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The scope of unconscious processing has long been, and still remains, a hotly debated issue. This is driven in part by the current diversity of methods to manipulate and measure perceptual consciousness. Here, we provide ten recommendations and nine outstanding issues about designing experimental paradigms, analyzing data, and reporting the results of studies on unconscious processing. These were formed through dialogue among a group of researchers representing a range of theoretical backgrounds. We acknowledge that some of these recommendations naturally do not align with some existing approaches and are likely to change following theoretical and methodological development. Nevertheless, we hold that at this stage of the field they are instrumental in evoking a much-needed discussion about the norms of studying unconscious processes and helping researchers make more informed decisions when designing experiments. In the long run, we aim for this paper and future discussions around the outstanding issues to lead to a more convergent corpus of knowledge about the extent – and limits – of unconscious processing.
Multilingual language control is commonly investigated using picture-naming paradigms with explicit instructions when to switch between languages. In daily life, language switching also occurs without external cues. Cued language-switching tasks usually show a switch cost (i.e., slower responses on switch than non-switch trials). Findings of switch costs in response times are mixed for voluntary language switching. This pre-registered study uses a bilingual picture-naming paradigm to compare voluntary and cued language switching in 25 highly proficient Dutch-English bilinguals using EEG. We analysed the N2 ERP component and midfrontal theta oscillations, two common electrophysiological markers of cognitive control in task and language switching. We observed significantly smaller behavioural switch costs in the voluntary task. This suggests that voluntary language switching is less effortful than switching based on external cues. However, we found no electrophysiological switch effects in either task. We discuss factors which may contribute to the inconsistency between behavioural and electrophysiological findings.
Mood disorders are characterized by great heterogeneity in clinical manifestation. Uncovering such heterogeneity using neuroimaging-based individual biomarkers, clinical behaviors, and genetic risks, might contribute to elucidating the etiology of these diseases and support precision medicine.
Methods
We recruited 174 drug-naïve and drug-free patients with major depressive disorder and bipolar disorder, as well as 404 healthy controls. T1 MRI imaging data, clinical symptoms, and neurocognitive assessments, and genetics were obtained and analyzed. We applied regional gray matter volumes (GMV) and quantile normative modeling to create maturation curves, and then calculated individual deviations to identify subtypes within the patients using hierarchical clustering. We compared the between-subtype differences in GMV deviations, clinical behaviors, cell-specific transcriptomic associations, and polygenic risk scores. We also validated the GMV deviations based subtyping analysis in a replication cohort.
Results
Two subtypes emerged: subtype 1, characterized by increased GMV deviations in the frontal cortex, cognitive impairment, a higher genetic risk for Alzheimer's disease, and transcriptionally associated with Alzheimer's disease pathways, oligodendrocytes, and endothelial cells; and subtype 2, displaying globally decreased GMV deviations, more severe depressive symptoms, increased genetic vulnerability to major depressive disorder and transcriptionally related to microglia and inhibitory neurons. The distinct patterns of GMV deviations in the frontal, cingulate, and primary motor cortices between subtypes were shown to be replicable.
Conclusions
Our current results provide vital links between MRI-derived phenotypes, spatial transcriptome, genetic vulnerability, and clinical manifestation, and uncover the heterogeneity of mood disorders in biological and behavioral terms.
This paper examines the issue of derivative pricing within the framework of a fractional stochastic volatility model. We present a deterministic partial differential equation system to derive an approximate expression for the derivative price. The proposed approach allows for the stochastic volatility to be expressed as a composition of deterministic functions of time and a fractional Ornstein–Uhlenbeck process. We apply this method to the European option pricing under the fractional Stein–Stein volatility model, demonstrating its feasibility and reliability through numerical simulations. Our numerical simulations also illustrate the impact of the parameters in the fractional stochastic volatility model on the option price.
Competition among the two-plasmon decay (TPD) of backscattered light of stimulated Raman scattering (SRS), filamentation of the electron-plasma wave (EPW) and forward side SRS is investigated by two-dimensional particle-in-cell simulations. Our previous work [K. Q. Pan et al., Nucl. Fusion 58, 096035 (2018)] showed that in a plasma with the density near 1/10 of the critical density, the backscattered light would excite the TPD, which results in suppression of the backward SRS. However, this work further shows that when the laser intensity is so high ($>{10}^{16}$ W/cm2) that the backward SRS cannot be totally suppressed, filamentation of the EPW and forward side SRS will be excited. Then the TPD of the backscattered light only occurs in the early stage and is suppressed in the latter stage. Electron distribution functions further show that trapped-particle-modulation instability should be responsible for filamentation of the EPW. This research can promote the understanding of hot-electron generation and SRS saturation in inertial confinement fusion experiments.
Currently there is lack of knowledge on how new types of alternative fuels and their storage conditions change the droplet evaporation characteristics. Liquid fuel is commonly stored in wide varieties of containers, where fuel characteristics may change because of the exposure to the material of the container. This study evaluates the impact of different storage containers on droplet evaporation characteristics of different fuels. It was found that there is a distinct phase transition between high volatility to low volatility phase in each fuel stored in steel drums verses fuel that is stored in plastic drums. The type of fuel contaminated by polymer additive has a high impact on fuel droplet burn rates. Polymer additives also have an impact on nucleate boiling, sub-droplets and soot particles. The burning rate constant, K, of selected pure aromatics, various fuel mixtures and Jet A with different cetane numbers have been evaluated. Research has shown that in the low volatility combustion phase a trend reduction of lowest boiling point pure aromatic burning rate to the highest boiling point pure aromatic burning rate is obvious. Irregular change in droplet diameter between the high volatility phase and low volatility phase during the combustion of aromatics blend was observed. This work has also evaluated the relationship between burning rates and cetane numbers.
To meet the increasing communication demands, the satellites need to be equipped with the high-accuracy and large-aperture antennas. One of the effective methods to construct the modular antennas with ultra-high accuracy and ultra-large aperture is on-orbit assembly technology. During the on-orbit assembly missions, the assembly error is a key factor to affect the surface accuracy of the modular antennas. This paper studies the node design of each module and the assembly error analysis of the modular antennas. A design method of the module nodes is presented with consideration of the assembly gap between two modules. Meanwhile, a soft connection mechanism is designed to ensure the mobility among the assembly modules. To investigate the transmission law of the assembly errors, an analytical model of assembly error is derived based on the exponential product method. In order to establish the deformation surface with rotation and displacement assembly errors, an error ball concept is proposed by the analytical model. To decrease the assembly errors, the actuators are installed among some modules. Moreover, an adjustment method is proposed to obtain the adjustment amounts of actuators. Finally, the correctness of analytical model and the effectiveness of the adjustment method are demonstrated by the numerical simulations.
Fully rough wall-sheared turbulence is composed of an inner and outer layer, the former occupied by sinuous structures sustained by the well-known autonomous inner cycle, the latter occupied by inclined parcels of momentum deviations relative to the average. The outer-layer structures are also known as uniform momentum zones (UMZs), where the presence of successive UMZs manifests instantaneously with a distinct ‘staircase’ pattern in streamwise velocity. Direct numerical simulation (DNS) of fully rough channel turbulence was recently used to interpret UMZs as wakes originating from antecedent bluff-body-like interactions within the inner layer (Anderson & Salesky, J. Fluid Mech., vol. 906, 2020, A8). Wake-scaling arguments agreed precisely with instantaneous results from DNS. Foremost among these results was evidence that the instantaneous wall-normal gradient of streamwise velocity exhibited scaling of ${\sim }x_3^{-1/2}$, where $x_3$ is wall-normal location; this is in contrast to logarithmic scaling, which requires the wall-normal gradient of streamwise velocity to scale as ${\sim }x_3^{-1}$. Herein, wake-scaling arguments have been advanced and compared against results from wall-modelled large-eddy simulation (LES). New results from the ‘bottom up’ wake-scaling arguments agree with LES results, such that the shear associated with the instantaneous staircase-like streamwise velocity follows a clear trend. We have leveraged conditional sampling during LES – predicated upon instantaneous low-frequency, high-magnitude surface stress values known to correspond to large-scale inertial-layer coherence – to further assess the predictive value of the wake-scaling arguments. Model results compare favourably.
Childhood behavioral problems are highly prevalent in school-aged children and are associated with poor long-term outcomes. Yet little is known about their association with patterns of partnering in adulthood.
Objectives
To (1) describe patterns of partnering from age 18-35 years in a large population-based sample, and (2) examine the association between childhood behavioural problems and adult partnering patterns.
Methods
Behavioural ratings were prospectively obtained from teachers when children (n=2960) were aged 10-12 years – for inattention, hyperactivity, aggression-opposition, anxiety and prosociality – and linked to their tax return records from age 18-35 years. We used group-based trajectory modelling to identify distinct trajectories of partnering (married or cohabitating) and multinomial regression models to examine the association between childhood behaviour and trajectory group membership.
Results
Five distinct trajectories of partnering were identified: early-partnered (n=420, 14.4%), mid-partnered (n=620, 21.3%), late-partnered (n=570, 19.2%), early-separated (n=460, 15.5%), and delayed-or-unpartnered (n=890, 30.0%). After adjustment for sex and family background, children rated as being anxious or inattentive were more likely to remain unpartnered from age 18 to 35 years, while those rated as aggressive-oppositional or inattentive were more likely to separate and return to unpartnered status. Prosocial behaviours were consistently associated with earlier and more sustained partnership. Participants in the early-separated and delayed-or-unpartnered trajectories were also more likely to have left high school without a diploma and to have lower earnings.
Conclusions
Childhood behavioural problems were associated with increased likelihood of being unpartnered and of partnership dissolution, which has implications for the psychological health and wellbeing of individuals and their families.
A uniform distribution of roughness elements of height, $h$, enhances turbulent momentum exchanges in wall flows of thickness, $\delta$. For $\delta/h$ above a nominal threshold, this distribution of elements enhances drag, but does not induce structural response to outer-/inertial-layer turbulence. Large-scale spatial variability in element attributes, however, can induce $\delta$-scale response in the instantaneous and Reynolds-averaged flow. For the case of a large-scale heterogeneity aligned orthogonal and parallel to the primary transport direction, the Reynolds-averaged flow responds with formation of an internal boundary layer (IBL) and counter-rotating secondary cells, respectively. For oblique flow-heterogeneity alignments, Anderson (J. Fluid Mech., vol. 886, 2020, p. A15), showed that IBL formation persists for flow-heterogeneity aligned at a series of oblique angles, before abruptly collapsing and transitioning to counter-rotating secondary cells at a critical obliquity. We define flow-roughness obliquity angle with symbol, $\theta$, where $\theta = 0$ and ${\rm \pi}/2$ corresponds with streamwise and spanwise heterogeneity, respectively, while the critical obliquity angle is denoted by $\theta_c$. We have used large-eddy simulation to perform a comprehensive parametric assessment on the effect of obliquity, element height, and spacing between adjacent ‘rows’ of elements, all of which is intended to identify the aforementioned critical obliquity. We once again report the aforementioned IBL persistence. It is shown that this response is a product of successive element sheltering, which can be recorded via the element frontal area index: as obliquity angle increases, there is a critical obliquity at which downflow elements fall in the sheltering zone of upflow elements; we find that $\theta_c = 22 {\rm \pi}/ 56$.
To evaluate the impacts of guanidinoacetic acid (GAA) and coated folic acid (CFA) on growth performance, nutrient digestion and hepatic gene expression, fifty-two Angus bulls were assigned to four groups in a 2 × 2 factor experimental design. The CFA of 0 or 6 mg/kg dietary DM folic acid was supplemented in diets with GAA of 0 (GAA−) or 0·6 g/kg DM (GAA+), respectively. Average daily gain (ADG), feed efficiency and hepatic creatine concentration increased with GAA or CFA addition, and the increased magnitude of these parameters was greater for addition of CFA in GAA− diets than in GAA+ diets. Blood creatine concentration increased with GAA or CFA addition, and greater increase was observed when CFA was supplemented in GAA+ diets than in GAA− diets. DM intake was unchanged, but rumen total SCFA concentration and digestibilities of DM, crude protein, neutral-detergent fibre and acid-detergent fibre increased with the addition of GAA or CFA. Acetate:propionate ratio was unaffected by GAA, but increased for CFA addition. Increase in blood concentrations of albumin, total protein and insulin-like growth factor-1 (IGF-1) was observed for GAA or CFA addition. Blood folate concentration was decreased by GAA, but increased with CFA addition. Hepatic expressions of IGF-1, phosphoinositide 3-kinase, protein kinase B, mammalian target of rapamycin and ribosomal protein S6 kinase increased with GAA or CFA addition. Results indicated that the combined supplementation of GAA and CFA could not cause ADG increase more when compared with GAA or CFA addition alone.
In conventional linear parameter-varying (LPV) modelling and gain scheduling control design for turbojet engines, the linearisation is performed at a set of equilibrium points, and the validity of such LPV models is ensured near the equilibria. However, the linear model can only provide an approximate description of the engine’s state when the system operates away from equilibrium. In this paper, it is suggested that such linearisation should be carried out not only at equilibrium states but also in transient (off-equilibrium) operating regimes. This will result in a global approximation to the system states whether equilibrium or off-equilibrium. Theoretically, the transient control performance can be improved by introducing such an off-equilibrium linearisation-based control procedure. Subsequently, a gain scheduling control procedure based on off-equilibrium linearisation models is proposed by using sum-of-squares (SOS) programming, which, compared with many convex programming methods, can provide less conservative results. The resulting off-equilibrium linearisation-based nonlinear control procedure with SOS programming can capture a wide range of transient engine dynamics with better accuracy, and further achieve better control performance.
This study aimed to investigate the benefit of Bonebridge devices in patients with single-sided deafness.
Method
Five patients with single-sided deafness who were implanted with Bonebridge devices were recruited in a single-centre study. Participants’ speech perception and horizontal sound localisation abilities were assessed at 6 and 12 months post-operatively. Speech intelligibility in noisy environments was measured in three different testing conditions (speech and noise presented from the front, speech and noise presented from the front and contralateral (normal ear) side separately, and speech presented from the ipsilateral (implanted Bonebridge) side and noise from the contralateral side). Sound localisation was evaluated in Bonebridge-aided and Bonebridge-unaided conditions at different stimuli levels (65, 70 and 75 dB SPL).
Results
All participants showed a better capacity for speech intelligibility in quiet environments with the Bonebridge device. The speech recognition threshold with the Bonebridge device was significantly decreased at both short- and long-term follow up in the speech presented from the ipsilateral (implanted Bonebridge) side and noise from the contralateral side condition (p < 0.05). Additionally, participants maintained similar levels of sound localisation between the Bonebridge-aided and unaided conditions (p > 0.05). However, the accuracy of localisation showed some improvement at 70 dB SPL and 75 dB SPL post-operatively.
Conclusion
The Bonebridge device provides the benefit of improved speech perception performance in patients with single-sided deafness. Sound localisation abilities were neither improved nor worsened with Bonebridge implantation at the follow-up assessments.
Ovarian follicle selection is a natural biological process in the pre-ovulatory hierarchy in birds that drives growing follicles to be selected within the ovulatory cycle. Follicle selection in birds is strictly regulated, involving signaling pathways mediated by dietary nutrients, gonadotrophic hormones and paracrine factors. This study aimed to test the hypothesis that dietary Ca may participate in regulating follicle selection in laying ducks through activating the signaling pathway of cyclic adenosine monophosphate (cAMP)/protein kinase A (PKA)/extracellular signal-regulated kinase (ERK), possibly mediated by gonadotrophic hormones. Female ducks at 22 weeks of age were initially fed one of two Ca-deficient diets (containing 1.8% or 0.38% Ca) or a Ca-adequate control diet (containing 3.6% Ca) for 67 days (depletion period), then all birds were fed the Ca-adequate diet for an additional 67 days (repletion period). Compared with the Ca-adequate control, ducks fed 0.38% Ca during the depletion period had significantly decreased (P < 0.05) numbers of hierarchical follicles and total ovarian weight, which were accompanied by reduced egg production. Plasma concentration of FSH was decreased by the diet containing 1.8% Ca but not by that containing 0.38%. The ovarian content of cAMP was increased with the two Ca-deficient diets, and phosphorylation of PKA and ERK1/2 was increased with 0.38% dietary Ca. Transcripts of ovarian estradiol receptor 2 and luteinizing hormone receptor (LHR) were reduced in the ducks fed the two Ca-deficient diets (P < 0.05), while those of the ovarian follicle stimulating hormone receptor (FSHR) were decreased in the ducks fed 0.38% Ca. The transcript abundance of ovary gap junction proteins, A1 and A4, was reduced with the Ca-deficient diets (P < 0.05). The down-regulation of gene expression of gap junction proteins and hormone receptors, the increased cAMP content and the suppressed hierarchical follicle numbers were reversed by repletion of dietary Ca. These results indicate that dietary Ca deficiency negatively affects follicle selection of laying ducks, independent of FSH, but probably by activating cAMP/PKA/ERK1/2 signaling pathway.
There seems to be geographical differences in decisions about breast conserving surgery (BCS) in breast cancer patients. This study was to evaluate patients’ attitude to BCS and to assess the factors affecting cancer practice in West China.
Methods:
A structured questionnaire was distributed to 184 patients, eliciting information about the patients’ characteristics, occupation, education, family life, recognition of illness, knowledge about BCS, the main means of gaining surgery information, selecting surgery approaches, preferences to breast reservation.
Results:
In all, 163 patients completed the questionnaire. The results indicated that only 7.4% of patients received BCS and 23% of the remaining patients desired to have BCS and the affecting factors were significantly associated with their family life, recognition of illness and the main means of gaining surgery information (P < 0.05). No associations were between BCS selecting and the other variables studied. The most frequent reasons for selecting BCS were keeping the female shape and improving quality of life (71%), the second most were postoperative recovery, minimal influence of physical function (47%) and patients’ knowledge about BCS (42%). The most frequent reasons for not selecting BCS were uncertainty about BCS results and worry about recurrence (81%), the second most was the elderly age unnecessary for BCS (40%).
Conclusions:
The findings indicate that breast cancer patients in West China do not take BCS as the first choice as the best treatment method. It is warranted that further study of more patients, attitude of patients’ partners and physicians to BCS.
To introduce some questionnaires related to family environment such as FAD-GFS (The General Functioning Scale of the MacMaster Family Activity Device), SLE (stressful life events), FSQ (Family Stresses Questionnaire), FLQ (Family Life Questionnaire), EFQ (Everyday Feelings Questionnaire) and evaluate their validity and reliability.
Methods
Using cross-sectional design. The general questionnaire, FAD-GFS, SLE, FSQ, FLQ, EFQ were used to collect information about family environment from 504 parents of only children FACESII-CV and Index of General Affect were used as scale of criteria related.
Results
The reliability and validity of FAD-GFS, SLE, FSQ, FLQ, EFQ is: Cronbach coefficient were 0.695 to 0.749; re-test reliability were 0.712 to 0.901; The scores of the scale in those questionnaires were correlated with each factor significantly and the coefficient of correlation is more than those between each factor of those scales. The correlation between the scores of FSQ, EFQ and the scores of Index of General Affect was-0.192, 0.539; The correlation between the scores of FAD-GFS, FLQ the score of total and three factor differently and the scores of family cohesion scores (FACESII-CV) was -0.423, 0.237, 0.514, 0.302, 0.210.
Conclusion
FAD-GFS, SLE, FSQ, FLQ, EFQ has good reliability and validity, in line with requirements of psychometric and is useful as a tool to evaluate the family environment.
When constrained by limited resources, how do we choose axioms of rationality? The target article relies on Bayesian reasoning that encounter serious tractability problems. We propose another axiomatic foundation: quantum probability theory, which provides for less complex and more comprehensive descriptions. More generally, defining rationality in terms of axiomatic systems misses a key issue: rationality must be defined by humans facing vague information.
The strong-coupling mode, called the “quasimode”, is excited by stimulated Brillouin scattering (SBS) in high-intensity laser–plasma interactions. Also SBS of the quasimode competes with SBS of the fast mode (or slow mode) in multi-ion species plasmas, thus leading to a low-frequency burst behavior of SBS reflectivity. Competition between the quasimode and the ion-acoustic wave (IAW) is an important saturation mechanism of SBS in high-intensity laser–plasma interactions. These results give a clear explanation of the low-frequency periodic burst behavior of SBS and should be considered as a saturation mechanism of SBS in high-intensity laser–plasma interactions.
We examine whether underwriters price up weakly demanded initial public offerings (IPOs) to prevent withdrawal. Our empirical strategy exploits a discontinuity in the distribution of IPO prices around the low boundary of the filing range. Offerings with a high ex ante withdrawal probability that are priced at this boundary are likely priced up to meet issuers’ reservation prices. We compare the aftermarket returns of these IPOs to the returns of other weakly demanded offerings where issuers’ reservation prices were likely not binding, and we identify a negative 8.4-percentage-point differential attributable to the aggressive pricing inherent in setting the price at the low boundary when withdrawal risk is high.