For near-future missions planed for Mars Sample Return (MSR), an international working group organized by the Committee on Space Research (COSPAR) developed the sample safety assessment framework (SSAF). For the SSAF, analytical instruments were selected by taking the practical limitations of hosting them within a facility with the highest level of biosafety precautions (biosafety level 4) and the precious nature of returned samples into account. To prepare for MSR, analytical instruments of high sensitivity need to be tested on effective Mars analogue materials. As an analogue material, we selected a rock core of basalt, a prominent rock type on the Martian surface. Two basalt samples with aqueous alteration cached in Jezero crater by the Perseverance rover are planned to be returned to Earth. Our previously published analytical procedures using destructive but spatially sensitive instruments such as nanoscale secondary ion mass spectrometry (NanoSIMS) and transmission electron microscopy coupled to energy-dispersive spectroscopy revealed microbial colonization at clay-filled fractures. With an aim to test the capability of an analytical instrument listed in SSAF, we now extend that work to conventional Fourier transform infrared (FT-IR) microscopy with a spatial resolution of 10 μm. Although Fe-rich smectite called nontronite was identified after crushing some portion of the rock core sample into powder, the application of conventional FT-IR microscopy is limited to a sample thickness of <30 μm. In order to obtain IR-based spectra without destructive preparation, a new technique called optical-photothermal infrared (O-PTIR) spectroscopy with a spatial resolution of 0.5 μm was applied to a 100 μm thick section of the rock core. By O-PTIR spectroscopic analysis of the clay-filled fracture, we obtained in-situ spectra diagnostic to microbial cells, consistent with our previously published data obtained by NanoSIMS. In addition, nontronite identification was also possible by O-PTIR spectroscopic analysis. From these results, O-PTIR spectroscopy is suggested be superior to deep ultraviolet fluorescence microscopy/μ-Raman spectroscopy, particularly for smectite identification. A simultaneous acquisition of the spatial distribution of structural motifs associated with biomolecules and smectites is critical for distinguishing biological material in samples as well as characterizing an abiotic background.

Background: In June 2019, the Maryland Department of Health (MDH) was notified of a hospitalized patient with Candida auris bloodstream infection. The MDH initiated a contact investigation to identify additional patients with C. auris colonization. Many of the contacts had been discharged home from the hospital and were therefore not available for screening. Healthcare facilities in Maryland, Virginia, and Washington, DC, submit patient data to a regional health information exchange (HIE) called the Chesapeake Regional Information System for our Patients (CRISP). CRISP includes a notification system that alerts providers when flagged patients have healthcare encounters. We aimed to use this system to identify discharged C. auris contacts on their next inpatient encounter to rapidly screen them and to detect new cases. Methods:C. auris contacts were defined as patients located on an inpatient unit on the same day, receiving wound care from the same team, or having a procedure in the same operating room on the same day as the index patient or any patients subsequently identified as having C. auris infection or colonization detected either during the normal course of clinical care or through screening. Contacts who remained hospitalized were screened during inpatient point prevalence surveys (PPSs). Contacts discharged to postacute-care facilities were screened by facility staff. Contacts who had been discharged home were flagged in CRISP, and MDH staff received CRISP encounter alerts when these patients were readmitted. MDH staff then contacted the admitting facilities to recommend screening for C. auris. Axilla and groin swabs were collected and tested by rt-PCR at the Mid-Atlantic Regional Antibiotic Resistance Laboratory Network laboratory. Results: As of October 8, 2019, 4,017 contacts were identified. Among these, 936 (23%) contacts at 56 healthcare facilities (33 acute-care hospitals and 23 postacute-care facilities) were screened for C. auris, and 10 patients with C. auris colonization were identified (1.1% of contacts who underwent C. auris screening). Of these, 6 (60%) were identified through CRISP notification and 4 (40%) were identified by PPSs conducted in acute-care hospitals. Conclusions: In this ongoing C. auris outbreak, a large proportion of colonized patients was identified using an electronic encounter notification system within a regional HIE. This approach was effective for identifying opportunities to screen contacts at their next healthcare encounter and can augment other means of case detection, like PPSs. HIEs should incorporate mechanisms to facilitate contact tracing for public health investigations.

Funding: None

Disclosures: None

Advances in technological innovation have been deployed to support autonomous or semi-autonomous vehicles in many industries. A question that remains unanswered is why very little progress has been made in remote pilotage over the past 15 years. This paper draws together theories from innovation management and the high reliability organisation literatures to shed light on this question. Using a case study of two Australian ports, we examine a business case for remote pilotage demonstrating that despite positive cost benefit models, ambiguities in benefits exist throughout the ecosystem. The discussion sheds light on unique challenges that port executives face where it is necessary to simultaneously develop a strategy to: (1) manage the internal innovation process, and (2) manage the external consequences of the innovation by mobilising allies, managing opponents, and converting those who are indifferent to the innovation. The main contribution of this paper is to show that any assessment of the innovation challenge facing remote pilotage and enhanced navigational assistance requires the maritime industry to ask new questions not previously considered.

Public health and the emergency care community must work together to effectively achieve a state of community-wide disaster preparedness. The identification of model communities with good working relationships between their emergency care community and public health agencies may provide useful information on establishing and strengthening relationships in other communities. Seven model communities were identified: Boston, Massachusetts; Clark County, Nevada; Eau Claire, Wisconsin; Erie County, New York; Louisville, Kentucky; Livingston County, New York; and Monroe County, New York. This article describes these communities and provides a summary of common findings. Specifically, we recommend that communities foster respectful working relationships between agency leaders, hold regular face-to-face meetings, educate each other on their expertise and roles during a disaster, develop response plans together, work together on a day-to-day basis, identify and encourage a leader to facilitate these relationships, and share resources. (Disaster Med Public Health Preparedness. 2007;1:142–145)

The seventh annual Teaching and Learning Conference (TLC) was held in Philadelphia, Pennsylvania, from February 5 to 7, 2010, with 224 attendees onsite. The theme for the meeting was “Advancing Excellence in Teaching Political Science.” Using the working-group model, the TLC track format encourages in-depth discussion and debate on research dealing with the scholarship of teaching and learning.

This article deals with the provisions for the lawful detention and compulsory treatment of patients in England and Wales. The 2007 amendments to the Mental Health Act 1983 redefine ‘mental disorder’ and ‘medical treatment’ and remove the classifications required for longer-term detention, abolishing the so-called ‘treatability test’ and introducing a new appropriate-treatment test. ‘Learning disability’ is brought within the definition of mental disorder but only if ‘associated with abnormally aggressive or seriously irresponsible conduct’. The exclusion for promiscuity, other immoral conduct or sexual deviancy is repealed; the exclusion for dependence on alcohol and drugs is retained. The revised definition of ‘medical treatment’ includes psychological treatment and removes the requirement that treatment is under medical supervision. The basic structure of the 1983 Act is retained. Use of the powers is discretionary. The principles of the Mental Capacity Act 2005 are imported into the decision-making framework through the wording of the Mental Health Act Code of Practice.

The paper reports on the fourth (2010) season of fieldwork of the Cyrenaican Prehistory Project, and on further results of analyses of artefacts and organic materials collected in the 2009 season. Ground-based LiDar has provided both an accurate 3D scan of the Haua Fteah cave and information on the cave's morphometry or origins. The excavations in the cave focussed on Middle Palaeolithic or Middle Stone Age ‘Pre-Aurignacian’ layers below the base of the Middle Trench beside the McBurney Deep Sounding (Trench D) and on Final Palaeolithic ‘Oranian’ layers beside the upper part of the Middle Trench (Trench M). Although McBurney referred to the upper part of the Deep Sounding as more or less sterile, the 2010 excavations found evidence for small-scale but regular human presence in the form of stone artefacts and debitage, though given the sedimentary context the latter are unlikely to represent in situ knapping. The excavations of Trench M extended from the basal Capsian layers investigated in 2009 through Oranian layers to the transition with the Dabban Upper Palaeolithic. Some 17,000 lithic pieces have been studied from the Capsian and Oranian layers excavated in Trench M, in an area measuring less than 2 m by 1 m by 1.1 m deep, along with numerous animal bones, molluscs, and macrobotanical remains, as well as occasional shell beads. Preliminary studies of the lithics, bones, molluscs, and plant remains are revealing the changing character of late Pleistocene (Oranian) and early Holocene (Capsian) occupation in the Haua Fteah. Alongside the work in the Haua Fteah, the project continued its assessment of the Quaternary and archaeological sequences of the Cyrenaican coastland and completed a transect survey of surface lithic materials and their landform contexts from the pre-desert across the Gebel Akhdar to the coast, with a new focus on the al-Marj basin. Significant differences are emerging in patterns of Middle Palaeolithic and later hominin occupation and palaeodemography.

The paper reports on the third (2009) season of fieldwork of the Cyrenaican Prehistory Project, and on further results from the analysis of materials collected in the previous (2007 and 2008) fieldwork. Sediments in a 14 m-deep core drilled beside the McBurney trench provide an invaluable overview of the overall stratigraphic sequence, including at depths reached by the 1950s Deep Sounding but not yet investigated by the present project. Sampling of newly-exposed faces of the original excavation trench for dating (14C, ESR, OSL, U-series) and palaeoenvirommental indicators continued. Excavation was begun of sediments assigned to the early Holocene Libyco-Capsian (McBurney's Layer X), and of Pre-Aurignacian layers beside the top of the Deep Sounding. The Libyco-Capsian layers are particularly prolific in lithic debris, shells, and animal bones; preliminary analysis of the lithics suggests a development from Typical to Upper Capsian within the layers excavated in 2009. Geoarchaeological survey along the littoral to the west and east of the Haua Fteah identified complex sequences spanning most of the last interglacial-glacial cycle. Geoarchaeological survey south of the Haua Fteah characterized the major landforms of the Gebel Akhdar mountain and of the pre-desert and desert-edge zones further south, with Late Stone Age (Upper Palaeolithic and Epipalaeolithic) material being found especially on the southern side of the Gebel Akhdar, and Middle Stone Age (Middle Palaeolithic) material in the pre-desert and desert regions. The first suite of 14C dates (from charcoal samples taken in 2007) indicates the use of the Haua Fteah by Oranian hunter-gatherers during the Last Glacial Maximum and in the succeeding millennia, but not in the Younger Dryas cold/dry phase (c. 11,000–10,000 cal. BC), with Libyco-Capsian occupation resuming soon after the beginning of the Holocene c. 9000 cal. BC, suggesting that the cave, and perhaps the Gebel Akhdar in general, have a complex history as refugia for human settlement during the Pleistocene.

The 1950s excavations by Charles McBurney in the great Haua Fteah cave in northeast Libya revealed a deep (14 m) sequence of human occupation going back at least 100,000 years, with evidence for the presence of both Neanderthals and Modern Humans in the Pleistocene, and for Neolithic farmers in the Holocene. In 2007 a renewed programme of archaeological and geomorphological investigation began with the objective of improving understanding of the cave's occupation sequence and, combined with fieldwork in the landscape, of the history of landscape change and human responses to it. The initial season of fieldwork removed the upper c. 4.5 m of backfill in the McBurney trench; established the robustness of the original faces and their suitability for analytical interventions; recorded detailed running sections spanning from the present day to (at least) the Last Glacial Maximum c. 20,000 years ago; and indicated the potential of the surviving archaeology to reveal not just sequence but also activities or ‘taskscapes’ at the site. The geomorphological fieldwork identified rich sequences of later Quaternary deposits (marine, colluvial, alluvial, aeolian) with the potential to provide significant results regarding the history of climate and environment in the region. Archaeological survey around the cave indicates that the variability of the surface lithic evidence appears to reflect real differences in past human behaviour and use of the landscape and not just post-depositional taphonomic processes. Fifty years after the extraordinary pioneering work of McBurney and his colleagues, the new work demonstrates the continued potential of the Haua Fteah's unique occupation sequence and the multi-period ‘human landscapes’ around it to transform understanding of early human societies in North Africa.

The global population of the Critically Endangered Raso Lark Alauda razae was estimated in January 2003 at 93–103 birds and in November 2003 at 76–87 birds. Of these, only 25–35% were females. Counts were based on observations of individually colour-ringed and measured birds. Birds were not breeding during the January visit, and were concentrated in two small areas at opposite ends of the island of Raso. This distribution differed substantially from that recorded previously during the breeding season. Three different feeding strategies were apparent: flocking, aggregating around key resources and feeding singly or in pairs. Birds moving to new feeding areas immediately adopted the feeding strategy of other birds present. Birds were seen drinking seawater on several occasions. In November 2003, birds were breeding but nest survival was extremely low due to high rates of egg predation. No evidence was detected of introduced predators on Raso. However, a population of feral cats was found on nearby Santa Luzia, prohibiting natural colonization or deliberate introduction of Raso Lark to the island, despite much apparently suitable habitat there. Faecal analyses showed that these cats feed largely on skinks. Increased tourism development on neighbouring islands is identified as a potential threat to the species.