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This article seeks both to reassess the dynamics of the Northern Irish civil rights movement during the mid to late 1960s, as well as to suggest a new understanding of the role of parliamentary forces in furthering the goals of social movements. During the 1960s, Northern Ireland underwent significant socio-political upheaval, centred on the rights of the region’s Catholic minority and their long-term concerns regarding democratic representation, unemployment and housing. The resulting civil rights movement sought to avoid the traditional ethno-nationalist fault lines of Ulster politics and appealed directly to the British government and people, bypassing the devolved Stormont parliament with its permanent Protestant-Unionist majority. While vital work has been done to analyse this important period, aspects of British-based activism for civil rights in Northern Ireland have not yet been fully scrutinised. One key British group was the Campaign for Democracy in Ulster (CDU). Primarily made up of backbench Labour MPs, the CDU pursued civil rights at Westminster by advocating for governmental inquiries and legislative reform to address Catholic grievances. Although highly energetic, the CDU faced deep constitutional barriers and the organisation’s efforts have generally been seen as unsuccessful. However, new archival work and a reappraisal of previous studies suggests a more nuanced view. The CDU had more influence than the organisation itself believed. This has implications not only for our understanding of the civil rights movement, but also for interpreting the actions of groups such as the CDU, described here as ‘Parliamentary Activists’, both historically and in the present day.
The growth of the study of the history of Africa south of the Sahara is an interesting example of contemporary intellectual developments. Until the mid-1950's African history was ignored by the historical profession in the United States even more completely than in Europe; and if an American historian had paused to consider why this was so, he would probably have anticipated Trevor-Roper's well-known verdict that the history of sub-Saharan Africa is undiscoverable (on the ground that it is not documented) and that, even if it were discoverable, it would be devoid of intellectual significance (on the ground that traditional African societies were barbarous and static). No professor with tenure at an American university was designated as a historian of sub-Saharan Africa; American publishers had produced very few books or articles dealing with African history, and Americans generally knew scarcely anything about it.
There were, however, several pioneer activities which were on the periphery of African history. At Howard University there were long-established courses on Negro history, inspired by W. E. B. DuBois and Carter Woodson, which included some West African material, but the American historical establishment paid little attention to this work. William L. Hansberry, who lectured on precolonial African history for some years, was never given tenure by the Howard authorities and was eventually excluded from the faculty. At Northwestern University, Melville Herskovits founded a program of African Studies in 1947. He invited historians to attend the seminars conducted under the program, and he himself published a book on the kingdom of Dahomey and was interested in questions of change as well as structure in African societies. Nevertheless, Herskovits was by training and status an anthropologist, and the history department at Northwestern did not provide lecture courses or seminars on African history before 1958.
Functional impairment in daily activities, such as work and socializing, is part of the diagnostic criteria for major depressive disorder and most anxiety disorders. Despite evidence that symptom severity and functional impairment are partially distinct, functional impairment is often overlooked. To assess whether functional impairment captures diagnostically relevant genetic liability beyond that of symptoms, we aimed to estimate the heritability of, and genetic correlations between, key measures of current depression symptoms, anxiety symptoms, and functional impairment.
Methods
In 17,130 individuals with lifetime depression or anxiety from the Genetic Links to Anxiety and Depression (GLAD) Study, we analyzed total scores from the Patient Health Questionnaire-9 (depression symptoms), Generalized Anxiety Disorder-7 (anxiety symptoms), and Work and Social Adjustment Scale (functional impairment). Genome-wide association analyses were performed with REGENIE. Heritability was estimated using GCTA-GREML and genetic correlations with bivariate-GREML.
Results
The phenotypic correlations were moderate across the three measures (Pearson’s r = 0.50–0.69). All three scales were found to be under low but significant genetic influence (single-nucleotide polymorphism-based heritability [h2SNP] = 0.11–0.19) with high genetic correlations between them (rg = 0.79–0.87).
Conclusions
Among individuals with lifetime depression or anxiety from the GLAD Study, the genetic variants that underlie symptom severity largely overlap with those influencing functional impairment. This suggests that self-reported functional impairment, while clinically relevant for diagnosis and treatment outcomes, does not reflect substantial additional genetic liability beyond that captured by symptom-based measures of depression or anxiety.
We present a dataset of 1,119 radiocarbon dates and their contexts for Oaxaca, Mexico, a best effort to include all published dates, plus hundreds of unpublished samples. We illustrate its potential and limitations with five examples: (1) dated stratigraphy in stream cutbanks show how aggradation, downcutting, and stability responded to global climate and human activities; (2) 14C samples from Late/Terminal Formative contexts allow interregional comparisons of temple and palace construction, use, and abandonment; (3) new 14C dates provide better understanding of events during the Late Classic/Epiclassic, a problematic time in the ceramic chronology; (4) individual Classic/Postclassic residential contexts had long durations—several hundred years; and (5) model constraints from other data permit refinement at times of calibration curve deviation, as during AD 1400–1600. We recommend further chronological refinement with best-practice standards, new samples, existing collections, and statistical modeling.
Direct numerical simulation (DNS) studies of power-law (PL) fluids are performed for purely viscous-shear-thinning ($n\in [0.5,0.75]$), Newtonian ($n=1$) and purely viscous-shear-thickening ($n=2.0$) fluids, considering two Reynolds numbers ($Re_{\tau }\in [395,590]$), and both smooth and rough surfaces. We carefully designed a numerical experiment to isolate key effects and simplify the complex problem of turbulent flow of non-Newtonian fluids over rough surfaces, enabling the development of a theoretical model to explain the observed phenomena and provide predictions. The DNS results of the present work were validated against literature data for smooth and rough Newtonian turbulent flows, as well as smooth shear-thinning cases. A new analytical expression for the mean velocity profile – extending the classical Blasius $1/7$ profile to power-law fluids – was proposed and validated. In contrast to common belief, the decrease in $n$ leads to smaller Kolmogorov length scales and the formation of larger structures, requiring finer grids and longer computational domains for accurate simulations. Our results confirm that purely viscous shear-thinning fluids exhibit drag reduction, while shear-thickening fluids display an opposite trend. Interestingly, we found that viscous-thinning turbulence shares similarities with Newtonian transitional flows, resembling the behaviour of shear-thinning, extensional-thickening viscoelastic fluids. This observation suggests that the extensional and elastic effects in turbulent flows within constant cross-section geometries may not be significant. However, the shear-thickening case exhibits characteristics similar to high-Reynolds-number Newtonian turbulence, suggesting that phenomena observed in such flows could be studied at significantly lower Reynolds numbers, reducing computational costs. In the analysis of rough channels, we found that the recirculation bubble between two roughness elements is mildly influenced by the thinning nature of the fluid. Moreover, we observed that shear-thinning alters the flow in the fully rough regime, where the friction factor typically reaches a plateau. Our results indicate the possibility that, at sufficiently high Reynolds numbers, this plateau may not exist for shear-thinning fluids. Finally, we provide detailed turbulence statistics for different rheologies, allowing, for the first time, an in-depth study of the effects of rheology on turbulent flow over rough surfaces.
Patients with posttraumatic stress disorder (PTSD) exhibit smaller regional brain volumes in commonly reported regions including the amygdala and hippocampus, regions associated with fear and memory processing. In the current study, we have conducted a voxel-based morphometry (VBM) meta-analysis using whole-brain statistical maps with neuroimaging data from the ENIGMA-PGC PTSD working group.
Methods
T1-weighted structural neuroimaging scans from 36 cohorts (PTSD n = 1309; controls n = 2198) were processed using a standardized VBM pipeline (ENIGMA-VBM tool). We meta-analyzed the resulting statistical maps for voxel-wise differences in gray matter (GM) and white matter (WM) volumes between PTSD patients and controls, performed subgroup analyses considering the trauma exposure of the controls, and examined associations between regional brain volumes and clinical variables including PTSD (CAPS-4/5, PCL-5) and depression severity (BDI-II, PHQ-9).
Results
PTSD patients exhibited smaller GM volumes across the frontal and temporal lobes, and cerebellum, with the most significant effect in the left cerebellum (Hedges’ g = 0.22, pcorrected = .001), and smaller cerebellar WM volume (peak Hedges’ g = 0.14, pcorrected = .008). We observed similar regional differences when comparing patients to trauma-exposed controls, suggesting these structural abnormalities may be specific to PTSD. Regression analyses revealed PTSD severity was negatively associated with GM volumes within the cerebellum (pcorrected = .003), while depression severity was negatively associated with GM volumes within the cerebellum and superior frontal gyrus in patients (pcorrected = .001).
Conclusions
PTSD patients exhibited widespread, regional differences in brain volumes where greater regional deficits appeared to reflect more severe symptoms. Our findings add to the growing literature implicating the cerebellum in PTSD psychopathology.
Alcohol misuse among women has risen compared to men. Women experience barriers to engaging in patient-centered comparative effectiveness research (CER) that, in turn, limits the evidence base for addressing alcohol misuse in this population. In this manuscript, we describe WomenWise, a community-partnered project and outline how we co-developed community focused CER training curriculum and collaboratively planned future partnered learning sessions (PLSs) with Community Advisory Board (CAB) feedback. Through this approach we aim to empower women to contribute to future patient-centered CER and enhance the stakeholder capacity for future patient-centered research.
To mitigate the risk of harm to themselves or others, people with mental disorders may require compulsory admission to hospital for in-patient treatment. In England and Wales this is authorised under the Mental Health Act 1983 (MHA). Patients have the right to appeal against this involuntary detention at a hearing before the First-tier Tribunal (Health Education and Social Care Chamber) Mental Health, and psychiatrists may be called on to provide written and oral evidence to the tribunal. The purpose of this article is to help psychiatrists, particularly trainees, understand the sections of the MHA involved, the patient’s right of appeal, the role of the tribunal, their own role as a professional witness, and how to improve the quality of evidence they provide.
The Intergovernmental Negotiating Committee (INC) on plastic pollution are United Nations member states who will convene for the second part of the fifth session of the Intergovernmental Negotiating Committee in Geneva (INC5.2) 5-14 August, 2025 to negotiate a global plastics treaty. The Scientists’ Coalition for an Effective Plastics Treaty (‘The Scientists’ Coalition’) is an international network of independent scientific and technical experts who have been contributing robust science to treaty negotiators since INC1 in 2022. The Scientists’ Coalition established a series of working groups following INC5.1 in Busan, Korea 25 November – 1 December 2024. Each working group has produced science-based responses to the selected articles of ‘the Chair’s text’ (the latest version of the draft global plastics treaty text). This Letter to the Editor summarises those responses.
The COVID-19 pandemic and associated restrictive measures affected the mental health and well-being of individuals globally. We assessed non-modifiable and modifiable factors associated with the change in well-being and mental health from pre- to during the COVID-19 pandemic in South Africa.
Methods:
A cross-sectional online survey was conducted from 26-April-2020 to 22-April-2021. Paired samples t-tests were conducted to assess change in well-being (measured on The World Health Organization-Five Well-Being Index (WHO-5)) and mental health (a validated composite psychopathology p-score). Sociodemographic, environmental, clinical and behavioral factors associated with change in outcomes were examined.
Results:
The sample comprised of 1866 adults (M age=44.26±17.36 years, female=78.9%). Results indicated a significant decrease in well-being (p<0.001) and increase in p-score (p<0.001) from pre- to during the pandemic. Having a prior mental health condition was associated with a worsening well-being score, while being female was associated with a worsening p-score. Being of Black African descent was associated with improved p-score and higher socioeconomic status (SES) was associated with improved well-being. Factors associated with worsening of both well-being and the p-score included adulthood adversity, financial loss since COVID-19, and placing greater importance on direct contact/interactions and substance use as coping strategies. Higher education level and endorsing studying/learning something new as a very important coping strategy were associated with improved well-being and p-score.
Conclusion:
Findings inform the need for targeted interventions to reduce and prevent adverse well-being and mental health outcomes during a pandemic, especially among vulnerable groups.
This chapter explores the complex representations of the Black middle class in August Wilson’s American Century Cycle, with particular attention given to Radio Golf. After providing contextual material on the Black middle class in culture and literature, it examines the importance of Harmond Wilks, the real estate developer and aspiring politician at the center of the play who eventually rejects conventional notions of Black aspiration and uplift for African values of community, family, and cultural origins. The chapter demonstrates how Wilks’s trajectory from being a son of privilege to becoming a community rebel highlights Wilson’s evolving views about the potential of the Black elite and the need for their participation to change the world for Black Americans.
Multicenter clinical trials are essential for evaluating interventions but often face significant challenges in study design, site coordination, participant recruitment, and regulatory compliance. To address these issues, the National Institutes of Health’s National Center for Advancing Translational Sciences established the Trial Innovation Network (TIN). The TIN offers a scientific consultation process, providing access to clinical trial and disease experts who provide input and recommendations throughout the trial’s duration, at no cost to investigators. This approach aims to improve trial design, accelerate implementation, foster interdisciplinary teamwork, and spur innovations that enhance multicenter trial quality and efficiency. The TIN leverages resources of the Clinical and Translational Science Awards (CTSA) program, complementing local capabilities at the investigator’s institution. The Initial Consultation process focuses on the study’s scientific premise, design, site development, recruitment and retention strategies, funding feasibility, and other support areas. As of 6/1/2024, the TIN has provided 431 Initial Consultations to increase efficiency and accelerate trial implementation by delivering customized support and tailored recommendations. Across a range of clinical trials, the TIN has developed standardized, streamlined, and adaptable processes. We describe these processes, provide operational metrics, and include a set of lessons learned for consideration by other trial support and innovation networks.
Variation between general practices in the rate of consultations for musculoskeletal pain conditions may signal important differences in access to primary care, perceived usefulness, or available alternative sources of care; however, it might also just reflect differences in underlying ‘need’ between practices’ registered populations. In a study of 30 general practices in Staffordshire, we calculated the proportion of adults consulting for a musculoskeletal pain condition, then examined this in relation to selected practice and population characteristics, including the estimated prevalence of self-reported musculoskeletal problems and chronic pain in each practices’ registered population. Between September 2021 and July 2022, 18,388 adults were consulted for a musculoskeletal pain condition. After controlling for length of recruitment, time of year, and age-sex structure, the proportion consulting varied up to two-fold between practices but was not strongly associated with the prevalence of self-reported long-term musculoskeletal problems, chronic pain, and high-impact chronic pain.
The objective is to determine if a practical face-to-face emergency disaster incident response training program delivered in the clinical setting will improve self-reported confidence and assessed knowledge of emergency department (ED) nurses to respond to disasters.
Methods
A single site prospective pre-test and post-test randomized controlled trial was adopted for this study. The intervention was a practical face-to-face training program, while the control group completed the required annual mandatory hospital online training.
Results
There was a large difference in post-test median self-reported confidence between groups. There was also a large difference in the proportion of subjects who reached satisfactory levels of self-reported confidence post-test. Regarding assessed knowledge, there was a moderate difference in post-test median knowledge between groups. There was also a moderate difference in the proportion who reached satisfactory levels of knowledge post-test.
Conclusions
This study has shown that ED nurses who undertake a practical face-to-face disaster preparedness education program in the clinical setting, are better prepared to respond to emergency disaster incidents. Organizations should consider the use of a practical structured face-to-face emergency disaster incident response education program to complement and enhance any online emergency and disaster training.
Aims: This study aimed to review prior research on tabletop role-playing games (TTRPG) as a therapeutic tool for neurodiverse individuals and identify gaps in the field to direct future research.
Methods: A comprehensive systematic review of available literature on the use of TTRPGs in the neurodiverse population was completed, with no limitations to publication language or date. This was completed using appropriate medical subject headings (MeSH terms) and ProQuest to search 21 electronic data bases. Papers were superficially reviewed using the title and abstract to determine if they met the inclusion criteria and relevant articles were reviewed in full.
Results: The systematic search resulted in the identification of 5 relevant articles, containing a combination of peer-reviewed journal articles (n=3), and dissertations/theses (n=2). The majority of papers (n=3) were published in the western world, with others coming from Japan (n=1) and Brazil (n = 1).
Conclusion: Existing literature suggests that TTRPGs offer significant benefits for neurodiverse individuals, particularly in enhancing social skills, communication, and overall social functioning. Kato’s (2019) qualitative case study showed that TTRPGs improved social functioning, intentional communication, and cooperative decision-making in youth with autism spectrum disorder (ASD). Henning et al. (2024) echoed these findings, though they were not statistically significant. The benefits of TTRPGs were also demonstrated by Parks (2021), remarking that TTRPGs allow autistic young adults to practice social roles and skills at their own pace. Atherton et al. (2024) expanded this by showing that TTRPGs helped autistic adults form social connections in a safe, structured setting, promoting community and friendship. A shift in focus was seen in the study presented by Rubin-Budick (2022), which focused on the perspective of the therapist over the participants. This research gave an overriding consensus on the effectiveness of TTRPGs in improving emotional attunement and social engagement. Whilst the current body of research highlights these potential benefits, it is important to note that the studies conducted so far have been limited by small sample sizes and narrow participant demographics, with an overriding focus on ASD over other neurodiverse conditions.
Overall, available literature suggests that TTRPGs can enhance social development, communication, and emotional well-being in neurodiverse individuals. This review has also highlighted the need to explore the role of TTRPGs as a therapeutic tool in a wider range of neurodiverse conditions, with particular reference to attention deficit hyperactivity disorder (ADHD).
In the common law tradition, legal decisions are supposed to be grounded in both statute and precedent, with legal training guiding practitioners on the most important and relevant touchstones. But actors in the legal system are also human, with the failings and foibles seen throughout society. This may lead them to take methodological shortcuts, even to relying on unknown internet users for determinations of a legal source’s relevance. In this chapter, we investigate the influence on legal judgments of a pervasive, but unauthoritative source of legal knowledge: Wikipedia. Using the first randomized field experiment ever undertaken in this area – the gold standard for identifying causal effects – we show that Wikipedia shapes judicial behavior. Wikipedia articles on decided cases, written by law students, guide both the decisions that judges cite as precedents and the textual content of their written opinions. Collectively, our study provides clear empirical evidence of a new form of influence on judges’ application of the law – easily accessible, user-generated online content.
Wilms tumor (WT) is the most common renal malignancy in children, with a peak incidence between the ages of 3 and 4 years. This study aimed to evaluate the clinicopathological features, treatment characteristics and survival outcomes of patients managed for WT at the study site.
Methods:
This was a quantitative cross-sectional study involving 137 pediatric patients diagnosed with and managed for WT between 2012 and 2021. Total population sampling was used for participant selection. Data were analyzed using SPSS software, with Kaplan-Meier and Cox regression analysis used to estimate survival rates and examine prognostic factors. P-values < 0·05 were considered statistically significant.
Results:
The 2- and 5-year overall survival (OS) rates were 75% and 70%, respectively, while the disease-free survival (DFS) rates at 2- and 5-years were both 79%. Pathological staging significantly impacted OS and DFS (p = 0·000), while age, gender, weight and risk stratification did not show statistically significant differences. The left kidney was the most common primary site (51%), with an even male to female gender ratio of 1:1. Metastases were most common in the chest (n = 19, 13·8%) and lungs (n = 13, 9·5%).
Conclusions:
Pathological stage was the most significant prognostic factor for both OS and DFS, emphasizing the importance of early detection and timely intervention. While the 2- and 5-year OS and DFS rates represent an improvement over previous studies in Ghana, they remain suboptimal compared to outcomes in high-income countries. A holistic, coordinated institutional treatment regimen has enhanced patient compliance, survival outcomes and follow-up care.