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This chapter addresses the role of oxytocin and vasopressin in shaping social behavior, reviewing both human and animal studies. The chapter critiques the early optimism around oxytocin’s ability to foster trust and emotional understanding, providing evidence from failed replication studies and highlighting the effects of sex, context, and brain region-specific interactions. It also assesses clinical research on oxytocin as a potential treatment for autism spectrum disorder, pointing out the limitations of current approaches and the complexity of translating animal research into human applications.
Parental prenatal mood and anxiety disorders (PMADs) are linked to child neurodevelopmental disorders (NDDs), but evaluations of the magnitude and mechanisms of this association are limited. This study estimates the strength of the association and whether it is impacted by genetic and environmental factors.
Methods
A systematic search of PubMed, CENTRAL, PsycINFO, OVID, and Google Scholar was performed for articles published from January 1988 to September 2025. Of 2,420 articles screened, 74 met the inclusion criteria. Meta-analyses were conducted on 21 studies, and 53 were included in the narrative synthesis. We conducted random-effects meta-analyses, along with tests for heterogeneity (I2) and publication bias (Egger’s test). The review followed PRISMA and MOOSE guidelines.
Results
Maternal PMADs were associated with a significantly increased risk of attention-deficit/hyperactivity disorder (ADHD; odds ratio [OR] 1.91, 95% confidence interval [CI] 1.45–2.52) and autism spectrum disorder (ASD; OR 1.75, 95% CI 1.43–2.14) in children. Paternal PMADs were also associated with the risk of NDDs, with combined odds for ASD and ADHD (OR = 1.23, 95% CI 1.14–1.33). Several studies suggested that the link between parental PMADs and offspring NDDs might be impacted by both genetic and environmental factors, including the impact of ongoing parental depression on child behavior.
Conclusions
Parental PMADs are associated with increased risk of NDDs in children. These findings likely reflect a combination of inherited liability and environmental processes; clarifying mechanisms will require genetically informed designs. Regardless of mechanism, offering optional, family-centered developmental support may help promote child well-being in families where a parent is experiencing PMADs.
Neurodivergence encompasses neurodevelopmental conditions including autism, attention-deficit hyperactivity disorder (ADHD) and Tourette syndrome. Particular physical traits, notably those linked to joint hypermobility, have an established association with both neurodivergence and bipolar affective disorder.
Aims
This case-control study tested, first, whether the presence of joint hypermobility predicted bipolar affective disorder and, secondly, whether neurodivergent characteristics were important in understanding this relationship.
Method
Data were collected from 52 participants with self-reported clinical diagnoses of bipolar affective disorder and from a comparison group of 54 participants without diagnosis of bipolar affective disorder. All participants were assessed on screening instruments for autism (Ritvo Autism Asperger Diagnostic Scale; RAADS-R), ADHD (Wender Utah Rating Scale; WURS) and joint hypermobility. Group differences were explored, and odds ratios calculated for the presence of bipolar and neurodivergence given the presence of hypermobility. A mediation analysis was performed to determine the contribution of neurodivergent characteristics to the relationship between joint hypermobility and bipolar affective disorder.
Results
The presence of joint hypermobility significantly predicted the presence of bipolar disorder (odds ratio 5.1; 95% CI = 2.1, 12.4). In the bipolar affective disorder group, the prevalence of likely autism and ADHD was greater (84.6 and 65.4% respectively) than in the comparison group (22.2 and 3.7% respectively). The odds ratio for a diagnosis of bipolar affective disorder was 18.2 (95% CI = (6.70, 49.41)) in those meeting the threshold for likely autism; and 46.89 (95% CI = 9.96, 220.74) in participants meeting the threshold for likely ADHD. Mediation analysis showed that autistic, ADHD and pooled neurodivergent characteristics mediated the link between joint hypermobility and bipolar affective disorder.
Conclusions
This suggests a potential mechanism for affective pathophysiology, through developmental characteristics associated with joint hypermobility. The appreciation of interacting physical and neurodivergent traits to the expression of psychiatric illness has implications for diagnostic formulation, personalised medicine and service design.
Some individuals may compensate for their underlying social cognitive vulnerabilities, therefore exhibiting adaptive real-world social behavior through enhanced attentional mechanisms despite underlying social cognitive challenges. From a developmental psychopathology framework, adaptive behaviors vary dimensionally in the community and across development to promote compensation. Yet, compensation in the broader community of children without categorical clinical diagnoses has not yet been studied. Moreover, the extent to which compensation demonstrates stability versus change is unknown. This study examines childhood social compensation longitudinally in a community-ascertained sample (N = 315) of 7–17 year-old (M = 12.15, SD = 2.97) children (33% non-white, 44% female). Compared to children with equally poor emotion recognition but substantially more real-world social behavior challenges, high compensators demonstrated better attentional alerting (d = 0.81, p < 0.001) without the “cost” of internalizing symptoms. Results showed both stability and instability in compensation group membership over time, with the high compensation group more likely to have unstable classification relative to the no compensation group (OR = 0.26, p = 0.001). Taken together, this study clarifies the processes underlying social compensation in the community and suggests a developmental psychopathology perspective is valuable in understanding how compensation develops across the lifespan. Such work has the potential to inform practices and policies that support social adaptation and promote resilience.
The goal of this article is to provide a balanced assessment of the significance autism has for the scientific study of language. While linguistic profiles in autism vary greatly, spanning from a total absence of functional language to verbal levels within the typical range, the entire autism spectrum is robustly characterized by lifelong disabilities in intersubjective communication and persistent difficulties in adopting the perspective of other people. In that sense, autism constitutes a unique profile in which linguistic competence is dissociated from communication skills. Somewhat paradoxically, autism is often mentioned to underscore the importance of mind reading for language use and of intersubjective communication for the emergence of language. Yet experimental studies on pragmatics in autism indicate that many pragmatic processes unfold without adopting one's conversational partner's perspective. Moreover, the patterns of language acquisition and learning in autism represent a strong challenge to the central role constructionist theories assign to socio-communicative skills. Data on autism thus force a reconsideration of the a priori conceptual boundaries on language learnability that shape the foundational debates between constructionist and nativist linguistic theories.
In his target article, ‘Autism, constructionism, and nativism’, Kissine (2021) argues that data from autism should be taken into consideration in the debate about L1 acquisition. This paper responds to Kissine's piece by pointing out several of its underlying assumptions and suggesting directions for future research on the topic. Traditional framings of autism as a deficit have recently been challenged in favor of an identity-based approach, the neurodiversity paradigm, which suggests that autistic speech should not be measured in terms of its resemblance to nonautistic speech and that literature on intercultural miscommunication may offer insights into autistic communication. There are some indications that distinct autistic discourse practices may be identifiable in communities of practice, and studies on autistic literacy could benefit from considering the theoretical perspectives found in literature on multimodality and translanguaging. Finally, research on language acquisition might be strengthened by the incorporation of holistic neurocognitive theories about autistic minds.
Despite policy calling for compulsory education in China, many children with autism are not in school. This article examines the establishment of autism-related non-governmental organizations (NGOs) in China to meet needs not being met by the state. We focus on the background and motivation in founding and running these NGOs, after first considering the broader context of state decentralization and NGOs roles in supplementing welfare needs in reforming societies, and the educational policy context of China. This study used mixed methods, including questionnaires with open-ended and limited choice questions, and follow-up discussion email. The goals of NGO leaders—more than 50% of whom are parents of children with autism—are to make up for where government implementation of educational policy is insufficient; help others and advocate for inclusion in society; and do meaningful work. Implications from these findings are discussed.
The constructionist approach argues that communication is central to language learning, language use, and language change. We argue that the approach provides a useful perspective on how autistic children learn language, as it anticipates variable outcomes and suggests testable predictions. First, a reduced ability and interest in tracking the attention and intentions of others should negatively impact early language development, and a wealth of evidence indicates that it does. Second, and less discussed until recently, a hyperfocus on specifics at the expense of generalizations, common among people on the spectrum, should also negatively impact language development, and recent evidence suggests this is also the case. Pace Kissine's 2021 target article, it is unsurprising that children can learn some second language from watching videos, and it is unclear how an appeal to ‘innate’ language-specific knowledge could explain the range of outcomes of individuals on the autism spectrum.
This article defends a new type of preferential hiring. Rather than compensating groups for past or present employment-related discrimination, it seeks to ensure that groups with disproportionate unemployment rates that are due significantly – but not necessarily wholly – to their members having relatively narrow competencies, such as autistic individuals and people with hearing loss, ADHD and lower education levels, are prioritized for jobs that match their abilities. After defending such competency-based preferential hiring based on its benefits for persons with narrower competencies and for societies more broadly, I address several criticisms, including concerns that this approach may be stigmatizing.
Transgender and gender diverse (TGD) people show different trajectories after gender transition. While some continue to transition, others detransition (DT), that is, stop or reverse the process. Both populations experience poor mental health, but no study has compared whether they have different psychological profiles and needs. This exploratory study compared TGD and DT participants in terms of psychopathological symptoms, personality variables, and the possible presence of eating disorders (ED) and autism spectrum disorders (ASD). A total of 29 TGD participants (M age = 28.28, 72.4% female at birth) and 21 DT participants (M age = 29.19, 66.7% female at birth) completed the Personality Assessment Inventory (PAI), the Sick-Control-One stone-Fat-Food (SCOFF), and the 10-item Autism Quotient (AQ-10). Of these, 28% screened positive for ED and 28% for ASD, and the percentage for ASD was higher in the DT group. TGD participants had elevated scores on borderline features and mania, whereas DT participants had elevated scores on anxiety-related disorders. The TGD group showed significantly higher scores on antisocial features, alcohol problems, and dominance, and significantly higher rates of self-harm; the DT group had significantly higher scores on phobias and significantly higher rates of social detachment. Both groups exhibited elevated scores on suicidal ideation, stress, and nonsupport. The results suggest that TGD and DT participants may have different psychological profiles, with TGD participants exhibiting more externalizing symptoms and DT participants reporting more neurodiversity and internalizing symptoms. The findings highlight common and distinct vulnerabilities and needs that should be considered in clinical practice.
In this chapter, we examine the foundations of the development of social cognition—how children come to understand themselves and others. We begin by looking at the development of theory of mind– how children come to understand that people’s behavior is influenced by their beliefs and desires. We then examine the development of social learning, the acquisition of social information and behavior, which is responsible for humans’ ability to transfer information with such high fidelity from one person (and generation) to another. We then examine the development of the self, including self-concept, self-esteem, and self-efficacy. We conclude the chapter by looking at a related topic, identity formation in adolescence, including the development of ethnic identity.
As a result of its complexity, integration of multiple functions and brain regions, and prolonged development, decision-making is particularly vulnerable to deficit or dysfunction. Decision-making deficits have been described in schizophrenia, psychopathy, autism and depression. A commonality in proposed explanations is that of differences in the way networks associated with decision-making are structured. In some cases it may be over-connection, in others under-connection.
Relative to the general population, autistic adults are at elevated risk for depression. Factors related to this risk are poorly understood, yet identifying such factors is important for improving mental health in autistic people. Emotion regulation (ER) challenges may be one such factor. However, few studies have examined ER challenges and depression in autistic adults. We examined ER challenges, depressive symptomatology and their associations in 775 (aged 18–83 years) autistic adults using network analysis, a method that permits identification of key components of ER and depression and their interrelatedness. Three non-regularized weighted undirected networks were estimated: ER challenges, depressive symptomatology, and combined ER-depressive challenges. Community structures revealed in the ER challenges and depressive symptomatology networks align with theoretical/nosological models of ER challenges/depressive symptoms as well as extant research using network analysis to examine these constructs. The combined ER challenges-depressive symptomatology network indicated that ER challenges and depressive symptomatology are interrelated but distinct constructs. These preliminary findings using cross-sectional data provide a first step in understanding associations between a candidate factor in depression vulnerability in autistic adults – ER challenges – and identify important future research directions.
We aimed to quantify attention-deficit hyperactivity disorder (ADHD) and autism assessment requests, and explore correlations with public interest and COVID-19 restrictions. We collected data on referrals to adult ADHD or autism services, Google searches for ‘autism’ or ‘ADHD’, birth gender ratios, ADHD prescriptions in England and COVID-19 restriction measures in four countries.
Results
ADHD assessment demand tripled from July 2020 to January 2023, with Google searches for ADHD rising in parallel. Autism referrals and searches saw smaller, similarly timed rises. Female referrals outstripped males. ADHD prescriptions rose particularly in those aged 30–34 years. Google searches for ADHD unexpectedly rose from July 2020 in four countries, correlating with sustained intensity of national COVID-19 restrictions.
Clinical implications
Public interest may have driven demand for ADHD assessments, with COVID-19 restrictions encouraging social media use facilitated by easy electronic information access. The public has decided that ADHD is important, independent of professional views. It is now critical that a consensus is reached to determine who benefits most from an ADHD diagnosis and medication.
This chapter provides an overview of neurodevelopmental disorders (NDDs) in children and young people. The definition and classification of NDDs is discussed, including key differences between ICD-10 and ICD-11 and the problematic use of language in diagnostic classifications, which is at odds with the social model of disability. Important stages of a multidisciplinary assessment of NDDs include a detailed developmental history, a psychosocial history, observation of the child, an assessment of the child’s communication and learning and supplementary rating scales. The role of professionals such as Community Paediatricians, Speech and Language Therapists, Occupational Therapists, teachers and Educational Psychologists is highlighted. Features of the main NDDs are outlined, including Autism Spectrum Disorder, Attention Deficit Hyperactivity Disorder, Specific Disorders of Development and Language and Tic disorders. Finally, an overview of treatment approaches and their evidence base is explored.
Sensory Over-Responsivity Disorder (SORD) is characterized by extreme sensitivity to everyday sensory input, which can interfere with children’s emotional, behavioral and social development. Despite growing interest, limited research has explored its developmental effects in the absence of other psychiatric diagnoses. This study investigated self-regulation and related clinical features in preschool children with SORD who did not meet diagnostic criteria for autism spectrum disorder, attention-deficit/hyperactivity disorder (ADHD), or obsessive-compulsive disorder. The sample included 15 children with SORD and 15 typically developing controls, matched by age and gender. Diagnoses were made using the Preschool Age Psychiatric Assessment, and comorbidities were excluded using Diagnostic Classification of Mental Health and Developmental Disorders of Infancy and Early Childhood: Revised Edition criteria. Self-regulation was assessed through the Head-Toes-Knees-Shoulders-Revised task. While no significant differences were found in autistic traits, repetitive behaviors or executive functioning, children with SORD demonstrated significantly poorer self-regulation (p < .001). Poorer self-regulation was strongly associated with greater SORD severity, elevated ADHD symptoms, lower social interaction and increased emotional and sensory reactivity. These findings suggest that self-regulation difficulties are a core feature of SORD, even in the absence of comorbid psychiatric disorders. Early identification and interventions targeting self-regulation may help improve long-term outcomes for children affected by SORD.
Off-licence psychotropic use in people with intellectual disability and/or autism, in the absence of psychiatric illness, is a major public health concern in England.
Aims
To ascertain and compare views of psychiatrists and non-psychiatrists working with people with intellectual disability and/or autism on psychotropic medication optimisation for this population.
Method
A cross-sectional survey of 13 questions was disseminated online among psychiatrists and other health professionals working with people with intellectual disability and/or autism across England, using a non-discriminatory exponential snowballing technique leading to non-probability sampling. The questionnaire covered demographic characteristics, perceived barriers/benefits of psychotropic optimisation (including ethnicity) and views on implementation of a national medicine optimisation programme. Quantitative analysis used chi-squared, Mann–Whitney and unpaired t-tests, with significance taken as P < 0.05. Thematic analysis of free-text responses was undertaken with Braun and Clarke’s methodology.
Results
Of 219 respondents, significant differences in attitudes to most issues emerged between psychiatrists (n = 66) and non-psychiatrists (n = 149). Psychiatrists had less optimism of a successful national medication optimisation programme if commissioned, or achieving 50% reduction in psychotropic overprescribing and inappropriate psychotropic prescribing generally. Perceived barriers to reducing overmedication differed significantly between the psychiatrists and non-psychiatrists, Thematic analysis identified five themes (system issues, resources, medication challenges, family and carers, and training and alternatives/structure).
Conclusions
This is the first study to highlight important differences between psychiatrists and non-psychiatrists’ attitudes to psychotropic optimisation despite respondents overall being broadly supportive of its need. A major finding is the hitherto unquantified concerns of patient ethnicity and its impact on psychotropic optimisation principles.
Autistic adolescents are at higher risk of self-harm, suicidal behaviours, and emotion dysregulation compared with their non-autistic peers. Dialectical behaviour therapy (DBT) is an evidence-based treatment for self-harm and suicidal behaviour with emerging literature of the application of DBT for autistic populations. Despite this, no qualitative research has investigated the experiences of autistic adolescents of standard DBT. Therefore, this study aimed to explore autistic adolescents’ experiences of non-adapted DBT. Ten adolescents who had or were seeking an autism diagnosis, and were in a DBT programme, completed semi-structured interviews. Qualitative data from the interviews were analysed using reflexive thematic analysis. Themes were generated for each objective. Objective 1 included themes about the lived experience of autistic adolescents accessing DBT, including: ‘The impact of invalidation’, ‘Fostering acceptance and understanding’, ‘What does autism mean to me?’, and ‘Autism and mental health difficulties’. The themes regarding Objective 2 were about the experiences of the various modes of DBT and were organised by each client-facing mode. Objective 3 included themes highlighting the experience of utilising DBT skills in daily life, which included: ‘Barriers to skills use’, ‘Supporting skills use’, and ‘Skills practice or masking?’. Finally, Objective 4 included themes regarding the recommendations participants had for optimising DBT for autistic people: ‘Improving written materials’ and ‘General accessibility advice’. These findings suggest for DBT therapists to embody cultural humility, curiosity, validation, and flexibility when building neuro-affirmative competencies for supporting autistic individuals. Results are discussed in relation to the application and acceptability of DBT for this group.
Key learning aims
(1) Recent publications (e.g. Keenan et al., 2023) have explored the experience of autistic adults accessing DBT and highlighted the need for clinicians to work collaboratively with clients and make reasonable adjustments to improve autistic adults’ understanding and adherence to DBT.
(2) To date, no qualitative studies have explored the experience of autistic adolescents accessing the Rathus and Miller (2015) Adolescent DBT model. The current study explores the views of autistic adolescents on how autism is discussed and considered by clinicians when supporting them to access different components of DBT when describing the strengths and barriers they experience.
(3) Adopting a bottom-up approach, we identify key themes from adolescents’ perspectives on how to support them to access and engage with different DBT components, ranging from making environmental adaptations to meet individual sensory needs to improve accessibility, to providing more opportunities for personalised learning using neuro-affirmative examples that can improve generalisability of skills in everyday life. We provide recommendations for clinicians to consider on ways of adapting the process and content of DBT to increase accessibility and engagement for autistic adolescents in treatment.
Autistic high school students overwhelmingly have a poor experience of school. Research into this stage of life is limited, and researchers have tended not to talk to autistic students directly, instead hearing from non-autistic observers such as teachers and parents. This study aimed to address this gap in our knowledge by interviewing autistic students in mainstream high schools about their experience of school and their ideas for how this could be improved. Ten autistic students (13 to 20 years old) in Australian high schools were interviewed. Students overwhelmingly reported a negative experience. Most said their ideal school would be one where teachers and peers had greater understanding about autism and teachers had training in autism. By including the student voice, this research makes a valuable contribution to our understanding of autistic students’ school experience, adding depth and detail, and including what they would like to see changed. Importantly, the interview data also challenged misconceptions about what autistic students prioritised. The voice of autistic teens can make an important contribution to policies and practices aimed at improving their experience of school.