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Fast Radio Bursts (FRBs) are millisecond dispersed radio pulses of predominately extra-galactic origin. Although originally discovered at GHz frequencies, most FRBs have been detected between 400 and 800 MHz. Nevertheless, only a handful of FRBs were detected at radio frequencies $\le$400 MHz. Searching for FRBs at low frequencies is computationally challenging due to increased dispersive delay that must be accounted for. Nevertheless, the wide field of view (FoV) of low-frequency telescopes – such as the the Murchison Widefield Array (MWA), and prototype stations of the low-frequency Square Kilometre Array (SKA-Low) – makes them promising instruments to open a low-frequency window on FRB event rates, and constrain FRB emission models. The standard approach, inherited from high-frequencies, is to form multiple tied-array beams to tessellate the entire FoV and perform the search on the resulting time series. This approach, however, may not be optimal for low-frequency interferometers due to their large FoVs and high spatial resolutions leading to a large number of beams. Consequently, there are regions of parameter space in terms of number of antennas and resolution elements (pixels) where interferometric imaging is computationally more efficient. Here we present a new high-time resolution imager BLINK implemented on modern graphical processing units (GPUs) and intended for radio astronomy data. The main goal for this imager is to become part of a fully GPU-accelerated FRB search pipeline. We describe the imager and present its verification on real and simulated data processed to form all-sky and widefield images from the MWA and prototype SKA-Low stations. We also present and compare benchmarks of the GPU and CPU code executed on laptops, desktop computers, and Australian supercomputers. The code is publicly available at https://github.com/PaCER-BLINK-Project/imager and can be applied to data from any radio telescope.
In most ancient cultures, what we now call religion was interwoven throughout all aspects of life and did not always form a discrete cultural domain. Nevertheless, its principal symbols and traditions can be sufficiently distinguished to allow for a fruitful examination of the relationship of law and religion in antiquity. This chapter pursues that endeavour, with particular attention to instances when the sources at our disposal indicate, explicitly or implicitly, that law was relying on religious ideas to achieve legal ends. The chapter considers the role of religion in legitimizing law, in public law and governance, in legal transactions and proceedings, and in the determination and punishment of wrongdoing. It ultimately seeks to add clarity and specificity to the scholarly description of how law and religion interacted in the ancient world.
Simple extended constant capacitance surface complexation models have been developed to represent the adsorption of polyaromatic dyes (9-aminoacridine, 3,6-diaminoacridine, azure A and safranin O) to kaolinite, and the competitive adsorption of the dyes with Cd. The formulation of the models was based on data from recent publications, including quantitative adsorption measurements over a range of conditions (varying pH and concentration), acid-base titrations and attenuated total reflectance-Fourier transform infrared spectroscopic data. In the models the dye molecules adsorb as aggregates of three or four, forming outer-sphere complexes with sites on the silica face of kaolinite. Both electrostatic and hydrophobic interactions are implicated in the adsorption processes. Despite their simplicity, the models fit a wide range of experimental data, thereby supporting the underlying hypothesis that the flat, hydrophobic, but slightly charged silica faces of kaolinite facilitate the aggregation and adsorption of the flat, aromatic, cationic dye molecules.
The strong adsorption to kaolinite of four polyaromatic, cationic dyes (9-aminoacridine, 3,6-diaminoacridine, azure A and safranin O), which adsorb much less to alumina or silica, was investigated by means of acid-base titrations, measurements of adsorption at varying pH and dye concentration, and by ATR-FTIR spectroscopy. The four dyes adsorb to kaolinite to similar extents, with little change over the pH range 3–10, but at higher pH (above the pKas of the dyes) the adsorption of 9-aminoacridine and 3,6-diaminoacridine decreases, that of azure A increases, and that of safranin O stays approximately constant. Although the dyes adsorb to kaolinite much more strongly than metal ions do, titration and spectroscopic data show that there is only limited chemical interaction between the adsorbed dyes and the kaolinite surface. The results indicate that electrostatic interaction between the dye molecules and the kaolinite surface is necessary for adsorption, but that hydrophobic interactions also contribute. It is proposed that the relatively hydrophobic silica faces of kaolinite, which carry low-density permanent negative charge, facilitate aggregation and adsorption of the positively charged, flat, aromatic dye molecules.
The competitive adsorption to kaolinite between Cd(II) and four polyaromatic dyes (9-aminoacridine, 3,6-diaminoacridine, azure A and safranin O) was studied in 5 mM KNO3 at 25°C. Under these conditions, Cd adsorbs to the silica face of kaolinite between about pH 4 and 6.5, but at higher pH, adsorbed Cd is progressively relocated to the crystal edges. In the presence of dye, less Cd adsorbed to kaolinite below pH 7. If sufficient dye was added to saturate the kaolinite surface, Cd adsorption was totally suppressed up to ∼pH 6. At higher pH, Cd followed the characteristic pattern for edge adsorption. In separate experiments 9-aminoacridine and azure A displaced pre-adsorbed Cd from kaolinite. The displacement curves were initially linear, with one Cd ion being displaced for every 13 dye molecules adsorbed at pH 5.5, and one Cd ion for every 35 dye molecules at pH 7.5. The interpretation of these results is that the dyes bind to kaolinite much more strongly than Cd(II) does, but only to the silica face.
Childhood adversities (CAs) predict heightened risks of posttraumatic stress disorder (PTSD) and major depressive episode (MDE) among people exposed to adult traumatic events. Identifying which CAs put individuals at greatest risk for these adverse posttraumatic neuropsychiatric sequelae (APNS) is important for targeting prevention interventions.
Methods
Data came from n = 999 patients ages 18–75 presenting to 29 U.S. emergency departments after a motor vehicle collision (MVC) and followed for 3 months, the amount of time traditionally used to define chronic PTSD, in the Advancing Understanding of Recovery After Trauma (AURORA) study. Six CA types were self-reported at baseline: physical abuse, sexual abuse, emotional abuse, physical neglect, emotional neglect and bullying. Both dichotomous measures of ever experiencing each CA type and numeric measures of exposure frequency were included in the analysis. Risk ratios (RRs) of these CA measures as well as complex interactions among these measures were examined as predictors of APNS 3 months post-MVC. APNS was defined as meeting self-reported criteria for either PTSD based on the PTSD Checklist for DSM-5 and/or MDE based on the PROMIS Depression Short-Form 8b. We controlled for pre-MVC lifetime histories of PTSD and MDE. We also examined mediating effects through peritraumatic symptoms assessed in the emergency department and PTSD and MDE assessed in 2-week and 8-week follow-up surveys. Analyses were carried out with robust Poisson regression models.
Results
Most participants (90.9%) reported at least rarely having experienced some CA. Ever experiencing each CA other than emotional neglect was univariably associated with 3-month APNS (RRs = 1.31–1.60). Each CA frequency was also univariably associated with 3-month APNS (RRs = 1.65–2.45). In multivariable models, joint associations of CAs with 3-month APNS were additive, with frequency of emotional abuse (RR = 2.03; 95% CI = 1.43–2.87) and bullying (RR = 1.44; 95% CI = 0.99–2.10) being the strongest predictors. Control variable analyses found that these associations were largely explained by pre-MVC histories of PTSD and MDE.
Conclusions
Although individuals who experience frequent emotional abuse and bullying in childhood have a heightened risk of experiencing APNS after an adult MVC, these associations are largely mediated by prior histories of PTSD and MDE.
Barriers to research participation by racial and ethnic minority group members are multi-factorial, stem from historical social injustices and occur at participant, research team, and research process levels. The informed consent procedure is a key component of the research process and represents an opportunity to address these barriers. This manuscript describes the development of the Strengthening Translational Research in Diverse Enrollment (STRIDE) intervention, which aims to improve research participation by individuals from underrepresented groups.
Methods:
We used a community-engaged approach to develop an integrated, culturally, and literacy-sensitive, multi-component intervention that addresses barriers to research participation during the informed consent process. This approach involved having Community Investigators participate in intervention development activities and using community engagement studios and other methods to get feedback from community members on intervention components.
Results:
The STRIDE intervention has three components: a simulation-based training program directed toward clinical study research assistants that emphasizes cultural competency and communication skills for assisting in the informed consent process, an electronic consent (eConsent) framework designed to improve health-related research material comprehension and relevance, and a “storytelling” intervention in which prior research participants from diverse backgrounds share their experiences delivered via video vignettes during the consent process.
Conclusions:
The community engaged development approach resulted in a multi-component intervention that addresses known barriers to research participation and can be integrated into the consent process of research studies. Results of an ongoing study will determine its effectiveness at increasing diversity among research participants.
To assess the contribution of different food groups to total salt purchases and to evaluate the estimated reduction in salt purchases if mandatory maximum salt limits in South African legislation were being complied with.
Design:
This study conducted a cross-sectional analysis of purchasing data from Discovery Vitality members. Data were linked to the South African FoodSwitch database to determine the salt content of each food product purchased. Food category and total annual salt purchases were determined by summing salt content (kg) per each unit purchased across a whole year. Reductions in annual salt purchases were estimated by applying legislated maximum limits to product salt content.
Setting:
South Africa.
Participants:
The study utilised purchasing data from 344 161 households, members of Discovery Vitality, collected for a whole year between January and December 2018.
Results:
Vitality members purchased R12·8 billion worth of food products in 2018, representing 9562 products from which 264 583 kg of salt was purchased. The main contributors to salt purchases were bread and bakery products (23·3 %); meat and meat products (19 %); dairy (12·2 %); sauces, dressings, spreads and dips (11·8 %); and convenience foods (8·7 %). The projected total quantity of salt that would be purchased after implementation of the salt legislation was 250 346 kg, a reduction of 5·4 % from 2018 levels.
Conclusions:
A projected reduction in salt purchases of 5·4 % from 2018 levels suggests that meeting the mandatory maximum salt limits in South Africa will make a meaningful contribution to reducing salt purchases.
Irrespective of our life paths, the ability to initiate and sustain effective interactions with others is a key determinant of success and fulfillment. Conflicts occur on a regular basis, hence a level of personal insight is vital. As physicians and healthcare professionals, we can help our patients by better understanding the components of emotional intelligence (EQ) and suggesting how they can incorporate the best attitudes and behaviors into their lives. We can be far more effective in this mission if we model the desired traits in our professional and personal actions. This standard is a challenge, given the often-demanding nature of our clinical responsibilities and the need to achieve balance with family and friends. Yet, it is vital if we are to maintain fulfillment throughout our lives.
Brain health diplomacy aims to influence the global policy environment for brain health (i.e. dementia, depression, and other mind/brain disorders) and bridges the disciplines of global brain health, international affairs, management, law, and economics. Determinants of brain health include educational attainment, diet, access to health care, physical activity, social support, and environmental exposures, as well as chronic brain disorders and treatment. Global challenges associated with these determinants include large-scale conflicts and consequent mass migration, chemical contaminants, air quality, socioeconomic status, climate change, and global population aging. Given the rapidly advancing technological innovations impacting brain health, it is paramount to optimize the benefits and mitigate the drawbacks of such technologies.
Objective:
We propose a working model of Brain health INnovation Diplomacy (BIND).
Methods:
We prepared a selective review using literature searches of studies pertaining to brain health technological innovation and diplomacy.
Results:
BIND aims to improve global brain health outcomes by leveraging technological innovation, entrepreneurship, and innovation diplomacy. It acknowledges the key role that technology, entrepreneurship, and digitization play and will increasingly play in the future of brain health for individuals and societies alike. It strengthens the positive role of novel solutions, recognizes and works to manage both real and potential risks of digital platforms. It is recognition of the political, ethical, cultural, and economic influences that brain health technological innovation and entrepreneurship can have.
Conclusions:
By creating a framework for BIND, we can use this to ensure a systematic model for the use of technology to optimize brain health.
Cognitive behavioral therapy (CBT) is an effective treatment for many patients suffering from major depressive disorder (MDD), but predictors of treatment outcome are lacking, and little is known about its neural mechanisms. We recently identified longitudinal changes in neural correlates of conscious emotion regulation that scaled with clinical responses to CBT for MDD, using a negative autobiographical memory-based task.
Methods
We now examine the neural correlates of emotional reactivity and emotion regulation during viewing of emotionally salient images as predictors of treatment outcome with CBT for MDD, and the relationship between longitudinal change in functional magnetic resonance imaging (fMRI) responses and clinical outcomes. Thirty-two participants with current MDD underwent baseline MRI scanning followed by 14 sessions of CBT. The fMRI task measured emotional reactivity and emotion regulation on separate trials using standardized images from the International Affective Pictures System. Twenty-one participants completed post-treatment scanning. Last observation carried forward was used to estimate clinical outcome for non-completers.
Results
Pre-treatment emotional reactivity Blood Oxygen Level-Dependent (BOLD) signal within hippocampus including CA1 predicted worse treatment outcome. In contrast, better treatment outcome was associated with increased down-regulation of BOLD activity during emotion regulation from time 1 to time 2 in precuneus, occipital cortex, and middle frontal gyrus.
Conclusions
CBT may modulate the neural circuitry of emotion regulation. The neural correlates of emotional reactivity may be more strongly predictive of CBT outcome. The finding that treatment outcome was predicted by BOLD signal in CA1 may suggest overgeneralized memory as a negative prognostic factor in CBT outcome.
The role that vitamin D plays in pulmonary function remains uncertain. Epidemiological studies reported mixed findings for serum 25-hydroxyvitamin D (25(OH)D)–pulmonary function association. We conducted the largest cross-sectional meta-analysis of the 25(OH)D–pulmonary function association to date, based on nine European ancestry (EA) cohorts (n 22 838) and five African ancestry (AA) cohorts (n 4290) in the Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium. Data were analysed using linear models by cohort and ancestry. Effect modification by smoking status (current/former/never) was tested. Results were combined using fixed-effects meta-analysis. Mean serum 25(OH)D was 68 (sd 29) nmol/l for EA and 49 (sd 21) nmol/l for AA. For each 1 nmol/l higher 25(OH)D, forced expiratory volume in the 1st second (FEV1) was higher by 1·1 ml in EA (95 % CI 0·9, 1·3; P<0·0001) and 1·8 ml (95 % CI 1·1, 2·5; P<0·0001) in AA (Prace difference=0·06), and forced vital capacity (FVC) was higher by 1·3 ml in EA (95 % CI 1·0, 1·6; P<0·0001) and 1·5 ml (95 % CI 0·8, 2·3; P=0·0001) in AA (Prace difference=0·56). Among EA, the 25(OH)D–FVC association was stronger in smokers: per 1 nmol/l higher 25(OH)D, FVC was higher by 1·7 ml (95 % CI 1·1, 2·3) for current smokers and 1·7 ml (95 % CI 1·2, 2·1) for former smokers, compared with 0·8 ml (95 % CI 0·4, 1·2) for never smokers. In summary, the 25(OH)D associations with FEV1 and FVC were positive in both ancestries. In EA, a stronger association was observed for smokers compared with never smokers, which supports the importance of vitamin D in vulnerable populations.
Quality improvement (QI) analytic methodology is rarely encountered in the emergency medicine literature. We sought to comparatively apply QI design and analysis techniques to an existing data set, and discuss these techniques as an alternative to standard research methodology for evaluating a change in a process of care.
Methods
We used data from a previously published randomized controlled trial on triage-nurse initiated radiography using the Ottawa ankle rules (OAR). QI analytic tools were applied to the data set from this study and evaluated comparatively against the original standard research methodology.
Results
The original study concluded that triage nurse-initiated radiographs led to a statistically significant decrease in mean emergency department length of stay. Using QI analytic methodology, we applied control charts and interpreted the results using established methods that preserved the time sequence of the data. This analysis found a compelling signal of a positive treatment effect that would have been identified after the enrolment of 58% of the original study sample, and in the 6th month of this 11-month study.
Conclusions
Our comparative analysis demonstrates some of the potential benefits of QI analytic methodology. We found that had this approach been used in the original study, insights regarding the benefits of nurse-initiated radiography using the OAR would have been achieved earlier, and thus potentially at a lower cost. In situations where the overarching aim is to accelerate implementation of practice improvement to benefit future patients, we believe that increased consideration should be given to the use of QI analytic methodology.
To assess the safety against failure of rock slopes in cold regions, such as high mountain areas, where stability is potentially maintained by ice in rock discontinuities, the shear strength of ice-filled rock joints was investigated in a series of direct shear-box tests. To permit control and repeatability, the experiments were conducted using simulated rock specimens. These were cast in the laboratory using high-strength concrete. Laboratory measurements showed that at a constant rate of shearing, the interface shear strength between ice and a joint surface of repeatable roughness is a function of both temperature and normal stress.
Field experiments were conducted during 1992 and 1993 at Kalispell and Moccasin, MT, to determine the influence of application timing on the efficacy of reduced rate postemergence applications of imazamethabenz and diclofop in spring barley. Herbicides were applied at their respective 1 × and ½ × use rates at either 1, 2, or 3 weeks after crop emergence (WAE). While excellent wild oat control was sometimes achieved with reduced rates, there was no consistent relationship between wild oat growth stage and the level of control at either site regardless of the herbicide or rate applied. This response suggests that efficacy is governed not only by wild oat growth stage, but also by weed demographics and environmental considerations. Barley yield and adjusted gross return values were highest at Kalispell when imazamethabenz treatments were applied at 1 WAE, regardless of the level of wild oat control. Adjusted gross return values were similar for the 1 × and ½ × imazamethabenz treatments. Yields and adjusted gross returns with diclofop treatments were more related to the level of wild oat control at Kalispell, with the 1 × diclofop treatments providing the greatest yields and adjusted gross return values. The level of wild oat control at Moccasin had minimal effect on barley yield and adjusted gross returns, with both values being comparable to the nontreated check.
This study aimed to specify the neural mechanisms underlying the link between low household income and diminished executive control in the preschool period. Specifically, we examined whether individual differences in the neural processes associated with executive attention and inhibitory control accounted for income differences observed in performance on a neuropsychological battery of executive control tasks. The study utilized a sample of preschool-aged children (N = 118) whose families represented the full range of income, with 32% of families at/near poverty, 32% lower income, and 36% middle to upper income. Children completed a neuropsychological battery of executive control tasks and then completed two computerized executive control tasks while EEG data were collected. We predicted that differences in the event-related potential (ERP) correlates of executive attention and inhibitory control would account for income differences observed on the executive control battery. Income and ERP measures were related to performance on the executive control battery. However, income was unrelated to ERP measures. The findings suggest that income differences observed in executive control during the preschool period might relate to processes other than executive attention and inhibitory control.
The montane inselbergs of northern Mozambique have been comparatively little-studied, yet recent surveys have shown they have a rich biodiversity with numerous endemic species. Here we present the main findings from a series of scientific expeditions to one of these inselbergs, Mt Mabu, and discuss the conservation implications. Comprehensive species lists of plants, birds, mammals and butterflies are presented. The most significant result was the discovery of a c. 7,880 ha block of undisturbed rainforest, most of it at medium altitude (900–1,400 m), a forest type that is not well represented elsewhere. It is possibly the largest continuous block of this forest type in southern Africa. To date, 10 new species (plants, mammals, reptiles and butterflies) have been confirmed from Mt Mabu, even though sampling effort for most taxonomic groups has been low. The species assemblages indicate a relatively long period of isolation and many species found are at the southern limit of their range. Conservationists are now faced with the challenge of how best to protect Mt Mabu and similar mountains in northern Mozambique, and various ways that this could be done are discussed.