Predicting the terminus position of Greenland’s marine-terminating glaciers remains a major challenge for ice-sheet modeling. Improving model parameterizations requires understanding the dominant drivers of terminus change. Here, we employ the Liang–Kleeman information flow method to quantify the contributions of bed slope, sea-ice concentration, runoff, air temperature and ocean thermal forcing to changes in glacier terminus position and frontal ablation. We focus on three major marine-terminating glaciers, Jakobshavn Isbræ (JI), Kangerlussuaq Glacier (KG) and Helheim Glacier (HG), between 2000 and 2021. Our analysis reveals that atmospheric and oceanic forcings exert comparable influence on glacier retreat, with their causal effects demonstrating pronounced seasonal variability. These drivers dominate during the summer months while exerting minimal impact in winter. Analysis of ocean thermal forcing highlights the 0–100 m surface layer as the primary driver of terminus variability for JI and KG, underscoring the critical role of surface-ocean processes. Notably, despite theoretical relevance, bed slope at kilometer scales shows no significant causal influence, emphasizing the nonlinearity and complexity of topographic controls. Finally, we develop a parameterized statistical model that explains 53–66% of the variance in frontal ablation for the highly responsive JI and KG, but only 38% for the less sensitive HG.