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To investigate the association of dietary patterns (DPs) with prediabetes and Type 2 Diabetes among Tibetan adults, first to identify DPs associated with abdominal obesity and examine their relationships with prediabetes and type 2 diabetes. Additionally, the study aims to investigate the mediating effects of body fat distribution and altitude on the associations between these DPs and the prevalence of prediabetes and Type 2 Diabetes.
Design:
An open cohort among Tibetans.
Setting:
Community-based.
Participants:
The survey recruited 1003 participants registered for health check-ups from November to December 2018, and 1611 participants from December 2021 to May 2022. During the baseline and follow-up data collection, 1818 individuals participated in at least one of the two surveys, with 515 of them participating in both.
Results:
Two DPs were identified by reduced rank regression (RRR). DP1 had high consumption of beef and mutton, non-caloric drink, offal, and low intake in tubers and roots, salty snacks, onion and spring onion, fresh fruits, desserts and nuts and seeds; DP2 had high intake of whole grains, Tibetan cheese, light-colored vegetables and pork and low of sugar-sweetened beverages, whole-fat dairy and poultry. Individuals in the highest tertile of DP1 showed higher risks of prediabetes (OR 95% CI) 1.35 (1.05, 1.73) and T2D 1.36 (1.05, 1.76). In the highest tertile of DP2 exhibited an elevated risk of T2D 1.63 (1.11, 2.40) in fully adjustment.
Conclusion:
Abdominal adiposity-related DPs are positively associated with T2D. Promoting healthy eating should be considered to prevent T2D among Tibetan adults.
This paper presents a low-profile miniaturized dual-band antenna utilizing the quarter-mode substrate integrated waveguide (QMSIW) structure. The two modes of TE110 and TE220 of a single QMSIW structure are employed, enabling a dual-band operation. The frequency ratio between the two bands can be tuned by loading a capacitive structure, which is comprised of a capacitive-loaded patch and a short circuit post, inside the QMSIW structure. By introducing parasitic QMSIW structures through magnetic coupling, a dual-band antenna with enhanced bandwidths is achieved. The antenna has dimensions of smaller than 400 mm2 (0.048λL2) with a uniform height of 1.4 mm (0.016λL). Measurement results indicate that the −6 dB impedance bandwidths of the antennas can cover the 5G N78 (3.3–3.6 GHz) and N79 (4.8–5 GHz) bands, and the average efficiencies is better than −2.5 dB. To the authors’ knowledge, the proposed designs offer dual-wideband operation while having the smallest planar dimension compared to the previously reported antennas. Furthermore, an extended electric coupling dual-band antenna configuration is also described and measured, which achieves similar bandwidth extension as the proposed antenna.
We aimed to validate in-body bioelectrical impedance analysis (BIA) measures with dual-energy X-ray absorptiometry (DXA) as reference and describe the body composition (BC) profiling of Tibetan adults.
Design:
This cross-sectional study included 855 participants (391 men and 464 women). Correlation and Bland–Altman analyses were performed for method agreement of in-body BIA and DXA. BC were described by obesity and metabolic status.
Setting:
In-body BIA and DXA have not been employed to characterise the BC of the Tibetan population living in the Qinghai–Tibet Plateau.
Participants:
A total of 855 Tibetan adults, including 391 men and 464 women, were enrolled in the study.
Results:
Concordance correlation coefficient for total fat mass (FM) and total lean mass (LM) between in-body BIA and DXA were 0·91 and 0·89. The bias of in-body BIA for percentages of total FM and total LM was 0·91 % (2·46 %) and –1·74 % (–2·80 %) compared with DXA, respectively. Absolute limits of agreement were wider for total FM in obese men and women and for total LM in overweight men than their counterparts. Gradience in the distribution of total and regional FM content was observed across different BMI categories and its combinations with waist circumference and metabolic status.
Conclusions:
In-body BIA and DXA provided overall good agreement at the group level in Tibetan adults, but the agreement was inferior in participants being overweight or obese.
History effects play a significant role in determining the velocity in boundary layers with pressure gradients, complicating the identification of a velocity scaling. This work pivots away from traditional velocity analysis to focus on fluid acceleration in boundary layers with strong adverse pressure gradients. We draw parallels between the transport equation of the velocity in an equilibrium spatially evolving boundary layer and the transport equation of the fluid acceleration in temporally evolving boundary layers with pressure gradients, establishing an analogy between the two. To validate our analogy, we show that the laminar Stokes solution, which describes the flow immediately after the application of a pressure gradient force, is consistent with the present analogy. Furthermore, fluid acceleration exhibits a linear scaling in the wall layer and transitions to logarithmic scaling away from the wall after the initial period, mirroring the velocity in an equilibrium boundary layer, lending further support to the analogy. Finally, by integrating fluid acceleration, a velocity scaling is derived, which compares favourably with data as well.
This study explores an interesting fluid–structure interaction scenario: the flow past a flexible filament fixed at two ends. The dynamic performance of the filament under various inclination angles ($\theta$) was numerically investigated using the immersed boundary method. The motion of the filament in the $\theta$–$Lr$ space was categorised into three flapping modes and two stationary modes, where $Lr$ is the ratio of filament length to the distance between its two ends. The flow fields for each mode and their transitions were introduced. A more in-depth analysis was carried out for flapping at a large angle (FLA mode), which is widely present in the $\theta$–$Lr$ space. The maximum width $W$ of the time-averaged shape of the filament has been shown to strongly correlate with the flapping frequency. After non-dimensionalising based on $W$, the flapping frequency shows little variation across different $Lr$ and $\theta$. Moreover, two types of lift variation process were also identified. Finally, the total lift, drag and lift-to-drag ratio of the system were studied. Short filaments, such as those with $Lr\leqslant 1.5$, were shown to significantly increase lift and the lift-to-drag ratio over a wide range of $\theta$ compared with a rigid plate. Flow field analysis concluded that the increases in pressure difference on both sides of the filament, along with the upper part of the flexible filament having a normal direction closer to the $y$ direction, were the primary reasons for the increase in lift and lift-to-drag ratio. This study can provide some guidance for the potential applications of flexible structures.
Substantial changes resulting from the interaction of environmental and dietary factors contribute to an increased risk of obesity, while their specific associations with obesity remain unclear. We identified inflammation-related dietary patterns (DP) and explored their associations with obesity among urbanised Tibetan adults under significant environmental and dietary changes. Totally, 1826 subjects from the suburbs of Golmud City were enrolled in an open cohort study, of which 514 were followed up. Height, weight and waist circumference were used to define overweight and obesity. DP were derived using reduced rank regression with forty-one food groups as predictors and high-sensitivity C-reactive protein and prognostic nutritional index as inflammatory response variables. Altitude was classified as high or ultra-high. Two DP were extracted. DP-1 was characterised by having high consumptions of sugar-sweetened beverages, savoury snacks, and poultry and a low intake of tsamba. DP-2 had high intakes of poultry, pork, animal offal, and fruits and a low intake of butter tea. Participants in the highest tertiles (T3) of DP had increased risks of overweight and obesity (DP-1: OR = 1·37, 95 % CI 1·07, 1·77; DP-2: OR = 1·48, 95 % CI 1·18, 1·85) than those in the lowest tertiles (T1). Participants in T3 of DP-2 had an increased risk of central obesity (OR = 2·25, 95 % CI 1·49, 3·39) than those in T1. The positive association of DP-1 with overweight and obesity was only significant at high altitudes, while no similar effect was observed for DP-2. Inflammation-related DP were associated with increased risks of overweight and/or obesity.
A high-energy pulsed vacuum ultraviolet (VUV) solid-state laser at 177 nm with high peak power by the sixth harmonic of a neodymium-doped yttrium aluminum garnet (Nd:YAG) amplifier in a KBe2BO3F2 prism-coupled device was demonstrated. The ultraviolet (UV) pump laser is a 352 ps pulsed, spatial top-hat super-Gaussian beam at 355 nm. A high energy of a 7.12 mJ VUV laser at 177 nm is obtained with a pulse width of 255 ps, indicating a peak power of 28 MW, and the conversion efficiency is 9.42% from 355 to 177 nm. The measured results fitted well with the theoretical prediction. It is the highest pulse energy and highest peak power ever reported in the VUV range for any solid-state lasers. The high-energy, high-peak-power, and high-spatial-uniformity VUV laser is of great interest for ultra-fine machining and particle-size measurements using UV in-line Fraunhofer holography diagnostics.
In contemporary neuroimaging studies, it has been observed that patients with major depressive disorder (MDD) exhibit aberrant spontaneous neural activity, commonly quantified through the amplitude of low-frequency fluctuations (ALFF). However, the substantial individual heterogeneity among patients poses a challenge to reaching a unified conclusion.
Methods
To address this variability, our study adopts a novel framework to parse individualized ALFF abnormalities. We hypothesize that individualized ALFF abnormalities can be portrayed as a unique linear combination of shared differential factors. Our study involved two large multi-center datasets, comprising 2424 patients with MDD and 2183 healthy controls. In patients, individualized ALFF abnormalities were derived through normative modeling and further deconstructed into differential factors using non-negative matrix factorization.
Results
Two positive and two negative factors were identified. These factors were closely linked to clinical characteristics and explained group-level ALFF abnormalities in the two datasets. Moreover, these factors exhibited distinct associations with the distribution of neurotransmitter receptors/transporters, transcriptional profiles of inflammation-related genes, and connectome-informed epicenters, underscoring their neurobiological relevance. Additionally, factor compositions facilitated the identification of four distinct depressive subtypes, each characterized by unique abnormal ALFF patterns and clinical features. Importantly, these findings were successfully replicated in another dataset with different acquisition equipment, protocols, preprocessing strategies, and medication statuses, validating their robustness and generalizability.
Conclusions
This research identifies shared differential factors underlying individual spontaneous neural activity abnormalities in MDD and contributes novel insights into the heterogeneity of spontaneous neural activity abnormalities in MDD.
Studies on obesity and risk factors from a life-course perspective among residents in the Tibet Plateau with recent economic growth and increasing obesity are important and urgently needed. The birth cohort in this area provides a unique opportunity to examine the association between maternal dietary practice and neonatal obesity. The study aims to detect the prevalence of obesity among neonates, associated with maternal diet and other factors, supporting life-course strategies for obesity control. A cohort of pregnant women was enrolled in Tibet Plateau and followed till childbirth. Dietary practice during pregnancy was assessed using the Chinese FFQ – Tibet Plateau version, food items and other variables were associated with the risk for obesity of neonates followed by logistic regression, classification and regression trees (CART) and random forest. Of the total 1226 mother–neonate pairs, 40·5 % were Tibetan and 5·4 % of neonates with obesity. Consuming fruits as a protective factor for obesity of neonates with OR (95 % CI) = 0·61 (0·43, 0·87) from logistic regression; as well as OR = 0·20 (0·12, 0·35) for consuming fruits (≥ weekly) from CART. Removing fruit consumption to avoid overshadowing effects of other factors, the following were influential from CART: maternal education (more than middle school, OR = 0·22 (0·13, 0·37)) and consumption of Tibetan food (daily, OR = 3·44 (2·08, 5·69). Obesity among neonates is prevalent in the study population. Promoting healthy diets during pregnancy and strengthening maternal education should be part of the life-course strategies for obesity control.
The mean flow in a turbulent boundary layer (TBL) deviates from the canonical law of the wall (LoW) when influenced by a pressure gradient. Consequently, LoW-based near-wall treatments are inadequate for such flows. Chen et al. (J. Fluid Mech., vol. 970, 2023, A3) derived a Navier–Stokes-based velocity transformation that accurately describes the mean flow in TBLs with arbitrary pressure gradients. However, this transformation requires information on total shear stress, which is not always readily available, limiting its predictive power. In this work, we invert the transformation and develop a predictive near-wall model. Our model includes an additional transport equation that tracks the Lagrangian integration of the total shear stress. Particularly noteworthy is that the model introduces no new parameters and requires no calibration. We validate the developed model against experimental and computational data in the literature, and the results are favourable. Furthermore, we compare our model with equilibrium models. These equilibrium models inevitably fail when there are strong pressure gradients, but they prove to be sufficient for boundary layers subjected to weak, moderate and even moderately high pressure gradients. These results compel us to conclude that history effects in mean flow, which negatively impact the validity of equilibrium models, can largely be accounted for by the material time derivative term and the pressure gradient term, both of which require no additional modelling.
A primary objective of integral methods, such as the momentum integral method, is to discern the physical processes contributing to skin friction. These methods encompass the momentum, kinetic energy and angular momentum integrals. This paper reformulates existing integrals based on the double-averaged Navier–Stokes equations, and extends their application to flows over rough walls. Our derivation yields distinct decompositions for the bottom-wall viscous friction coefficient, denoted as $C_S$, and the roughness element drag coefficient $C_R$. The decompositions comprise three terms: a viscous term, a turbulent term and a roughness (dispersive) term – regardless of the flow configuration, be it channel or boundary layer. Notably, when these integrals are evaluated for laminar flow scenarios, only the viscous term remains significant. In addition, we elucidate the spatial distributions of the terms within these decompositions. To demonstrate the practicality of our formulations, we apply them to analyse data from direct numerical simulations of turbulent half-channel flows. These flows feature aligned and staggered cubical roughness at various packing densities. Our analyses, based on kinetic-energy-oriented decompositions, reveal that when the surface coverage density $\lambda _p$ is small, the dominant terms within the decompositions are the viscous and turbulent terms. With increasing $\lambda _p$, the viscous dissipation term decreases, while the turbulent production term increases and then decreases. These variations arise from a subdued near-wall cycle and the development of a shear layer at the height of the cubes.
The assessment of seed quality and physiological potential is essential in seed production and crop breeding. In the process of rapid detection of seed viability using tetrazolium (TZ) staining, it is necessary to spend a lot of labour and material resources to explore the pretreatment and staining methods of hard and solid seeds with physical barriers. This study explores the TZ staining methods of six hard seeds (Tilia miqueliana, Tilia henryana, Sassafras tzumu, Prunus subhirtella, Prunus sibirica, and Juglans mandshurica) and summarizes the TZ staining conditions required for hard seeds by combining the difference in fat content between seeds and the kinship between species, thus providing a rapid viability test method for the protection of germplasm resources of endangered plants and the optimization of seed bank construction. The TZ staining of six species of hard seeds requires a staining temperature above 35 °C and a TZ solution concentration higher than 1%. Endospermic seeds require shorter staining times than exalbuminous seeds. The higher the fat content of the seeds, the lower the required incubation temperature and TZ concentration for staining, and the longer the staining time. And the closer the relationship between the two species, the more similar their staining conditions become. The TZ staining method of similar species can be predicted according to the genetic distance between the phylogenetic trees, and the viability of new species can be detected quickly.
Head-up tilt test (HUTT) is an important tool in the diagnosis of pediatric vasovagal syncope. This research will explore the relationship between syncopal symptoms and HUTT modes in pediatric vasovagal syncope.
Methods:
A retrospective analysis was performed on the clinical data of 2513 children aged 3–18 years, who were diagnosed with vasovagal syncope, from Jan. 2001 to Dec. 2021 due to unexplained syncope or pre-syncope. The average age was 11.76 ± 2.83 years, including 1124 males and 1389 females. The patients were divided into the basic head-up tilt test (BHUT) group (596 patients) and the sublingual nitroglycerine head-up tilt test (SNHUT) group (1917 patients) according to the mode of positive HUTT at the time of confirmed pediatric vasovagal syncope.
Results:
(1) Baseline characteristics: Age, height, weight, heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP), and composition ratio of syncope at baseline status were higher in the BHUT group than in the SNHUT group (all P < 0.05). (2) Univariate analysis: Age, height, weight, HR, SBP, DBP, and syncope were potential risk factors for BHUT positive (all P < 0.05). (3) Multivariate analysis: syncope was an independent risk factor for BHUT positive, with a probability increase of 121% compared to pre-syncope (P<0.001).
Conclusion:
The probability of BHUT positivity was significantly higher than SNHUT in pediatric vasovagal syncope with previous syncopal episodes.
The super-temporal-resolution (STR) reconstruction of turbulent flows is an important data augmentation application for increasing the data reach in measurement techniques and understanding turbulence dynamics. This paper proposes a data assimilation (DA) strategy based on weak-constraint four-dimensional variation to conduct an STR reconstruction in a turbulent jet beyond the Nyquist limit from given low-sampling-rate observations. Highly resolved large-eddy simulation (LES) data are used to produce synthetic measurements, which are used as observations and for validation. A segregated assimilation procedure is realised to assimilate the initial condition, inflow boundary condition and model error separately. Different types of observational data are tested. The first type is down-sampled LES data containing many small-scale turbulence structures with or without synthetic noise. The DA results show that the temporal variation of the small-scale structures is well recovered even with noise in the observations. The spectra are resolved to a frequency approximately one order of magnitude higher than what can be captured within the Nyquist limit. The second type of observation is low-sampling-rate tomographic particle image velocimetry (tomo-PIV) data with or without the injection of small-scale structures. The modulation between the large-scale structures contained in the tomo-PIV fields and the small scales injected from the observations is improved. The resultant small scales in the STR reconstruction have the characteristics of authentic turbulence to a considerable extent. Additionally, DA yields much smaller errors in the prediction of particle positions when compared with the Wiener filter, demonstrating the great potential for Lagrangian particle tracking in measurement techniques.
Here, we report the generation of MeV alpha-particles from H-11B fusion initiated by laser-accelerated boron ions. Boron ions with maximum energy of 6 MeV and fluence of 109/MeV/sr@5 MeV were generated from 60 nm-thick self-supporting boron nanofoils irradiated by 1 J femtosecond pulses at an intensity of 1019 W/cm2. By bombarding secondary hydrogenous targets with the boron ions, 3 × 105/sr alpha-particles from H-11B fusion were registered, which is consistent with the theoretical yield calculated from the measured boron energy spectra. Our results demonstrated an alternative way toward ultrashort MeV alpha-particle sources employing compact femtosecond lasers. The ion acceleration and product measurement scheme are referential for the studies on the ion stopping power and cross section of the H-11B reaction in solid or plasma.
The ordering conformation of surfactant molecules in intercalated montmorillonite prepared at various concentrations was investigated by 13C MAS NMR. The 13C MAS NMR study demonstrates the coexistence of ordered and disordered chain conformations. Two main resonance peaks are associated with the backbone alkyl chains: the resonance at 33 ppm corresponds to the ordered conformation (all-trans), and the resonance at 30 ppm corresponds to the disordered conformation (mixture of trans and gauche). Deconvolution of 13C MAS NMR spectra indicates that the ordering conformation of surfactant molecules within the gallery of montmorillonite depends very much on their orientation and packing density. When amine chains are oriented parallel to the silicate layers, the amount of all-trans conformer decreases with the increase of amine concentration. However, the amount of all-trans conformer increases with the increase of amine concentration when amine chains radiate from the silicate layers. Furthermore, 13C MAS NMR spectra show that the intercalated surfactant molecules in the clay minerals never attained the complete liquidlike or solidlike behavior.
Preterm children with very low birthweight (VLBW) / extremely low birthweight (ELBW) with normal early development had been found poorer executive functions (EFs) at preschool-age (Ni, Huang & Guo, 2011). The previous study found that the risks of deficits in EFs at preschool-age of preterm children can be attenuated by more supportive home environment (Taylor & Clark, 2016). However, former studies didn't investigate the effect of birthweight and home environment on cognitive EFs of preterm children simultaneously, especially those with normal early development. The present study aims to investigate the predictive effect of birthweight and home environment on the cognitive EFs of VLBW / ELBW preterm children.
Participants and Methods:
The preterm children were recruited from the Premature Baby Foundation of Taiwan. Inclusion criteria were their scores of Bayley Scales of Infant and Toddler Development, second or third edition at 12 and 24 months, and Wechsler Preschool and Primary Scale of Intelligence, Revised Edition at 5 years old were higher than 70. Exclusion criteria were visual impairment, hearing impairment, and cerebral palsy. There was a total of 287 preterm children with age 6 recruited in the present study. Preterm children were then divided into VLBW group (n=202, birthweight between 1001-1500g) and ELBW group (n=85, birthweight less than 1000g). The typical children included 89 term-born healthy and typically developing children with age 6, who were recruited from comparable social status families in the community. Four types of cognitive EFs including 22 indicators were assessed. Inhibition ability including 8 indicators was assessed through Comprehensive Nonverbal Attention Test Battery (CNAT), cognitive flexibility including 6 indicators was assessed through Wisconsin Card Sorting Test (WCST), working memory including 2 indicators was assessed through Digit Span Subtest of Wechsler Intelligence Scale for Children-IV (WISC-IV) and Knox's Cube Test (KCT), planning ability including 6 indicators was assessed through Tower of London (ToL). The home environment was assessed through Home Observation for Measurement of the Environment (HOME), Revised edition. Data were analyzed with Stepwise Regression.
Results:
Results showed that the regression model with birthweight significantly predicted 83.3% of planning ability indicators, 83.3% of cognitive flexibility indicators, and 50% of working memory indicators. Among indicators mentioned above, birthweight has been found the greatest predictive effect on summation-of score of ToL (R2=.04, p<.001). The regression model with HOME significantly predicted 66.7% of planning ability indicators, 16.7% of cognitive flexibility indicators, and 12.5% of inhibition ability indicators. Among the indicators mentioned above, HOME has been found the greatest predictive effect on rule-1 of ToL (R2=.027, p=.001). The regression model with birthweight and HOME significantly predicted 50% of planning ability indicators. Among indicators mentioned above, the regression model has been found the greatest predictive effect on summation-of-score of ToL (R2=.061, p<.001).
Conclusions:
Both birthweight and home environment have been found significantly predicted different types of cognitive EFs at preschool-age of VLBW / ELBW preterm children with normal early development. Though the home environment doesn't have such a great predictive effect as birthweight is, both birthweight and home environment are significant predictors of planning ability.
Fast neutron absorption spectroscopy is widely used in the study of nuclear structure and element analysis. However, due to the traditional neutron source pulse duration being of the order of nanoseconds, it is difficult to obtain a high-resolution absorption spectrum. Thus, we present a method of ultrahigh energy-resolution absorption spectroscopy via a high repetition rate, picosecond duration pulsed neutron source driven by a terawatt laser. The technology of single neutron count is used, which results in easily distinguishing the width of approximately 20 keV at 2 MeV and an asymmetric shape of the neutron absorption peak. The absorption spectroscopy based on a laser neutron source has one order of magnitude higher energy-resolution power than the state-of-the-art traditional neutron sources, which could be of benefit for precisely measuring nuclear structure data.
Inflammation plays a critical role in the progression of chronic liver diseases, and diet can modulate inflammation. Whether an inflammatory dietary pattern is associated with higher risk of hepatic steatosis or fibrosis remains unclear. We aimed to investigate the associations between inflammatory dietary pattern and the odds of hepatic steatosis and fibrosis.
Design:
In this nationwide cross-sectional study, diet was measured using two 24-h dietary recalls. Empirical dietary inflammatory pattern (EDIP) score was derived to assess the inflammatory potential of usual diet, which has been validated to highly predict inflammation markers in the study population. Controlled attenuation parameter (CAP) and liver stiffness measurement (LSM) were derived from FibroScan to define steatosis and fibrosis, respectively.
Setting:
US National Health and Nutrition Examination Survey.
Participants:
4171 participants aged ≥18 years.
Results:
A total of 1436 participants were diagnosed with S1 steatosis (CAP ≥ 274 dB/m), 255 with advanced fibrosis (LSM ≥ 9·7 kPa). Compared with those in the lowest tertile of EDIP-adherence scores, participants in the highest tertile had 74 % higher odds of steatosis (OR: 1·74, 95 % CI (1·26, 2·41)). Such positive association persisted among never drinkers, or participants who were free of hepatitis B and/or C. Similarly, EDIP was positively associated with CAP in multivariate linear model (P < 0·001). We found a non-significant association of EDIP score with advanced fibrosis or LSM (P = 0·837).
Conclusions:
Our findings suggest that a diet score that is associated with inflammatory markers is associated with hepatic steatosis. Reducing or avoiding pro-inflammatory diets intake might be an attractive strategy for fatty liver disease prevention.