This study considers the global instability of unidirectional flows through single, and double, bifurcation models using linear stability and direct numerical simulation (DNS). The motivation is respiratory flows, so we consider flow in both directions, through two geometries. We identify conditions (quantified by the Reynolds number,
${Re}=U^*D/\nu$, where
$U^*$ is the peak centreline velocity,
$D$ is the primary pipe diameter and
$\nu$ is the kinematic viscosity) where temporal fluctuations occur using DNS. We calculate the linear stability of the steady flows, identifying the critical Reynolds number and leading unstable modes. For flows from single to double pipe, the critical Reynolds number is dependent on the number of bifurcations in the domain, but the mode structures are similar, with growth observed in regions dominated by longitudinal vortices formed by the centrifugal imbalance of flows passing through curved bifurcations. Flows in the opposite direction, from double to single pipe, also depend on the number of bifurcations in the domain. The flow through the double-bifurcation case undergoes two spatial symmetry-breaking bifurcations, altering the mode structure and critical Reynolds number. In all cases, the critical Reynolds number closely matches with temporal fluctuations observed from DNS, suggesting transition is the result of a linear instability, similar to other curved geometries like toroidal and helical pipes. We compare the frequencies of the modes with the frequencies observed from DNS, finding a close match during both initial and saturated flows. These results are important for understanding respiratory flows where turbulent mixing and streaming contribute to gas transport.