The target backsheath field acceleration mechanism is one of the main mechanisms of laser-driven proton acceleration (LDPA) and strongly depends on the comprehensive performance of the ultrashort ultra-intense lasers used as the driving sources. The successful use of the SG-II Peta-watt (SG-II PW) laser facility for LDPA and its applications in radiographic diagnoses have been manifested by the good performance of the SG-II PW facility. Recently, the SG-II PW laser facility has undergone extensive maintenance and a comprehensive technical upgrade in terms of the seed source, laser contrast and terminal focus. LDPA experiments were performed using the maintained SG-II PW laser beam, and the highest cutoff energy of the proton beam was obviously increased. Accordingly, a double-film target structure was used, and the maximum cutoff energy of the proton beam was up to 70 MeV. These results demonstrate that the comprehensive performance of the SG-II PW laser facility was improved significantly.

Background: Lower socioeconomic status is associated with worse outcomes after stroke. We evaluated the differences in acute revascularization treatments in patients with acute ischemic stroke (AIS) who were materially deprived compared to those who were not. Methods: In a population-based cohort study, we used linked administrative data to identify community-dwelling adults hospitalized for AIS between 2017-2022 in Ontario, Canada. The main exposure was neighborhood-level material deprivation quintiles. Multivariable logistic regression was used to obtain the adjusted odds ratio (aOR) of receiving revascularization treatments (thrombolysis or thrombectomy) for patients in each deprivation quintile compared to the least deprived quintile. Results: We identified 57,709 patients (median age 74 years; 45.9% female). Compared to patients in the least deprived quintile, those with higher deprivation were younger and more likely to have hypertension and diabetes, but less likely to have atrial fibrillation. Compared to patients in the least deprived quintile, fewer patients in the very deprived quintile (17.9% vs 19.6%, aOR 0.88, 95%CI [0.82,0.95]) and in the most deprived quintile (16.6% vs 19.6%, 0.77 [0.71,0.83]) received revascularization treatments. Conclusions: Our results suggest disparities in the use of acute ischemic stroke revascularization treatments by socioeconomic status despite access to universal health care.

We derive from first principles analytic relations for the second- and third-order moments of $\boldsymbol{\mathsf{m}}$, the spatial gradient of fluid velocity $\boldsymbol{u}$, $\boldsymbol{\mathsf{m}} = \nabla \boldsymbol{u}$, in compressible turbulence, which generalize known relations in incompressible flows. These relations, although derived for homogeneous flows, hold approximately for a mixing layer. We also discuss how to apply these relations to determine all the second- and third-order moments of the velocity gradient experimentally for isotropic compressible turbulence.

The spatio-temporal characteristics of turbulent separations beneath semi-submerged bluff bodies with different undersurface roughness conditions are studied using a time-resolved particle image velocimetry. The Reynolds number based on the free-stream velocity and submergence depth was fixed to 14 400. Three different undersurface conditions – smooth, sandpaper roughness and cube roughness – were examined. The results showed that wall roughness reduces the mean reattachment length, and suppresses the Reynolds stresses in the second half of the mean separation bubble. The Kelvin–Helmholtz instability is observed at the leading edge of the smooth bluff body, but is bypassed in the rough cases. In the first half of the mean separation bubble, the frequencies in the separated shear layer migrate to lower values in a discrete manner through the vortex pairing mechanism. Consequently, multiple vortex shedding motions at different frequencies are nested in the separated shear layer, and the cores of shed vortices are aligned near the isopleth of free-stream velocity. The shed vortex is accompanied with multiple vortices along the edge of mean flow reversal in the upstream locations. These vortices are influenced significantly by wall roughness. A low-frequency flapping motion manifests as enlargement/shrinkage of reverse flow areas in the first half of the mean separation bubble. The frequencies of flapping motion in the smooth and sandpaper cases are similar, but are relatively lower than that in the cube roughness case. This flapping motion is associated with an extremely large vortex shed from the mean reattachment point to the free-stream region.

To investigate the effects of culture media with different lactate concentrations on early embryonic development, data collected from our patients undergoing preimplantation genetic testing (PGT) were assessed using the EmbryoScope™ time-lapse culturing system. After intracytoplasmic sperm injection (ICSI), sibling oocytes were cultured in the same EmbryoScope (Vitrolife) slides including two different commercially available media. The patients with fewer than five mature oocytes were not included in the analyses. All embryos were hatched on day 3, and trophectoderm biopsies (n = 212) were performed accordingly. PGT for aneuploidy (PGT-A) on biopsied materials was carried out using next generation sequencing. Morphokinetic parameters, fertilization, irregular division, degeneration, blastulation, euploidy, and pregnancy rates of embryos cultured in LifeGlobal Global Total medium (LGGT) and Continuous Single Culture-NX Complete medium (CSCM-NXC) were compared. There were no differences observed in time to pronuclear fade, or in time spent as 2-cell (cc2) and 3-cell (s2), to 4-cell, 5-cell, morula and blastocyst stages (P > 0.05). Embryos reached the 2-cell (t2) and 3-cell (t3) stages significantly faster in LGGT (P < 0.05), whereas embryos grown in CSCM-NXC with lower lactate reached starting blastulation significantly sooner (P = 0.026). However, there were no statistical differences observed in fertilization, blastulation, degeneration, irregular division euploidy, and pregnancy rates between the two groups (P > 0.05). Even though pregnancy and fertilization rates did not indicate statistical differences, results are significant to provide better insight on potential roles of lactate in embryo development. These finding will advance the fundamental knowledge of human embryo development and assisted reproductive technologies.

This manuscript details the strategy employed for categorising food items based on their processing levels into the four NOVA groups. Semi-quantitative food frequency questionnaires (FFQs) from the Nurses’ Health Studies (NHS) I and II, the Health Professionals Follow-up Study (HPFS) and the Growing Up Today Studies (GUTS) I and II cohorts were used. The four-stage approach included: (i) the creation of a complete food list from the FFQs; (ii) assignment of food items to a NOVA group by three researchers; (iii) checking for consensus in categorisation and shortlisting discordant food items; (iv) discussions with experts and use of additional resources (research dieticians, cohort-specific documents, online grocery store scans) to guide the final categorisation of the short-listed items. At stage 1, 205 and 315 food items were compiled from the NHS and HPFS, and the GUTS FFQs, respectively. Over 70 % of food items from all cohorts were assigned to a NOVA group after stage 2. The remainder were shortlisted for further discussion (stage 3). After two rounds of reviews at stage 4, 95⋅6 % of food items (NHS + HPFS) and 90⋅7 % items (GUTS) were categorised. The remaining products were assigned to a non-ultra-processed food group (primary categorisation) and flagged for sensitivity analyses at which point they would be categorised as ultra-processed. Of all items in the food lists, 36⋅1 % in the NHS and HPFS cohorts and 43⋅5 % in the GUTS cohorts were identified as ultra-processed. Future work is needed to validate this approach. Documentation and discussions of alternative approaches for categorisation are encouraged.

Separating and reattaching turbulent flows induced by a forward-facing step subjected to an incoming fully developed turbulent channel flow are studied using direct numerical simulation. The step height is one quarter of the channel height, and the Reynolds number based on friction velocity and half-channel height at the inlet is 180. The three-dimensional spatio-temporal characteristics of separation bubbles upstream and downstream of the step are analysed with particular attention to the effects of impinging hairpin structures and the topology of principal stretching. Immediately upstream of the step, the fluctuating vorticity parallel to the mean streamlines is significant. On the frontal surface of the step, strong spanwise skin friction appears in the form of alternating positive and negative values in vertical strips. Over the step, the principal stretching switches orientation along a curve emanating from the leading edge, which is termed the principal stretching line (PSL). The reverse flows upstream and downstream of the step possess dominant and harmonic frequencies that mirror those of the incoming flow. As a hairpin structure leans over the step, the associated vorticity is deformed by the principal stretching. Specifically, PSL marks the lower bound of the deformed hairpin legs, and an opposite-signed pair of counter-rotating quasi-streamwise vortices are induced near the top surface of the step. Consequently, the separation bubbles upstream of and over the step are enlarged and suppressed, respectively. For a sufficiently strong hairpin structure interacting with the step, an open-type separation occurs upstream of the step, while dual separation bubbles appear over the step.

The effects of large-scale motion (LSM) on the spatio-temporal dynamics of separated shear layers induced by a forward-facing step submerged in a thick turbulent boundary layer (TBL) are investigated using a time-resolved particle image velocimetry. The Reynolds number based on the free-stream velocity and step height was 13 200. The oncoming TBL was developed over a cube-roughened surface and the thickness was 6.5 times the step height. The step height was chosen to coincide with the elevation where the dominant frequency of streamwise fluctuating velocity in the TBL occurred. At this elevation, the local turbulence intensity was 14.5 %. Distinct regions of elevated Reynolds stresses were observed upstream and downstream of the leading edge of the step. The unsteady dynamics of the separation bubbles upstream and downstream of the step was investigated using the reverse flow area. Both separation bubbles exhibit low-frequency flapping motion, and the dominant frequency of the downstream separation bubble is identical to the dominant frequency of the streamwise fluctuating velocity in the oncoming TBL at the step height. As the low-velocity region of LSM passes over the step, the downstream separation bubble is enlarged and subsequently undergoes a high-frequency oscillation. Turbulence motions were partitioned into low-, medium- and high-frequency regimes based on spectral analysis of the Reynolds stresses. The contributions from these partitioned turbulence motions are used to elucidate the effects of LSM on the elevated Reynolds stresses in the shear layers upstream and downstream of the step.

The spatio-temporal dynamics of separation bubbles induced by surface-mounted bluff bodies with different spanwise widths and submerged in a thick turbulent boundary layer is experimentally investigated. The streamwise extent of the bluff bodies is fixed at 2.36 body heights and the spanwise aspect ratio ($AR$), defined as the ratio between the width and height, is increased from 1 to 20. The thickness of the upstream turbulent boundary layer is 4.8 body heights, and the dimensionless shear and turbulence intensity evaluated at the body height are 0.23 % and 15.8 %, respectively, while the Reynolds number based on the body height and upstream free-stream velocity is 12 300. For these upstream conditions and limited streamwise extent of the bluff bodies, two distinct and strongly interacting separation bubbles are formed over and behind the bluff bodies. A time-resolved particle image velocimetry is used to simultaneously measure the velocity field within these separation bubbles. Based on the dynamics of the mean separation bubbles over and behind the bluff bodies, the flow fields are categorized into three-dimensional, transitional and two-dimensional regimes. The results indicate that the low-frequency flapping motions of the separation bubble on top of the bluff body with $\mathit{AR}=1$ are primarily influenced by the vortex shedding motion, while those with larger aspect ratios are modulated by the large-scale streamwise elongated structures embedded in the oncoming turbulent boundary layer. For $\mathit{AR}=1$ and 20, the flapping motions in the wake region are strongly influenced by those on top of the bluff bodies but with a time delay that is dependent on the $AR$. Moreover, an expansion of the separation bubble on the top surface tends to lead to an expansion and contraction of separation bubbles in the wake of $\mathit{AR}=20$ and 1, respectively. As for the transitional case of $\mathit{AR}=8$, the separation bubbles over and behind the body are in phase over a wide range of time difference. The dynamics of the shear layer in the wake region of the transitional case is remarkably more complex than the limiting two-dimensional and three-dimensional configurations.

Turbulent separation bubbles over and behind a two-dimensional forward–backward-facing step submerged in a deep turbulent boundary layer are investigated using a time-resolved particle image velocimetry. The Reynolds number based on the step height and free-stream velocity is 12 300, and the ratio of the streamwise length to the height of the step is 2.36. The upstream turbulent boundary layer thickness is 4.8 times the step height to ensure a strong interaction of the upstream turbulence structures with the separated shear layers over and behind the step. The velocity measurements were performed in streamwise–vertical planes at the channel mid-span and streamwise–spanwise planes at various vertical distances from the wall. The unsteady characteristics of the separation bubbles and their associated turbulence structures are studied using a variety of techniques including linear stochastic estimation, proper orthogonal decomposition and variable-interval time averaging. The results indicate that the low-frequency flapping motion of the separation bubble over the step is induced by the oncoming large-scale alternating low- and high-velocity streaky structures. Dual separation bubbles appear periodically over the step at a higher frequency than the flapping motion, and are attributed to the inherent instability in the rear part of the mean separation bubble. The separation bubble behind the step exhibits a flapping motion at the same frequency as the separation bubble over the step, but with a distinct phase delay. At instances when an enlarged separation bubble is formed in front of the step, a pair of vertical counter-rotating vortices is formed in the immediate vicinity of the leading edge.

With the rapid development of telescopes, both temporal cadence and the spatial resolution of observations are increasing. This in turn generates vast amount of data, which can be efficiently searched only with automated detections in order to derive the features of interest in the observations. A number of automated detection methods and algorithms have been developed for solar activities, based on the image processing and machine learning techniques. In this paper, after briefly reviewing some automated detection methods, we describe our efficient and versatile automated detection method for solar filaments. It is able not only to recognize filaments, determine the features such as the position, area, spine, and other relevant parameters, but also to trace the daily evolution of the filaments. It is applied to process the full disk Hα data observed in nearly three solar cycles, and some statistic results are presented.