Estimates of test size (probability of Type I error) were obtained for several specific repeated measures designs. Estimates were presented for configurations where the underlying covariance matrices exhibited varying degrees of heterogeneity. Conventional variance ratios were employed as basic statistics in order to produce estimates of size for a conventional test, an ∊-adjusted test, and ∊-adjusted test and a conservative test. Indices for empirical distributions of two estimators of ∊j, a measure of covariance heterogeneity, were also provided.

Dickite and kaolinite are polymorphs of Al4(Si4O10)(OH)8. Dickite traditionally is regarded as hydrothermal, based on field and laboratory evidence. Dickite and kaolinite occur in cavities in phylloid algal limestones, in interstices of biocalcarenites and sandstones, and along joints, fractures, and stylolites, in Pennsylvanian rocks exposed throughout 9600 square miles of southeastern Kansas. The stratigraphic interval of approximately 1100 ft extends from the Fort Scott Limestone (Desmoinesian) through the Lecompton Limestone (Virgilian). The best crystallized dickites are found in porous algal limestones as pockets of glistening white powder composed of well developed pseudohexagonal plates up to 40 μ across. Very well crystallized kaolinites occur similarly, except the crystals are much smaller. Less well crystallized dickites and b-axis disordered kaolinites occur in less porous rocks. Variations in crystal size and morphological development are genetically significant.

Dickite-kaolinite distribution is related to: (1) stratigraphic alternation of limestones and impervious shales; (2) gentle, westward regional dip; (3) thick, mound-like buildups of highly porous algal limestones, miles in length and width; (4) igneous intrusions (early Tertiary?) in Woodson and Wilson counties. Dickite is confined to an elliptical area 125 miles long northeast-southwest, extending 60 miles eastward from the intrusions. Dickite is associated preferentially with porous algal mounds. Kaolinite occurs in less porous rocks within the dickite area, and also is abundant well beyond. Heated groundwaters, possibly mixed with magmatic waters, moved readily up-dip and along strike outward from the intrusions through the conduit-like algal mounds; dickite was deposited from such solutions. Where water movement was restricted or where water had travelled tens of miles from the intrusions, water temperature fell below the limit for dickite crystallization, and kaolinite precipitated instead. Kansas dickite, unlike most other reported dickites, formed in rocks that were neither deeply buried nor extensively altered hydrothermally.

Four chlorite polytypes of Bailey and Brown (1962) have been identified by X-ray diffraction in clay-size chlorites of soils, sediments, and sedimentary rocks: (1) IIb, the polytype of common metamorphic and igneous chlorites; (2) Ib(ß = 90°); (3) Ib(ß = 97°); (4) Ia. An additional stacking arrangement. Iba, is defined herein as disordered chlorite which lacks an h0l diffraction band in the 2.4–2.5 Å region.

Most type-I chlorites are authigenic, as demonstrated by thin-section petrography. Type-I chlorites form during diagenesis, or less commonly during halmyrolysis, at temperatures and pressures less than those of low-grade metamorphism. A type-1 crystallization sequence is proposed, from least to most stable: Iba → Ib(ß = 97°) → Ib(ß = 90°). Conditions of low-grade metamorphism usually are necessary to cause conversion of Iba(ß = 90°) to IIb, the most stable and common polytype. Chemical composition has little or no influence upon polytype relative stabilities; temperature is much more important.

Sediment source areas with high relief, abundant rainfall, cold climate, and which contain IIb-chlorite-bearing metamorphic rocks, may yield essentially unweathered IIb chlorite to sites of deposition. Thus, clay-size IIb chlorite in unmetamorphosed sedimentary rocks can be interpreted as detrital. Caution is required, however, because IIb may be able to form authigenically at submetamor-phic temperatures, because it is the most stable polytype. Petrographic evidence is useful in such cases.

Chlorite polytypism as a geothermometer can be applied to several geologic problems: (1) the authigenic versus detrital origin of clay minerals in sedimentary rocks, particularly in graywacke matrix; (2) the recognition of diagenetic facies or gradients, areally and stratigraphically, within given geologic provinces; (3) the detection of hydrothermal and incipient metamorphic effects. Chlorite polytypism merits general application as an interpretive tool.

Rabbit farming is a form of low input agriculture that has potential to address food security and poverty in East Africa and beyond. For low input agriculture, farmers utilize local and affordable farm resources making it accessible across income levels. Understanding barriers and facilitators to rabbit farming could increase effectiveness of this form of low input agriculture in communities struggling with low food security and poverty, particularly for indigenous, smallholder farms. News media is an available source of data about community perceptions and practices on issues such as rabbit farming, food security, and poverty. For this qualitative study, researchers applied a priori and open coding text analysis to examine recurring themes in news media representations regarding perceptions of rabbit farming in East Africa. Results reveal that community members view rabbit farming as a community strategy that promotes better nutrition and food security while reducing poverty. Important themes included how gender and other cultural norms shaped efforts, and the role of sustainability and climate change on farming practices. Further, the easy cultivation of rabbits, funding, and protective policy and support of indigenous smallholder farms were perceived as facilitators for rabbit farming. Finally, investment in infrastructure for market, production, and knowledge-transfer of best production and business practices were considered critical to success for rabbit farmers throughout East Africa.

While fetal alcohol spectrum disorder (FASD) has primarily been thought of as a neurodevelopmental condition, research is beginning to highlight its ‘whole-body’ implications. Accordingly, the current study sought to provide a snapshot of potential health issues. Caregivers of children (median age of 12 years) with an FASD diagnosis were invited to participate in an online survey. Information relating to sample demographics, FASD status of the child and health outcomes were collected. The prevalence of health conditions reported in the FASD sample was compared against national prevalence data. Multiple linear regression utilising a stepwise approach was used to investigate potential predictors of the number of diagnosed health conditions. Survey data were from an international cohort (n = 197), with the majority of respondents based in Australia (40.2%) or the United States (27.7%). The most commonly reported diagnosed health conditions were eye conditions (44.7%), asthma (34.5%), heart conditions (34.0%) and skin conditions (27.4%). Binomial testing indicated the proportion of children diagnosed with these disorders was generally higher in the current FASD population, compared to national prevalence data. Indicators of metabolic dysfunction including diabetes and obesity were not significantly different compared to national prevalence data. Age of FASD diagnosis, existence of comorbid mental health conditions and the primary caregiver being in paid work were identified as being associated with the prevalence of diagnosed health conditions. Overall, the study has provided an up-to-date snapshot of health problems reported in a sample of children with FASD, confirming their increased risk of adverse health outcomes.

Changed spatial configurations at sowing have been investigated as a strategy to minimize interspecific competition and improve the establishment and persistence of multi-species plantings in pastures, but the impact of this practice on the soil microbiome has received almost no previous research attention. Differences in populations of bacteria and fungi in the surface 10 cm of soil in the third year following pasture establishment were quantified using quantitative polymerase chain reaction and terminal restriction fragment length polymorphism methods. Populations were compared on, and between, drill rows sown to either the perennial grass phalaris (Phalaris aquatica L.), perennial legume lucerne (alfalfa; Medicago sativa L.) or the annual legume subterranean clover (Trifolium subterraneum L.). Results showed that soil microbial abundance and diversity were related to plant distribution across the field at the time of sampling and to soil chemical parameters including total carbon (C), mineral nitrogen (N), pH, and available phosphorus (P), potassium (K) and sulfur (S). Despite the 27-month lag since sowing, pasture species remained concentrated around the original drill row with very little colonization of the inter-row area. The abundance and diversity of bacterial and fungal populations were consistently greater under drill rows associated with higher total C concentrations in the surface soil compared with the inter-row areas. Our results showed that the pH and available nutrients were similar between the subterranean clover drill row and the inter-row, suggesting that soil microbial populations were not impacted directly by these soil fertility parameters, but rather were related to the presence or absence of plants. The abundance of bacteria and fungi were numerically lower under phalaris rows compared to rows sown to legumes. The richness and diversity of fungal populations were lowest between rows where lucerne was planted. Possible explanations for this observation include a lower C:N ratio of lucerne roots and/or a lack of fibrous roots at the soil surface compared to the other species, illustrating the influence of contrasting plant types on the soil microflora community. This study highlights the enduring legacy of the drill row on the spatial distribution of plants well into the pasture phase of a cropping rotation and discusses the opportunity to enhance the microbiome of cropping soils on a large scale during the pasture phase by increasing plant distribution across the landscape.

Media and scholastic accounts describe a strong backlash against attempts to advance gay rights. Academic research, however, increasingly raises questions about the sharply negative and enduring opinion change that characterizes backlash among the mass public. How can we reconcile the widespread backlash described by the media with the growing body of academic research that finds no evidence of the opinion change thought to be its hallmark trait? We argue that rather than widespread opinion change, what appears to be backlash against gay rights is more consistent with elite-led mobilization—a reaction by elites seeking to prevent gays and lesbians from achieving full incorporation in the polity. We present evidence from what is widely considered to be a classic case of anti-gay backlash, the 2010 Iowa Judicial Retention Election. Analysis of campaign contribution data in Iowa versus other states between 2010 and 2014, and voter roll-off data exploiting a unique feature of the 2010 retention election supports this argument. The results simultaneously explain how reports of backlash might occur despite increased support for gay rights, and an academic literature that finds no evidence of backlash.

Increasing evidence indicates that gut microbiota may influence colorectal cancer risk. Diet, particularly fibre intake, may modify gut microbiota composition, which may affect cancer risk. We investigated the relationship between dietary fibre intake and gut microbiota in adults. Using 16S rRNA gene sequencing, we assessed gut microbiota in faecal samples from 151 adults in two independent study populations: National Cancer Institute (NCI), n 75, and New York University (NYU), n 76. We calculated energy-adjusted fibre intake based on FFQ. For each study population with adjustment for age, sex, race, BMI and smoking, we evaluated the relationship between fibre intake and gut microbiota community composition and taxon abundance. Total fibre intake was significantly associated with overall microbial community composition in NYU (P=0·008) but not in NCI (P=0·81). In a meta-analysis of both study populations, higher fibre intake tended to be associated with genera of class Clostridia, including higher abundance of SMB53 (fold change (FC)=1·04, P=0·04), Lachnospira (FC=1·03, P=0·05) and Faecalibacterium (FC=1·03, P=0·06), and lower abundance of Actinomyces (FC=0·95, P=0·002), Odoribacter (FC=0·95, P=0·03) and Oscillospira (FC=0·96, P=0·06). A species-level meta-analysis showed that higher fibre intake was marginally associated with greater abundance of Faecalibacterium prausnitzii (FC=1·03, P=0·07) and lower abundance of Eubacterium dolichum (FC=0·96, P=0·04) and Bacteroides uniformis (FC=0·97, P=0·05). Thus, dietary fibre intake may impact gut microbiota composition, particularly class Clostridia, and may favour putatively beneficial bacteria such as F. prausnitzii. These findings warrant further understanding of diet–microbiota relationships for future development of colorectal cancer prevention strategies.

Neutron scattering studies have indicated that the non-coordinated water at smectite surfaces has a similar mobility to that of bulk water, but that the water coordinated to the cations is immobile on the time scale of the neutron measurements. Thus hydrophylic polymers can readily displace the non-coordinated water and bind to the silicate surface, and to the exchangeable cations through a water-bridge mechanism. Poly(ethylene oxide) molecules with molecular weights up to 4000 appear to be bound to Na-montmorillonite in flattened conformations at the clay surface. Poly(vinyl alcohol) is extensively bound by Na-montmorillonite and by Na-Laponite (a synthetic hectorite-like clay); as binding progresses fewer molecule segments can contact the surface and so at the higher levels of adsorption extensive loops of polymer extend away from the silicate surface. Some polyanions provide good protection for smectites against flocculation with salt. The abilities of such polymers to protect the clays is dependent both on the extents of the charges and on the solution conformations which these polymers can assume.

Introduction: In 2016, the Emergency Department (ED) Return Visit Quality Program (RVQP) was developed to promote a culture of quality in Ontario EDs, by mandating large-volume EDs to audit charts of patients who had a return visit leading to hospital admission (RV). This program provides an opportunity to identify possible adverse events (AEs) and quality issues, which can then be addressed to improve patient care. Methods: The RVQP requires EDs to audit a set number of 72-hour RVs for potential AEs/quality issues, as well as all 7-day RVs for one of three key paired sentinel diagnoses (acute myocardial infarction, subarachnoid hemorrhage, and pediatric sepsis). Submitted audits and their AEs/quality issues were analyzed by a team of emergency physicians with quality improvement (QI) expertise, and qualitative metrics were derived. Using the general inductive method, we conducted a qualitative analysis with Health Quality Ontario (HQO), and HQO completed an independent analysis of the submitted narrative reports. Our objective is to report on the qualitative and quantitative metrics of the program, and to explore emerging themes from the AEs/quality issues identified. Results: There were 36,304 72-hour RVs flagged, which represent 0.99% of all 3,672,708 ED visits in the province of Ontario for the 86 EDs participating in the first year of the program. Overall, 2,584 audits were conducted. For the audits involving all-cause 72-hour RVs, 571 (24%) of cases had AEs/quality issues identified. Of the 219 audits involving sentinel diagnoses, 107 (49%) audits identified AEs/quality issues. The qualitative analysis revealed 11 themes, which were classified into three groups : issues related to patient characteristics or actions (elder care, patient risk profile, left without being seen); issues related to actions or processes of the ED team (physician cognitive lapses, handover/communication, high risk medications, documentation, radiology, vital signs); and healthcare system issues (imaging/test availability, discharge planning). Over one hundred local QI projects were completed or planned as a result of the audits performed. Conclusion: The RVQP promotes a culture of quality by highlighting potential AEs and quality themes that can then be targeted to increase patient safety and quality of care in Ontario EDs. Numerous QI projects were undertaken in the first year of the program, and future efforts will monitor the completion and success of these. The program can be easily adapted in other jurisdictions.

A study was conducted to evaluate the response of glyphosate- and dicamba-tolerant (GDT) soybean and weed control from cover crop different termination intervals before and after soybean planting. Cover crop biomass was highest when terminated at planting, decreased with the 7- and 14-d preplant (DPP) and day-after-planting (DAP) timings, and again at the 14 DPP and DAP timings. Glyphosate+dicamba provided total control of cover crops by 21 DAP. Cover crop termination timing did not influence soybean population or yield. Palmer amaranth control at the 21 and 28 d after termination (DAT) was 97% to 99%. Differences in Palmer amaranth control were not detected among herbicide programs or termination intervals at the end of season rating, and all treatments provided ≥97% control. Although differences in Palmer amaranth control were not apparent at the end of the season, the delay in cover crop affected the number of days until 10-cm Palmer amaranth was present. When utilizing a wheat+hairy vetch cover crop in DGT soybeans, producers should delay cover crop termination until 11 to 14 DPP and make at least one POST application of glyphosate+dicamba+an additional herbicide mode of action (MOA) to maximize Palmer amaranth control and soybean yields.

Limitations of access have long restricted exploration and investigation of the cavities beneath ice shelves to a small number of drillholes. Studies of sea-ice underwater morphology are limited largely to scientific utilization of submarines. Remotely operated vehicles, tethered to a mother ship by umbilical cable, have been deployed to investigate tidewater-glacier and ice-shelf margins, but their range is often restricted. The development of free-flying autonomous underwater vehicles (AUVs) with ranges of tens to hundreds of kilometres enables extensive missions to take place beneath sea ice and floating ice shelves. Autosub2 is a 3600 kg, 6.7 m long AUV, with a 1600 m operating depth and range of 400 km, based on the earlier Autosub1 which had a 500 m depth limit. A single direct-drive d.c. motor and five-bladed propeller produce speeds of 1–2 m s−1. Rear-mounted rudder and stern-plane control yaw, pitch and depth. The vehicle has three sections. The front and rear sections are free-flooding, built around aluminium extrusion space-frames covered with glass-fibre reinforced plastic panels. The central section has a set of carbon-fibre reinforced plastic pressure vessels. Four tubes contain batteries powering the vehicle. The other three house vehicle-control systems and sensors. The rear section houses subsystems for navigation, control actuation and propulsion and scientific sensors (e.g. digital camera, upward-looking 300 kHz acoustic Doppler current profiler, 200 kHz multibeam receiver). The front section contains forward-looking collision sensor, emergency abort, the homing systems, Argos satellite data and location transmitters and flashing lights for relocation as well as science sensors (e.g. twin conductivity–temperature–depth instruments, multibeam transmitter, sub-bottom profiler, AquaLab water sampler). Payload restrictions mean that a subset of scientific instruments is actually in place on any given dive. The scientific instruments carried on Autosub are described and examples of observational data collected from each sensor in Arctic or Antarctic waters are given (e.g. of roughness at the underside of floating ice shelves and sea ice).