original tweets by Canadian federal party leaders in 2022, we compare the prevalence and intensity of three characteristic populist discourses: “people-centrism,” “anti-elitism” and “exclusion of others.” Our results raise questions about the role of party ideology in shaping populist communication styles, by revealing a convergence among opposition leaders around primarily economic representations of the “people” and political portrayals of the “elite.” We also confirm the hunch that Canada is “exceptional” with respect to the prevalence of “exclusion of others,” demonstrating that this discourse is rare and has not been embraced by mainstream politics. Finally, the study adds to the skepticism about the value of “people-centrism” to operationalizing populism, given the widespread nature of this discourse.
Surgical resection for pterygopalatine fossa schwannomas can be challenging due to the complex anatomy and potential morbidity. Gamma knife radiosurgery (GKRS) offers a minimally invasive alternative with precise targeting and minimal damage to surrounding structures.
Case report
A 21-year-old female patient who had a history of progressive left-sided facial numbness over the past year and was diagnosed with progressive pterygopalatine fossa schwannoma underwent gamma knife radiosurgery. The radiological and clinical outcomes of the patient were evaluated over a period of 15 years, with the patient remaining symptom-free and experiencing no adverse effects from the treatment.
Conclusion
The patient’s positive outcome, with significant tumour reduction and symptom relief, underscores the potential of this non-invasive technique as a primary treatment modality for schwannomas in challenging anatomical locations.
We present the design and deployment of a capsule endoscope via external electromagnets for locomotion in large volumes alongside its digital twin implementation based on interval type-2 fuzzy logic systems (IT2-FLSs). To perform locomotion, we developed an external mechanism comprising five external electromagnets on a two-dimensional translational platform that is to be placed underneath the patients’ bed and integrated multiple Neodymium magnets into the capsule. The interaction between the central bottom external electromagnet and the internal magnet forms a fixed body frame at the capsule center, allowing rotation. The interaction between the external electromagnets and the two internal magnets results in rotation. The elevation of the capsule is accomplished due to the interaction between the upper external electromagnet and the internal magnets. Through simulations, we model the capsule rotation as a function of torque and drive voltages. We validated the proposed locomotion approach experimentally and observed that the results are highly nonlinear and uncertain. Thus, we define a regression problem in which IT2-FLSs, capable of representing nonlinearity and uncertainty, are learned. To verify the proposed locomotion approach and test the IT2-FLS, we leverage our experimental effort to a stomach phantom and finally to an ex vivo bovine stomach. The experimental results validate the locomotion capability and show that the IT2-FLS can capture uncertainties while resulting in satisfactory prediction performance. To showcase the benefit in a clinical scenario, we present a digital twin implementation of the proposed approach in a virtual environment that can link physical and virtual worlds in real time.
The family medicine residents and final year medical students are challenged with increased workload and they experience various emotions during their clinical trainings. They are confronted with uncertainties in their role descriptions and they witness illness, suffering and deaths as part of their everyday duties which may lead to burnout. Only several studies have focused on these experiences to find out what the family medicine residents and medical students were literally feeling.
Aim:
The aim of this study was to explore the family medicine residents’ and final year medical students’ emotions during their clinical trainings.
Method:
This qualitative study was performed with 15 family medicine residents and 24 final-year medical students using a convenience sample from two medical faculties to explore and analyze their emotions. Data were gathered by means of focus group interviews, including six interviews conducted and recorded through online meetings. Data were analyzed for themes using a thematic analysis approach. Since the interviews reached saturation in terms of content, the interviews were terminated at the end of sixth focus group meetings. Each interview took an average of 45–60 min.
Results:
Three main themes emerged from the data regarding residents’ and interns’ emotions. These were the “clinical climate’s role”, “emotions during patient encounters” and “coping strategies with negative emotions”. The most commonly encountered emotions were tension and anxiety followed by frustration and uncertainty.
Conclusions:
The family medicine residents and final-year medical students are challenged with emotions during their clinical trainings. Therefore, medical educators have to be aware of the need to support them in reflecting their emotions by prioritizing residents’and interns’ well-being.
We aimed to discuss our unit’s experience performing left ventriculotomies on children.
Methods:
Between 2000 and 2022, we identified paediatric patients who required left ventriculotomy. Relevant information was gathered retrospectively.
Results:
There were eight patients who underwent surgical procedure including left ventriculotomy. The range of weight and age was between 4.5 and 50 kg and 5 months to 17 years, respectively. Left ventriculotomy was primarily performed for the excision of cardiac masses in all but one who had pseudoaneurysm repair. There were no deaths that occurred early or late. Pre-operative and post-operative ejection fractions and fractional shortening values were comparable. There was no arrhythmia detected post-operatively.
Conclusions:
We conclude that an apical left ventriculotomy does not compromise the function of the left ventricle, even in young infants. In selected patients, it may be used safely for surgical access to the left ventricle.
This article traces the influence of Front National (FN) on the transformation of mainstream French narratives of laïcité since 1989, with particular attention to education policy. It argues that the FN’s right-wing populist rhetoric, particularly the systematic securitisation of Islam as a threat to the ‘people’, facilitated the more widespread reframing of laïcité as a Republican defence mechanism, operating primarily through the school system. Laïcité was increasingly deployed in mainstream discourses and legislative measures to address two interrelated security concerns: the immediate safety of the school by the promotion of neutrality, and the overall wellbeing of the Republic via the prevention of radicalisation. Analysing this process in two specific periods (1989–2004 and 2005–2019), the article demonstrates that the FN’s populist agenda came to be in a symbiotic relationship with the centre-right and centre-left parties. While established parties gradually incorporated the FN’s securitisation narrative in their policymaking, the FN went through a process of ‘normalisation’ by claiming ownership of laïcité as a way to frame its anti-Islam stance in a more acceptable Republican discourse.
Approximately 1.7% of all epileptic seizures are induced by drugs, mostly psychotropics. Although the risk is known to be the lowest, a few reports notified quetiapine-induced epileptic convulsions. We report two additional cases.
Case 1
Twenty-five-year old man suffering from paranoid psychosis was given quetiapine for persisting symptoms. He also had myoclonic disorder which has become worse just after administering quetiapine. Physical, neurological and laboratory findings were normal. He once had a generalized seizure in our clinic. The electroencephalography (EEG) revealed an epileptic focus on frontal region. He has been diagnosed as frontal lobe epilepsy exacerbated by quetiapine. He has recovered and was doing well after withdrawn the drug.
Case 2
Twenty-three-year old women who had bipolar disorder was hospitalized due to a manic episode. Physical examination and routine laboratory tests were normal. Lithium at 600mg/d and quetiapine at 300 mg/d were started. Quetiapine has been gradually increased up to 900 mg/d at which the myoclonic symptoms first noted. They were disappeared after quetiapin was tapered to 600 mg/d. To control manic symptoms, quetiapine dosage had to be increased up to 700 mg/d again, but myoclonus was reappeared. Quetiapin was replaced with risperidon and manic symptoms subsided. No myoclonic seizures were noted during follow-up.
Conclusion
EEG abnormalities particularly likely with clozapine and olanzapine, moderate with risperidone, and the lowest with quetiapine. The risk of quetiapine-induced epilepsy was estimated as 0.75%. Evaluating of patients for the epileptic background is important in selecting proper antipsychotic medication.
The amygdala whis is part of limbic system is activated in case of fear and anxiety. This study evaluated the effects of oxytocin on the basolateral amygdala(BLA) in spontaneous EEG.
Materials and methods
In this study 7 Sprague-Dawley adult male rats were used.Under anesthesia with the help of drill by opening a small hole,then by taking bregma as reference with the stereotaxic method(Anteroposterior:−2.8 mm, Lateral:+4.8 mm,Ventrodorsal:−8.5 mm), bipolar EEG electrode was placed to the BLA.Electrodes were fixed by using a dental restorations material.
Electrodes placed 3 days later, the animals are awake in their cages, spontaneous EEG recordings taken from the amygdala. Then, rats (n = 7) 0.9% isotonic NaCl intraperitoneally applied, the EEG was recorded amygdala their cages.
1 day later to the same rats(n = 7) oxytocin 10 IU/Kg were applied IP,5 minutes later of injection of oxytocin EEG records were taken in their own cage.
System records were taken 20 minutes by Biopac MP30 amplifier system in the range of 1–60 Hz band,with 10.000 amplification. We affirmed electrode location histologically following euthanisation.
Results
There is significant(p < 0.05) diminution in delta frequency (&64.4 ± 10.9) of rats which is administred isotonic than spontan EEG records (%79.5 ± 12.8).
There is significant(p< 0.05) increasement in delta frequency (76.8±12.5)of rats which is administred oxytocin than isotonic injected rats (%64.4±10.9).
Conclusion
Anxiety caused by injection of isotonic,is augmented EEG frequency if we compare with resting EEG records.Oxytocin,diminue the EEG frequency of rats which has injection anxiety.This results show electrophyiologicly that oxytocin is an powerfull anxiolytic.
The literature on the development of secularism in Turkey, or laiklik, often cites the national state builders’ positivist worldviews as a principal explanatory factor. Accordingly, the legal-institutional form Turkish secularism took in the 1920s and 1930s is derived, to a large extent, from the Unionists’ and Republicans’ science-driven, antireligious ideologies. Going beyond solely ideational narratives, this article places the making of secularism in Turkey in the context of the sociopolitical contention for national-capitalist state building. In so doing, the article contributes to the latest “spatiotemporal” turn in the secularization literature, characterized by an increased attention to historical critical junctures, and sensitivity to multiple secularities occurring in Western as well as non-Western geographies. Based on a bridging of the secularization scholarship with that of state formation, and building extensively on Turkish archival material, I argue that the trajectory, fluctuations, and contradictions of secularization can be closely associated with two intertwined master processes: (1) the construction of internal and external sovereign state capacity, and (2) geographically specific trajectories of class formation/dynamics. The Turkish case demonstrates that secular settlements cannot be explained away simply by reference to the guiding ideas of actors. Contentious episodes such as civil-bureaucratic conflict, war and geopolitics, and class struggles/alliances make a significant imprint on the secularizing process.
While there has been extensive research conducted on Byzantine religious architecture in Cappadocia, little work has been done on agricultural installations there. The valley of Mavrucandere in Cappadocia contains a settlement which has a remarkable agrarian installation complex. Resembling a factory, this area highlights the architectural and the organizational structure of the wine-presses in Cappadocia. In the light of the new findings, this article aims to examine the organization of the wine-making process, the location of the installations in the settlement, and the importance of the installations for the region's trade activities during the Byzantine period.
Strategies for the involvement of primary care in the management of patients with presumed or diagnosed dementia are heterogeneous across Europe. We wanted to explore attitudes of primary care physicians (PCPs) when managing dementia: (i) the most popular cognitive tests, (ii) who had the right to initiate or continue cholinesterase inhibitor or memantine treatment, and (iii) the relationship between the permissiveness of these rules/guidelines and PCP's approach in the dementia investigations and assessment.
Methods:
Key informant survey. Setting: Primary care practices across 25 European countries. Subjects: Four hundred forty-five PCPs responded to a self-administered questionnaire. Two-step cluster analysis was performed using characteristics of the informants and the responses to the survey. Main outcome measures: Two by two contingency tables with odds ratios and 95% confidence intervals were used to assess the association between categorical variables. A multinomial logistic regression model was used to assess the association of multiple variables (age class, gender, and perceived prescription rules) with the PCPs’ attitude of “trying to establish a diagnosis of dementia on their own.”
Results:
Discrepancies between rules/guidelines and attitudes to dementia management was found in many countries. There was a strong association between the authorization to prescribe dementia drugs and pursuing dementia diagnostic work-up (odds ratio, 3.45; 95% CI 2.28–5.23).
Conclusions:
Differing regulations about who does what in dementia management seemed to affect PCP's engagement in dementia investigations and assessment. PCPs who were allowed to prescribe dementia drugs also claimed higher engagement in dementia work-up than PCPs who were not allowed to prescribe.
In 2007 two stelae, each bearing figures of the Storm-god leading a ruler and aduplicate Hieroglyphic Luwian text, were discovered atUluçınar (formerly Arsuz), on the Turkish coast south ofIskenderun. The inscription is the work of a Suppiluliuma, son of Manana, kingof the land of Walastin, now understood as the Luwian designation of the Amuqplain with its capital at the Iron Age site of Tell Tayinat. The stelae,probably dating to the later tenth century BC, record the successful reign ofthe ruler and his happy relations with the Storm-god. Historically important isa passage which describes this Amuq king's victory over the Cilician plain, thecity of Adana and the land of Hiyawa.
This paper summarizes a study initiated by the Turkish General Directorate of Agricultural Research and ICARDA/CIMMYT Wheat Improvement Program on the adoption of five new winter and spring wheat varieties developed and released by the Turkish national breeding program and through international collaboration in the past 10 years. The study results are based on a survey of 781 households selected randomly in the Adana, Ankara, Diyarbakir, Edirne, and Konya provinces of Turkey. The five new wheat varieties are compared to old improved varieties released prior to 1995 that are also still grown by farmers. Technical and biological indicators of impacts including crop productivity are measured to determine the impact of these varieties. Yield stability is assessed by comparing average yields in normal, good and dry years and by comparing the coefficients of variation of yields by variety. Profitability is measured by the gross margin generated per unit of land. Household income from wheat and for all economic activities are estimated and compared between adopters and non-adopters. Adopters of the new varieties have higher per-capita income than non-adopters as compared to the same group using old varieties. However, the overall impact of the improved varieties is generally low, mainly due to their low adoption levels. Farmers’ knowledge and perception of certain variety characteristics and unavailability of adequate and timely seed are the main reasons. Increasing adoption has the potential to improve household income and this requires revising wheat impact pathway to achieve the expected impact.
Edwards syndrome is the second most commonly seen trisomy. It was first described by John Hamilton Edwards in 1960. Although most cases result in termination or foetal loss, live births have been documented in 5%. Edwards syndrome is characterized by multisystem anomalies, of which holoprosencephaly (HPE) is observed in 4–8% of cases. The clinical findings correspond to the degree of HPE malformation. Convulsions and endocrinopathies are among the severe clinical findings. The most common endocrinopathies are central diabetes insipidus (DI), hypothyroidism, hypocortisolism and growth hormone deficiency. The coexistence of holoproencephaly and DI in Edwards syndrome was discussed under the light of literature.
We report on significant asymmetry phenomena, including failure mode, fracture strength, and plasticity under compression and tension, for Zr- and Ti-based composites containing ductile dendrites. The failure of the Zr-based composite always occurs in a shear mode with a small strength asymmetry and different plasticity under tension and compression. In contrast, the Ti-based composite exhibits a significant high strength asymmetry and zero tensile plasticity although its compressive plasticity is high. We propose that the ratio, α=τ0/σ0 (τ0 and σ0 are the intrinsic shear and cleavage strengths), is a substantial parameter controlling the strength asymmetry and the failure mode of various materials.
Tuberculosis of the parotid gland is very rare and clinically indistinguishable from a neoplasm. Thus the diagnosis of parotid gland involvement with tuberculosis has traditionally been made after surgical resection. We present a case which was diagnosed on fine needle aspiration cytology and managed medically.
High-cycle fatigue (HCF) studies were performed on zirconium (Zr)-based bulk metallic glasses (BMGs): Zr41.2Ti13.8Ni10Cu12.5Be22.5, in atomic percent. The HCF experiments were conducted using an electrohydraulic machine at a frequency of 10 Hz with a R ratio of 0.1 and under tension-tension loading, where R = σmin./σmax., where σmin. and σmax. are the applied minimum and maximum stresses, respectively. The test environment was air. A high-speed and high-sensitivity thermographic-infrared (IR) imaging system has been used for nondestructive evaluation of temperature evolution during fatigue testing of BMGs. Limited temperature evolution was observed during fatigue. However, no sparking phenomenon was observed at the final moment of fracture of this BMG. At high stress levels (σmax. > 864 MPa), the fatigue lives of Batch 59 are longer than those of Batch 94 due to the presence of oxides in Batch 94. Moreover, the fatigue-endurance limit of Batch 59 (703 MPa) is somewhat greater than that of Bath 94 (615 MPa) in air. The fatigue-endurance limit of Ti-6–4 is greater than this BMG, but Al 7075 has the lowest fatigue life. The vein pattern with a melted appearance were observed in the apparent melting region. The fracture morphology indicates that fatigue cracks initiate from some defects.
Due to their very low thermal conductivities and large thermal expansion values, bulk metallic glasses (BMGs) undergo differential cooling during processing. Large thermal gradients are generated across a specimen leading to residual stress buildup. A thin surface layer contains compressive stresses balanced by tension in the middle. Such stresses can not only influence the mechanical behavior of BMGs, but they can also lead to problems during manufacturing of large or intricate components. Analytical and finite element modeling was used to predict the values and distribution of such stresses as a function of processing conditions. Neutron diffraction measurements were then performed on model specimens which included crystalline phases as “strain gages”. It was shown that significant stresses, on the order of several hundred MPa, can be generated in BMGs. Modeling and diffraction results are presented and their implications discussed.