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Quantum field theory predicts a nonlinear response of the vacuum to strong electromagnetic fields of macroscopic extent. This fundamental tenet has remained experimentally challenging and is yet to be tested in the laboratory. A particularly distinct signature of the resulting optical activity of the quantum vacuum is vacuum birefringence. This offers an excellent opportunity for a precision test of nonlinear quantum electrodynamics in an uncharted parameter regime. Recently, the operation of the high-intensity Relativistic Laser at the X-ray Free Electron Laser provided by the Helmholtz International Beamline for Extreme Fields has been inaugurated at the High Energy Density scientific instrument of the European X-ray Free Electron Laser. We make the case that this worldwide unique combination of an X-ray free-electron laser and an ultra-intense near-infrared laser together with recent advances in high-precision X-ray polarimetry, refinements of prospective discovery scenarios and progress in their accurate theoretical modelling have set the stage for performing an actual discovery experiment of quantum vacuum nonlinearity.
In response to the COVID-19 pandemic, we rapidly implemented a plasma coordination center, within two months, to support transfusion for two outpatient randomized controlled trials. The center design was based on an investigational drug services model and a Food and Drug Administration-compliant database to manage blood product inventory and trial safety.
Methods:
A core investigational team adapted a cloud-based platform to randomize patient assignments and track inventory distribution of control plasma and high-titer COVID-19 convalescent plasma of different blood groups from 29 donor collection centers directly to blood banks serving 26 transfusion sites.
Results:
We performed 1,351 transfusions in 16 months. The transparency of the digital inventory at each site was critical to facilitate qualification, randomization, and overnight shipments of blood group-compatible plasma for transfusions into trial participants. While inventory challenges were heightened with COVID-19 convalescent plasma, the cloud-based system, and the flexible approach of the plasma coordination center staff across the blood bank network enabled decentralized procurement and distribution of investigational products to maintain inventory thresholds and overcome local supply chain restraints at the sites.
Conclusion:
The rapid creation of a plasma coordination center for outpatient transfusions is infrequent in the academic setting. Distributing more than 3,100 plasma units to blood banks charged with managing investigational inventory across the U.S. in a decentralized manner posed operational and regulatory challenges while providing opportunities for the plasma coordination center to contribute to research of global importance. This program can serve as a template in subsequent public health emergencies.
The Sustainable Development Goals (SDGs) adopted in 2015 represent an important opportunity to improve learning globally. In this light, this chapter draws on a unique set of early literacy assessment results and demographic information from six African countries (Ghana, Kenya, Liberia, Malawi, Tanzania, and Zambia) to better understand the role that language plays in influencing early reading outcomes. While these data have been published in individual country reports, the information has not been analyzed and released prominently in the narrative surrounding learning outcomes in the region, although data like those presented in this chapter have begun to reverse this tendency. Following this introduction, a brief history is provided of postcolonial trends in literacy acquisition and language policyin sub-Saharan Africa from about 1960 to the present day, documenting the current language of instruction policies for twenty countries. Key questions are also outlined to drive the interest in gaining a better understanding of the variation in literacy acquisition in a selection of target countries for which we have data; then the chapter documents the data and methods usedas well as the results. Finally, the chapter discusses the implications of this work a for future policy and planning to achieve the promises made under the SDGs.
Risk of suicide-related behaviors is elevated among military personnel transitioning to civilian life. An earlier report showed that high-risk U.S. Army soldiers could be identified shortly before this transition with a machine learning model that included predictors from administrative systems, self-report surveys, and geospatial data. Based on this result, a Veterans Affairs and Army initiative was launched to evaluate a suicide-prevention intervention for high-risk transitioning soldiers. To make targeting practical, though, a streamlined model and risk calculator were needed that used only a short series of self-report survey questions.
Methods
We revised the original model in a sample of n = 8335 observations from the Study to Assess Risk and Resilience in Servicemembers-Longitudinal Study (STARRS-LS) who participated in one of three Army STARRS 2011–2014 baseline surveys while in service and in one or more subsequent panel surveys (LS1: 2016–2018, LS2: 2018–2019) after leaving service. We trained ensemble machine learning models with constrained numbers of item-level survey predictors in a 70% training sample. The outcome was self-reported post-transition suicide attempts (SA). The models were validated in the 30% test sample.
Results
Twelve-month post-transition SA prevalence was 1.0% (s.e. = 0.1). The best constrained model, with only 17 predictors, had a test sample ROC-AUC of 0.85 (s.e. = 0.03). The 10–30% of respondents with the highest predicted risk included 44.9–92.5% of 12-month SAs.
Conclusions
An accurate SA risk calculator based on a short self-report survey can target transitioning soldiers shortly before leaving service for intervention to prevent post-transition SA.
A straight cylindrical duct is considered containing an axial mean flow that is uniform everywhere except within a boundary layer near the wall, which need not be thin. Within this boundary layer the mean flow varies parabolically. The linearized Euler equations are Fourier transformed to give the Pridmore-Brown equation, for which the Green's function is constructed using Frobenius series. The critical layer gives a non-modal contribution from the continuous spectrum branch cut, and dominates the downstream pressure perturbation in certain cases, particularly for thicker boundary layers. The continuous spectrum branch cut is also found to stabilize what are otherwise convectively unstable modes by hiding them behind the branch cut. Overall, the contribution from the critical layer is found to give a neutrally stable non-modal wave when the source is located within the sheared flow region, and to decay algebraically along the duct as $O(x^{-{5}/{2}})$ for a source located with the uniform flow region. The Frobenius expansion, in addition to being numerically accurate close to the critical layer where other numerical methods lose accuracy, is also able to locate modal poles hidden behind the branch cut, which other methods are unable to find; this includes the stabilized hydrodynamic instability. Matlab code is provided to compute the Green's function.
Recent advances in the measurement of bedforms beneath active ice streams have been made using ground-based grid profiling using impulse radar systems operating with centre frequencies in the 3–5 MHz range. Surveys of Rutford Ice Stream and Pine Island Glacier have shown that features such as mega-scale glacial lineations with topographic relief of as little as 3 m can be traced for many kilometres downstream under more than 2 km of fast-moving ice. In the discussion of these data, it is often asked ‘How is it possible to map such fine-scale topography with such a low-frequency radar’. In answering that question, the key point is the distinction between the precision of a radar range measurement to a single, isolated reflective interface and the ability to resolve the presence of two closely-spaced interfaces of similar reflectivity (commonly referred to as the vertical resolution). This paper will discuss and illustrate this distinction and use the case study of data acquired over Pine Island Glacier to examine the limits of precision of the radar range measurement.
Determining best practices for managing free farrowing systems is crucial for uptake. Cross-fostering, the exchange of piglets between litters, is routinely performed amongst crate-housed sows. However, cross-fostering can increase fighting amongst the litter and may be more challenging within free farrowing systems as sows have more freedom to respond to cross-fostered piglets. This study compared the effect of either cross-fostering (FOS), or a control of sham-fostering (CON), of four focal piglets per litter on Day 6 postpartum in crates (CRATE) and free farrowing pens (PEN). The post-treatment behavioural responses of sows were recorded (Day 6 = 60 min; Day 7 = 300 min; n = 48), as were the average daily gain (ADG; g/day), total weight gain (TWG; kg) and body lesion scores of focal piglets and their littermates throughout lactation (Day 6, Day 8, Day 11 and Day 26; n = 539) and the post-weaning period (Day 29, Day 32 and Day 60; n = 108). On Day 6, though post-reunion latency to nursing did not differ, latency to successful nursing was longer amongst FOS than CON litters (P < 0.001), more so amongst CRATE FOS than PEN FOS (P < 0.01). On Day 7, PEN FOS sows had fewer successful nursing bouts (P < 0.05) and exhibited decreased lateral (P < 0.01) and increased ventral lying frequencies (P < 0.01) compared to all other housing and treatment combinations. Focal piglet ADG was lower for FOS than CON in the CRATE during Day 6 to Day 8 (P < 0.01) and lower in the PEN during Day 6 to Day 8 (P < 0.001), Day 8 to Day 11 (P < 0.01) and Day 11 to Day 26 (P < 0.05). The TWG of pre-weaned focal piglets (Day 6 to Day 26) was higher amongst CON than FOS litters (P = 0.01). Post-weaning, piglet ADG was higher for PEN than CRATE during Day 26 to Day 29 (P < 0.01) and higher for FOS than CON during Day 26 to Day 29 (P < 0.05), Day 29 to Day 32 (P < 0.001) and Day 32 to Day 60 (P < 0.01); thus, TWG was higher for FOS than CON during the weaner (P = 0.001) and the combined lactation and weaner periods (P = 0.09). In conclusion, sow behaviour was disrupted by cross-fostering in the crates and pens and continued to be disturbed on the following day amongst penned sows. FOS piglets exhibited reduced ADG after cross-fostering, which extended throughout lactation in the pens. However, the increased post-weaning weight gain of FOS piglets meant that their TWG was higher than CON piglets, irrespective of the farrowing system used.
Producers are interested in utilising farrowing systems with reduced confinement to improve sow welfare. However, concerns of increased mortality may limit commercial uptake. Temporary confinement systems utilise a standard crate which is opened 3 to 7 days postpartum, providing protection for neonatal piglets at their most vulnerable age and later increased freedom of movement for sows. However, there is anecdotal evidence that piglet mortality increases immediately after the temporary crate is opened. The current study aims were to determine if piglet mortality increases post-opening, to trial different opening techniques to reduce post-opening piglet mortality and to identify how the different opening techniques influence sow behaviour. Three opening treatments were implemented across 416 sows: two involved opening crates individually within each farrowing house when each litter reached 7 days of age, in either the morning or afternoon (AM or PM), with a control of the standard method used on the farm to open all crates in each farrowing house simultaneously once the average litter age reached 7 days (ALL). Behavioural observations were performed on five sows from each treatment during the 6 h after crate opening, and during the same 6 h period on the previous and subsequent days. Across all treatments, piglet mortality was significantly higher in the post-opening than pre-opening period (P<0.0005). Between opening treatments, there were significant differences in piglet mortality during the 2 days after crate opening (P<0.05), whilst piglet mortality also tended to differ from crate opening until weaning (P=0.052), being highest in ALL and lowest in PM. Only sows in the PM treatment showed no increase in standing behaviour but did show an increased number of potentially dangerous posture changes after crate opening (P=0.01), which may be partly attributed to the temporal difference in observation periods. Sow behaviour only differed between AM and ALL on the day before crate opening, suggesting the AM treatment disrupted behaviour pre-opening. Sows in AM and PM treatments showed more sitting behaviour than ALL, and therefore may have been more alert. In conclusion, increases in piglet mortality after crate opening can be reduced by opening crates individually, more so in the afternoon. Sow habituation to disturbance before crate opening may have reduced post-opening piglet mortality, perhaps by reducing the difference in pre- and post-opening sow behaviour patterns.
Global interest in alternative indoor farrowing systems is increasing, leading to a growing number of farms utilising such systems alongside standard crates. There is evidence that interchanging sows between different farrowing systems affects maternal behaviour, whilst the subsequent effect of this on piglet mortality is unknown. The current study hypothesised that second parity piglet mortality would be higher if a sow farrowed in a different farrowing system to that of her first parity. Retrospective farm performance records were used from 753 sows during their first and second parities. Sows farrowed in either standard crates (crates), temporary crates (360s) or straw-bedded pens (pens), with mortality recorded as occurring either pre- or post-processing. Inter- and intra-parity sow consistency in performance were also investigated. Overall, total piglet mortality reduced from the first to the second parity, being significantly higher in the crates and higher in the 360s during the first or second parity, respectively. In the second parity, an interaction of the current and previous farrowing systems resulted in the lowest incidence of crushing for sows housed in the same system as their first parity for the crates and pens, but not the 360s. Post-processing mortality was significantly higher in the crates if a sow previously farrowed in the 360s and vice versa. Sows which previously farrowed in a pen had a significantly larger litter size and lower pre-processing mortality from crushing in their second parity than sows previously housed in the crates or the 360s. No inter-parity consistency of sow performance was found, whilst intra-parity consistency was found in the first but not second parity. In conclusion, returning sows to the same farrowing system appears to reduce piglet mortality, whilst farrowing in a pen during the first parity significantly increased second parity litter size without increasing piglet mortality.
Guy of Warwick is England's other Arthur. Elevated to the status of national hero, his legend occupied a central place in the nation's cultural heritage from the Middle Ages to the modern period. Guy of Warwick: Icon and Ancestor spans the Guy tradition from its beginnings in Anglo-Norman and Middle English romance right through to the plays and prints of the early modern period and Spenser's Faerie Queene, including the visual tradition in manuscript illustration and material culture as well as the intersection of the legend with local and national history. This volume addresses important questions regarding the continuities and remaking of romance material, and the relation between life and literature. Topics discussed are sensitive to current critical concerns and include translation, reception, magnate ambition, East-West relations, the construction of "Englishness" and national identity, and the literary value of "popular" romance.
ALISON WIGGINS is Lecturer in English Language at the University of Glasgow; ROSALIND FIELD is Reader in Medieval Literature at Royal Holloway, University of London.
CONTRIBUTORS: JUDITH WEISS, MARIANNE AILES, IVANA DJORDJEVIC, ROSALIND FIELD, ALISON WIGGINS, A.S.G. EDWARDS, ROBERT ALLEN ROUSE, DAVID GRIFFITH, MARTHA W. DRIVER, SIAN ECHARD, ANDREW KING, HELEN COOPER
We present 1 and 100 MHz ground-based radar data from the onset region of Rutford Ice Stream, West Antarctica, which indicate the form and internal structure of isochrones. In the flow-parallel lines, modelled isochrone patterns reproduce the gross pattern of the imaged near-surface layers, assuming steady-state flow velocity from GPS records and the current accumulation rate for the last 200 years. We interpret this as indicating overall stability in flow in the onset region of Rutford Ice Stream throughout this period. However, in the cross-flow lines some local variability in accumulation is seen in areas close to the ice-stream margin where a number of tributaries converge towards the ice-stream onset zone. Episodic surface lowering events are observed followed by rapid fill episodes. The fill events indicate deposition towards the northwest, most likely generated by storm winds, which blow at an oblique angle to ice flow. More problematic is explaining the generation of episodic surface lowering in this area. We speculate this may be due to: changing ice-flow direction in the complex tributary area of the onset zone; a change in basal sediments or sedimentary landforms; a change in basal melt rates or water supply; or episodic lake drainage events in the fjord systems of the Ellsworth Subglacial Highlands. The study highlights the difficulty of assessing flow stability in the complex onset regions of West Antarctic ice streams.
We present seismic and radar data from the onset region of Rutford Ice Stream, West Antarctica, which show the form and internal structure of a variety of bed forms beneath an active ice stream. The ice flow in the area of our survey accelerates from 72 to >200 m a–1, the ice is 2200–3200 m thick, and the bed of the ice stream lies up to 2000 m below present sea level. We have imaged the internal structure of the bed forms with seismic reflection techniques and also observed radar reflections from below the bed in some circumstances. We observed a transverse moraine 2 km wide and 1.5 km long beneath the slower-flowing part of the ice stream, which we interpret to be composed of unconsolidated sediment undergoing active deformation near the ice–sediment interface. We observed drumlins of classical form with elongation ratios of between 1:1.5 and 1:4.0 where the surface flow speed exceeded 95 m a–1. The conformity of the internal structure of the bed forms with the ice base suggests that the bed forms are active depositional features in congruence with the observation of a contemporary drumlin-forming episode in the distal part of the same ice stream. These observations provide the first direct evidence of the association between ice-stream flow speed and bed-form shape.
Radar studies of firn on the ice sheets have revealed complex folds on its internal layering that form from the interplay of snow accumulation and ice flow. A mathematical theory for these fold structures is presented, for the case where the radar cross section lies along the ice-flow direction and where the accumulation rate and ice-flow velocity are time-invariant. Our model, which accounts for firn densification, shows how ‘information’ (the depth and slope of isochrones) propagates on the radargram to govern its layer undulations. This leads us to discover universal rules behind the pattern of layer slopes on a distance–age domain and understand why the loci of layer-fold hinges curve, emerge and combine on the radargram to form closed loops that delineate areas of rising and plunging isochrones. We also develop a way of retrieving the accumulation rate distribution and layer ages from steady isochrone patterns. Analysis of a radargram from the onset zone of Bindschadler Ice Stream, West Antarctica, indicates that ice flow and accumulation rates have been steady there for the past ∼400 years, and that spatial anomalies in the latter are coupled to surface topography induced by ice flow over the undulating ice-stream bed. The theory provides new concepts for the morphological interpretation of radargrams.
A glacier-wide ice-thickness distribution and bedrock topography is presented for Starbuck Glacier, Antarctic Peninsula. The results are based on 90 km of ground-based radio-echo sounding lines collected during the 2012/13 field season. Cross-validation with ice-thickness measurements provided by NASA's IceBridge project reveals excellent agreement. Glacier-wide estimates are derived using a model that calculates distributed ice thickness, calibrated with the radio-echo soundings. Additional constraints are obtained from in situ ice flow-speed measurements and the surface topography. The results indicate a reverse-sloped bed extending from a riegel occurring ~ 5 km upstream of the current grounding line. The deepest parts of the glacier are as much as 500 m below sea level. The calculated total volume of 80.7 ± 7.2 km3 corresponds to an average ice thickness of 312 ± 30 m.
On RADARSAT imagery, the southern margin of the onset zone of Bindschadler Ice Stream, West Antarctica, manifests a multi-banded feature, with brightness varying across the bands and oscillating along each band. Ground-based radar profiles across the margin reveal folds in the firn stratigraphy associated with this pattern and provide evidence for correlation between the depth of shallow isochrones and the RADARSAT backscatter intensity on each profile, allowing us to interpret the banded feature for firn-layer geometry in three dimensions. We use a kinematic model of isochrone depth evolution to show how layer folding and the band expression may result from deformation and advection in the near-surface flow field at ice-stream margins, even with steady flow. The model predicts the formation of longitudinally patterned bands when the ice-stream acceleration fluctuates along flow. Concerted study of the planform and stratigraphy of other RADARSAT-detected features on the ice sheets may help us understand their origin.
Flow at ice divides, their shape, size and internal structure depend not only on local conditions, but also on the flow regimes and past histories of the surrounding ice masses. Here we use field data from Kealey Ice Rise, Ellsworth Land, West Antarctica, in combination with flow modelling to investigate any possible signs of transients in the flow of the surrounding ice masses. Kealey Ice Rise shows linear surface features running parallel to its ridge in satellite imagery and a conspicuous layering in the ground-penetrating radar data known as double-peaked Raymond bumps. Through numerical modelling, by using an anisotropic full-Stokes thermomechanical flow solver, we analyse the evolution of Kealey Ice Rise and the timescales involved. We conclude that the features observed in the stratigraphy of Kealey Ice Rise require at least 3 ka of near-stationary flow conditions. However, we cannot exclude the possibility of a recent flow reorganization in the last century. We stress that the signs of stationary flow in radar stratigraphy observed in Kealey Ice Rise have been observed in other ice divides in the East Ellsworth Land area, suggesting stationary flow conditions over a millennial timescale in the region.
Ground-penetrating radar (GPR) is becoming a commonly applied technique in geomorphology. However, its use in the study of subglacial bedforms has yet to be fully explored and exploited. This paper presents the results of a GPR feasibility study conducted on a drumlinized terrain in Cumbria, UK, where five drumlins were investigated using multiple radar antenna frequencies. The site was selected for the presence of nearby bedrock outcrops, suggesting a shallow drumlinized diamict–bedrock contact and a permeable lithology. Despite the clayey sediment and unfavourable weather conditions, a considerable penetration depth of ~12 m was achieved when using a 50 MHz antenna, with a separation of 1 m, trace spacing of 1 m and 128-fold vertical stack. Results indicate that the drumlinized diamict is in direct erosional contact with the bedrock. While the internal drumlin geometry is generally chaotic on the stoss side, evidence of layering dipping downflow at an angle greater than the drumlin surface profile was found on the lee side. The inter-drumlin areas comprise ~4 m of infill sediment that masks part of the original drumlin profile. Overall, this study indicates that GPR can be deployed successfully in the study of glacial bedform sedimentary architecture.
A standard weed management system (system I) had a higher return above variable costs than did an intensive weed management system (system II) for two eastern Colorado cropping rotations. For continuous corn (Zea mays L.), the return above variable costs averaged $18.85/ha more under system I than under system II. For a barley (Hordeum vulgare L.)-corn-sugarbeet (Beta vulgaris L.) rotation, the return above variable costs averaged $20.48/ha more under System I than under System II. Based on alternative input (herbicide) and product prices, higher herbicide costs favored the standard weed management system, whereas higher crop prices favored the weed management system with the higher yields adjusted for quality. The probability that returns above variable costs differed between the two weed management systems depended upon the level of product prices and herbicide costs.