We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.
To save content items to your account,
please confirm that you agree to abide by our usage policies.
If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account.
Find out more about saving content to .
To save content items to your Kindle, first ensure no-reply@cambridge.org
is added to your Approved Personal Document E-mail List under your Personal Document Settings
on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part
of your Kindle email address below.
Find out more about saving to your Kindle.
Note you can select to save to either the @free.kindle.com or @kindle.com variations.
‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi.
‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.
An array of information about the Antarctic ice sheet can be extracted from ice-sheet internal architecture imaged by airborne ice-penetrating radar surveys. We identify, trace and date three key internal reflection horizons (IRHs) across multiple radar surveys from South Pole to Dome A, East Antarctica. Ages of ~38 ± 2.2, ~90 ± 3.6 and ~162 ± 6.7 ka are assigned to the three IRHs, with verification of the upper IRH age from the South Pole ice core. The resultant englacial stratigraphy is used to identify the locations of the oldest ice, specifically in the upper Byrd Glacier catchment and the Gamburtsev Subglacial Mountains. The distinct glaciological conditions of the Gamburtsev Mountains, including slower ice flow, low geothermal heat flux and frozen base, make it the more likely to host the oldest ice. We also observe a distinct drawdown of IRH geometry around South Pole, indicative of melting from enhanced geothermal heat flux or the removal of deeper, older ice under a previous faster ice flow regime. Our traced IRHs underpin the wider objective to develop a continental-scale database of IRHs which will constrain and validate future ice-sheet modelling and the history of the Antarctic ice sheet.
Remitted psychotic depression (MDDPsy) has heterogeneity of outcome. The study's aims were to identify subgroups of persons with remitted MDDPsy with distinct trajectories of depression severity during continuation treatment and to detect predictors of membership to the worsening trajectory.
Method
One hundred and twenty-six persons aged 18–85 years participated in a 36-week randomized placebo-controlled trial (RCT) that examined the clinical effects of continuing olanzapine once an episode of MDDPsy had remitted with sertraline plus olanzapine. Latent class mixed modeling was used to identify subgroups of participants with distinct trajectories of depression severity during the RCT. Machine learning was used to predict membership to the trajectories based on participant pre-trajectory characteristics.
Results
Seventy-one (56.3%) participants belonged to a subgroup with a stable trajectory of depression scores and 55 (43.7%) belonged to a subgroup with a worsening trajectory. A random forest model with high prediction accuracy (AUC of 0.812) found that the strongest predictors of membership to the worsening subgroup were residual depression symptoms at onset of remission, followed by anxiety score at RCT baseline and age of onset of the first lifetime depressive episode. In a logistic regression model that examined depression score at onset of remission as the only predictor variable, the AUC (0.778) was close to that of the machine learning model.
Conclusions
Residual depression at onset of remission has high accuracy in predicting membership to worsening outcome of remitted MDDPsy. Research is needed to determine how best to optimize the outcome of psychotic MDDPsy with residual symptoms.
An increased number of rogue waves, relative to standard distributions, can be induced by unidirectional waves passing over abrupt decreases in water depth. We investigate this phenomenon in a more general setting of multidirectional waves. We examine the influence of the directionality on the occurrence probability of rogue waves using laboratory experiments and fully nonlinear potential flow simulations. Based on the analysis of the statistics of random waves, we find that directional spreading reduces the formation probability of rogue waves relative to unidirectional seas. Nevertheless, for typical values of directional spreading in the ocean ($15^{\circ }\unicode{x2013}30^{\circ }$), our numerical results suggest that there is still a significant enhancement to the number of rogue waves just beyond the top of a depth discontinuity.
Neuropsychiatric symptoms (NPS) are common during the course of neurocognitive disorders. NPS have been previously reported in early and late stages of Alzheimer’s Disease. However, our understanding of NPS in high-risk states for dementia such as mild cognitive impairment (MCI) and major depressive disorder (MDD) is poor.
Objectives
To compare the frequency and factor structure of neuropsychiatric symptoms among individuals with Mild Cognitive Impairment (MCI), Major Depressive Disorder (MDD) in remission, and comorbid MCI and MDD (in remission) (MCI-D).
Methods
We used baseline data from the Prevention of Alzheimer’s Dementia with Cognitive Remediation Plus Transcranial Direct Current Stimulation in Mild Cognitive Impairment and Depression (PACt-MD) study, a multicenter trial across five academic sites in Toronto, Canada (clinical trial No. NCT0238667). We used ANOVA or χ2-test to compare frequency of NPS across groups. We used factor analysis of Neuropsychiatric Inventory Questionnaire (NPI-Q) items in the three groups.
Results
We included 374 participants with a mean age of 72.0 years (SD = 6.3). In the overall sample, at least one NPS was present in 64.2% participants, and 36.1 % had at least moderate severity NPS (36.1%). Depression (54%, χ2 < 0.001) and apathy (28.7%, χ2=0.002) were more prevalent in the MCI-D group as compared to MCI and MDD groups. In factor analysis, NPS grouped differently in MCI, MDD, and MCI-D groups. A “psychotic” subgroup emerged among MCI and MCI-D, but not in MDD. Night-time behaviors and disinhibition grouped differently across all three groups.
Conclusions
Prevalence of NPS seems higher in persons with MCI-D as compared to those with only MCI or MDD. The factor structure of NPS differed between MCI, MDD, and MCI-D groups. Future studies should investigate the association of NPS factors with cognition, function, and illness biomarkers.
When making directional surface gravity waves in a wave tank or when initialising numerical simulations of the ocean, the wave spectrum is often curtailed suppressing higher frequencies and wavenumbers. We consider the impact of doing this by numerically simulating two seminal experiments, those of Onorato et al. (J. Fluid Mech., vol. 627, 2009, pp. 235–257, R2) and Latheef & Swan (Proc. R. Soc. A, vol. 469, no. 2152, 2013, p. 20120696). We simulate waves using a fully nonlinear potential-flow model. We find that curtailing the spectrum can have a significant impact on the subsequent evolution. In particular, for cases where the spectrum has been curtailed, the nonlinear physics produces significantly more extreme or rogue waves than are observed in the case where the full spectral tail was included in the initial conditions, and this difference persists over tens of periods after the waves are initialised. This suggests that sea states that are ‘out of equilibrium’ (i.e. with their tails removed) can produce a greater number of rogue waves. We show this can also have an impact on predicted loads on offshore infrastructure.
Little is known about the relationship between psychomotor disturbance (PMD) and treatment outcome of psychotic depression. This study examined the association between PMD and subsequent remission and relapse of treated psychotic depression.
Methods
Two hundred and sixty-nine men and women aged 18–85 years with an episode of psychotic depression were treated with open-label sertraline plus olanzapine for up to 12 weeks. Participants who remained in remission or near-remission following an 8-week stabilization phase were eligible to participate in a 36-week randomized controlled trial (RCT) that compared the efficacy and tolerability of sertraline plus olanzapine (n = 64) with sertraline plus placebo (n = 62). PMD was measured with the psychiatrist-rated sign-based CORE at acute phase baseline and at RCT baseline. Spearman's correlations and logistic regression analyses were used to analyze the association between CORE total score at acute phase baseline and remission/near-remission and CORE total score at RCT baseline and relapse.
Results
Higher CORE total score at acute phase baseline was associated with lower frequency of remission/near-remission. Higher CORE total score at RCT baseline was associated with higher frequency of relapse, in the RCT sample as a whole, as well as in each of the two randomized groups.
Conclusions
PMD is associated with poorer outcome of psychotic depression treated with sertraline plus olanzapine. Future research needs to examine the neurobiology of PMD in psychotic depression in relation to treatment outcome.
We study the evolution of unidirectional water waves from a randomly forced input condition with uncorrelated Fourier components. We examine the kurtosis of the linearised free surface as a convenient proxy for the probability of a rogue wave. We repeat the laboratory experiments of Onorato et al. (Phys. Rev. E, vol. 70, 2004, 067302), both experimentally and numerically, and extend the parameter space in our numerical simulations. We consider numerical simulations based on the modified nonlinear Schrödinger equation and the fully nonlinear water wave equations, which are in good agreement. For low steepness, existing analytical models based on the nonlinear Schrödinger equation (NLS) are found to be accurate. For cases which are steep or have very narrow bandwidths, these analytical models over-predict the rate at which excess kurtosis develops. In these steep cases, the kurtosis in both our experiments and numerical simulations peaks before returning to an equilibrium level. Such transient maxima are not predicted by NLS-based analytical models. Above a certain threshold of steepness, the steady-state value of kurtosis is primarily dependent on the spectral bandwidth. We also examine how the average shape of extreme events is modified by nonlinearity over the evolution distance, showing significant asymmetry during the initial evolution, which is greatly reduced once the spectrum has reached equilibrium. The locations of the maxima in asymmetry coincide approximately with the locations of the maxima in kurtosis.
We have investigated steep three-dimensional surface gravity wave groups formed by dispersive focusing using a fully nonlinear potential flow solver. We find that third-order resonant interactions result in rapid energy transfers to higher wavenumbers and reduced directional spreading during focusing, followed by spectral broadening during defocusing, forming steep wave groups with augmented kinematics and a prolonged lifespan. If the wave group is initially narrow-banded, quasi-degenerate interactions arise, characterised by energy transfers along the resonance angle, ${\pm }35.26^{\circ }$, of the Phillips ‘figure-of-eight’ loop. Spectral broadening due to the quasi-degenerate interactions facilitates non-degenerate interactions, characterised by oblique energy transfers at approximately ${\pm }55^{\circ }$ to the spectral peak. We consider the influence of steepness, finite depth, directional spreading and the high-wavenumber tail on spectral evolution. Steepness is found to augment both the quasi-degenerate and non-degenerate interactions similarly. However, a reduction in depth is found to weaken the quasi-degenerate interactions more severely than the non-degenerate interactions. We observe that increased directional spreading reduces spectral evolution, partially because wave groups with more spreading focus for a shorter duration due to linear dispersion. However, we also find that directional spreading reduces the peak rates of energy transfer. Inclusion of the high-wavenumber tail of the Joint North Sea Wave Project spectrum further reduces rates of energy transfer compared with a Gaussian wavenumber spectrum. Thus, directional spreading and the high-wavenumber tail may be integral to a form of spectral equilibrium that reduces rapid energy transfers during a steep wave event.
This paper describes a model of electron energization and cyclotron-maser emission applicable to astrophysical magnetized collisionless shocks. It is motivated by the work of Begelman, Ergun and Rees [Astrophys. J. 625, 51 (2005)] who argued that the cyclotron-maser instability occurs in localized magnetized collisionless shocks such as those expected in blazar jets. We report on recent research carried out to investigate electron acceleration at collisionless shocks and maser radiation associated with the accelerated electrons. We describe how electrons accelerated by lower-hybrid waves at collisionless shocks generate cyclotron-maser radiation when the accelerated electrons move into regions of stronger magnetic fields. The electrons are accelerated along the magnetic field and magnetically compressed leading to the formation of an electron velocity distribution having a horseshoe shape due to conservation of the electron magnetic moment. Under certain conditions the horseshoe electron velocity distribution function is unstable to the cyclotron-maser instability [Bingham and Cairns, Phys. Plasmas 7, 3089 (2000); Melrose, Rev. Mod. Plasma Phys. 1, 5 (2017)].
Corn (Zea mays L. ‘Funk's G-83’) seedling leaves exposed to flame-generated ultra-high temperatures produced in flame cultivation were fixed in glutaraldehyde, post fixed in osmium tetroxide, and embedded in Araldite. In the light microscope, bundle sheath cells of flamed tissue were more heavily stained with Azure II and less vacuolated than were nonflamed cells. Heated mesophyll cells contained swollen, disrupted, and granular chloroplasts. Examination of flamed tissue by electron microscopy revealed granular, dispersed cytaplasm and altered membrane systems. Chloroplast lamellar systems and envelopes, tonoplasts, and plasmalemmas were disintegrated in both bundle sheath and mesophyll cells.
Dinitroaniline herbicides are major herbicides used to control annual grass weeds in cool-season turfgrasses. At least three herbicides, benefin, pendimethalin, and trifluralin are labeled preemergence to control weeds in established turfgrass. Prodiamine could be a competitive product. Benefin at 2.2 to 3.4 kg ai/ha, pendimethalin at 1.7 to 3.4 kg ai/ha, prodiamine at 0.6 to 1.7 kg ai/ ha, and benefin plus trifluralin at 1.1 plus 0.6 to 2.3 plus 1.1 kg ai/ha effectively control many annual grass weeds, including large and smooth crabgrass, yellow and green foxtail, barnyardgrass, goosegrass, fall panicum, and annual bluegrass. Most dinitroaniline herbicides provide residual preemergence weed control for the entire growing season. In general, Kentucky bluegrass, perennial ryegrass, tall fescue, red fescue, and other cool-season turfgrasses tolerate most of these herbicides, although higher-than-normal rates of any dinitroaniline herbicide could restrict root growth and cause stand thinning in turfgrass species.
Annual bluegrass (Poa annua L.) growing in bermudagrass completes its life cycle in May and dies leaving open spaces in the turfgrass. This occurs at a time when summer annual weeds are germinating and these weeds fill the space formerly occupied by the annual bluegrass. As the summer annual weeds die in the fall, annual bluegrass germinates and fills the space formerly occupied by the summer annual weeds. To control annual bluegrass, it is important to control the summer annual grasses and manage the bermudagrass [Cynodon dactylon (L.) Pers.] to maintain a competitive groundcover especially during the peak germination period for the weeds. Herbicide programs over a three-year period were designed to control annual grasses with treatments in April for large crabgrass [Digitaria sanguinalis (L.) Scop.], in May or June for goosegrass [Eleusine indica (L.) Gaertn.] and in late August for annual bluegrass. Oxadiazon [2-tert-butyl-4-(2,4-dichloro-5-isopropoxyphenyl)-δ2-1,3,4-ozadiazolin-5-one] applied in August gave complete control of annual bluegrass. Although oxadiazon has a long residual life in the soil, annual bluegrass was poorly controlled with treatments made in June. Fall (August or September) applications of benefin [N-butyl-N-ethyl-α,α,α-trifluoro-2,6-dinitro-p-toluidine], prosulfalin N-[[4-(dipropylamino)-3,5-dinitrophenyl] sulfonyl]-S,S-dimethylsulfilimine and butralin [4-(1,1-dimethylethyl-N-(1-methylpropyl)-2,6-dinitrobenzenamine] provided adequate control of annual bluegrass with only a few exceptions during the three-year period. Bensulide [O,O-diisopropyl phosphorodithioate S-ester with N-(2-mercaptoethyl)benzenesulfonamide] gave variable control of annual bluegrass; however, this was improved in programs with oxadiazon which provide goosegrass control during summer. In these studies, DCPA [dimethyl tetrachloroterephthalate], even with three applications a year, gave very little control of annual bluegrass. When oxadiazon was used in rotation with DCPA, adequate control was obtained.
Dimethyl 2,3,5,6-tetrachloroterephthalate (DCPA) on the soil surface inhibited rooting at bermudagrass (Cynodon dactylon L., var 328) stolon nodes. Histological studies of these root tips showed that cell division had ceased while cell enlargement continued for some time. Cells became excessively large and irregularly shaped. In corn (Zea may L., var. Pioneer 310), radicle cell size was about the same in both instances; however, treated tissue contained six times as many dinucleate cells as untreated radicle tissue. Numerous nuclei were at metaphase stage of mitosis in treated tissue. In untreated onion (Allium cepa L., var. Yellow Globe Danvers) root tips, many nuclei were found at anaphase and telophase stage of mitosis while very few cells were dividing in treated tissue.
Field studies were conducted from 1993 to 1995 to evaluate MON-12051 for turfgrass tolerance and control of yellow and purple nutsedges. The availability of herbicides for selective control of these weeds in turfgrass is limited. A sulfonylurea compound, MON-12051, has recently been developed for selective control of the nutsedges in turfgrass. When MON-12051 was applied at 0.07 to 0.14 kg ai/ha, the injury to Kentucky bluegrass, tall fescue, bermudagrass, and zoysiagrass was slight, with a maximum of 10% injury. At these rates, MON-12051 outperformed both bentazon and imazaquin in controlling yellow and purple nutsedges. Averaged over all tests 6 wk after treatment, yellow nutsedge control with MON-12051 was 83%. Control averaged 44% during the same period when treated with bentazon, whether applied once at 2.24 kg ai/ha or twice at 1.12 kg ai/ha. Purple nutsedge control averaged 96% when treated with MON-12051 in Kentucky bluegrass, while control was 42% with imazaquin applied at 0.19 and 0.43 kg ai/ha.
The rate of uptake and translocation of N,N-dimethyl-2,2-diphenylacetamide (diphenamid-14C) varied among different species. Apoplastic translocation of diphenamid occurred rapidly in tomato (Lycopersicon esculentum Mill.) seedlings, intermediate in bermudagrass (Cynodon dactylon L. ‘328’) and slowly in winged euonymus [Euonymus alatus (Thunb.) Seib. ‘compacta’]. Diphenamid-14C was dealkylated to give N-methyl-2,2-diphenylacetamide (MDA) in both winged euonymus and tomato plants. After 8 days, approximately 60% of the benzene-extractable labeled compounds from both plants was MDA and 39% was diphenamid. However, less of the radioactive material in winged euonymus was extracted.
Duration and spectrum of preemergence (PRE) weed control following isoxaben application at 0.56, 0.84, and 1.12 kg ai/ha in spring, fall, or spring plus fall (double) application were evaluated by field experiments. Residual activity of isoxaben was assessed by monitoring weed counts at two locations for 12 mo after treatment (MAT). Buckhorn plantain and dandelion control from spring-applied isoxaben at 1.12 kg/ha was > 90% at 4 MAT in Blacksburg but dropped to < 51% at 12 MAT. Isoxaben at 1.12 kg/ha applied in fall provided ≥ 90% control of buckhorn plantain for 8–9 MAT, with control ranging from 69 to 91% at approximately 12 MAT. Dandelion control with fall-applied isoxaben at 1.12 kg/ha ranged from 60 to 75%, 8–9 MAT. Fall application of 1.12 kg/ ha isoxaben at Virginia Beach controlled henbit and cornspeedwell for 2–3 MAT. Multiple applications of isoxaben improved weed control at Virginia Beach, but results were inconclusive at Blacksburg. In comparison, oxadiazon controlled white sweet clover and dandelion for 1 MAT following spring application in Blacksburg, but < 65% broadleaf control was observed at 4 MAT. Broadleaf weed control following single application of oxadiazon at 3.36 kg/ha was < 60% at 9 MAT Poor weed control resulted from spring applications of isoxaben and oxadiazon when a 25-cm precipitation occurred within 2 wk after application in one study.