Anthropogenic actions are likely to harm dung beetle populations directly through habitat loss and indirectly through the cascading effects of large mammal depletions. Despite the reliance of dung beetles on mammal dung, there are only a handful of studies that have directly assessed the impact of habitat degradation and associated mammalian loss on dung beetle populations in Africa. We evaluated whether patterns in dung beetle species abundance, richness, and body size can be associated with mammalian herbivore abundance and species richness, habitat structure, and the distance between sample sites. Additionally, we ascertained how the presence of elephants (Loxodonta africana) may affect a dung beetle assemblage by determining which species could be used as bioindicators of elephant presence. We found herbivore and overall mammal abundance explained 17% of dung beetle assemblage structure, 2% of dung beetle abundance, 10% of dung beetle species richness and, 15% of the variation in dung beetle body size. Habitat structure explained 27% of dung beetle assemblage structure, 11% of dung beetle abundance, and 14% of the variation in dung beetle body size. Spatial distance between trapping locations explained 13% of the dung beetle assemblage structure, 4% of species richness, 3% of abundance, and but had no effect on dung beetle body size. We also identified four dung beetle species that may be used in future management plans as bioindicators of elephant density Afromontane Forest in East Africa. This information may become especially important for future monitoring as it is predicted that the areas in which elephants occur in Afromontane Forest are set to decline due to deforestation, and the expansion and intensification of agriculture.

Vaccines have revolutionised the field of medicine, eradicating and controlling many diseases. Recent pandemic vaccine successes have highlighted the accelerated pace of vaccine development and deployment. Leveraging this momentum, attention has shifted to cancer vaccines and personalised cancer vaccines, aimed at targeting individual tumour-specific abnormalities. The UK, now regarded for its vaccine capabilities, is an ideal nation for pioneering cancer vaccine trials. This article convened experts to share insights and approaches to navigate the challenges of cancer vaccine development with personalised or precision cancer vaccines, as well as fixed vaccines. Emphasising partnership and proactive strategies, this article outlines the ambition to harness national and local system capabilities in the UK; to work in collaboration with potential pharmaceutic partners; and to seize the opportunity to deliver the pace for rapid advances in cancer vaccine technology.

The weighted euclidean distances model in multidimensional scaling (WMDS) represents individual differences as dimension saliences which can be interpreted as the orientations of vectors in a subject space. It has recently been suggested that the statistics of directions would be appropriate for carrying out tests of location with such data. The nature of the directional representation in WMDS is reviewed and it is argued that since dimension saliences are almost always positive, the directional representations will usually be confined to the positive orthant. Conventional statistical techniques are appropriate to angular representations of the individual differences which will yield angles in the interval (0, 90) so long as dimension saliences are nonnegative, a restriction which can be imposed. Ordinary statistical methods are also appropriate with several linear indices which can be derived from WMDS results. Directional statistics may be applied more fruitfully to vector representations of preferences.

Field experiments were conducted at Clayton and Rocky Mount, NC, during summer 2020 to determine the growth and fecundity of Palmer amaranth plants that survived glufosinate with and without grass competition in cotton. Glufosinate (590 g ai ha−1) was applied to Palmer amaranth early postemergence (5 cm tall), mid-postemergence (7 to 10 cm tall), and late postemergence (>10 cm tall) and at orthogonal combinations of those timings. Nontreated Palmer amaranth was grown in weedy, weed-free in-crop (WFIC) and weed-free fallow (WFNC) conditions for comparisons. Palmer amaranth control decreased as larger plants were treated; no plants survived the sequential glufosinate applications in both experiments. The apical and circumferential growth of Palmer amaranth surviving glufosinate treatments was reduced by more than 44% compared to the WFIC and WFNC Palmer amaranth in both experiments. The biomass of Palmer amaranth plants surviving glufosinate was reduced by more than 62% when compared with the WFIC and WFNC in all experiments. The fecundity of Palmer amaranth surviving glufosinate treatments was reduced by more than 73% compared to WFNC Palmer amaranth in all experiments. Remarkably, the plants that survived glufosinate were fecund as WFIC plants only in the Grass Competition experiment. The results prove that despite decreased vegetative growth of Palmer amaranth surviving glufosinate treatment, plants remain fecund and can be fecund as nontreated plants in cotton. These results suggest that a glufosinate-treated grass weed may not have a significant interspecific competition effect on Palmer amaranth that survives glufosinate. Glufosinate should be applied to 5 to 7 cm Palmer amaranth to cease vegetative and reproductive capacities.

Plateau icefields are large stores of fresh water, preconditioned to enhanced mass loss due to their gently sloping accumulation areas. Accurate modelling of their mass balance is therefore crucial for sea-level rise projections. Here, we use the COupled Snowpack and Ice surface energy and mass-balance model in PYthon (COSIPY) to simulate historical and future mass balance of the Juneau Icefield, Alaska – a high elevation (>1200 m) plateau icefield. We force the model with dynamically downscaled climate simulations, for both past and future (RCP 8.5) conditions. The icefield's mass balance decreased from a mean of −0.22 ± 0.38 m w.e. a−1 (1981–2019) to −1.52 ± 0.27 m w.e. a−1 (2031–2060), with many glaciers shifting from positive to negative mass balances at the start of the 21st century. This mass loss is attributed to projected rising air temperatures and reduced snowfall, causing the equilibrium line altitude to rise and triggering albedo and melt-elevation feedbacks. These processes exacerbate melt, potentially leading to increased glacier disconnections at icefalls.

Coastal wetlands are hotspots of carbon sequestration, and their conservation and restoration can help to mitigate climate change. However, there remains uncertainty on when and where coastal wetland restoration can most effectively act as natural climate solutions (NCS). Here, we synthesize current understanding to illustrate the requirements for coastal wetland restoration to benefit climate, and discuss potential paths forward that address key uncertainties impeding implementation. To be effective as NCS, coastal wetland restoration projects will accrue climate cooling benefits that would not occur without management action (additionality), will be implementable (feasibility) and will persist over management-relevant timeframes (permanence). Several issues add uncertainty to understanding if these minimum requirements are met. First, coastal wetlands serve as both a landscape source and sink of carbon for other habitats, increasing uncertainty in additionality. Second, coastal wetlands can potentially migrate outside of project footprints as they respond to sea-level rise, increasing uncertainty in permanence. To address these first two issues, a system-wide approach may be necessary, rather than basing cooling benefits only on changes that occur within project boundaries. Third, the need for NCS to function over management-relevant decadal timescales means methane responses may be necessary to include in coastal wetland restoration planning and monitoring. Finally, there is uncertainty on how much data are required to justify restoration action. We summarize the minimum data required to make a binary decision on whether there is a net cooling benefit from a management action, noting that these data are more readily available than the data required to quantify the magnitude of cooling benefits for carbon crediting purposes. By reducing uncertainty, coastal wetland restoration can be implemented at the scale required to significantly contribute to addressing the current climate crisis.

Field experiments were conducted at Clayton and Rocky Mount, North Carolina, during the summer of 2020 to determine the growth and fecundity of Palmer amaranth plants that survived glufosinate with and without grass competition in soybean crops. Glufosinate (590 g ai ha−1) was applied at early postemergence (when Palmer amaranth plants were 5 cm tall), mid-postemergence (7–10 cm), and late postemergence (>10 cm) and at orthogonal combinations of those timings. Nontreated Palmer amaranth was grown in weedy (i.e., intraspecific and grass competition), weed-free in-crop (WFIC), and weed-free fallow (WFNC) conditions for comparisons. No Palmer amaranth plants survived the sequential glufosinate applications and control decreased as the plants were treated at a larger size in both experiments. The apical and circumferential growth rate of Palmer amaranth surviving glufosinate was reduced by more than 44% compared with the WFNC Palmer amaranth. The biomass of Palmer amaranth plants that survived glufosinate was reduced by more than 87% compared with the WFNC Palmer amaranth. The fecundity of Palmer amaranth that survived glufosinate was reduced by more than 70% compared with WFNC Palmer amaranth. Palmer amaranth plants that survived glufosinate were as fecund as the WFIC Palmer amaranth in both experiments in soybean fields. The results prove that despite the significant vegetative growth rate decrease of Palmer amaranth that survived glufosinate, plants can be as fecund as nontreated plants. The trends in growth and fecundity of Palmer amaranth that survives glufosinate with and without grass competition were similar. These results suggest that glufosinate-treated grass weeds may not reduce the growth or fecundity of Palmer amaranth that survives glufosinate.

In parts of southern and western Asia, as elsewhere, the cannon once served as one of the most dramatic tools in the inventories of state executioners. The practice of ‘blowing from a gun’, by which the condemned was bound to the front of a cannon and quite literally blown to pieces, was most infamously employed in British India and the Princely States, and the vast majority of English-language scholarship focuses on these regions. However, blowing from guns was commonplace in several other contemporary states, and the British use of the practice has rarely been situated in this context. The tactic was considered especially useful in Persia and Afghanistan, where weak governance, rebellion, and rampant banditry all threatened the legitimacy of the nascent state in the nineteenth and early twentieth centuries. This article presents a history of the practice of execution by cannon in southern and western Asia, positioning it within the existing literature on public executions in the context of military and civilian justice. In doing so, the article seeks to situate the British use of the tactic within a broader regional practice, arguing that, whilst the British—following the Mughal tradition—used execution by cannon primarily in maintaining military discipline, states such as Persia and Afghanistan instead employed the practice largely in the civilian context. This article also provides a brief technical review of the practice, drawing upon numerous primary sources to examine execution by cannon within the Mughal empire, British India, Persia, and Afghanistan.

Using comprehensive account-level data, we separate Chinese retail investors into 5 groups and document strong heterogeneity in trading dynamics and performances. Retail investors with smaller account sizes cannot predict future returns correctly, display daily momentum patterns, fail to process public news, and show overconfidence and gambling preferences, while retail investors with larger account balances predict future returns correctly, display contrarian patterns, and incorporate public news in trading. Using performance measures established in previous literature, we find that smaller retail investors suffer from poor stock selection abilities and trading costs, while large retail investors’ stock selection abilities are offset by trading costs.

Glufosinate is an effective postemergence herbicide, and overreliance on this herbicide for weed control is likely to increase and select for glufosinate-resistant weeds. Common assays to confirm herbicide resistance are dose–response and molecular sequencing techniques; both can require significant time, labor, unique technical equipment, and a specialized skillset to perform. As an alternative, we propose an image-based approach that uses a relatively inexpensive multispectral sensor designed for unmanned aerial vehicles to measure and quantify surface reflectance from glufosinate-treated leaf disks. Leaf disks were excised from a glufosinate-resistant and glufosinate-susceptible corn (Zea mays L.), cotton (Gossypium hirsutum L.), and soybean [Glycine max (L.) Merr.] varieties and placed into a 24-well plate containing eight different concentrations (0 to 10 mM) of glufosinate for 48 h. Multispectral images were collected after the 48-h incubation period across five discrete wave bands: blue (475 to 507 nm), green (560 to 587 nm), red (668to 682 nm), red edge (717 to 729 nm), and near infrared (842 to 899 nm). The green leaf index (GLI; a metric to measure chlorophyll content) was utilized to determine relationships between measured reflectance from the tested wave bands from the treated leaf disks and the glufosinate concentration. Clear differences of spectral reflectance were observed between the corn, cotton, and soybean leaf disks of the glufosinate-resistant and glufosinate-susceptible varieties at the 10 mM concentration for select wave bands and GLI. Leaf disks from two additional glufosinate-resistant and glufosinate-susceptible varieties of each crop were subjected to a similar assay with two concentrations: 0 and 10 mM. No differences of spectral reflectance were observed from the corn and soybean varieties in all wave bands and the GLI. The leaf disks of the glufosinate-resistant and glufosinate-susceptible cotton varieties were spectrally distinct in the green, blue, and red-edge wave bands. The results provide a basis for rapidly detecting glufosinate-resistant plants via spectral reflectance. Future research will need to determine the glufosinate concentrations, useful wave bands, and susceptible/resistant thresholds for weeds that evolve resistance.

The Andes offers a particularly effective focus for an archaeology of mobility because their extreme topography compresses enormous vertical resource diversity across short horizontal distances. In this article, the authors combine findings from two large-scale archaeological studies of adjacent watersheds—the Nasca-Palpa Project and One River Project—to provide the necessary context in which to explore changing mobilities from the Archaic Period to the Inca Empire, and from the Pacific coast to the high Andes. Analyses of obsidian lithics and stable isotopes in human hair are used to argue that changing patterns of mobility offer a new way of defining the ‘Horizons’ that have long dominated concepts of periodisation here.

Humans have engineered their environments throughout the Holocene, especially in the construction of hydraulic infrastructure. In many regions, however, this infrastructure is difficult to date, including the vestiges of water-management systems in the Andean highlands. Focusing on silt reservoirs in the upper Ica drainage, Peru, the authors use cores and radiocarbon dates to demonstrate the pre-Hispanic construction of walls to enhance and expand wetlands for camelid pasture. Interventions dated to the Inca period (AD 1400–1532) indicate an intensification of investment in hydraulic infrastructure to expand production capacity in support of the state. The results are discussed in the context of the hydraulic strategies of other states and empires.

Glufosinate is among the few remaining effective herbicides for postemergence weed control in North Carolina crops. The evolution of glufosinate resistance in key weeds is currently not widespread in North Carolina, but to better assess the current status of glufosinate effectiveness, surveys were distributed at Extension meetings in 2019 and 2020. The surveys were designed to provide information about North Carolina farmers’ perception of glufosinate and its use. Survey results indicate that many North Carolina farmers (≥26%) apply glufosinate at the correct timing (5- to 10-cm weeds). In addition, North Carolina farmers (≥22%) are applying glufosinate as a complementary herbicide to other efficacious herbicides and to control herbicide-resistant weeds, suggesting that glufosinate is part of a diverse chemical weed management plan. Conversely, survey findings indicated that some farmers (13% to 17%) rely exclusively on glufosinate for weed control. Additionally, 28% to 30% of farmers reported glufosinate control failures, and control failures were observed on several weed species among corn, cotton, and soybean crops. The results of the survey suggest that most North Carolina farmers are currently stewarding glufosinate, but they also support the need for Extension personnel to keep educating farmers on how to correctly use glufosinate to delay the evolution of glufosinate-resistant weeds. Semiannual surveys should be distributed to monitor where glufosinate control failures occur and the weed species not being controlled.

We present a novel approach to developing a unified radiocarbon-based chronology for multiple sediment cores from a location where radiocarbon dating is challenging. We used 36 radiocarbon ages from eight terminal Pleistocene and Holocene sediment cores with correlated stratigraphies. Stratigraphic correlation was accomplished using a combination of high-resolution photography, high-resolution X-ray fluorescence-based elemental composition data, and volcanic tephra identification. Results show that despite problems associated with potential contamination or radiocarbon reservoir effect, a useful age-depth model has been created for the correlated lacustrine sections of these eight sediment cores, providing chronological controls for future paleoenvironmental analyses of the cores.

Established chronologies indicate a long-term ‘Hoabinhian’ hunter-gatherer occupation of Mainland Southeast Asia during the Terminal Pleistocene to Mid-Holocene (45 000–3000 years ago). Here, the authors re-examine the ‘Hoabinhian’ sequence from north-west Thailand using new radiocarbon and luminescence data from Spirit Cave, Steep Cliff Cave and Banyan Valley Cave. The results indicate that hunter-gatherers exploited this ecologically diverse region throughout the Terminal Pleistocene and the Pleistocene–Holocene transition, and into the period during which agricultural lifeways emerged in the Holocene. Hunter-gatherers did not abandon this highland region of Thailand during periods of environmental and socioeconomic change.

The state of Maryland identified its first case of coronavirus disease 2019 (COVID-19) on March 5, 2020. The Baltimore Convention Center (BCCFH) quickly became a selected location to set up a 250-bed inpatient field hospital and alternate care site. In contrast to other field hospitals throughout the United States, the BCCFH remained open throughout the pandemic and took on additional COVID-19 missions, including community severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) diagnostic testing, monoclonal antibody infusions for COVID-19 outpatients, and community COVID-19 vaccinations.

To prevent the spread of pathogens during operations, infection prevention and control guidelines were essential to ensure the safety of staff and patients. Through multi-agency collaboration, use of infection prevention best practices, and answering what we describe as PPE-ESP, an operational framework was established to reduce infection risks for those providing or receiving care at the BCCFH during the COVID-19 pandemic.

Hand hygiene compliance decreased significantly when opportunities exceeded 30 per hour. At higher workloads, the number of healthcare worker types involved and the proportion of hand hygiene opportunities for which physicians and other healthcare workers were responsible increased. Thus, care complexity and risk to patients may both increase with workload.