Background: Dural tears (DT) are relatively common spine surgery complications, increasing risks of cerebrospinal fluid leaks, adverse events, and prolonged hospitalization. This study sought to identify DT predictors and compare postoperative outcomes including adverse events, revision, emergency room (ER) care, and length of stay between DT and non-DT cohorts. Methods: Retrospective analysis of elective spine surgery patients at a single tertiary centre. Variables included demographics, DT repair techniques, risk factors, post-operative adverse events, ER care within 30 days post-op, and revision. Binary logistic regression was used to analyze risk factors while hierarchical logistic and linear regressions analyzed postoperative events. Results: 6.6% of patients experienced DTs, with patches used in 40% of repairs. Age was a risk factor for DT (EXP(B)=1.039, CI [1.016, 1.063]), while minimally invasive surgery (MIS) (EXP(B)=0.521, CI [.297, .912]) reduced risk. DTs were associated with increased rates of cardiac arrest (EXP(B) = 3.966, CI [1.046, 15.033]), urinary retention (EXP(B)=2.408, CI [1.218, 4.759]), revision (EXP(B)=4.574, CI [1.941, 10.779]), ER visits (EXP(B)=1.975, CI [1.020, 3.826]), and length of stay (B=3.42, p<0.001). Conclusions: MIS seems to be associated with decreased DT risk. DTs are also associated with post-operative cardiac arrest, urinary retention, required revision surgery, and visits to the ER within 30 days post-op.

Rasch proposed an exact conditional inference approach to testing his model but never implemented it because it involves the calculation of a complicated probability. This paper furthers Rasch’s approach by (1) providing an efficient Monte Carlo methodology for accurately approximating the required probability and (2) illustrating the usefulness of Rasch’s approach for several important testing problems through simulation studies. Our Monte Carlo methodology is shown to compare favorably to other Monte Carlo methods proposed for this problem in two respects: it is considerably faster and it provides more reliable estimates of the Monte Carlo standard error.

I develop a survey method for estimating social influence over individual political expression, by combining the content-richness of document scaling with the flexibility of survey research. I introduce the “What Would You Say?” question, which measures self-reported usage of political catchphrases in a hypothetical social context, which I manipulate in a between-subjects experiment. Using Wordsticks, an ordinal item response theory model inspired by Wordfish, I estimate each respondent’s lexical ideology and outspokenness, scaling their political lexicon in a two-dimensional space. I then identify self-censorship and preference falsification as causal effects of social context on respondents’ outspokenness and lexical ideology, respectively. This improves upon existing survey measures of political expression: it avoids conflating expressive behavior with populist attitudes, it defines preference falsification in terms of code-switching, and it moves beyond trait measures of self-censorship, to characterize relative shifts in the content of expression between different contexts. I validate the method and present experiments demonstrating its application to contemporary concerns about self-censorship and polarization, and I conclude by discussing its interpretation and future uses.

Text is a major medium of contemporary interpersonal communication but is difficult for social scientists to study unless they have significant resources or the skills to build their own research platform. In this paper, we introduce a cloud-based software solution to this problem: ReChat, an online research platform for conducting experimental and observational studies of live text conversations. We demonstrate ReChat by applying it to a specific phenomenon of interest to political scientists: conversations among co-partisans. We present results from two studies, focusing on (1) self-selection factors that make chat participants systematically unrepresentative and (2) a pre-registered analysis of loquaciousness that finds a significant association between speakers’ ideological extremity and the amount they write in the chat. We conclude by discussing practical implications and advice for future practitioners of chat studies.

Fatty acids are essential molecules, which function as structural components, energy sources, and signaling mediators(1). Subcutaneous adipose tissue (SAT) is the largest fat depot and plays a crucial role in maintaining health and homeostasis(2,3). While regulation and health impacts of circulating fatty acid levels are well established, less is known about the regulation of fatty acid levels within adipose tissue itself. The aim of this study was to investigate the effect of dietary and genetic contribution to fatty acid contents in adipose tissue and identify the interaction between single nucleotide polymorphism (SNP) and diet on adipose fatty acids.

In 427 healthy female twins from TwinsUK, 18 types of fatty acids were measured in SAT biopsies alongside genotype, RNA-Seq and clinical phenotypes. Dietary intake was collected by food frequency questionnaire. The associations between dietary intake and adipose fatty acids were tested with linear mixed models, adjusting for age, smoking, physical activity, index of multiple deprivation, energy intake, and relatedness. Genome-wide association studies (GWAS) were performed adjusting for age.

The association between dietary scores, food intake, nutrient intake and fatty acid levels in adipose tissue were examined. Most dietary scores were positively correlated with polyunsaturated fatty acid (PUFA) but negatively correlated with trans-unsaturated fatty acid (TFA) (PFDR < 0.05). We highlighted the positive association between polyunsaturated margarine and fish intake and PUFA levels, as well as butter and cream intake and saturated fatty acid (SFA) levels (PFDR < 0.05). Negative associations between fresh red meat including lamb and beef, butter, and cream intake and PUFA levels in adipose tissue were observed (PFDR < 0.05). Regarding nutrient intake, PUFA, SFA, TFA, cholesterol, vitamin D, and vitamin E were correlated with fatty acid levels in adipose tissue (PFDR < 0.05). To reveal local genetic regulation of fatty acids in adipose tissue, we performed GWAS and identified 10 fatty acid-associated genetic loci across 13 fatty acids (i.e. palmitic acid/palmitoleic acid – at the SCD locus, dihomo-γ-linolenic acid/arachidonic acid at the FADS1 locus, P < 5 × 10-8). The integration of adipose gene expression data revealed the mediation effects of SCD and FADS1 expressions in the associations between FADS1 SNP and the conversion of unsaturated fatty acids. We took forward two GWAS lead SNPs (SCD SNP and FADS1 SNP) to test the SNP-by-diet interaction on adipose fatty acids. Milk intake showed SNP-by-diet interaction with FADS1 SNP for linoleic acid and docosapentaenoic acid levels (P < 0.001). The interactions between roasted potatoes/chips and FADS1

SNP were significant for dihomo-γ-linolenic acid/linoleic acid (P < 0.001).

Adipose fatty acid levels were regulated by both genetic variants and dietary intake. We found suggestive evidence for the interaction of genetic variant and diet.

According to the Laozi one of the ways to cultivate and grasp Dao is through “remaining female” and “nourishing the mother.” The term mother is used in reference to the beginning of all existence—“the mother of all under heaven,” “the mother of all existences.” The mother is both an active force of generation and the concreteness of the generated beings. In this sense, the feminine attribute of motherhood is a living embodiment of Dao. In the world of myriad phenomena, the mother provides a location of interaction between “absence” and “presence,” between wu and you. In this paper, I suggest an analysis of the metaphor of mother and other “feminine roles” in early Daoist thought through a textual examination of the Laozi. Considering the intellectual background in Warring States period China in which the common understanding of the universe and all phenomena is revealed through the interactions of correlative and complementary forces, the esteem of one over the other—the feminine over the male, the mother over father—is outstanding and deserves serious investigation. The question is what can we learn from the feminine, what can femininity teach us about the world, its generation, and even political practice?

We review successes and challenges from five recent subglacial bedrock drilling campaigns intended to find evidence for Antarctic Ice Sheet retreat during warm periods in the geologic past. Insights into times when the polar ice sheets were smaller than present serve as guiding information for modeling efforts that aim to predict the rate and magnitude of future sea level rise that would accompany major retreat of the Antarctic Ice Sheet. One method to provide direct evidence for the timing of deglaciations and minimum extent of prior ice sheets is to extract subglacial bedrock cores for cosmogenic nuclide analysis from beneath the modern ice sheet surface. Here we summarize the lessons learned from five field seasons tasked with obtaining bedrock cores from shallow depths (<120 m beneath ice surface) across West Antarctica since 2016. We focus our findings on drilling efforts and technology and geophysical surveys with ground-penetrating radar. Shallow subglacial drilling provides a high risk, high reward means to test for past instabilities of the Antarctic Ice Sheet, and we highlight key challenges and solutions to increase the likelihood of success for future subglacial drilling efforts in polar regions.

Pompey owned numerous properties in Italy, but except for a few residential villas little is known of their location or economic function. However, two amphora stamps have been attributed to him, which show that he was involved in the manufacture of amphorae, and probably in the production of the wine. Four tile stamps, found in the vicinity of Gravina in Puglia and at a villa at San Gilio in the upper Bradano valley, can also be attributed to Pompey for reasons discussed in detail in this paper. Since they were found in locations close to a drove road, it is inferred that Pompey had invested in properties which could be used as pasture for transhumant sheep. The circumstances in which he acquired the estate near Gravina are discussed, and it is suggested that it fell within the territory of Silvium and is likely to have been acquired by him after the War of Spartacus in which the settlement was destroyed. It is also suggested that the estate was bought by Octavian in the sale of Pompey's properties, which was still ongoing in 44 BC.

The importance of precipitation rate as an effective control on illite and kaolanite formation during diagenesis has been examined by measuring precipitation rates, from Al fluid concentration, in a Dickson fluid-sampling vessel at 160°-250° and 500 bars (50 MPa). These experiments are considered to be analogues of the precipitation of clays in sandstones from porewaters containing dissolved carboxylic acids, which have a transient stability and may influence aluminosilicate solubility. Precipitated illite had a lath-shaped morphology and its composition was consistent with authigenic illite in sandstones. Kaolinite formed tabular rather than vermicular shaped crystals. Kaolinite precipitation rate was two orders of magnitude faster than illite precipitation and was rate-limited by the decomposition of oxalate; kaolinite formation should be equilibrium-controlled at virtually all stages of burial. Extrapolation of illite precipitation rate to burial temperatures indicates that the first appearance of illite in a burial sequence may be kinetically controlled. A model of illite precipitation based on these experimental results has been used to predict the time required to precipitate illite during burial of a sandstone, taking into account temperature changes during burial. For northern North Sea examples, a predicted illitization threshold of -60°C occurring at 60–80 Ma corresponds to the observed initiation of authigenic illite precipitation. Times of around 2–5 Ma would be required to reach a 98% approach to equilibrium at this threshold. The main phase of illite precipitation in the northern North Sea basin is a later, hydrologically controlled event (30-50 Ma). Equilibrium would be approached in around 0.1 Ma during this phase, which is consistent with the narrow illite K/Ar age range (1-5 Ma) recorded for some sequences.

Specialty care is associated with improved outcomes for adults with adult CHD and must be extended to the underserved. A retrospective cohort study was performed to describe the provision of care to adult CHD patients in America’s largest municipal public health system including patient demographics, diagnostic and therapeutic procedures, and adherence to guideline-recommended surveillance. We identified 229 adult CHD patients aged >18 years through electronic medical records. The most common diagnoses were atrial septal defect, ventricular septal defect, patent ductus arteriosus, and valvular pulmonary stenosis. In total, 65% had moderate or greater anatomic complexity. A large number of patients were uninsured (45%), non-white (96%), and non-English speaking (44%). One hundred forty-six patients (64%) presented with unrepaired primary defects. Fifty eight patients underwent primary repair during the study period; 48 of those repairs were surgical and 10 were transcatheter. Collaboration with an affiliated Comprehensive Care Center was utilised for 28% of patients. A high proportion of patients received adult CHD speciality visits (78%), echocardiograms (66%), and electrocardiograms (56%) at the guideline-recommended frequency throughout the study period. There was no significant difference in the rate of adherence to guideline-recommended surveillance based on insurance status, race/ethnicity, or primary language status. The proportion of patients who had guideline-recommended adult CHD visits, echocardiograms, and electrocardiograms was significantly lower for those with more advanced physiological stages. These results can inform the provision of adult CHD care in other public health system settings.

Research framed around issues of diversity and representation in STEM is often controversial. The question of what constitutes a valid critique of such research, or the appropriate manner of airing such a critique, thus has a heavy ideological and political subtext. Here, we outline an attempt to comment on a paper recently published in the research journal Physical Review – Physics Education Research (PRPER). The article in question claimed to find evidence of ‘whiteness’ in introductory physics from analysis of a six-minute video. We argue that even if one accepts the rather tenuous proposition that ‘whiteness’ is sufficiently well defined to observe, the study lacks the proper controls, checks and methodology to allow for confirmation or disconfirmation of the authors’ interpretation of the data. The authors of the whiteness study, however, make the stunning claim that their study cannot be judged by standards common in science. We summarize our written critique and its fate, along with a brief description of its genesis as a response to an article in which senior officers of the American Physical Society (which publishes PRPER) explained that the appropriate venue for addressing issues with the paper at hand is via normal editorial processes.

Canadian election campaigns often see a proliferation of political signs at the start of an election, but are they worth the effort? We examined official results at the poll level (N = 785) from elections agencies and the quantities of household signs recorded in internal political party databases (Green Parties of Canada, Manitoba, and Ontario). Overall, the results suggest that the use of household signs is an effective form of political campaigning in Canada for nongoverning parties. Analyses suggest that every sign placed per 100 registered electors is associated with an increase of 0.5–1.5 per cent vote share. The presence of household signs was associated with an increase of 1.5–3.4 per cent vote share. Further, preliminary evidence also suggests a possible diminishing returns trend: the per-sign rate of increase in vote share may slow down at higher densities. We discuss the implications of the results, including the possible curvilinear trend.

This “Keywords Redux” article examines the significance of drugs (psychoactive substances) in Victorian culture and literature, theorizing their potential for both performance enhancement and for pleasure.

The aim of this study was to assess welfare outcomes of electrical stunning as a means of restraint in farmed grower saltwater crocodiles (Crocodylus porosus). Physical handling of a stunned, unconscious crocodile is far safer for the operator than handling a fully conscious animal. Electroencephalogram (EEG) was recorded before and after the application of electrical stunning at 50 Hz or 400 Hz using an electrical stunner applied to the cranial plate (Position 1: P1–50 Hz; n = 31, P1–400 Hz; n = 29) or immediately behind the skull (Position 2: P2–50 Hz; n = 29; P2–400 Hz; n = 30). For all electrical stuns, percentage total EEG power in a 10-s epoch decreased in the alpha and beta frequency bands; and increased in the delta and lower frequencies bands. All electrical stuns resulted in increased strength of signal, based on the quadratic mean EEG power in all frequency bands of the EEG. Greatest change in power occurred in the delta frequency band, with P1–50 Hz. This was greater than with P2–50 Hz; while decibel change using 400 Hz at either position was intermediate and not significantly different from either. Application of either electrical stunner at position 1 resulted in seizure-like activity and activation in low frequencies, but at position 2 this was not consistent across all animals. The ability of the electrical stunning equipment to consistently induce recoverable unconsciousness could be ranked in decreasing order as: P1–50 Hz > P1–400 Hz = P2–50 Hz > P2–400 Hz. Based on behavioural observations, all animals in the study appeared to stunned however evaluation of duration of EEG changes indicates that use of the electrical stunning equipment at 50 Hz would allow some margin for inaccuracies in tong placement, while achieving a consistently reliable stun.

The prevention of unnecessary suffering at slaughter is considered to be an imperative and, as such, the majority of animals slaughtered under industrial conditions are stunned prior to slaughter by mechanical, electrical or gas inhalation means. However, many Orthodox Jewish and Muslim communities do not accept pre-slaughter stunning. Those Jewish and Muslim communities that do accept pre-slaughter stunning require that any such stun is fully reversible in order to meet the requirements of their religious laws. Head-only electrical stunning is widely used in sheep, as it is a reversible method of stunning, but in cattle, the stun duration can be so short that the animal may regain consciousness during exsanguination. The concept of using electromagnetic radiation to induce insensibility has been proposed. Early attempts to induce insensibility and death in laboratory species were successful, but the technology to apply the technique to larger animals was not available at that time. More recently, however, technological advances have led to new work in the areas of transcranial magnetic stimulation and microwave irradiation, both of which are potential methods of inducing a recoverable stun in larger species.

This paper compares the behavior of individuals playing a classic two-person deterministic prisoner’s dilemma (PD) game with choice data obtained from repeated interdependent security prisoner’s dilemma games with varying probabilities of loss and the ability to learn (or not learn) about the actions of one’s counterpart, an area of recent interest in experimental economics. This novel data set, from a series of controlled laboratory experiments, is analyzed using Bayesian hierarchical methods, the first application of such methods in this research domain.

We find that individuals are much more likely to be cooperative when payoffs are deterministic than when the outcomes are probabilistic. A key factor explaining this difference is that subjects in a stochastic PD game respond not just to what their counterparts did but also to whether or not they suffered a loss. These findings are interpreted in the context of behavioral theories of commitment, altruism and reciprocity. The work provides a linkage between Bayesian statistics, experimental economics, and consumer psychology.