We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.
To save content items to your account,
please confirm that you agree to abide by our usage policies.
If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account.
Find out more about saving content to .
To save content items to your Kindle, first ensure no-reply@cambridge.org
is added to your Approved Personal Document E-mail List under your Personal Document Settings
on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part
of your Kindle email address below.
Find out more about saving to your Kindle.
Note you can select to save to either the @free.kindle.com or @kindle.com variations.
‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi.
‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.
The identification of predictors of treatment response is crucial for improving treatment outcome for children with anxiety disorders. Machine learning methods provide opportunities to identify combinations of factors that contribute to risk prediction models.
Methods
A machine learning approach was applied to predict anxiety disorder remission in a large sample of 2114 anxious youth (5–18 years). Potential predictors included demographic, clinical, parental, and treatment variables with data obtained pre-treatment, post-treatment, and at least one follow-up.
Results
All machine learning models performed similarly for remission outcomes, with AUC between 0.67 and 0.69. There was significant alignment between the factors that contributed to the models predicting two target outcomes: remission of all anxiety disorders and the primary anxiety disorder. Children who were older, had multiple anxiety disorders, comorbid depression, comorbid externalising disorders, received group treatment and therapy delivered by a more experienced therapist, and who had a parent with higher anxiety and depression symptoms, were more likely than other children to still meet criteria for anxiety disorders at the completion of therapy. In both models, the absence of a social anxiety disorder and being treated by a therapist with less experience contributed to the model predicting a higher likelihood of remission.
Conclusions
These findings underscore the utility of prediction models that may indicate which children are more likely to remit or are more at risk of non-remission following CBT for childhood anxiety.
A self-medication hypothesis has been proposed to explain the association between cannabis use and a number of psychiatric and behavioral problems. However, there is little knowledge on reasons for use and reactions while intoxicated, in cannabis users who suffer from depression or problems controlling violent behavior.
Methods:
We assessed 119 cannabis dependent subjects using the Schedules of Clinical Assessment in Neuropsychiatry (SCAN), parts of the Addiction Severity Index (ASI), and questionnaires on reasons for cannabis use and reactions to cannabis use while intoxicated. Participants with lifetime depression, and problems controlling violent behavior, were compared to subjects without such problems. Validity of the groupings was corroborated by use of a psychiatric treatment register, previous use of psychotropic medication, and convictions for violence.
Results:
Subjects with lifetime depression used cannabis for the same reasons as others. While under the influence of cannabis, they more often experienced depression, sadness, anxiety and paranoia, and they were less likely to report happiness or euphoria. Participants reporting problems controlling violent behavior more often used cannabis to decrease aggression, decrease suspiciousness, and for relaxation; while intoxicated they more often reacted with aggression.
Conclusions:
Subjects with prior depression do not use cannabis as a mean of self-medication. They are more likely to experience specific increases of adverse symptoms while under the influence of cannabis, and are less likely to experience specific symptom relief. There is some evidence that cannabis is used as a mean of self-medication for problems controlling aggression.
Electric indoor lighting can disturb sleep and increase depressive symptoms; both common complaints in psychiatric inpatients.
Aims
To improve quality of sleep in patients using an indoor hospital lighting environment simulating nature in intensity, color, and circadian timing.
Methods
Investigator-blinded parallel group randomized controlled effectiveness trial supplied with qualitative interviews in an inpatient psychiatric ward with fully automatic and adjustable lighting. Admitted patients received a room with a naturalistic lighting environment (intervention group) or lighting as usual (control group). The primary outcome was the Pittsburg Sleep Quality Index and secondary outcomes included the Major Depression Inventory and WHO-five Well- Being Index.
Results
In this ongoing trial, we included 28 patients (16 treated and 12 controls). Patients in the intervention group reported higher subjective sleep quality and sleep efficiency, lower use of sleep medication (mean difference, 4.68 mg; 95% CI, 0.54; 53.5), fewer depressive symptoms (mean difference, 5; 95% CI,–2; 13), but lower well-being (difference,–4 percentage points; 95% CI,–20; 16), compared with the control group. At discharge, fewer patients in the intervention group had experienced use of involuntary treatment. Qualitative data indicated no side effects apart from issues in performing indoor leisure activities in dim light.
Conclusions
A naturalistic lighting environment was safe and improved sleep and mood in our small patient sample. The trial integrated well with routine clinical care and our sample reflected the heterogeneity of the target population (Funded by Region Midtjylland and others; Clinicaltrials.gov number, NCT02653040)
Disclosure of interest
The authors have not supplied their declaration of competing interest.
We acquired center-line surface elevations from glaciers in the St Elias Mountains of Alaska/northwestern Canada using aircraft laser altimetry during 2000–05, and compared these with repeat measurements acquired in 2007. The resulting elevation changes were used to estimate the mass balance of 32 900 km2 of glaciers in the St Elias Mountains during September 2003 to August 2007, yielding a value of −21.2 ± 3.8 Gt a−1, equivalent to an area-averaged mass balance of −0.64 ± 0.12 m a−1 water equivalent (w.e.). High-resolution (2 arc-degrees spatial and 10 day temporal) Gravity Recovery and Climate Experiment (GRACE) mass-balance estimates during this time period were scaled to glaciers of the St Elias Mountains, yielding a value of −20.6 ± 3.0 Gt a−1, or an area-averaged mass balance of −0.63 ± 0.09 m a−1 w.e. The difference in balance estimates (altimetry minus GRACE) was −0.6 ± 4.8 Gt a−1, well within the estimated errors. Differences likely resulted from uncertainties in subgrid sampling of the GRACE mass concentration (mascon) solutions, and from errors in assigning an appropriate near-surface density in the altimetry estimates. The good correspondence between GRACE and aircraft altimetry data suggests that high-resolution GRACE mascon solutions can be used to accurately assess mass-balance trends of mountain glacier regions that are undergoing large changes.
The mass changes of the Gulf of Alaska (GoA) glaciers are computed from the Gravity Recovery and Climate Experiment (GRACE) inter-satellite range-rate data for the period April 2003–September 2007. Through the application of unique processing techniques and a surface mass concentration (mascon) parameterization, the mass variations in the GoA glacier regions have been estimated at high temporal (10 day) and spatial (2 × 2 arc-degrees) resolution. The mascon solutions are directly estimated from a reduction of the GRACE K-band inter-satellite range-rate data and, unlike previous GRACE solutions for the GoA glaciers, do not exhibit contamination by leakage from mass change occurring outside the region of interest. The mascon solutions reveal considerable temporal and spatial variation within the GoA glacier region, with the largest negative mass balances observed in the St Elias Mountains including the Yakutat and Glacier Bay regions. The most rapid losses occurred during the 2004 melt season due to record temperatures in Alaska during that year. The total mass balance of the GoA glacier region was −84 ± 5 Gt a−1 contributing 0.23 ± 0.01 mm a−1 to global sea-level rise from April 2003 through March 2007. Highlighting the large seasonal and interannual variability of the GoA glaciers, the rate determined over the period April 2003–March 2006 is −102 ± 5 Gt a−1, which includes the anomalously high temperatures of 2004 and does not include the large 2007 winter balance-year snowfall. The mascon solutions agree well with regional patterns of glacier mass loss determined from aircraft altimetry and in situ measurements.
During spring 2013, we performed 500 MHz, helicopter-borne impulsive ground-penetrating radar surveys of several glaciers and glacier forelands in south-central Alaska, USA. These surveys were designed to obtain spatially distributed measurements of snow accumulation spanning a broad range of continental and maritime climatic zones. Visual assessment of radar images shows that data quality varied with the terrains and was optimal for snow that covered smooth glacier ice and firn, smooth debris-covered areas and moraines, freshwater lake and river ice, tundra, and taiga. Conversely, returns from the base of the snowpack were unrecognizable over rough debris-covered glacier termini, icefalls and some high-altitude accumulation basins. Optimal flying speed was 15-20ms–1 (30–40kt). At these speeds, which are two to three times faster than previously reported for such surveys, we could still identify snow-depth data with confidence, at a point spacing of ~1.5-2.0m. Data quality on glaciers decreased with increased air speed, though useful echoes from the base of the snowpack were still obtained at 40-45 ms–1 (87 kt; data point spacing of 6-8 m). Similar high-speed surveys over non-glacial terrains were unsuccessful, as basal reflections were no longer recognizable.
The Glacier Bay region of southeast Alaska, USA, and British Columbia, Canada, has undergone major glacier retreat since the Little Ice Age (LIA). We used airborne laser altimetry elevation data acquired between 1995 and 2011 to estimate the mass loss of the Glacier Bay region over four time periods (1995–2000, 2000–05, 2005–09, 2009–11). For each glacier, we extrapolated from center-line profiles to the entire glacier to estimate glacier-wide mass balance, and then averaged these results over the entire region using three difference methods (normalized elevation, area-weighted method and simple average). We found that there was large interannual variability of the mass loss since 1995 compared with the long-term (post-LIA) average. For the full period (1995–2011) the average mass loss was 3.93 ± 0.89 Gt a−1 (0.6 ± 0.1 m w.e. a−1), compared with 17.8 Gt a−1 for the post-LIA (1770–1948) rate. Our mass loss rate is consistent with GRACE gravity signal changes for the 2003–10 period. Our results also show that there is a lower bias due to center-line profiling than was previously found by a digital elevation model difference method.
The Randolph Glacier Inventory (RGI) is a globally complete collection of digital outlines of glaciers, excluding the ice sheets, developed to meet the needs of the Fifth Assessment of the Intergovernmental Panel on Climate Change for estimates of past and future mass balance. The RGI was created with limited resources in a short period. Priority was given to completeness of coverage, but a limited, uniform set of attributes is attached to each of the ~198 000 glaciers in its latest version, 3.2. Satellite imagery from 1999–2010 provided most of the outlines. Their total extent is estimated as 726 800 ± 34 000 km2. The uncertainty, about ±5%, is derived from careful single-glacier and basin-scale uncertainty estimates and comparisons with inventories that were not sources for the RGI. The main contributors to uncertainty are probably misinterpretation of seasonal snow cover and debris cover. These errors appear not to be normally distributed, and quantifying them reliably is an unsolved problem. Combined with digital elevation models, the RGI glacier outlines yield hypsometries that can be combined with atmospheric data or model outputs for analysis of the impacts of climatic change on glaciers. The RGI has already proved its value in the generation of significantly improved aggregate estimates of glacier mass changes and total volume, and thus actual and potential contributions to sea-level rise.
We have determined the ice mass evolution of the Antarctic and Greenland ice sheets (AIS and GIS) and Gulf of Alaska (GOA) glaciers from a new GRACE global solution of equal-area surface mass concentration parcels (mascons) in equivalent height of water. The mascons were estimated directly from the reduction of the inter-satellite K-band range-rate (KBRR) observations, taking into account the full noise covariance, and formally iterating the solution. The new solution increases signal recovery while reducing the GRACE KBRR observation residuals. The mascons were estimated with 10 day and 1 arcdeg equal-area sampling, applying anisotropic constraints. An ensemble empirical mode decomposition adaptive filter was applied to the mascon time series to compute annual mass balances. The details and causes of the spatial and temporal variability of the land-ice regions studied are discussed. The estimated mass trend over the total GIS, AIS and GOA glaciers for the time period 1 December 2003 to 1 December 2010 is −380 ± 31 Gt a−1, equivalent to −1.05 ± 0.09 mm a−1 sea-level rise. Over the same time period we estimate the mass acceleration to be −41 ± 27 Gt a−2 , equivalent to a −0.11 ± 0.08 mm a−2 sea-level acceleration. The trends and accelerations are dependent on significant seasonal and annual balance anomalies.
Anxiety disorders are common, and cognitive–behavioural therapy (CBT) is a first-line treatment. Candidate gene studies have suggested a genetic basis to treatment response, but findings have been inconsistent.
Aims
To perform the first genome-wide association study (GWAS) of psychological treatment response in children with anxiety disorders (n = 980).
Method
Presence and severity of anxiety was assessed using semi-structured interview at baseline, on completion of treatment (post-treatment), and 3 to 12 months after treatment completion (follow-up). DNA was genotyped using the Illumina Human Core Exome-12v1.0 array. Linear mixed models were used to test associations between genetic variants and response (change in symptom severity) immediately post-treatment and at 6-month follow-up.
Results
No variants passed a genome-wide significance threshold (P=5×10–8) in either analysis. Four variants met criteria for suggestive significance (P<5×10–6) in association with response post-treatment, and three variants in the 6-month follow-up analysis.
Conclusions
This is the first genome-wide therapygenetic study. It suggests no common variants of very high effect underlie response to CBT. Future investigations should maximise power to detect single-variant and polygenic effects by using larger, more homogeneous cohorts.
We previously reported an association between 5HTTLPR genotype and outcome following cognitive–behavioural therapy (CBT) in child anxiety (Cohort 1). Children homozygous for the low-expression short-allele showed more positive outcomes. Other similar studies have produced mixed results, with most reporting no association between genotype and CBT outcome.
Aims
To replicate the association between 5HTTLPR and CBT outcome in child anxiety from the Genes for Treatment study (GxT Cohort 2,n = 829).
Method
Logistic and linear mixed effects models were used to examine the relationship between 5HTTLPR and CBT outcomes. Mega-analyses using both cohorts were performed.
Results
There was no significant effect of 5HTTLPR on CBT outcomes in Cohort 2. Mega-analyses identified a significant association between 5HTTLPR and remission from all anxiety disorders at follow-up (odds ratio 0.45,P = 0.014), but not primary anxiety disorder outcomes.
Conclusions
The association between 5HTTLPR genotype and CBT outcome did not replicate. Short-allele homozygotes showed more positive treatment outcomes, but with small, non-significant effects. Future studies would benefit from utilising whole genome approaches and large, homogenous samples.
Seasonal affective disorder (SAD) is characterised by recurrent episodes in autumn and winter of depression, hypersomnia, augmented appetite with carbohydrate craving, and weight gain, and can be successfully treated with bright light. Circadian rhythm hypotheses (summarized in) have stimulated research into the pathophysiology of SAD, postulating that:
1.The illness is a consequence of delayed phase position,
2.It is correlated with diminished circadian amplitude, or
3.It results from changes in the nocturnal duration between dusk and dawn e.g. of low core body temperature or melatonin secretion. Light is considered to act directly on the circadian pacemaker (‘Process C’) and not on sleep dependent processes (‘Process S’). Thus successful treatment of SAD must act via mechanisms within known retinohypothalamic pathways. Conversely, emergence of SAD symptoms may reflect inappropriate neurobiological response to decreasing daylength.
We have obtained deep g, r, and i-band Subaru and ultra-deep 3.6 μm IRAC images of parts of the multiply-wrapped stellar stream around the nearby edge-on galaxy NGC 5907. We have fitted the surface brightness measurements of the stream with FSPS stellar population synthesis models to derive the metallicity and age of the brightest parts of the stream. The resulting relatively high metallicity ([Fe/H] = −0.3) is consistent with a major merger scenario but a satellite accretion event cannot be ruled out.
This study was designed to evaluate the effects of algal and yeast β-glucans on the porcine gastrointestinal microbiota, specifically the community of Lactobacillus, Bifidobacterium and coliforms. A total of 48 pigs were fed four diets over a 28-day period to determine the effect that each had on these communities. The control diet consisted of wheat and soya bean meal. The remaining three diets contained wheat and soya bean meal supplemented with β-glucan at 250 g/tonne from Laminaria digitata, Laminaria hyperborea or Saccharomyces cerevisiae. Faecal samples were collected from animals before feeding each diet and after the feeding period. The animals were slaughtered the following day and samples were collected from the stomach, ileum, caecum, proximal colon and distal colon. Alterations in Lactobacillus in the gastrointestinal tract (GIT) were analysed using denaturing gradient gel electrophoresis (DGGE) profiles generated by group-specific 16S rRNA gene PCR amplicons. Plate count analysis was also performed to quantify total coliforms. DGGE profiles indicated that all β-glucan diets provoked the emergence of a richer community of Lactobacillus. The richest community of lactobacilli emerged after feeding L. digitata (LD β-glucan). Plate count analysis revealed that the L. hyperborea (LH β-glucan) diet had a statistically significant effect on the coliform counts in the proximal colon in comparison with the control diet. β-glucan from L. digitata and S. cerevisiae also generally reduced coliforms but to a lesser extent. Nevertheless, the β-glucan diets did not significantly reduce levels of Lactobacillus or Bifidobacterium. DGGE analysis of GIT samples indicated that the three β-glucan diets generally promoted the establishment of a more varied range of Lactobacillus species in the caecum, proximal and distal colon. The LH β-glucan had the most profound reducing effect on coliform counts when compared with the control diet and diets supplemented with L. digitata and S. cerevisiae β-glucans.
We estimated the population density of the globally threatened Elfin-woods Warbler Setophaga angelae within two forest types at different elevations in the Luquillo Experimental Forest in north-eastern Puerto Rico. Population densities ranged from 0.01 to 0.02 individuals/ha in elfin woodland and 0.06–0.26 individuals/ha in palo colorado forest in 2006, with average rates of decline since 1989 of 0.002–0.01 and 0.003–0.06 individuals/ha respectively. These estimates show a significant general declining trend from c.0.2 individuals/ha in 1989 in elfin woodland to c.0.02/ha in 2006, and from 1 to 0.2 in palo colorado forest. Although variation in estimated population density depended on the statistical method used, we document and discuss possible causes of an overall population decline from 1989 to 2006, lending support to previous initiatives to reclassify the species from the IUCN Red List category of “Vulnerable” to “Endangered”.
We present an update on the performance of our 2 mm bolometer camera GISMO (the Goddard IRAM 2 Millimeter Observer), which is used for astronomical observations at the IRAM 30 m Telescope. The camera is optimized to efficiently observe dusty high-redshift galaxies. GISMO uses a monolithic 8 by 16 Backshort Under Grid (BUG) array with superconducting Transition Edge Sensors (TES). It serves as a testbed for our close-packed superconducting bolometer technologies and guides us in optimizing the design of future fast, low background bolometer cameras. Illustrated by astronomical observations we obtained recently, we demonstrate the scientific potential of the camera, highlighted by the detection of two high redshift galaxies.
The Montserrat Oriole Icterus oberi is endemic to the Caribbean island of Montserrat where, prior to 1995, it was widely distributed across the island's three main interior mountain ranges: the Centre, Soufriere and South Soufriere Hills. In July 1995, a long-dormant volcano on Chances Peak in the Soufriere Hills began to erupt. Since then the forest habitat of the oriole on the Soufriere and South Soufriere Hills has been devastated by pyroclastic flows and surges, heavy ash eruptions and rock falls. The Montserrat Oriole populations that inhabited these two mountain ranges have probably been lost. In December 1997, a census of the remaining Centre Hills population was undertaken to assess its status in the face of the heavy ash fall that occurred earlier the same year. To do this, a systematic grid of 140 sample points was overlaid on an area of 1,437.5 n a encompassing the Centre Hills, and a 10-minute count of all bird species was undertaken at 137 of these points during an eight-day survey period. The distance from the point to each oriole detected was measured and records of all other species were allocated to one of five distance bands radiating out from the point. Distance sampling was used to model densities, and thus to estimate population sizes, of eight bird species in the study area. It was estimated that 4,000 (95% CIs 1,500–7,800) Montserrat Orioles remain in the Centre Hills and thus the world. Although the probability of pyroclastic flows and surges overrunning the Centre Hills is considered rerrtote, it is recommended that the Montserrat Oriole be classified as Globally Threatened (Endangered) under the revised IUCN threat categories because of its loss of breeding habitat since 1995.
Ten patients with seasonal affective disorder received the following treatments for 5 days each: (a) artificial daylight (2500 lux) from 20.00 to 23.00 and from 07.00 to 10.00 hours; (b) red light (300 lux) from 20.00 to 23.00 and from 07.00 to 10.00 hours; (c) artificial daylight (2500 lux) from 22.00 to 23.00 and from 07.00 to 08.00 hours. The antidepressant effect of treatment (a) was superior to that of treatment (b), suggesting that the effect of light treatment in winter depression is more than that of a placebo. The antidepressant effect of treatment (a) was superior to that of treatment (c), although these two treatments equally suppressed plasma melatonin concentrations. Consequently, in these patients there is a dissociation between the effect of light treatment on melatonin and the reduction of depression ratings.